Journal article
Genetic determinants of height growth assessed longitudinally from infancy to adulthood in the northern finland birth cohort 1966
U Sovio, AJ Bennett, LY Millwood, J Molitor, PF O'Reilly, N J.Timpson, M Kaakinen, J Laitinen, J Haukka, D Pillas, I Tzoulaki, J Molitor, C Hoggart, LJM Coin, J Whittaker, A Pouta, AL Hartikainen, NB Freimer, E Widen, L Peltonen Show all
Plos Genetics | PUBLIC LIBRARY SCIENCE | Published : 2009
Abstract
Recent genome-wide association (GWA) studies have identified dozens of common variants associated with adult height. However, it is unknown how these variants influence height growth during childhood. We derived peak height velocity in infancy (PHV1) and puberty (PHV2) and timing of pubertal height growth spurt from parametric growth curves fitted to longitudinal height growth data to test their association with known height variants. The study consisted of N = 3,538 singletons from the prospective Northern Finland Birth Cohort 1966 with genotype data and frequent height measurements (on average 20 measurements per person) from 0-20 years. Twenty-six of the 48 variants tested associated with..
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Awarded by European Commission
Funding Acknowledgements
Financial support was received from the Academy of Finland (project grants 104781, 120315 and Center of Excellence in Complex Disease Genetics), University Hospital Oulu, Biocenter, University of Oulu, Finland, NHLBI grant 5R01HL087679-02 through the STAMPEED program (1RL1MH083268-01), ENGAGE project and grant agreement HEALTH-F4-2007-201413, the Medical Research Council (studentship grant G0500539, centre grant G0600705), the Wellcome Trust (project grant GR069224), UK, and the Research Council UK fellowship. The DNA extractions, sample quality controls, biobank up-keeping and aliquotting was performed in the national Public Health Institute, Biomedicum Helsinki, Finland and supported financially by the Academy of Finland and Biocentrum Helsinki. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.