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PROF Andrew Brooks

Positions

Academic, Microbiology and Immunology

Immunology (Natural killer cells, Herpes simplex virus, MHC)

Overview

Has subject area

For 2008 6 Digit Code
- Cellular Immunology
Seo 2008 6 Digit Code
- Immune System and Allergy

Affiliation

Member of

Australasian Society for Immunology. Member 2009 -

Publications

Selected publications

2017
- Journal Articles Refereed
  - MHC-I peptides get out of the groove and enable a novel mechanism of HIV-1 escape. Nature Structural and Molecular Biology. 24. 2017
  - Nasal-associated lymphoid tissues (NALTs) support the recall but not priming of influenza virus-specific cytotoxic T cells. Proceedings of the National Academy of Sciences of the United States of America. 114. 2017
  - Pattern recognition receptor immunomodulation of innate immunity as a strategy to limit the impact of influenza virus. Journal of Leukocyte Biology. 101. 2017
  - Resident memory CD8(+) T cells in the upper respiratory tract prevent pulmonary influenza virus infection. 2017
  - The molecular basis for peptide repertoire selection in the Human Leucocyte Antigen (HLA) C*06:02 molecule. 2017
2016
- Journal Articles Refereed
  - DC-SIGN and L-SIGN Are Attachment Factors That Promote Infection of Target Cells by Human Metapneumovirus in the Presence or Absence of Cellular Glycosaminoglycans. Journal of Virology. 90. 2016
  - Endocytic function is critical for influenza A virus infection via DC-SIGN and L-SIGN. Scientific Reports. 6. 2016
  - Killer cell immunoglobulin-like receptor 3DL1 polymorphism defines distinct hierarchies of HLA class I recognition. Journal of Experimental Medicine. 213. 2016
  - Neutralizing inhibitors in the airways of naive ferrets do not play a major role in modulating the virulence of H3 subtype influenza A viruses. Virology. 494. 2016
  - Recognition of the Major Histocompatibility Complex (MHC) Class Ib Molecule H2-Q10 by the Natural Killer Cell Receptor Ly49C. Journal of Biological Chemistry. 291. 2016
  - The C-type Lectin Langerin Functions as a Receptor for Attachment and Infectious Entry of Influenza A Virus. Journal of Virology. 90. 2016
2015
- Journal Articles Refereed
  - A bird's eye view of NK cell receptor interactions with their MHC class I ligands. Immunological Reviews. 267. 2015
  - Antibodies targeting Clec9A promote strong humoral immunity without adjuvant in mice and non-human primates. European Journal of Immunology. 45. 2015
  - Endogenous Murine BST-2/Tetherin Is Not a Major Restriction Factor of Influenza A Virus Infection. PLoS One. 10. 2015
  - Human CD8 T lymphocytes recognize Mycobacterium tuberculosis antigens presented by HLA-E during active tuberculosis and express type 2 cytokines. European Journal of Immunology. 45. 2015
  - Infection of Mouse Macrophages by Seasonal Influenza Viruses Can Be Restricted at the Level of Virus Entry and at a Late Stage in the Virus Life Cycle. Journal of Virology. 89. 2015
  - Limited Internodal Migration of T Follicular Helper Cells after Peripheral Infection with Herpes Simplex Virus-1. Journal of Immunology. 195. 2015
  - Peptide-Dependent Recognition of HLA-B*57:01 by KIR3DS1. Journal of Virology. 89. 2015
  - Peptide-Dependent Recognition of HLA-B*57:01 by KIR3DS1 (vol 89, pg 5213, 2015). Journal of Virology. 89. 2015
  - Spatiotemporally Distinct Interactions with Dendritic Cell Subsets Facilitates CD4(+) and CD8(+) T Cell Activation to Localized Viral Infection. Immunity. 43. 2015
  - The Interaction of KIR3DL1*001 with HLA Class I Molecules Is Dependent upon Molecular Microarchitecture within the Bw4 Epitope. Journal of Immunology. 194. 2015
  - The Presence of HLA-E-Restricted, CMV-Specific CD8(+) T Cells in the Blood of Lung Transplant Recipients Correlates with Chronic Allograft Rejection. PLoS One. 10. 2015
  - The Structure of the Atypical Killer Cell Immunoglobulin-like Receptor, KIR2DL4. Journal of Biological Chemistry. 290. 2015
- Other Refereed Contribution to Refereed Journals
