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PROF Paul A Gleeson

Positions

Academic, Biochemistry and Molecular Biology

Publications

Selected publications

2019
- Journal Articles
  - FcRn mediates fast recycling of endocytosed albumin and IgG from early macropinosomes in primary macrophages.. Journal of Cell Science. 2019
  - Form and function of the Golgi apparatus: scaffolds, cytoskeleton and signalling. FEBS Letters. 2019
  - Intersectin-1 interacts with the golgin GCC88 to couple the actin network and Golgi architecture. Molecular Biology of the Cell. 30. 2019
  - The role of membrane trafficking in the processing of amyloid precursor protein and production of amyloid peptides in Alzheimer's disease. Biochimica et Biophysica Acta-Biomembranes. 1861. 2019
  - The trans-Golgi network is a major site for alpha-secretase processing of amyloid precursor protein in primary neurons. Journal of Biological Chemistry. 294. 2019
- Journal Articles Refereed
  - A role for Rab11 in the homeostasis of the endosome-lysosomal pathway. Experimental Cell Research. 380. 2019
  - Cargo Sorting at the trans-Golgi Network for Shunting into Specific Transport Routes: Role of Arf Small G Proteins and Adaptor Complexes. Cells. 8. 2019
2018
- Journal Articles
  - The Golgi architecture and cell sensing. Biochemical Society Transactions. 46. 2018
- Journal Articles Refereed
  - GGA1 regulates signal-dependent sorting of BACE1 to recycling endosomes, which moderates A beta production. Molecular Biology of the Cell. 29. 2018
  - GGA1 regulates signal-dependent sorting of BACE1 to recycling endosomes, which moderates A? production. Molecular Biology of the Cell. 29. 2018
  - Half-life-extended recombinant coagulation factor IX-albumin fusion protein is recycled via the FcRn-mediated pathway. Journal of Biological Chemistry. 293. 2018
  - The Golgi ribbon in mammalian cells negatively regulates autophagy by modulating mTOR activity. Journal of Cell Science. 131. 2018
2017
- Journal Articles Refereed
  - Amyloid precursor protein traffics from the Golgi directly to early endosomes in an Arl5b-and AP4-dependent pathway. Traffic. 18. 2017
  - Increased endogenous antigen presentation in the periphery enhances susceptibility to inflammation-induced gastric autoimmunity in mice. European Journal of Immunology. 47. 2017
  - Signal dependent transport of a membrane cargo from early endosomes to recycling endosomes. European Journal of Cell Biology. 96. 2017
  - The Function of the Golgi Ribbon Structure - An Enduring Mystery Unfolds!. Bioessays. 39. 2017
2016
- Journal Articles Refereed
  - Dysregulation of intracellular trafficking and endosomal sorting in Alzheimer's disease: controversies and unanswered questions. Biochemical Journal. 473. 2016
  - Emerging Insights into the Roles of Membrane Tethers from Analysis of Whole Organisms: The Tip of an Iceberg? 2016
  - Rapamycin results in Bim-mediated loss of thymic regulatory T cells during development in organ culture. International Immunology. 28. 2016
2015
- Book Chapters
  - Organizational Cell Biology: An Overview. Encyclopedia of Cell Biology. 2015
- Research Book Chapters
  - Application of flow cytometry to analyze intracellular location and trafficking of cargo in cell populations. Membrane Trafficking: Second Edition. Humana Press. 2015
- Journal Articles Refereed
  - Application of flow cytometry to analyze intracellular location and trafficking of cargo in cell populations.. Methods in Molecular Biology. 1270. 2015
  - Sorting nexin 5 selectively regulates dorsal-ruffle-mediated macropinocytosis in primary macrophages. Journal of Cell Science. 128. 2015
- Conference Proceedings
  - Post-translational modifications of beta-secretase (BACE1) sorting signal regulates endosomal trafficking and amyloid beta production. Molecular Biology of the Cell. 2015
2014
- Journal Articles Refereed
  - C9ORF72, implicated in amytrophic lateral sclerosis and frontotemporal dementia, regulates endosomal trafficking. Human Molecular Genetics. 23. 2014
  - Helios defines T cells being driven to tolerance in the periphery and thymus. European Journal of Immunology. 44. 2014
  - High-Throughput Quantitation of Intracellular Trafficking and Organelle Disruption by Flow Cytometry. Traffic. 15. 2014
  - Membrane tethering.. F1000 Prime Reports. 6. 2014
