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PROF Paul A Gleeson

Positions

Academic, Biochemistry and Molecular Biology

Publications

Selected publications

2019
- Journal Articles
  - Intersectin-1 interacts with the golgin GCC88 to couple the actin network and Golgi architecture 2019
  - The role of membrane trafficking in the processing of amyloid precursor protein and production of amyloid peptides in Alzheimer's disease. Biochimica et Biophysica Acta-Biomembranes. 1861. 2019
2018
- Journal Articles
  - GGA1 regulates signal-dependent sorting of BACE1 to recycling endosomes, which moderates A? production. Molecular Biology of the Cell. 29. 2018
- Journal Articles Refereed
  - GGA1 regulates signal-dependent sorting of BACE1 to recycling endosomes, which moderates A beta production. Molecular Biology of the Cell. 29. 2018
2017
- Journal Articles Refereed
  - Amyloid precursor protein traffics from the Golgi directly to early endosomes in an Arl5b-and AP4-dependent pathway. Traffic. 18. 2017
  - The Function of the Golgi Ribbon Structure - An Enduring Mystery Unfolds!. Bioessays. 39. 2017
2016
- Journal Articles Refereed
  - Dysregulation of intracellular trafficking and endosomal sorting in Alzheimer's disease: controversies and unanswered questions. Biochemical Journal. 473. 2016
  - Emerging Insights into the Roles of Membrane Tethers from Analysis of Whole Organisms: The Tip of an Iceberg? 2016
  - Rapamycin results in Bim-mediated loss of thymic regulatory T cells during development in organ culture. International Immunology. 28. 2016
2015
- Book Chapters
  - Organizational Cell Biology: An Overview. Encyclopedia of Cell Biology. 2015
- Research Book Chapters
  - Application of flow cytometry to analyze intracellular location and trafficking of cargo in cell populations. Membrane Trafficking: Second Edition. 2015
- Journal Articles Refereed
  - Application of flow cytometry to analyze intracellular location and trafficking of cargo in cell populations. Methods in Molecular Biology. 1270. 2015
2014
- Journal Articles Refereed
  - C9ORF72, implicated in amytrophic lateral sclerosis and frontotemporal dementia, regulates endosomal trafficking. Human Molecular Genetics. 23. 2014
  - Helios defines T cells being driven to tolerance in the periphery and thymus. European Journal of Immunology. 44. 2014
  - Membrane tethering. F1000 Prime Reports. 6. 2014
2013
- Book Chapters
  - Autoimmune Gastritis and Pernicious Anemia. The Autoimmune Diseases: Fifth Edition. 2013
- Journal Articles Refereed
  - Expression of HIV-1 Vpu Leads to Loss of the Viral Restriction Factor CD317/Tetherin from Lipid Rafts and Its Enhanced Lysosomal Degradation. PLoS One. 8. 2013
  - Intracellular Itinerary of Internalised β-Secretase, BACE1, and Its Potential Impact on β-Amyloid Peptide Biogenesis. Traffic. 14. 2013
  - Rab6a/a' Are Important Golgi Regulators of Pro-Inflammatory TNF Secretion in Macrophages. PLoS One. 8. 2013
2012
- Journal Articles Refereed
  - Conjugation of Transferrin to Azide-Modified CdSe/ZnS Core-Shell Quantom Dots using Cyclootyne Click Chemistry. Angewandte Chemie - International Edition. 51. 2012
2011
- Journal Articles Refereed
  - Intracellular trafficking of the β-secretase and processing of amyloid precursor protein.. IUBMB Life. 63. 2011
  - Macropinocytosis: an endocytic pathway for internalising large gulps. Immunology and Cell Biology. 89. 2011
2010
- Journal Articles Refereed
  - Identification of different itineraries and retromer components for endosome-to-Golgi transport of TGN38 and Shiga toxin.. European Journal of Cell Biology. 89. 2010