  - Spatiotemporally Distinct Interactions with Dendritic Cell Subsets Facilitates CD4<sup>+</sup> and CD8<sup>+</sup> T Cell Activation to Localized Viral Infection, Immunity. 43 (2015) 554-565. Immunity. 43. 2015
2014
- Journal Articles
  - Distinct APC subtypes drive spatially segregated CD4<sup>+</sup> and CD8<sup>+</sup> T-cell effector activity during skin infection with HSV-1. PLoS Pathogens. 10. 2014
- Journal Articles Refereed
  - A Single Amino Acid Substitution in the Hemagglutinin of H3N2 Subtype Influenza A Viruses Is Associated with Resistance to the Long Pentraxin PTX3 and Enhanced Virulence in Mice. Journal of Immunology. 192. 2014
  - Analysis of CD8 T-cells recognising Mycobacterium tuberculosis antigen presented by HLA-E molecule. Immunology. 143. 2014
  - Anti-HIV Antibody-Dependent Activation of NK Cells Impairs NKp46 Expression. Journal of Immunology. 192. 2014
  - Distinct APC Subtypes Drive Spatially Segregated CD4+ and CD8+ T-Cell Effector Activity during Skin Infection with HSV-1. PLoS Pathogens. 10. 2014
  - Mutational and Structural Analysis of KIR3DL1 Reveals a Lineage-Defining Allotypic Dimorphism That Impacts Both HLA and Peptide Sensitivity. Journal of Immunology. 192. 2014
  - The Ly49 natural killer cell receptors: a versatile tool for viral self-discrimination. Immunology and Cell Biology. 92. 2014
  - The Macrophage Galactose-Type Lectin Can Function as an Attachment and Entry Receptor for Influenza Virus. Journal of Virology. 88. 2014
  - The Structure of the Cytomegalovirus-Encoded m04 Glycoprotein, a Prototypical Member of the m02 Family of Immunoevasins. Journal of Biological Chemistry. 289. 2014
2013
- Journal Articles
  - Erratum: Recognition of the nonclassical MHC class i molecule H2-M3 by the receptor Ly49A regulates the licensing and activation of NK cells (Nature Immunology (2012) 13 (1171-1177). Nature Immunology. 14. 2013
- Journal Articles Refereed
  - Addition of Glycosylation to Influenza A Virus Hemagglutinin Modulates Antibody-Mediated Recognition of H1N1 2009 Pandemic Viruses. Journal of Immunology. 190. 2013
  - Age-Associated Cross-reactive Antibody-Dependent Cellular Cytotoxicity Toward 2009 Pandemic Influenza A Virus Subtype H1N1. Journal of Infectious Diseases. 208. 2013
  - Contribution of Thy1(+) NK cells to protective IFN-gamma production during Salmonella Typhimurium infections. Proceedings of the National Academy of Sciences of the United States of America. 110. 2013
  - Cross-Reactive Influenza-Specific Antibody-Dependent Cellular Cytotoxicity Antibodies in the Absence of Neutralizing Antibodies. Journal of Immunology. 190. 2013
  - HLA Peptide Length Preferences Control CD8+ T Cell Responses. Journal of Immunology. 191. 2013
  - Polymorphism in Human Cytomegalovirus UL40 Impacts on Recognition of Human Leukocyte Antigen-E (HLA-E) by Natural Killer Cells. Journal of Biological Chemistry. 288. 2013
  - Recognition of vitamin B metabolites by mucosal-associated invariant T cells. Nature Communications. 4. 2013
  - Serum Amyloid P Is a Sialylated Glycoprotein Inhibitor of Influenza A Viruses. PLoS One. 8. 2013
  - Targeting of a natural killer cell receptor family by a viral immunoevasin. Nature Immunology. 14. 2013
- Journal Articles Unrefereed Letters or Notes
  - Non-classical MHC Class I molecules regulating natural killer cell function. OncoImmunology. 2. 2013
2012
- Journal Articles Refereed
  - A structural basis for antigen presentation by the MHC class Ib molecule, Qa-1b.. Journal of Immunology. 188. 2012
  - Cell-surface receptors on macrophages and dendritic cells for attachment and entry of influenza virus. Journal of Leukocyte Biology. 92. 2012
  - Comparison of Influenza and SIV Specific CD8 T Cell Responses in Macaques. PLoS One. 7. 2012
  - DEC-205 is a cell surface receptor for CpG oligonucleotides. Proceedings of the National Academy of Sciences of the United States of America. 109. 2012
  - Degenerate Recognition of MHC Class I Molecules with Bw4 and Bw6 Motifs by a Killer Cell Ig-like Receptor 3DL Expressed by Macaque NK Cells. Journal of Immunology. 189. 2012
  - MHC class Ib-Restricted CD8 T Cells Differ in Dependence on CD4 T Cell Help and CD28 Costimulation over the Course of Mouse Polyomavirus Infection. Journal of Immunology. 188. 2012