  - The role of endosomes in innate and adaptive immunity. Seminars in Cell & Developmental Biology. 31. 2014
  - Transient Systemic Inflammation Does Not Alter the Induction of Tolerance to Gastric Autoantigens by Migratory Dendritic Cells. Journal of Immunology. 192. 2014
  - Transient Treg-cell depletion in adult mice results in persistent self-reactive CD4(+) T-cell responses. European Journal of Immunology. 44. 2014
2013
- Book Chapters
  - Autoimmune Gastritis and Pernicious Anemia. The Autoimmune Diseases: Fifth Edition. 2013
- Journal Articles Refereed
  - Cargo trafficking between endosomes and the trans-Golgi network. Histochemistry and Cell Biology. 140. 2013
  - Expression of HIV-1 Vpu Leads to Loss of the Viral Restriction Factor CD317/Tetherin from Lipid Rafts and Its Enhanced Lysosomal Degradation. PLoS One. 8. 2013
  - Independent trafficking of the KCNQ1 K+ channel and H+-K+-ATPase in gastric parietal cells from mice. American Journal of Physiology - Gastrointestinal and Liver Physiology. 304. 2013
  - Intracellular Itinerary of Internalised beta-Secretase, BACE1, and Its Potential Impact on beta-Amyloid Peptide Biogenesis. Traffic. 14. 2013
  - Pathogenic T cells persist after reversal of autoimmune disease by immunosuppression with regulatory T cells. European Journal of Immunology. 43. 2013
  - Rab6a/a ' Are Important Golgi Regulators of Pro-Inflammatory TNF Secretion in Macrophages. PLoS One. 8. 2013
- Other Refereed Contribution to Refereed Journals
  - Imaging and Quantitation Techniques for Tracking Cargo along Endosome-to-Golgi Transport Pathways.. Cells. 2. 2013
- Conference Proceedings
  - The Intracellular Itinerary of Internalized beta-Secretase and its impact on APP Processing: Role of Rab11 and Sorting Signals. Molecular Biology of the Cell. 2013
2012
- Journal Articles
  - Cargo sorting and endosome-to-Golgi retrograde transport pathways.. Molecular Biology of the Cell. 23. 2012
  - Roles of the Small G Protein Arl5b in Intracellular Membrane Transport. Molecular Biology of the Cell. 23. 2012
- Journal Articles Refereed
  - Arl5b is a Golgi-localised small G protein involved in the regulation of retrograde transport. Experimental Cell Research. 318. 2012
  - Conjugation of Transferrin to Azide-Modified CdSe/ZnS Core-Shell Quantum Dots using Cyclooctyne Click Chemistry. Angewandte Chemie - International Edition. 51. 2012
  - Recycling endosome-dependent and -independent mechanisms for IL-10 secretion in LPS-activated macrophages. Journal of Leukocyte Biology. 92. 2012
  - SNX5 is essential for efficient macropinocytosis and antigen processing in primary macrophages. Biology Open. 1. 2012
- Other Refereed Contribution to Refereed Journals
  - Tracking protein aggregation and mislocalization in cells with flow cytometry. Nature Methods. 9. 2012
2011
- Journal Articles
  - Intracellular Trafficking of the beta-Secretase and Processing of Amyloid Precursor Protein (vol 63, pg 721, 2011). IUBMB Life. 63. 2011
- Journal Articles Refereed
  - A Convenient Model of Severe, High Incidence Autoimmune Gastritis Caused by Polyclonal Effector T Cells and without Perturbation of Regulatory T Cells. PLoS One. 6. 2011
  - Endosome-to-Golgi transport pathways in physiological processes. Histology and Histopathology: cellular and molecular biology. 26. 2011
  - Identification of an Endocytosis Motif in an Intracellular Loop of Wntless Protein, Essential for Its Recycling and the Control of Wnt Protein Signaling. Journal of Biological Chemistry. 286. 2011
  - Intracellular Trafficking of the beta-Secretase and Processing of Amyloid Precursor Protein. IUBMB Life. 63. 2011
  - Macropinocytosis: an endocytic pathway for internalising large gulps. Immunology and Cell Biology. 89. 2011
  - Rab9-dependent retrograde transport and endosomal sorting of the endopeptidase furin. Journal of Cell Science. 124. 2011
  - Shaping the T-cell repertoire in the periphery. Immunology and Cell Biology. 89. 2011
  - The Golgi apparatus in the endomembrane-rich gastric parietal cells exist as functional stable mini-stacks dispersed throughout the cytoplasm. Biology of the Cell. 103. 2011
  - The Regulation of Endosome-to-Golgi Retrograde Transport by Tethers and Scaffolds. Traffic. 12. 2011
  - c-Rel Controls Multiple Discrete Steps in the Thymic Development of Foxp3(+) CD4 Regulatory T Cells. PLoS One. 6. 2011
2010
- Journal Articles Refereed