  - TGN golgins, Rabs and cytoskeleton: regulating the Golgi trafficking highways.. Trends in Cell Biology. 20. 2010
2009
- Journal Articles Refereed
  - Regulation of HLA class I surface expression requires CD99 and p230/golgin-245 interaction. Blood. 113. 2009
  - The localization of the Golgin GCC185 is independent of Rab6A/A' and Arl1.. Cell. 138. 2009
2008
- Book Chapters
  - Structure and domain organization of the trans-Golgi network. The Golgi Apparatus: State of the Art 110 Years after Camillo Golgi's Discovery. 2008
- Journal Articles Refereed
  - A role for SNX5 in the regulation of macropinocytosis.. BMC Cell Biology. 9. 2008
  - A trans-Golgi network golgin is required for the regulated secretion of TNF in activated macrophages in vivo. Proceedings of the National Academy of Sciences of the United States of America. 105. 2008
  - Identification of a novel group of putative Arabidopsis thaliana beta-(1,3)-galactosyltransferases. Plant Molecular Biology. 68. 2008
2007
- Journal Articles Refereed
  - Asymmetric CLASP-Dependent Nucleation of Noncentrosomal Microtubules at the trans-Golgi Network. Developmental Cell. 12. 2007
  - The Golgin GCC88 is Required for Efficient Retrograde Transport of Cargo from the Early Endosomes to the Trans-Golgi Network. Molecular Biology of the Cell. 18. 2007
  - The trans-Golgi network golgin, GCC185, is required for endosome-to-Golgi transport and maintenance of Golgi structure. Traffic. 8. 2007
2006
- Journal Articles Refereed
  - Visualisation of macropinosome maturation by the recruitment of sorting nexins. Journal of Cell Science. 119. 2006
2005
- Journal Articles Refereed
  - E-Cadherin Transport from the trans-Golgi Network in Tubulovesicular Carriers is Selectively Regulated by Golgin-97.. Traffic. 6. 2005
  - Reciprocal changes in trefoil 1 and 2 expression in stomachs of mice with gastic unit hypertrophy and inflammation. Journal of Pathology. 207. 2005
2004
- Journal Articles Refereed
  - Domains of the TGN: coats, tethers and G proteins. Traffic. 5. 2004
  - Growth factors associated with gastric mucosal hypertrophy in autoimmune gastritis. American Journal of Physiology - Gastrointestinal and Liver Physiology. 287. 2004
  - Mammalian GRIP domain proteins differ in their membrane binding properties and are recruited to distinct domains of the TGN. Journal of Cell Science. 117. 2004
2003
- Journal Articles Refereed
  - GRIP Domain-mediated Targeting of Two New Coiled-coil Proteins, GCC88 and GCC185, to Subcompartments of the trans-Golgi Network. Journal of Biological Chemistry. 278. 2003
2002
- Journal Articles
  - The Phox homology (PX) domain-dependent, 3-phosphoinositide-mediated association of sorting nexin-1 with an early sorting endosomal compartment is required for its ability to regulate epidermal growth factor receptor degradation. Journal of Biological Chemistry. 277. 2002
2001
- Journal Articles Refereed
  - Trafficking and localisation of resident Golgi glycosylation enzymes.. Biochimie. 83. 2001
2000
- Journal Articles
  - Medial Golgi but not late golgi glycosyltransferases exist as high molecular weight complexes. Role of luminal domain in complex formation and localization. Journal of Biological Chemistry. 275. 2000
1999
- Journal Articles
  - A novel Golgi-localisation domain shared by a class of coiled-coil peripheral membrane proteins. Current Biology. 9. 1999
  - Autoimmune gastritis results in disruption of gastric epithelial cell development. American Journal of Physiology - Gastrointestinal and Liver Physiology. 277. 1999
  - Immnopathogenesis of autoimmune gastritis and pernicious anemia 1999
  - The Golgi-targeting sequence of the peripheral membrane protein p230. Journal of Cell Science. 112. 1999