  - Neutrophils sustain effective CD8+ T-cell responses in the respiratory tract following influenza infection. Immunology and Cell Biology. 90. 2012
  - Recognition of the nonclassical MHC class I molecule H2-M3 by the receptor Ly49A regulates the licensing and activation of NK cells. Nature Immunology. 13. 2012
  - Soluble Host Defense Lectins in Innate Immunity to Influenza Virus. Journal of Biomedicine and Biotechnology. 2012. 2012
  - The fate of influenza A virus after infection of human macrophages and dendritic cells.. Journal of General Virology. 93. 2012
2011
- Journal Articles
  - Diverse roles of non-diverse molecules: MHC class Ib molecules in host defense and control of autoimmunity. Current Opinion in Immunology. 23. 2011
  - Immunoreceptor intramembrane assembly How opposites attract. Immunology and Cell Biology. 89. 2011
  - Killer cell immunoglobulin-like receptor 3DL1-mediated recognition of human leukocyte antigen B. Nature. 479. 2011
  - V beta 2 natural killer T cell antigen receptor-mediated recognition of CD1d-glycolipid antigen. Proceedings of the National Academy of Sciences of the United States of America. 108. 2011
- Journal Articles Refereed
  - A Molecular Basis for the Exquisite CD1d-Restricted Antigen Specificity and Functional Responses of Natural Killer T Cells. Immunity. 34. 2011
  - A semi-invariant Vα10+ T cell antigen receptor defines a population of natural killer T cells with distinct glycolipid antigen-recognition properties. Nature Immunology. 12. 2011
  - Blood-Stage Plasmodium berghei Infection Generates a Potent, Specific CD8+ T-Cell Response Despite Residence Largely in Cells Lacking MHC I Processing Machinery. Journal of Infectious Diseases. 204. 2011
  - Correlation between sialic acid expression and infection of murine macrophages by different strains of influenza virus. Microbes and Infection. 13. 2011
  - Different patterns of peripheral migration by memory CD4(+) and CD8(+) T cells. Nature. 477. 2011
  - Glycosylation of the hemagglutinin modulates the sensitivity of H3N2 influenza viruses to innate proteins in airway secretions and virulence in mice. Virology. 413. 2011
  - Inhibition of lectin-mediated innate host defences in vivo modulates disease severity during influenza virus infection. Immunology and Cell Biology. 89. 2011
  - N-Linked Glycosylation Facilitates Sialic Acid-Independent Attachment and Entry of Influenza A Viruses into Cells Expressing DC-SIGN or L-SIGN. Journal of Virology. 85. 2011
  - Receptor specificity of the influenza virus hemagglutinin modulates sensitivity to soluble collectins of the innate immune system and virulence in mice. Virology. 413. 2011
  - Responses of Mouse Airway Epithelial Cells and Alveolar Macrophages to Virulent and Avirulent Strains of Influenza A Virus. Viral Immunology. 24. 2011
  - Specific Sites of N-Linked Glycosylation on the Hemagglutininof H1N1 Subtype Influenza AVirus Determine Sensitivity toInhibitors of the Innate Immune System and Virulence inMice. Journal of Immunology. 187. 2011
  - The Role of Neutrophils during Mild and Severe Influenza Virus Infections of Mice. PLoS One. 6. 2011
- Conference Proceedings
  - Live Attenuated Influenza-SIV Vaccines: Efficacy Against Mucosal Challenge in Macaques. AIDS Research and Human Retroviruses. 2011
2010
- Journal Articles Refereed
  - Allelic polymorphism in the T cell receptor and its impact on immune responses. Journal of Experimental Medicine. 207. 2010
  - Critical Role of Airway Macrophages in Modulating Disease Severity during Influenza Virus Infection of Mice. Journal of Virology. 84. 2010
  - Depletion of Gr-1+, but not Ly6G+, immune cells exacerbates virus replication and disease in an intranasal model of herpes simplex virus type 1 infection. Journal of General Virology. 91. 2010
  - Gr-1+ cells, but not neutrophils, limit virus replication and lesion development following flank infection of mice with herpes simplex virus type-1. Virology. 407. 2010
