DR Laura Edgington-Mitchell

DR Laura Edgington-Mitchell

Positions

  • Activity-Based Probes for Proteases
  • Protease Biochemistry
  • Protease Inhibitors
  • Proteases in Cancer and Inflammation

Overview

OverviewText1

  • Dr. Laura Edgington-Mitchell obtained her PhD in Cancer Biology from Stanford University in California in 2012. Studying under Prof. Matthew Bogyo, she specialised in synthesising activity-based probes (ABPs) to study the activity and function of proteases involved in cell death and cancer. She pioneered new methods to detect protease activity by noninvasive optical imaging. In 2013, Dr. Edgington-Mitchell initiated postdoctoral studies with Dr. Belinda Parker at La Trobe University. There, she used ABPs targeting cysteine cathepsin proteases to study their contribution during breast cancer metastasis to bone and revealed new functions for these enzymes during the differentiation of tumour-induced immune cells into osteoclasts. In 2015, she was awarded an NHMRC Peter Doherty Fellowship. Under the mentorship of Prof. Nigel Bunnett, she established an independent research program at the Monash Institute of Pharmaceutical Sciences. There, she continued to expand the repertoire of chemical tools to study diverse protease families and explored their roles in inflammatory bowel disease, irritable bowel syndrome, pancreatitis, and cancer. Her work on proteases in oral cancer in collaboration with Prof. Brian Schmidt led to an appointment as an Adjunct Associate Professor at the New York University College of Dentistry. In January 2018, Dr. Edgington-Mitchell was awarded a Grimwade Fellowship and an ARC DECRA Fellowship and joined the Department of Biochemistry and Molecular Biology, University of Melbourne, Bio21 Molecular Science and Biotechnology Institute as a laboratory head. Building on a foundation in chemical biology, her research group aims to validate proteases as therapeutic targets in cancer and inflammation, with a particular focus on proteases that activate G Protein-Coupled Receptors (GPCRs) such as protease-activated receptor 2 (PAR2). Extended Publication List on Google Scholar: https://scholar.google.com/citations?user=7julmp4AAAAJ&hl=en   

Affiliation

Member of

  • International Proteolysis Society. Member 2009 -

Publications

Selected publications

Research

Awards

Education and training

  • PhD, Stanford University 2012
  • BA, Transylvania University 2006

Awards and honors

  • Fellow of the Australian Research Council, 2018
  • NHMRC Fellowship, 2015

Linkages

Supervision

Available for supervision

  • Y