1998
- Journal Articles
  - Genetic defect in N-acetylglucosaminyltransferase I gene of a ricin-resistant baby hamster kidney mutant. Biochemical Journal. 336. 1998
  - Pernicious anemia 6 (multiple letters). New England Journal of Medicine. 338. 1998
  - Targeting of proteins to the Golgi apparatus. Histochemistry and Cell Biology. 109. 1998
1996
- Journal Articles
  - Analysis of mononuclear cell infiltrate and cytokine production in murine autoimmune gastritis. Gastroenterology. 110. 1996
  - Glycosylation defect in Lec1 Chinese hamster ovary mutant is due to a point mutation in N-acetylglucosaminyltransferase 1 gene. Journal of Biological Chemistry. 271. 1996
  - Molecular characterization of trans-Golgi p230: A human peripheral membrane protein encoded by a gene on chromosome 6p12-22 contains extensive coiled-coil α-helical domains and a granin motif. Journal of Biological Chemistry. 271. 1996
  - p230 is associated with vesicles budding from the trans-Golgi network. Journal of Cell Science. 109. 1996
1995
- Journal Articles
  - Renal expression of the gene encoding the gastric H⁺ -K⁺ -ATPase β- subunit. American Journal of Physiology: Renal Physiology. 268. 1995
1994
- Journal Articles
  - Glycoconjugates in autoimmunity 1994
  - Glycoconjugates in autoimmunity. Biochimica et Biophysica Acta-Gene Structure & Expression. 1197. 1994
  - Heterogeneity of human anti‐Golgi auto‐antibodies: Reactivity with components from 35 to 260 kDa. Immunology and Cell Biology. 72. 1994
  - Medial-Golgi retention of N-acetylglucosaminyltransferase I: Contribution from all domains of the enzyme. Journal of Biological Chemistry. 269. 1994
  - Post-translational modifications distinguish cell surface from golgi-retained β1,4 galactosyltransferase molecules. Golgi localization involves active retention. Glycobiology. 4. 1994
  - Targeting of proteins to the Golgi apparatus. Glycoconjugate Journal. 11. 1994
1993
- Journal Articles
  - Autoimmunity: The paradigm of autoimmune gastritis. Today's Life Science. 5. 1993
1992
- Journal Articles
  - Erratum: The signal for Golgi retention of bovine β1,4- galactosyltransferase is in the transmembrane domain (The Journal of Biological Chemistry (1992) 267 (4084-4096)). Journal of Biological Chemistry. 267. 1992
  - Human autoantibodies as reagents to conserved golgi components: Characterization of a peripheral, 230-kDa compartment-specific golgi protein. Journal of Biological Chemistry. 267. 1992
  - Rapid purification of the gastric H⁺ /K⁺ -ATPase complex by tomato-lectin affinity chromatography. Biochemical Journal. 283. 1992
  - The signal for Golgi retention of bovine beta 1,4-galactosyltransferase is in the transmembrane domain.. Journal of Biological Chemistry. 267. 1992
  - The signal for golgi retention of bovine β1,4-galactosyltransferase is in the transmembrane domain. Journal of Biological Chemistry. 267. 1992
  - The transmembrane and flanking sequences of β1,2-N- acetylglucosaminyltransferase I specify medial-Golgi localization. Journal of Biological Chemistry. 267. 1992
  - diagnostic elisa for parietal cell autoantibody using tomato lectin-purified gastric h⁺ /k⁺ -atpase (proton pump). Autoimmunity. 12. 1992
1991
- Journal Articles
  - Identification of components of the endoplasmic reticulum and Golgi complex by murine autoreactive monoclonal antibodies. Immunology. 72. 1991
  - Molecular targets in pernicious anaemia. Immunology Today. 12. 1991
  - Reverse immunoaffinity chromatography: Application to the purification of the 60- to 90-kDa gastric parietal cell autoantigen associated with autoimmune gastritis. Analytical Biochemistry. 194. 1991
1990