  - Hard wiring of T cell receptor specificity for the major histocompatibility complex is underpinned by TCR adaptability. Proceedings of the National Academy of Sciences of the United States of America. 107. 2010
  - Influenza viruses differ in ability to infect macrophages and to induce a local inflammatory response following intraperitoneal injection of mice. Immunology and Cell Biology. 88. 2010
  - Natural Killer Cell Activation in the Lung Allograft Early Posttransplantation. Transplantation. 89. 2010
  - Pandemic H1N1 Influenza A Viruses Are Resistant to the Antiviral Activities of Innate Immune Proteins of the Collectin and Pentraxin Superfamilies. Journal of Immunology. 185. 2010
  - The Structure and Stability of the Monomorphic HLA-G Are Influenced by the Nature of the Bound Peptide. Journal of Molecular Biology. 397. 2010
2009
- Journal Articles Refereed
  - A Protective Vaccine Delivery System for In Vivo T Cell Stimulation Using Nanoengineered Polymer Hydrogel Capsules. ACS Nano. 3. 2009
  - Cross-presentation of viral and self antigens by skin-derived CD103+ dendritic cells. Nature Immunology. 10. 2009
  - Differential Recognition of CD1d-α-Galactosyl Ceramide by the Vβ8.2 Vβ7 Semi-invariant NKT T Cell Receptors. Immunity. 31. 2009
  - Killer Ig-like receptor ligand mismatch directs NK cell expansion in vitro. Journal of Immunology. 183. 2009
  - Loss of a single N-linked glycan from the hemagglutinin of influenza virus is associated with resistance to collectins and increased virulence in mice. Respiratory Research. 10. 2009
  - Neutrophils Ameliorate Lung Injury and the Development of Sever Disease during Influenza Infection. Journal of Immunology. 183. 2009
  - T Cell Allorecognition via Molecular Mimicry. Immunity. 31. 2009
  - The shaping of T cell receptor recognition by self-tolerance. Immunity. 30. 2009
- Conference Proceedings
  - RECOGNITION OF HLA-E BY NATURAL KILLER CELLS IS IMPACTED BY VARIATION IN CYTOMEGALOVIRUS UL40 SEQUENCES IN HAEMOPOIETIC STEM CELL TRANSPLANTATION. Human Immunology. 2009
  - THE EFFECT OF KIR HAPLOTYPE ON CLINICAL OUTCOME FOLLOWING HLA-MATCHED SIBLING HAEMOPOIETIC STEM CELL TRANSPLANTATION. Human Immunology. 2009
2008
- Journal Articles Refereed
  - Antiviral Activity of the Long Chain Pentraxin PTX3 against Influenza Viruses. Journal of Immunology. 180. 2008
  - Application of CD27 as a marker for distinguishing human NK cell subsets. International Immunology. 20. 2008
  - CD94-NKG2A recognition of human leukocyte antigen (HLA)-E bound to an HLA class I leader sequence. Journal of Experimental Medicine. 205. 2008
  - Porcine cells express more than one functional ligand for the human lymphocyte activating receptor NKG2D. Xenotransplantation. 15. 2008
  - Protection afforded by live attenuated SIV is associated with rapid killing kinetics of CTLs. Journal of Medical Primatology. 37. 2008
  - Subtle changes in peptide conformation profoundly affect recognition of the non-classical MHC class I molecule HLA-E by the CD94-NKG2 natural killer cell receptors. Journal of Molecular Biology. 377. 2008
  - The major histocompatibility complex class Ib molecule HLA-E at the interface between innate and adaptive immunity. Tissue Antigens. 72. 2008
  - The role of neutrophils in the the upper and lower respiratory tract during influenza virus infection of mice. Respiratory Research. 9. 2008
- Conference Proceedings
  - Inhibition of Influenza Viruses By Proteins of the Innate Immune System 2008
2007
- Journal Articles Refereed
  - A role for plasmacytoid dendritic cells in the rapid IL-18-dependent activation of NK cells following HSV-1 infection. European Journal of Immunology. 37. 2007
  - CD8+ T-cell maturation following lung transplantation: The differential impact of CMV and acute rejection. Transplant Immunology. 18. 2007
  - Glycosylation as a target for recognition of influenza viruses by the innate immune system. Advances in Experimental Medicine and Biology. 598. 2007
  - IL-18, but not IL-12, Regulates NK Cell Activity following Intranasal Herpes Simplex Virus Type 1 Infection. Journal of Immunology. 179. 2007
