Professor Gustavo Duque is a world leader in ageing and musculoskeletal research. Prof. Duque is a geriatrician and a clinical and biomedical researcher with special interest in the mechanisms and treatment of osteoporosis, sarcopenia and frailty in older persons. His initial training included Internal Medicine at Javeriana University (Colombia) and Geriatric Medicine, which he completed at McGill University in Montreal (Canada). Subsequently, he obtained his PhD at McGill University in 2003 with a thesis entitled ‘Molecular Changes of the Aging Osteoblast’ under the supervision of Dr. Richard Kremer. Between 2003 and November 2007, he joined the faculty at McGill University Medical School as a member of the Division of Geriatric Medicine and as Researcher at the Lady Davis Institute for Medical Research. In November 2007, he moved to Australia to join the Faculty as Associate Professor and Head of the Division of Geriatric Medicine and Director of the Musculoskeletal Ageing Research Program at Sydney Medical School Nepean -University of Sydney. In 2012, he was promoted to Professor of Medicine at the University of Sydney. In 2015, Professor Duque moved to Melbourne to assume a new position as Chair of Medicine and Director of the Australian Institute for Musculoskeletal Science at the University of Melbourne.
Prof. Duque's major research interests include the elucidation of the mechanisms of age-related bone loss, osteoporosis, sarcopenia and frailty. He is also looking at the effect of vitamin D, exercise and proteins on bone and muscle mass. As Director of the Fracture Prevention Program at Western Health, he has implemented a Falls and Fractures Clinic, where patients are assessed for falls and fractures risk in a comprehensive manner, and a Fracture Liaison Service linking his innovative programs with GPs in the community.• He has served as a member of several peer-review panels in major funding agencies in Canada (FRSQ and CIHR) and Australi
Pontificia Universidad Javeriana, Bogota 1996
University of Caldas 1990
Awards and honors
Fellow of the Royal Australasian College of Physicians,
Available for supervision
Professor Gustavo Duque is a world leader in musculoskeletal research. Prof. Duque is a geriatrician and biomedical researcher with a particular interest in the mechanisms and treatment of osteoporosis, sarcopenia and frailty in older persons. Prof. Duque's major research interests include the elucidation of the mechanisms of age-related bone loss, osteoporosis, sarcopenia and frailty. He is also looking at the effect of vitamin D, exercise and proteins on bone and muscle mass. Finally, he is implementing a new Falls and Fractures clinic at Sunshine Hospital where patients are assessed for falls and fractures risk in a comprehensive manner. Prof. Duque's research programs include: BASIC SCIENCES - Cell lines: osteoblasts, mesenchymal stem cells (able to differentiate into myocytes, adipocytes and osteoblasts), adipocytes, osteocytes. - Cell-cell interaction: Trans-differentiation, autophagy, lipotoxicity, apoptosis, proteins of the nuclear envelope, effect of hormones (i.e. vitamin D, PTH, estrogens, etc), and effect of compounds (PPARgamma inhibitor, fatty acid synthase inhibitor, apoptosis inhibitors, farnesyl transferase inhibitors, autophagy inhibitors). - Animal models (already available): progeria (Zmpste and lamin A/C knockout), mice treated with PPARgamma inhibitor, fatty acid synthase inhibitor, and picolinic acid. - Testing new pathways in bone and fat cells: Kynurenine pathway, fatty acid synthase, ceramide. - Circulating osteoprogenitors (COP) cells as diagnostic and therapeutic approach for osteosarcopenia and frailty - Mechanisms of Osteosarcopenia (Muscle and bone interphase) TRANSLATIONAL - Image analysis of muscle and bone fat: Using image analysis software (Tomovision) we can look at how much fat infiltration is happening within muscle and bone marrow in humans and animal models. - Biomarkers for frailty CLINICAL SCIENCES: - COP Study: Analysis of circulating osteo-progenitors, effect of age, hormone levels and correlation with bone and muscle