- Journal Articles
  - N-linked oligosaccharides of the murine transferrin receptor from a plasmacytoma cell line. Comparison with total cellular N-glycans. Biochimica et Biophysica Acta - General Subjects. 1036. 1990
  - Poly-N-acetyllactosamine-specific tomato lectin interacts with gastric parietal cells: Identification of a tomato-lectin binding 60-90x103 Mr membrane glycoprotein of tubulovesicles. Journal of Cell Science. 95. 1990
1989
- Journal Articles
  - Characterization of the hydroxyproline-rich protein core of an arabinogalactan-protein secreted from suspension-cultured Lolium multiflorum (Italian ryegrass) endosperm cells. Biochemical Journal. 264. 1989
  - Effect of glycosylation inhibitors on the structure and function of the murine transferrin receptor. European Journal of Biochemistry. 186. 1989
  - Gastric parietal cell antigens of 60-90, 92, and 100-120 kDa associated with autoimmune gastritis and pernicious anemia. Role of N-glycans in the structure and antigenicity of the 60-90-kDa component. Journal of Biological Chemistry. 264. 1989
1988
- Journal Articles
  - Complex carbohydrates of plants and animals--a comparison.. Current Topics in Microbiology and Immunology. 139. 1988
1985
- Journal Articles
  - Binding and uptake of the toxic lectin modeccin by baby hamster kidney (BHK) cells. Isolation of mutants defective in the internalization of modeccin. Journal of Cell Science. VOL. 76. 1985
  - Structures of N-Glycans of a Ricin-Resistant Mutant of Baby Hamster Kidney Cells. Synthesis of High-Mannose and Hybrid N-Glycans. Biochemistry. 24. 1985
1984
- Journal Articles
  - Galactosyl transferases of baby hamster kidney (BHK) cells: Characterization of two oligosaccharide products synthesised using bovine asialo submaxillary‐gland mucin as acceptor. European Journal of Biochemistry. 144. 1984
1983
- Journal Articles
  - Control of branching during the biosynthesis of asparagine-linked oligosaccharides 1983
  - Control of glycoprotein synthesis.. Journal of Biological Chemistry. 258. 1983
  - Enzymatic control of oligosaccharide branching during synthesis of membrane glycoproteins 1983
  - Glycosyltransferases Involved in Elongation of N-Glycosidically Linked Oligosaccharides of the Complex or N-Acetyllactosamine Type. Methods in Enzymology. 98. 1983
1982
- Journal Articles
  - Oligosaccharide branching of glycoproteins: biosynthetic mechanisms and possible biological functions.. Royal Society of London Philosophical Transactions - Biological Sciences. 300. 1982
1980
- Journal Articles
  - ARABINOGALACTANS OF SEXUAL AND SOMATIC TISSUES OF GLADIOLUS AND LILIUM. Phytochemistry. 19. 1980
  - COMPARISON OF THE STRUCTURES OF THE MAJOR COMPONENTS OF THE STIGMA AND STYLE SECRETIONS OF GLADIOLUS - THE ARABINO-3,6-GALACTANS. Carbohydrate Research. 83. 1980
  - Carbohydrate composition of the oligosaccharide units of the haemagglutinin from the Hong Kong influenza virus A/Memphis/102/72.. Biochemical Journal. 189. 1980
1979
- Journal Articles
  - ISOLATION OF AN ARABINOGALACTAN PROTEIN BY LECTIN AFFINITY CHROMATOGRAPHY ON TRIDACNIN-SEPHAROSE-4B. Analytical Biochemistry. 92. 1979
  - Pollen-stigma interactions: Identification and characterization of surface components with recognition potential. Proceedings of the National Academy of Sciences of the United States of America. 76. 1979
  - STRUCTURAL STUDIES ON THE MAJOR COMPONENT OF GLADIOLUS STYLE MUCILAGE, AN ARABINOGALACTAN-PROTEIN. Biochemical Journal. 181. 1979
1976
- Journal Articles
  - Aryl acylamidase activity in larvae of the webbing clothes moth, Tineola bisselliella. Comparative Biochemistry and Physiology. B: Comparative Biochemistry. 53. 1976