  - Killing Kinetics of Simian Immunodeficiency Virus-Specific CD8+ T Cells: Implications for HIV Vaccine Strategies. Journal of Immunology. 179. 2007
  - The Heterodimeric Assembly of the CD94-NKG2 Receptor Family and Implications for Human Leukocyte Antigen-E Recognition. Immunity. 27. 2007
- Conference Proceedings
  - Glycosylation as a target for recognition of influenza viruses by the innate immune system. Advances in Experimental Medicine and Biology. 2007
  - Porcine cells express more than one functional ligand for the human NK cell activating receptor NKG2D. Xenotransplantation. 2007
2006
- Research Book Chapters
  - Assays for T cell function. Induction and Measurement of Cytotoxic T Lymphocyte Activity. Current Protocols in Immunology. John Wiley & Sons. 2006
- Journal Articles
  - Induction and measurement of cytotoxic T lymphocyte activity. 2006
- Journal Articles Refereed
  - A structural perspective on MHC class Ib molecules in adaptive immunity. Trends in Immunology (formerly Immunology Today). 27. 2006
  - CMV-specific CD8+ T-cell dynamics in the blood and the lung allograft reflect viral reactivation following lung transplantation. American Journal of Transplantation. 6. 2006
  - MHC class I allele frequencies in pigtail macaques of diverse origin. Immunogenetics. 58. 2006
  - NK cells contribute to the early clearance of HSV-1 from the lung but cannot control replication in the central nervous system following intranasal infection. European Journal of Immunology. 36. 2006
  - NK cells promote peritoneal xenograft rejection through an IFN-γ-dependent mechanism. Xenotransplantation. 13. 2006
  - Responses against islet antigens in NOD mice prevented by tolerance to proinsulin but not IGRP. Journal of Clinical Investigation. 116. 2006
  - Structural basis for a major histocompatability complex class 1b-restricted T cell response. Nature Immunology. 7. 2006
  - The human cytomegalorvirus glycoprotein UL16 traffics through the plasma membrane and the nuclear envelope. Cellular Microbiology. 8. 2006
2005
- Journal Articles Refereed
  - Crystal structure of HLA-G: A nonclassical MHC class I molecule expressed at the fetal-maternal interface. Proceedings of the National Academy of Sciences of the United States of America. 102. 2005
  - DX5/CD49b-Positive T Cells Are Not Synonymous with CD1d-Dependent NKT Cells1. Journal of Immunology. 175. 2005
  - The pigtail macaque MHC class I allele Mane-A*10 presents an immundominant SIV Gag epitope: identification, tetramer development and implications of immune escape and reversion. Journal of Medical Primatology. 34. 2005
- Journal Articles Unrefereed
  - T-cell grit: large clonal expansions of virus-specific CD8+ T cells can dominate in the peripheral circulation for at least 18 years. Blood. 106. 2005
- Conference Proceedings
  - Identification of CD4 T cell epitopes important for the recognition of HSV-1 in C57BI/6 mice. Tissue Antigens. 2005
  - Insights into effective SIV gag-specific CD8+T cell responses and fitness costs of viral escape. Tissue Antigens. 2005
  - NK cells contribute to the early clearance of HSV-1 from the lung but cannot control replication in the central nervous system following intranasal infection. Tissue Antigens. 2005
  - NK cells mediate control of viral replication in the nerves following HSV-1 flank zosteriform infection. Tissue Antigens. 2005
  - Neutrophil recruitment and activation following intranasal infection with different influenza viruses. Tissue Antigens. 2005
  - Plasmacytoid and conventional dendritic cells mediate rapid cytokine-dependent activation of NK cells to herpes simplex virus type 1. Tissue Antigens. 2005
  - Recognition of the Non-Classical MHC Class I Molecule, HLA-E, by the Adaptive Immune System 2005
  - Soluble MICA and reduced expression of NKG2D in preclinical type-1 diabetics. Tissue Antigens. 2005
  - The role of peptide in the recognition of HLA-E by cytomegalovirus-specific CD8+T cells. Tissue Antigens. 2005
2004
- Journal Articles Refereed
  - Analysis of Pigtail Macaque Major Histocompatibility Complex Class I Molecules Presenting Immunodominant Simian Immunodeficiency Virus Epitopes. Journal of Virology. 79. 2004
