A/PROF Seth Masters

A/PROF Seth Masters


  • Inflammation (Innate immunity, inflammasome, infection, diabetes, inflammatory bowel disease, microbiota, arthritis)



  • A/Prof Seth Masters was appointed as a Lab Head in the Inflammation division at the Walter and Eliza Hall Institute in 2011.

    Our laboratory studies inflammation generated by the innate immune system. This can happen in many different contexts, including during infection, when cells die, or when genetic mutations activate innate immune pathways causing autoinflammatory disease. Inflammation contributes to the development of many chronic inflammatory diseases including rheumatoid arthritis, Crohn’s disease and type 2 diabetes.

    Previously we have made discoveries relevant to all of these areas. We maintain close links to industry and the clinic to make sure our discoveries can continue to have a direct effect on human health in the future. www.wehi.edu.au/people/seth-masters    


Member of

  • Australian Society of Biochemistry and Molecular Biology. Member 2013 -
  • Immunology Group Victoria. IgV committee member 2013 -
  • Australian Society of Immunology. Member 2012 -
  • International Society for Systemic Autoinflammatory Diseases. Member 2011 -


Selected publications


Additional Grant Information

  • The Masters lab is currently funded by: The NHMRC, Ramaciotti foundation, Diabetes Australia Research Trust and the Victorian Endowment for Science Knowledge and Innovation.   


Education and training

  • PhD, Walter and Eliza Hall Institute of Medical Research 2006
  • BSc(Hons), University of Melbourne 2000

Awards and honors

  • HHMI-Wellcome International Research Scholar, 2017
  • Milstein Award, 2014
  • Young Investigator, International Society of Systemic Autoinflammatory Diseases, 2013
  • NHMRC Fellowship, 2012
  • Tallpoppy Award, Australian Institute of Policy and Science, 2012
  • For the discovery of DIRA, National Institutes of Health, 2009
  • C.J. Martin Research Fellowship (National Health & Medical Research Council, Australia), 2009
  • Post-doctoral Investigator Award, International Cytokine Society, 2008



Available for supervision

  • Y

Supervision Statement

  • The Masters lab is currently looking for enthusiastic students who are interested in inflammation and innate immunity.

    Our research discovers new pathways that are important for chronic inflammatory diseases, and we also collaborate with the Royal Melbourne and Childrens Hospitals to identify causes of rare innate immune diseases. This interface between basic research and clinical application is an exciting area to work, as many different anti-inflammatory therapies are available when mechanisms of innate immune disease can be discovered.