  - Identification of different itineraries and retromer components for endosome-to-Golgi transport of TGN38 and Shiga toxin. European Journal of Cell Biology. 89. 2010
  - TGN golgins, Rabs and cytoskeleton: regulating the Golgi trafficking highways. Trends in Cell Biology. 20. 2010
2009
- Journal Articles Refereed
  - Regulation of HLAclass I surface expression requires CD99 and p230/golgin-245 interaction. Blood. 113. 2009
  - The Localization of the Golgin GCC185 Is Independent of Rab6A/A ' and Arl1. Cell. 138. 2009
2008
- Book Chapters
  - Structure and domain organization of the trans-Golgi network. The Golgi Apparatus: State of the Art 110 Years after Camillo Golgi's Discovery. 2008
- Research Book Chapters
  - Structure and domain oganisation of the trans-Golgi network. The Golgi Apparatus. Springer. 2008
- Journal Articles Refereed
  - A role for SNX5 in the regulation of macropinocytosis. BMC Cell Biology. 9. 2008
  - A trans-Golgi network golgin is required for the 14 regulated secretion of TNF in activated macrophages in vivo. Proceedings of the National Academy of Sciences of the United States of America. 105. 2008
  - Extrathymic mechanisms of T cell tolerance: Lessons from autoimmune gastritis. Journal of Autoimmunity. 31. 2008
  - Identification of a novel group of putative Arabidopsis thaliana beta-(1,3)-galactosyltransferases. Plant Molecular Biology. 68. 2008
  - Impact of glycans on T-cell tolerance to glycosylated self-antigens. Immunology and Cell Biology. 86. 2008
  - Isolation, culture and adenoviral transduction of parietal cells from mouse gastric mucosa. Biomedical Materials. 3. 2008
  - Leishmania adaptor protein-1 subunits are required for normal lysosome traffic, flagellum biogenesis, lipid homeostasis, and adaptation to temperatures encountered in the mammalian host. Eukaryotic Cell. 7. 2008
- Other Refereed Contribution to Refereed Journals
  - The sweet side of immunology: glycobiology of the immune system. Immunology and Cell Biology. 86. 2008
2007
- Journal Articles Refereed
  - Asymmetric CLASP-dependent nucleation of noncentrosomal microtubules at the trans-Golgi network. Developmental Cell. 12. 2007
  - New insights into membrane trafficking and protein sorting. International Review of Cytology. 261. 2007
  - The Golgin GCC88 is required for efficient retrograde transport of cargo from the early endosomes to the trans-Golgi network. Molecular Biology of the Cell. 18. 2007
  - The trans-Golgi network golgin, GCC185, is required for endosome-to-Golgi transport and maintenance of Golgi structure. Traffic. 8. 2007
  - prevention of autoimmune gastritis in mice requires extra-thymic T-cell deletion and suppression by regulatory T cells. Gastroenterology. 133. 2007
2006
- Journal Articles Refereed
  - CD4(+) CD25(+) regulatory T cells modulate the T-cell and antibody responses in Helicobacter-infected BALB/c mice. Infection and Immunity. 74. 2006
  - CD4(+)CD25(+) regulatory T cells inhibit the antigen-dependent expansion of self-reactive T cells in vivo. Journal of Immunology. 176. 2006
  - Capacity of the Golgi apparatus for cargo transport prior to complete assembly. Molecular Biology of the Cell. 17. 2006
  - Control of immune responses by immunoregulatory T cells. Archivum Immunologiae et Therapiae Experimntalis. 54. 2006
  - Guarding the immune system: Suppression of autoimmunity by CD4+CD25(+) immunoregulatory T cells. Immunology and Cell Biology. 84. 2006
  - Visualisation of macropinosome maturation by the recruitment of sorting nexins. Journal of Cell Science. 119. 2006
2005
- Journal Articles
  - The trans-Golgi network GRIP-domain proteins form alpha-helical homodimers.. Biochemical Journal. 388. 2005
- Journal Articles Refereed
  - A novel mammalian retromer component, Vps26B. Traffic. 6. 2005
  - E-cadherin transport from the trans-Golgi network in tubulovesicular carriers is selectively regulated by Golgin-97. Traffic. 6. 2005
  - Promiscuous thymic expression of an autoantigen gene does not result in negative selection of pathogenic T cells. Journal of Immunology. 175. 2005
  - Reciprocal changes in trefoil 1 and 2 expression in stomachs of mice with gastric unit hypertrophy and inflammation. Journal of Pathology. 207. 2005
  - Shaping the T cell repertoire to a bona fide autoantigen: lessons from autoimmune gastritis. Current Opinion in Immunology. 17. 2005