  - Crystal structure of the human T cell receptor CD3εγ heterodimer complexed to the therapeutic mAB OKT3. Proceedings of the National Academy of Sciences of the United States of America. 101. 2004
  - Distinct migrating and nonmigrating dendritic cell populations are involved in MHC class I-restricted antigen presentation after lung infection with virus. Proceedings of the National Academy of Sciences of the United States of America. 101. 2004
  - Herpes Simplex Virus-Specific CD8+ T Cells Can Clear Established Lytic Infections from Skin and Nerves and Can Partially Limit the Early Spread of Virus after Cutaneous Inoculation. Journal of Immunology. 172. 2004
  - Natural HLA class I polymorphism controls the pathway of antigen presentation and susceptibility to viral evasion. Journal of Experimental Medicine. 200. 2004
  - Persistent expression of CD94/NKG2 receptors by virus-specific CD8 T cells is initiated by TCR-mediated signals. International Immunology. 16. 2004
  - The production and purification of the human T-cell receptors, the CD3εγ and CD3εδ heterodimers: complex formation and crystallization with OKT3, a therapeutic monoclonal antibody. Acta Crystallographica Section D - Biological Crystallography. D60. 2004
  - Truncated HLA-G isoforms are retained in the endoplasmic reticulum and insufficiently provide HLA-E ligands. Human Immunology. 65. 2004
- Conference Proceedings
  - Impact of natural HLA class I polymorphism and the pathway of antigen presentation. Genes and Immunity. 2004
  - The 2.1 angstrom crystal structure of the human T cell receptor CD3E Gamma heterodimer complexed to the therapeutic MAB OKT3. Genes and Immunity. 2004
2003
- Journal Articles Refereed
  - A Naturally Selected Dimorphism within the HLA-B44 Supertype Alters Class I Structure, Peptide Repertoire, and T Cell Recognition. Journal of Experimental Medicine. 198. 2003
  - A Structural Basis for the Selection of Dominant αβ T Cell Receptors in Antiviral Immunity. Immunity. 18. 2003
  - Genetic Control of NKT Cell Numbers Maps to Major Diabetes and Lupus Loci1. Journal of Immunology. 171. 2003
  - Intrathymic NKT cell development is blocked by the presence of α-galactosylceramide. European Journal of Immunology. 33. 2003
  - Novel strategy for identification of candidate cytotoxic T-cell epitopes from human preproinsulin. Tissue Antigens. 62. 2003
  - Virus infection expands a biased subset of T cells that bind tetrameric class I peptide complexes. European Journal of Immunology. 33. 2003
2002
- Journal Articles
  - Prime-boost immunization generates a high frequency, high-avidity CD8(+) cytotoxic T lymphocyte population. International Immunology. 14. 2002
  - Role that each NKG2A immunoreceptor tyrosine-based inhibitory motif plays in mediating the human CD94/NKG2A inhibitory signal. Journal of Immunology. 169. 2002
  - The 1.5 angstrom crystal structure of a highly selected antiviral T cell receptor provides evidence for a structural basis of immunodominance. Structure. 10. 2002
  - The 1.5 Å crystal structure of a highly selected antiviral T cell receptor provides evidence for a structural basis of immunodominance. Structure. 10. 2002
- Journal Articles Refereed
  - Identification of a dominant self-ligand bound to three HLA B44 alleles and the preliminary crystallographic analysis of recombinant forms of each complex. FEBS Letters. 527. 2002
  - Peripheral Deletion of Autoreactive CD8 T Cells by Cross Presentation of Self-Antigen Occurs by a Bcl-2-inhibitable Pathway Mediated by Bim. Journal of Experimental Medicine. 196. 2002
  - Progression of Armed CTL from Draining Lymph Node to Spleen Shortly After Localized Infection with Herpes Simplex Virus 11. Journal of Immunology. 168. 2002
  - The 1.5 Å Crystal Structure of a Highly Selected Antiviral T Cell Receptor Provides Evidence for a Structural Basis of Immunodominance. Structure. 10. 2002
  - The Structure of HLA-B8 Complexed to an Immunodominant Viral Determinant: Peptide-Induced Conformational Changes and a Mode of MHC Class I Dimerization1. Journal of Immunology. 169. 2002