Research

Investigator on

Contract
- CONTRACT CONCERNING MICRODATA RESEARCH PROJECT 7688 administered by Biochemistry and Molecular Biology 2015 - 2016
- BIOLOGY OF THE PROTEIN CLATHRIN HEAVY CHAIN awarded by UNIVERSITY OF CALIFORNIA 2009 -
Grant
- DEFINING THE ANTEROGRADE AND ENDOCYTIC TRAFFICKING PATHWAYS IN PRIMARY NEURONS; RELEVANCE TO DYSFUNCTIONAL TRAFFICKING OF BACE1 AND APP IN ALZHEIMER’S DISEASE (Project Grants) awarded by NHMRC 2019 - 2021
- CONFOCAL AND SINGLE MOLECULE MICROSCOPES FOR SYSTEMS MICROSCOPY (NON-LEAD) (Linkage Infrastructure (Equipment and Facilities)) awarded by UNIVERSITY OF NEW SOUTH WALES 2018
- THE CELL BIOLOGY OF THE ALBUMIN-FCRN RECEPTOR RECYCLING SYSTEM (Linkage Projects) awarded by AUST RESEARCH COUNCIL 2017 - 2020
- QTOF MASS SPECTROMETER RESEARCH INITIATIVES FUND COLLABORATIVE EQUIPMENT GRANT (RIF Collaborative Equipment Grant) awarded by UNIVERSITY OF MELBOURNE 2017 - 2018
- The function of the ribbon structure of the Golgi apparatus in vertebrates (Discovery Projects) awarded by AUST RESEARCH COUNCIL 2016 - 2018
- MEMBRANE TRAFFICKING OF BACE1 AND AMYLOID PRECURSOR PROTEIN IN PRIMARY NEURONS AND THE PRODUCTION OF ABETA AMYLOID PEPTIDES (Project Grants) awarded by NHMRC 2015 - 2018
- A VIDEO-RATE NANOSCOPY FACILITY FOR SUPER-RESOLUTION IMAGING (ARC LIEF Internal Contributions) awarded by UNIVERSITY OF MELBOURNE 2014 - 2016
- Intracellular trafficking and function of a recycling receptor which prolongs the serum half-life of novel therapeutic proteins (Linkage Projects) awarded by AUST RESEARCH COUNCIL 2013 - 2017
- THREE-DIMENSIONAL CRYO ELECTRON MICROSCOPY FACILITY (Linkage Infrastructure (Equipment and Facilities)) awarded by AUST RESEARCH COUNCIL 2013 - 2014
- Treg cell therapy (Project Grants) awarded by NHMRC 2012 - 2015
- Alzheimer's disease and the generation of neurotoxic peptides (Project Grants) awarded by NHMRC 2012 - 2014
- REGULATION OF THE CARDIOVASCULAR DISEASE-ASSOCIATED PROTEASE INHIBITOR CYSTATIN C FOR THERAPEUTIC APPLICATION (Project Grants) awarded by NHMRC 2011 - 2013
- Regulated trafficking of K channels (Project Grants) awarded by NHMRC 2011 - 2013
- IMPROVING ACCESS FOR PEOPLE WITH DISABILITY THROUGH INCLUSIVE INFRASTRUCTURE DEVELOPMENT IN RURAL AND URBAN PNG (Australian Development Research Awards) awarded by AUSAID 2010 - 2013
- The structure and function of the trans-Golgi network- Role of golgins and G proteins (Discovery Projects) awarded by AUST RESEARCH COUNCIL 2010 - 2012
- Inhibition of pro-inflammatory cytokine secretion- A new route to therapeutics of chronic inflammatory disease (Linkage Projects) awarded by AUST RESEARCH COUNCIL 2009 - 2013
- Intracellular transport pathways (Project Grants) awarded by NHMRC 2009 - 2012
- Internalisation pathways into cells (Project Grants) awarded by NHMRC 2009 - 2011
- Multi-photon imaging for infection, immunity, and self recognition (Linkage Infrastructure (Equipment and Facilities)) awarded by AUST RESEARCH COUNCIL 2009
- Development of cellular therapies for autoimmunity (Project Grants) awarded by NHMRC 2008 - 2011
- The functional organisation of the trans-Golgi network: From cultured cells to physiological systems (Discovery Projects) awarded by AUST RESEARCH COUNCIL 2007 - 2010
- NINETEENTH INTERNATIONAL SYMPOSIUM ON GLYCOCONJUGATES (GLYCO-19) (International Science Linkages - Competitive Grants) awarded by DEPT OF EDUCATION SCIENCE & TRAINING 2007
- Organ-specific autoimmunity: The role of the thymus and periphery in shaping the gastric-specific T cell repertoire (Project Grants) awarded by NHMRC 2006 - 2008
- Cell biology of gastric acid secretion (Discovery Projects) awarded by AUST RESEARCH COUNCIL 2005 - 2007
- Population dynamics of tissue-specific effector and regulatory CD4+ T cells (Project Grants) awarded by NHMRC 2005 - 2007
- AUTOCLAVES (2) 2004 NHMRC EQUIPMENT GRANT ALLOCATION (Equipment Grants) awarded by NHMRC 2005 - 2006
- Sorting nexins and their role in endosomal trafficking (Project Grants) awarded by NHMRC 2004 - 2006
- The role of a novel family of Golgi proteins in maintaining the structure and function of the trans-Golgi network (Discovery Projects) awarded by AUST RESEARCH COUNCIL 2004 - 2006
- Investigating T cell tolerance and organ-specific auotimmunity using autoantigen deficient mice (Project Grants) awarded by NHMRC 2003 - 2006
- Biochemical, genomic & phenomic analysis of gastric parietal cells from wildtype & mutant mice (Discovery Projects) awarded by AUST RESEARCH COUNCIL 2003 - 2004

Awards

Education and training

PhD, University of Melbourne 1980

Supervision

Available for supervision

Y

Contact Details
- paul.gleeson@unimelb.edu.au
- 8344 2354
- Location
  - Level: 03 Room: 302, David Penington Building, Parkville
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