  - The trans-Golgi network GRIP-domain proteins form alpha-helical homodimers. Biochemical Journal. 388. 2005
- Conference Proceedings
  - Peripheral rather than thymic events are important in establishing tolerance to gastric autoantigens. Tissue Antigens. 2005
  - Prevention of autoimmune disease by CD4(+)CD25(+) regulatory T cells. Tissue Antigens. 2005
  - The role of H+/K+-ATPase transport in the regulation of parietal cell acid secretion and maintenance of gastric mucosal integrity. FASEB Journal. 2005
2004
- Journal Articles Refereed
  - Clathrin isoform CHC22, a component of neuromuscular and myotendinous junctions, binds sorting nexin 5 and has increased expression during myogenesis and muscle regeneration. Molecular Biology of the Cell. 15. 2004
  - Domains of the TGN: Coats, tethers and G proteins. Traffic. 5. 2004
  - Gastric parietal cell acid secretion in mice can be regulated independently of H+/K+ ATPase endocytosis. Gastroenterology. 127. 2004
  - Growth factors associated with gastric mucosal hypertrophy in autoimmune gastritis. American Journal of Physiology - Gastrointestinal and Liver Physiology. 287. 2004
  - Identification of a Golgi-localised GRIP domain protein from Arabidopsis thaliana. Planta. 219. 2004
  - Mammalian GRIP domain proteins differ in their membrane binding properties and are recruited to distinct domains of the TGN. Journal of Cell Science. 117. 2004
  - Sorting nexin 5 is localized to a subdomain of the early endosomes and is recruited to the plasma imembrane following EGF stimulation. Journal of Cell Science. 117. 2004
  - Thymic expression of a gastritogenic epitope results in positive selection of self-reactive pathogenic T cells. Journal of Immunology. 172. 2004
2003
- Journal Articles Refereed
  - GRIP domain-mediated targeting of two new coiled-coil proteins, GCC88 and GCC185, to subcompartments of the trans-Golgi network. Journal of Biological Chemistry. 278. 2003
  - Intracellular sorting and transport of proteins. Progress in Biophysics & Molecular Biology. 83. 2003
2002
- Journal Articles
  - The Phox Homology (PX) domain-dependent, 3-phosphoinositide-mediated association of sorting nexin-1 with an early sorting endosomal compartment is required for its ability to regulate epidermal growth factor receptor degradation. Journal of Biological Chemistry. 277. 2002
- Journal Articles Refereed
  - Endogenous H/K ATPase beta-subunit promotes T cell tolerance to the immunodominant gastritogenic determinant. Journal of Immunology. 169. 2002
  - Immunopathogenesis, loss of T cell tolerance and genetics of autoimmune gastritis.. Autoimmunity Reviews. 1. 2002
  - Perturbation of gastric mucosa in mice expressing the temperature-sensitive mutant of SV40 large T antigen. Potential for establishment of an immortalised parietal cell line. European Journal of Cell Biology. 81. 2002
  - Role of CD4(+)CD25(+) immunoregulatory T cells in the induction of autoimmune gastritis. Immunology and Cell Biology. 80. 2002
  - Targeting of the GRIP domain to the trans-Golgi network is conserved from protists to animals. European Journal of Cell Biology. 81. 2002
- Conference Proceedings
  - GRIP domain-mediated targeting of four human Golgins to the TGN: Recruitment of a GRIP protein to a subdomain of the TGN involved in the recycling of TGN38. Molecular Biology of the Cell. 2002
  - Insights into the cell biology, development and pathology of the gastric mucosa revealed in gastric H/K ATPase and gastrin-deficient mice 2002
2001
- Journal Articles Refereed
  - A large family of endosome-localized proteins related to sorting nexin 1. Biochemical Journal. 358. 2001
  - Defining T cell receptors which recognise the immunodominant epitope of the gastric autoantigen, the H/K ATPase beta-subunit. Autoimmunity. 33. 2001
  - Regulation of gastric epithelial cell development revealed in H+/K+-ATPase beta-subunit- and gastrin-deficient mice. American Journal of Physiology - Gastrointestinal and Liver Physiology. 281. 2001
  - Requirements for autoimmune responses to mouse gastric autoantigens. Immunology. 104. 2001
  - Steady-state localization of a medial-Golgi glycosyltransferase involves transit through the trans-Golgi network. Biochemical Journal. 358. 2001
  - The GRIP domain is a specific targeting sequence for a population of trans-Golgi network derived tubulo-vesicular carriers. Traffic. 2. 2001