  - The production, purification and crystallization of a soluble heterodimeric form of a highly selected T-cell receptor in its unliganded and liganded state.. Acta Crystallographica Section D - Biological Crystallography. 58. 2002
2001
- Journal Articles
  - Analysis of the role that each NKG2A ITIM motif plays in CD94/NKG2A signal initiation. FASEB Journal. 15. 2001
- Journal Articles Refereed
  - Conformational Plasticity Revealed by the Cocrystal Structure of NKG2D and Its Class I MHC-like Ligand ULBP3. Immunity. 15. 2001
  - Structure of killer cell immunoglobulin-like receptors and their recognition of the class I MHC molecules. Immunological Reviews. 181. 2001
2000
- Journal Articles
  - Aberrant development of thymocytes in mice lacking laminin-2 2000
  - Crystal structure of an NK cell immunoglobulin-like receptor in complex with its class I MHC ligand. Nature. 405. 2000
  - Crystal structure of the extracellular domain of a human FcγRIII. Immunity. 13. 2000
  - Differential splicing of antigen-encoding RNA reduces endogenous epitope presentation that regulates the expansion and cytotoxicity of T cells. Journal of Immunology. 165. 2000
  - Herpes simplex virus type 1-specific cytotoxic T-lymphocyte arming occurs within lymph nodes draining the site of cutaneous infection. Journal of Virology. 74. 2000
  - Junctional biases in the naive TCR repertoire control the CTL response to an immunodominant determinant of HSV-1. Immunity. 12. 2000
  - Natural killer cell recognition of HLA class I molecules 2000
  - Peptide-MHC class I tetrameric complexes display exquisite ligand specificity. Journal of Immunology. 165. 2000
  - Reconstitution of bacterial-expressed human CD94: The importance of the stem region for dimer formation. Protein Expression and Purification. 18. 2000
1999
- Journal Articles
  - Crystal structure of the HLA-Cw3 allotype-specific killer cell inhibitory receptor KIR2DL2. Proceedings of the National Academy of Sciences of the United States of America. 96. 1999
  - Human glioma-induced immunosuppression involves soluble factor(s) that alters monocyte cytokine profile and surface markers. Journal of Immunology. 162. 1999
  - Specific recognition of HLA-E, but not classical, HLA class I molecules by soluble CD94FNKG2A and NK cells. Journal of Immunology. 162. 1999
  - Structure of CD94 reveals novel C-type lectin fold: Implications for the NK cell-associated CD94/NKG2 receptors. Immunity. 10. 1999
1998
- Journal Articles
  - HLA-E is the ligand for the natural killer cell CD94/NKG2 receptors. Journal of Biomedical Science. 5. 1998
  - Recognition of human histocompatibility leukocyte antigen (HLA)-E complexed with HLA class I signal sequence-derived peptides by CD94/NKG2 confers protection from natural killer cell-mediated lysis. Journal of Experimental Medicine. 187. 1998
1997
- Journal Articles
  - NKG2A complexed with CD94 defines a novel inhibitory natural killer cell receptor. Journal of Experimental Medicine. 185. 1997
  - Peptides isolated from HLA-Cw*0304 confer different degrees of protection from natural killer cell-mediated lysis. Proceedings of the National Academy of Sciences of the United States of America. 94. 1997
1995
- Journal Articles
  - Peptide binding to MHC class I molecules: Implications for antigenic peptide prediction. Immunologic Research. 14. 1995
- Journal Articles Refereed
  - Antigen processing and presentation by a murine myoblast cell line. Clinical and Experimental Immunology. 102. 1995
1994
- Journal Articles
  - ANTIGEN PRESENTATION AND ASSEMBLY BY MOUSE I-A(K) CLASS-II MOLECULES IN HUMAN APC CONTAINING DELETED OR MUTATED HLA DM GENES. Journal of Immunology. 153. 1994
1993
- Journal Articles
  - CLASS-II-RESTRICTED PRESENTATION OF A HEN EGG LYSOZYME DETERMINANT DERIVED FROM ENDOGENOUS ANTIGEN SEQUESTERED IN THE CYTOPLASM OR ENDOPLASMIC-RETICULUM OF THE ANTIGEN PRESENTING CELLS. Journal of Immunology. 150. 1993
1991
- Journal Articles
  - CLASS-II-RESTRICTED PRESENTATION OF AN ENDOGENOUSLY DERIVED IMMUNODOMINANT T-CELL DETERMINANT OF HEN EGG LYSOZYME. Proceedings of the National Academy of Sciences of the United States of America. 88. 1991