  - The role of natural killer cells in the induction of autoimmune gastritis. Autoimmunity. 34. 2001
  - Trafficking and localisation of resident Golgi glycosylation enzymes. Biochimie. 83. 2001
2000
- Journal Articles
  - Homing and adhesion molecules in autoimmune gastritis. Journal of Leukocyte Biology. 67. 2000
  - Medial golgi but not late Golgi glycosyltransferases exist as high molecular weight complexes - Role of luminal domain in ln complex formation and localization. Journal of Biological Chemistry. 275. 2000
  - Peripheral T cell expansion in lymphopenic mice results in a restricted T cell repertoire. European Journal of Immunology. 30. 2000
  - Tolerance and autoimmunity to a gastritogenic peptide in TCR transgenic mice. International Immunology. 12. 2000
- Journal Articles Refereed
  - Hijacking a chaperone: manipulation of the MHC class II presentation pathway. Immunology Today. 21. 2000
  - The yeast inositol polyphosphate 5-phosphatases Inp52p and Inp53p translocate to actin patches following hyperosmotic stress: Mechanism for regulating phosphatidylinositol 4,5-bisphosphate at plasma membrane invaginations. Molecular and Cellular Biology. 20. 2000
1999
- Journal Articles
  - A novel Golgi-localisation domain shared by a class of coiled-coil peripheral membrane proteins. Current Biology. 9. 1999
  - Autoimmune gastritis results in disruption of gastric epithelial cell development.. American Journal of Physiology. 277. 1999
  - Gastric H+,K+-adenosine triphosphatase beta subunit is required for normal function, development, and membrane structure of mouse parietal cells. Gastroenterology. 117. 1999
  - Identification of a gastritogenic epitope of the H/K ATPase beta-subunit. Immunology. 96. 1999
  - Immnopathogenesis of autoimmune gastritis and pernicious anemia 1999
  - Species-specific distribution of alpha-galactosyl epitopes on the gastric H/K ATPase beta-subunit: relevance to the binding of human anti-parietal cell autoantibodies. Glycobiology. 9. 1999
  - The Golgi-targeting sequence of the peripheral membrane protein p230. Journal of Cell Science. 112. 1999
1998
- Journal Articles
  - CD4(+) T cells, but not CD8(+) T cells, are required for the development of experimental autoimmune gastritis. Immunology. 93. 1998
  - Genetic defect in N-acetylglucosaminyltransferase I gene of a ricin-resistant baby hamster kidney mutant. Biochemical Journal. 336. 1998
  - Targeting of proteins to the Golgi apparatus. Histochemistry and Cell Biology. 109. 1998
1997
- Journal Articles
  - Carbohydrates and antigen recognition by T cells. Glycobiology. 7. 1997
  - Expression of the gastric H/K-ATPase alpha-subunit in the thymus may explain the dominant role of the beta-subunit in the pathogenesis of autoimmune gastritis. Autoimmunity. 25. 1997
  - Immunization with gastric H+/K+-ATPase induces a reversible autoimmune gastritis. Immunology. 92. 1997
  - Mechanisms of disease: Pernicious anemia. New England Journal of Medicine. 337. 1997
1996
- Journal Articles
  - Analysis of mononuclear cell infiltrate and cytokine production in murine autoimmune gastritis. Gastroenterology. 110. 1996
  - From coiled tubules to a secretory canaliculus: A new model for membrane transformation and acid secretion by gastric parietal cells. Trends in Cell Biology. 6. 1996
  - Glycosylation defect in Lec1 Chinese hamster ovary mutant is due to a point mutation in N-acetylglucosaminyltransferase I gene. Journal of Biological Chemistry. 271. 1996
  - Interferon-gamma is required during the initiation of an organ-specific autoimmune disease. European Journal of Immunology. 26. 1996
  - Ligand-regulated transport of the Menkes copper P-type ATPase efflux pump from the Golgi apparatus to the plasma membrane: A novel mechanism of regulated trafficking. EMBO Journal. 15. 1996
  - Molecular characterization of trans-Golgi p230 - A human peripheral membrane protein encoded by a gene on chromosome 6p12-22 contains extensive coiled-coil alpha-helical domains and a granin motif. Journal of Biological Chemistry. 271. 1996
  - Organ-specific autoimmunity induced by lymphopenia. Immunological Reviews. 149. 1996
  - p230 is associated with vesicles budding from the trans-Golgi network. Journal of Cell Science. 109. 1996
1995
- Journal Articles
  - A novel method for isolating mononuclear cells from the stomachs of mice with experimental autoimmune gastritis. Autoimmunity. 21. 1995