Research

Investigator on

Contract
- The role of C-type lectin receptors in viral infection administered by Microbiology and Immunology 2014 -
- The role of CD4 T cells in immunity to herpes simplex virus administered by Microbiology and Immunology 2012 -
- TOOLS FOR ASSESSING THE HSV-1 SPECIFIC CD4 T CELL RESPONSE administered by Microbiology and Immunology 2011 -
- TOOLS FOR ASSESSING THE HSV-1 SPECIFIC CD4T CELL RESPONSE awarded by YALE UNIVERSITY 2010 -
- INTERACTIONS BETWEEN HUMAN MANNOSE-BINDING LECTIN AND VIRUS awarded by AUST RED CROSS BLOOD SERVICE 2009 -
Grant
- ANTIGEN PRESENTATION, RECOGNITION AND THE IMMUNE RESPONSE (Program Grants) awarded by NHMRC 2017 - 2021
- AFFINITY BIOSCIENCES CONTRACT (Innovation Connections Grants) awarded by AFFINITY BIO 2017 -
- EXPLORING THE ROLE OF HUMAN NATURAL KILLER CELLS IN TUMOUR IMMUNITY (Grants-in-Aid) awarded by MONASH UNIVERSITY 2016 -
- REGULATION OF NK CELL ACTIVATION BY MHC CLASS I MOLECULES (Project Grants) awarded by NHMRC 2014 - 2016
- PROGNOSTIC GENETIC MARKERS OF SEVERE DENGUE (A*Star Joint Call for Research) awarded by NHMRC 2013 - 2016
- ANTIGEN PRESENTATION RECOGNITION AND THE IMMUNE SYSTEM (Program Grants) awarded by NHMRC 2012 - 2016
- THE ROLE OF CD4+ T CELLS IN IMMUNITY TO HSV-1 (Project Grants) awarded by NHMRC 2011 - 2013
- Multi-photon imaging for infection, immunity, and self recognition (Linkage Infrastructure (Equipment and Facilities)) awarded by AUST RESEARCH COUNCIL 2009
- Immune recognition of HLA-E (Project Grants) awarded by NHMRC 2008 - 2010
- 2007 PROGRAM GRANT - (ANTIGEN PRESENTATION, RECOGNITION AND THE IMMUNE RESPONSE) (Program Grants) awarded by NHMRC 2007 - 2011
- The structural basis for recognition of HLA-E by both innate and adaptive immune systems. (Project Grants) awarded by NHMRC 2006 - 2008
- Antigen presentation, recognition and the immune response (Program Grants) awarded by NHMRC 2002 - 2006
- International Research and Research Training Fund (International Research & Research Training Fund (IRRTF)) awarded by UNIVERSITY OF MELBOURNE

Awards

Education and training

PhD, Flinders University of South Australia
BSc, Monash University
DipEd, Victorian College of the Arts

Linkages

Geographic focus

Australia

Supervision

Available for supervision

Y

Contact Details
- agbrooks@unimelb.edu.au
- 61 3 8344 9925
- fax: 61 3 9347 1540
- Location
  - Level: 05 Room: 522, Microbiology Building, Parkville
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