  - EXPRESSION OF A GASTRIC AUTOANTIGEN IN PANCREATIC-ISLETS RESULTS IN NONDESTRUCTIVE INSULITIS AFTER NEONATAL THYMECTOMY. European Journal of Immunology. 25. 1995
  - FAST FREEZE-FIXATION FREEZE-SUBSTITUTION REVEALS THE SECRETORY MEMBRANES OF THE GASTRIC PARIETAL-CELL AS A NETWORK OF HELICALLY COILED TUBULE - A NEW MODEL FOR PARIETAL-CELL TRANSFORMATION. Journal of Cell Science. 108. 1995
  - ORGAN-SPECIFIC AUTOIMMUNITY INDUCED BY ADULT THYMECTOMY AND CYCLOPHOSPHAMIDE-INDUCED LYMPHOPENIA. European Journal of Immunology. 25. 1995
  - RENAL EXPRESSION OF THE GENE ENCODING THE GASTRIC H+-K+-ATPASE BETA-SUBUNIT. American Journal of Physiology: Renal Physiology. 268. 1995
  - Renal expression of the gene encoding the gastric H(+)-K(+)-ATPase beta-subunit.. American Journal of Physiology. 268. 1995
1994
- Journal Articles
  - GLYCOCONJUGATES IN AUTOIMMUNITY 1994
  - Glycoconjugates in autoimmunity 1994
  - HETEROGENEITY OF HUMAN ANTI-GOLGI AUTOANTIBODIES - REACTIVITY WITH COMPONENTS FROM 35 TO 260 KDA. Immunology and Cell Biology. 72. 1994
  - MEDIAL-GOLGI RETENTION OF N-ACETYLGLUCOSAMINYLTRANSFERASE-I - CONTRIBUTION FROM ALL DOMAINS OF THE ENZYME. Journal of Biological Chemistry. 269. 1994
  - POSTTRANSLATIONAL MODIFICATIONS DISTINGUISH CELL-SURFACE FROM GOLGI-RETAINED BETA-1,4 GALACTOSYLTRANSFERASE MOLECULES - GOLGI LOCALIZATION INVOLVES ACTIVE RETENTION. Glycobiology. 4. 1994
  - TARGETING OF PROTEINS TO THE GOLGI-APPARATUS. Glycoconjugate Journal. 11. 1994
1993
- Journal Articles
  - ALPHA-SUBUNIT AND BETA-SUBUNIT OF THE GASTRIC H+/K+-ATPASE ARE CONCORDANTLY TARGETED BY PARIETAL-CELL AUTOANTIBODIES ASSOCIATED WITH AUTOIMMUNE GASTRITIS. Autoimmunity. 16. 1993
  - AN AUTOIMMUNE-DISEASE WITH MULTIPLE MOLECULAR TARGETS ABROGATED BY THE TRANSGENIC EXPRESSION OF A SINGLE AUTOANTIGEN IN THE THYMUS. Journal of Experimental Medicine. 178. 1993
  - Autoimmunity: The paradigm of autoimmune gastritis. Today's Life Science. 5. 1993
  - CLONING AND CHARACTERIZATION OF A GOLGI-ASSOCIATED GTP-BINDING PROTEIN HOMOLOG FROM LEISHMANIA-MAJOR. Molecular and Biochemical Parasitology. 62. 1993
  - GASTRIC PARIETAL-CELL DEVELOPMENT - EXPRESSION OF THE H+/K+ ATPASE SUBUNITS COINCIDES WITH THE BIOGENESIS OF THE SECRETORY MEMBRANES. Immunology and Cell Biology. 71. 1993
1992
- Journal Articles
  - AUTOIMMUNE GASTRITIS - TOLERANCE AND AUTOIMMUNITY TO THE GASTRIC H+/K+ ATPASE (PROTON PUMP). Autoimmunity. 13. 1992
  - DIAGNOSTIC ELISA FOR PARIETAL-CELL AUTOANTIBODY USING TOMATO LECTIN-PURIFIED GASTRIC H+/K+-ATPASE (PROTON PUMP). Autoimmunity. 12. 1992
  - HUMAN AUTOANTIBODIES AS REAGENTS TO CONSERVED GOLGI COMPONENTS - CHARACTERIZATION OF A PERIPHERAL, 230-KDA COMPARTMENT-SPECIFIC GOLGI PROTEIN. Journal of Biological Chemistry. 267. 1992
  - RAPID PURIFICATION OF THE GASTRIC H plus /K plus -ATPASE COMPLEX BY TOMATO-LECTIN AFFINITY-CHROMATOGRAPHY. Biochemical Journal. 283. 1992
  - STABLE EXPRESSION OF THE HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 ENVELOPE GLYCOPROTEIN IN TRANSFECTED L-CELLS. AIDS Research and Human Retroviruses. 8. 1992
  - THE MOUSE GASTRIC H,K-ATPASE BETA-SUBUNIT - GENE STRUCTURE AND COORDINATE EXPRESSION WITH THE ALPHA-SUBUNIT DURING ONTOGENY. Journal of Biological Chemistry. 267. 1992
  - THE SIGNAL FOR GOLGI RETENTION OF BOVINE-BETA-1,4-GALACTOSYLTRANSFERASE IS IN THE TRANSMEMBRANE DOMAIN. Journal of Biological Chemistry. 267. 1992
  - THE TRANSMEMBRANE AND FLANKING SEQUENCES OF BETA-1,2-N-ACETYLGLUCOSAMINYLTRANSFERASE-I SPECIFY MEDIAL-GOLGI LOCALIZATION. Journal of Biological Chemistry. 267. 1992
  - The signal for Golgi retention of bovine beta 1,4-galactosyltransferase is in the transmembrane domain.. Journal of Biological Chemistry. 267. 1992
1991
- Journal Articles
  - IDENTIFICATION OF COMPONENTS OF THE ENDOPLASMIC-RETICULUM AND GOLGI-COMPLEX BY MURINE AUTOREACTIVE MONOCLONAL-ANTIBODIES. Immunology. 72. 1991
  - MOLECULAR TARGETS IN PERNICIOUS-ANEMIA. Immunology Today. 12. 1991
  - MONOCLONAL-ANTIBODIES SPECIFIC FOR THE CORE PROTEIN OF THE BETA-SUBUNIT OF THE GASTRIC PROTON PUMP (H+/K+ ATPASE) - AN AUTOANTIGEN TARGETED IN PERNICIOUS-ANEMIA. European Journal of Biochemistry. 197. 1991
  - REVERSE IMMUNOAFFINITY CHROMATOGRAPHY - APPLICATION TO THE PURIFICATION OF THE 60-KDA TO 90-KDA GASTRIC PARIETAL-CELL AUTOANTIGEN ASSOCIATED WITH AUTOIMMUNE GASTRITIS. Analytical Biochemistry. 194. 1991
  - THE PARIETAL-CELL AUTOANTIBODIES RECOGNIZED IN NEONATAL THYMECTOMY-INDUCED MURINE GASTRITIS ARE THE ALPHA-SUBUNIT AND BETA-SUBUNIT OF THE GASTRIC PROTON PUMP. Gastroenterology. 101. 1991
1990
- Journal Articles
  - EXPRESSION OF HUMAN IMMUNODEFICIENCY VIRUS-1 (HIV-1) ENVELOPE GENE-PRODUCTS TRANSCRIBED FROM A HETEROLOGOUS PROMOTER - KINETICS OF HIV-1 ENVELOPE PROCESSING IN TRANSFECTED CELLS. Journal of Biological Chemistry. 265. 1990
  - N-LINKED OLIGOSACCHARIDES OF THE MURINE TRANSFERRIN RECEPTOR FROM A PLASMACYTOMA CELL-LINE - COMPARISON WITH TOTAL CELLULAR N-GLYCANS. BBA - General Subjects. 1036. 1990
  - POLY-N-ACETYLLACTOSAMINE-SPECIFIC TOMATO LECTIN INTERACTS WITH GASTRIC PARIETAL-CELLS - IDENTIFICATION OF A TOMATO-LECTIN BINDING 60-90X103MR MEMBRANE GLYCOPROTEIN OF TUBULOVESICLES. Journal of Cell Science. 95. 1990
  - THE 60-KDA TO 90-KDA PARIETAL-CELL AUTOANTIGEN ASSOCIATED WITH AUTOIMMUNE GASTRITIS IS A BETA-SUBUNIT OF THE GASTRIC H+/K+-ATPASE (PROTON PUMP). Proceedings of the National Academy of Sciences of the United States of America. 87. 1990
1989
- Journal Articles
  - CHARACTERIZATION OF THE HYDROXYPROLINE-RICH PROTEIN CORE OF AN ARABINOGALACTAN-PROTEIN SECRETED FROM SUSPENSION-CULTURED LOLIUM-MULTIFLORUM (ITALIAN RYEGRASS) ENDOSPERM CELLS. Biochemical Journal. 264. 1989
  - EFFECT OF GLYCOSYLATION INHIBITORS ON THE STRUCTURE AND FUNCTION OF THE MURINE TRANSFERRIN RECEPTOR. European Journal of Biochemistry. 186. 1989
  - GASTRIC PARIETAL-CELL ANTIGENS OF 60-90, 92, AND 100-120 KDA ASSOCIATED WITH AUTOIMMUNE GASTRITIS AND PERNICIOUS-ANEMIA - ROLE OF N-GLYCANS IN THE STRUCTURE AND ANTIGENICITY OF THE 60-90-KDA COMPONENT. Journal of Biological Chemistry. 264. 1989
1988
- Journal Articles
  - Complex carbohydrates of plants and animals--a comparison.. Current Topics in Microbiology and Immunology. 139. 1988
1985
- Journal Articles
  - BINDING AND UPTAKE OF THE TOXIC LECTIN MODECCIN BY BABY HAMSTER-KIDNEY (BHK) CELLS - ISOLATION OF MUTANTS DEFECTIVE IN THE INTERNALIZATION OF MODECCIN. Journal of Cell Science. 76. 1985
  - Effect of protein source in the concentrate on the performance of cows offered grass silage ad-libitum. 1985
  - STRUCTURES OF N-GLYCANS OF A RICIN-RESISTANT MUTANT OF BABY HAMSTER-KIDNEY CELLS - SYNTHESIS OF HIGH-MANNOSE AND HYBRID N-GLYCANS. Biochemistry. 24. 1985
1984
- Journal Articles
  - GALACTOSYL TRANSFERASES OF BABY HAMSTER-KIDNEY (BHK) CELLS - CHARACTERIZATION OF 2 OLIGOSACCHARIDE PRODUCTS SYNTHESIZED USING BOVINE ASIALO SUBMAXILLARY-GLAND MUCIN AS ACCEPTOR. European Journal of Biochemistry. 144. 1984
1983
- Journal Articles
1982
- Journal Articles
  - Oligosaccharide branching of glycoproteins: biosynthetic mechanisms and possible biological functions.. Royal Society of London Philosophical Transactions - Biological Sciences. 300. 1982
1981
- Journal Articles
  - Molecular aspects of recognition and response in the pollen-stigma interaction. 1981
1980
- Journal Articles
  - ARABINOGALACTANS OF SEXUAL AND SOMATIC TISSUES OF GLADIOLUS AND LILIUM. Phytochemistry. 19. 1980
  - CARBOHYDRATE-COMPOSITION OF THE OLIGOSACCHARIDE UNITS OF THE HEMAGGLUTININ FROM THE HONG-KONG INFLUENZA-VIRUS A-MEMPHIS-102-72. Biochemical Journal. 189. 1980
  - COMPARISON OF THE STRUCTURES OF THE MAJOR COMPONENTS OF THE STIGMA AND STYLE SECRETIONS OF GLADIOLUS - THE ARABINO-3,6-GALACTANS. Carbohydrate Research. 83. 1980
  - THE NATURE OF CALLOSE PRODUCED DURING SELF-POLLINATION IN SECALE-CEREALE. Planta. 148. 1980
1979
- Journal Articles
  - ISOLATION OF AN ARABINOGALACTAN PROTEIN BY LECTIN AFFINITY CHROMATOGRAPHY ON TRIDACNIN-SEPHAROSE-4B. Analytical Biochemistry. 92. 1979
  - Pollen-stigma interactions: Identification and characterization of surface components with recognition potential. Proceedings of the National Academy of Sciences of the United States of America. 76. 1979
  - STRUCTURAL STUDIES ON THE MAJOR COMPONENT OF GLADIOLUS STYLE MUCILAGE, AN ARABINOGALACTAN-PROTEIN. Biochemical Journal. 181. 1979
1978
- Journal Articles
  - CHARACTERIZATION AND LOCALIZATION OF BETA-LECTINS IN LOWER AND HIGHER-PLANTS. Australian Journal of Plant Physiology. 5. 1978
1976
- Journal Articles
  - Aryl acylamidase activity in larvae of the webbing clothes moth, Tineola bisselliella.. Comparative Biochemistry and Physiology. B: Comparative Biochemistry. 53. 1976

Research

Investigator on

Contract
- CONTRACT CONCERNING MICRODATA RESEARCH PROJECT 7688 administered by Biochemistry and Molecular Biology 2015 - 2016
- BIOLOGY OF THE PROTEIN CLATHRIN HEAVY CHAIN awarded by UNIVERSITY OF CALIFORNIA 2009 -
Grant
- DEFINING THE ANTEROGRADE AND ENDOCYTIC TRAFFICKING PATHWAYS IN PRIMARY NEURONS; RELEVANCE TO DYSFUNCTIONAL TRAFFICKING OF BACE1 AND APP IN ALZHEIMER’S DISEASE (Project Grants) awarded by NHMRC 2019 - 2021
- CONFOCAL AND SINGLE MOLECULE MICROSCOPES FOR SYSTEMS MICROSCOPY (NON-LEAD) (Linkage Infrastructure (Equipment and Facilities)) awarded by UNIVERSITY OF NEW SOUTH WALES 2018
- THE CELL BIOLOGY OF THE ALBUMIN-FCRN RECEPTOR RECYCLING SYSTEM (Linkage Projects) awarded by AUST RESEARCH COUNCIL 2017 - 2020
- QTOF MASS SPECTROMETER RESEARCH INITIATIVES FUND COLLABORATIVE EQUIPMENT GRANT (RIF Collaborative Equipment Grant) awarded by UNIVERSITY OF MELBOURNE 2017 - 2018
- The function of the ribbon structure of the Golgi apparatus in vertebrates (Discovery Projects) awarded by AUST RESEARCH COUNCIL 2016 - 2019
- MEMBRANE TRAFFICKING OF BACE1 AND AMYLOID PRECURSOR PROTEIN IN PRIMARY NEURONS AND THE PRODUCTION OF ABETA AMYLOID PEPTIDES (Project Grants) awarded by NHMRC 2015 - 2018
- A VIDEO-RATE NANOSCOPY FACILITY FOR SUPER-RESOLUTION IMAGING (ARC LIEF Internal Contributions) awarded by UNIVERSITY OF MELBOURNE 2014 - 2016
- Intracellular trafficking and function of a recycling receptor which prolongs the serum half-life of novel therapeutic proteins (Linkage Projects) awarded by AUST RESEARCH COUNCIL 2013 - 2017
- THREE-DIMENSIONAL CRYO ELECTRON MICROSCOPY FACILITY (Linkage Infrastructure (Equipment and Facilities)) awarded by AUST RESEARCH COUNCIL 2013 - 2014
- Treg cell therapy (Project Grants) awarded by NHMRC 2012 - 2015
- Alzheimer's disease and the generation of neurotoxic peptides (Project Grants) awarded by NHMRC 2012 - 2014
- REGULATION OF THE CARDIOVASCULAR DISEASE-ASSOCIATED PROTEASE INHIBITOR CYSTATIN C FOR THERAPEUTIC APPLICATION (Project Grants) awarded by NHMRC 2011 - 2013
- Regulated trafficking of K channels (Project Grants) awarded by NHMRC 2011 - 2013
- IMPROVING ACCESS FOR PEOPLE WITH DISABILITY THROUGH INCLUSIVE INFRASTRUCTURE DEVELOPMENT IN RURAL AND URBAN PNG (Australian Development Research Awards) awarded by AUSAID 2010 - 2013
- The structure and function of the trans-Golgi network- Role of golgins and G proteins (Discovery Projects) awarded by AUST RESEARCH COUNCIL 2010 - 2012
- Inhibition of pro-inflammatory cytokine secretion- A new route to therapeutics of chronic inflammatory disease (Linkage Projects) awarded by AUST RESEARCH COUNCIL 2009 - 2013
- Intracellular transport pathways (Project Grants) awarded by NHMRC 2009 - 2012
- Internalisation pathways into cells (Project Grants) awarded by NHMRC 2009 - 2011
- Multi-photon imaging for infection, immunity, and self recognition (Linkage Infrastructure (Equipment and Facilities)) awarded by AUST RESEARCH COUNCIL 2009
- Development of cellular therapies for autoimmunity (Project Grants) awarded by NHMRC 2008 - 2011
- The functional organisation of the trans-Golgi network: From cultured cells to physiological systems (Discovery Projects) awarded by AUST RESEARCH COUNCIL 2007 - 2010
- NINETEENTH INTERNATIONAL SYMPOSIUM ON GLYCOCONJUGATES (GLYCO-19) (International Science Linkages - Competitive Grants) awarded by DEPT OF EDUCATION SCIENCE & TRAINING 2007
- Organ-specific autoimmunity: The role of the thymus and periphery in shaping the gastric-specific T cell repertoire (Project Grants) awarded by NHMRC 2006 - 2008
- Cell biology of gastric acid secretion (Discovery Projects) awarded by AUST RESEARCH COUNCIL 2005 - 2007
- Population dynamics of tissue-specific effector and regulatory CD4+ T cells (Project Grants) awarded by NHMRC 2005 - 2007
- AUTOCLAVES (2) 2004 NHMRC EQUIPMENT GRANT ALLOCATION (Equipment Grants) awarded by NHMRC 2005 - 2006
- Sorting nexins and their role in endosomal trafficking (Project Grants) awarded by NHMRC 2004 - 2006
- The role of a novel family of Golgi proteins in maintaining the structure and function of the trans-Golgi network (Discovery Projects) awarded by AUST RESEARCH COUNCIL 2004 - 2006
- Investigating T cell tolerance and organ-specific auotimmunity using autoantigen deficient mice (Project Grants) awarded by NHMRC 2003 - 2006
- Biochemical, genomic & phenomic analysis of gastric parietal cells from wildtype & mutant mice (Discovery Projects) awarded by AUST RESEARCH COUNCIL 2003 - 2004

Awards

Education and training

PhD, University of Melbourne 1980

Supervision

Available for supervision

Y

Contact Details
- paul.gleeson@unimelb.edu.au
- 8344 2354
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  - Level: 03 Room: 302, David Penington Building, Parkville
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