Has subject area For 2008 6 Digit Code Cellular Immunology Seo 2008 6 Digit Code Immune System and Allergy
Selected publications 2019 Journal Articles Refereed Broadening our knowledge of the differences between HIV-2 and HIV-1 innate sensing: HIV-2 infected cells selectively express B7-H6 and engage NKp30 on natural killer cells. AIDS. 33. 2019 Classical Type 1 Dendritic Cells Dominate Priming of Th1 Responses to Herpes Simplex Virus Type 1 Skin Infection. Journal of Immunology. 202. 2019 Downregulation of MHC Class I Expression by Influenza A and B Viruses. Frontiers in Immunology. 10. 2019 Enrichment of Cytomegalovirus-induced NKG2C(+) Natural Killer Cells in the Lung Allograft. Transplantation. 103. 2019 IFITM3 and type I interferons are important for the control of influenza A virus replication in murine macrophages. 2019 The complex existence of gamma delta T cells following transplantation: the good, the bad and the simply confusing. Clinical & Translational Immunology. 8. 2019 Unique Transcriptional Architecture in Airway Epithelial Cells and Macrophages Shapes Distinct Responses following Influenza Virus Infection Ex Vivo. Journal of Virology. 93. 2019 2018 Journal Articles Refereed Activating killer-cell immunoglobulin-like receptor haplotype influences clinical outcome following HLA-matched sibling haematopoietic stem cell transplantation 2018 Changes in Gut Microbiota Prior to Influenza A Virus Infection Do Not Affect Immune Responses in Pups or Juvenile Mice. Frontiers in Cellular and Infection Microbiology. 8. 2018 Induction and Measurement of Cytotoxic T Lymphocyte Activity. 2018 Killer cell immunoglobulin-like receptor 3DL1 variation modifies HLA-B*57 protection against HIV-1. Journal of Clinical Investigation. 128. 2018 2017 Journal Articles Refereed A conserved energetic footprint underpins recognition of human leukocyte antigen-E by two distinct alpha beta T cell receptors. Journal of Biological Chemistry. 292. 2017 Host Cell Restriction Factors that Limit Influenza A Infection. Viruses. 9. 2017 MHC-I peptides get out of the groove and enable a novel mechanism of HIV-1 escape. Nature Structural and Molecular Biology. 24. 2017 Nasal-associated lymphoid tissues (NALTs) support the recall but not priming of influenza virus-specific cytotoxic T cells. Proceedings of the National Academy of Sciences of the United States of America. 114. 2017 Pattern recognition receptor immunomodulation of innate immunity as a strategy to limit the impact of influenza virus. Journal of Leukocyte Biology. 101. 2017 Resident memory CD8(+) T cells in the upper respiratory tract prevent pulmonary influenza virus infection 2017 The molecular basis for peptide repertoire selection in the human leukocyte antigen (HLA) C*06:02 molecule. Journal of Biological Chemistry. 292. 2017 2016 Journal Articles Refereed DC-SIGN and L-SIGN Are Attachment Factors That Promote Infection of Target Cells by Human Metapneumovirus in the Presence or Absence of Cellular Glycosaminoglycans. Journal of Virology. 90. 2016 Endocytic function is critical for influenza A virus infection via DC-SIGN and L-SIGN. Scientific Reports. 6. 2016 Killer cell immunoglobulin-like receptor 3DL1 polymorphism defines distinct hierarchies of HLA class I recognition. Journal of Experimental Medicine. 213. 2016 Neutralizing inhibitors in the airways of naive ferrets do not play a major role in modulating the virulence of H3 subtype influenza A viruses. Virology. 494. 2016 Recognition of the Major Histocompatibility Complex (MHC) Class Ib Molecule H2-Q10 by the Natural Killer Cell Receptor Ly49C. Journal of Biological Chemistry. 291. 2016 The C-type Lectin Langerin Functions as a Receptor for Attachment and Infectious Entry of Influenza A Virus. Journal of Virology. 90. 2016 2015 Journal Articles Refereed A bird's eye view of NK cell receptor interactions with their MHC class I ligands. Immunological Reviews. 267. 2015 Antibodies targeting Clec9A promote strong humoral immunity without adjuvant in mice and non-human primates. European Journal of Immunology. 45. 2015 Endogenous Murine BST-2/Tetherin Is Not a Major Restriction Factor of Influenza A Virus Infection. PLoS One. 10. 2015 Human CD8 T lymphocytes recognize Mycobacterium tuberculosis antigens presented by HLA-E during active tuberculosis and express type 2 cytokines. European Journal of Immunology. 45. 2015 Infection of Mouse Macrophages by Seasonal Influenza Viruses Can Be Restricted at the Level of Virus Entry and at a Late Stage in the Virus Life Cycle. Journal of Virology. 89. 2015 Limited Internodal Migration of T Follicular Helper Cells after Peripheral Infection with Herpes Simplex Virus-1. Journal of Immunology. 195. 2015 Peptide-Dependent Recognition of HLA-B*57:01 by KIR3DS1. Journal of Virology. 89. 2015 Spatiotemporally Distinct Interactions with Dendritic Cell Subsets Facilitates CD4(+) and CD8(+) T Cell Activation to Localized Viral Infection. Immunity. 43. 2015 The Interaction of KIR3DL1*001 with HLA Class I Molecules Is Dependent upon Molecular Microarchitecture within the Bw4 Epitope. Journal of Immunology. 194. 2015 The Presence of HLA-E-Restricted, CMV-Specific CD8(+) T Cells in the Blood of Lung Transplant Recipients Correlates with Chronic Allograft Rejection. PLoS One. 10. 2015 The Structure of the Atypical Killer Cell Immunoglobulin-like Receptor, KIR2DL4. Journal of Biological Chemistry. 290. 2015 Other Refereed Contribution to Refereed Journals Peptide-Dependent Recognition of HLA-B*57:01 by KIR3DS1 (vol 89, pg 5213, 2015). Journal of Virology. 89. 2015 Spatiotemporally Distinct Interactions with Dendritic Cell Subsets Facilitates CD4(+) and CD8(+) T Cell Activation to Localized Viral Infection (vol 43, pg 554, 2015). Immunity. 43. 2015 2014 Journal Articles Refereed A Single Amino Acid Substitution in the Hemagglutinin of H3N2 Subtype Influenza A Viruses Is Associated with Resistance to the Long Pentraxin PTX3 and Enhanced Virulence in Mice. Journal of Immunology. 192. 2014 Anti-HIV Antibody-Dependent Activation of NK Cells Impairs NKp46 Expression. Journal of Immunology. 192. 2014 Distinct APC Subtypes Drive Spatially Segregated CD4+ and CD8+ T-Cell Effector Activity during Skin Infection with HSV-1. PLoS Pathogens. 10. 2014 Distinct APC subtypes drive spatially segregated CD4+ and CD8+ T-cell effector activity during skin infection with HSV-1. PLoS Pathogens. 10. 2014 Mutational and Structural Analysis of KIR3DL1 Reveals a Lineage-Defining Allotypic Dimorphism That Impacts Both HLA and Peptide Sensitivity. Journal of Immunology. 192. 2014 The Ly49 natural killer cell receptors: a versatile tool for viral self-discrimination. Immunology and Cell Biology. 92. 2014 The Macrophage Galactose-Type Lectin Can Function as an Attachment and Entry Receptor for Influenza Virus. Journal of Virology. 88. 2014 The Structure of the Cytomegalovirus-Encoded m04 Glycoprotein, a Prototypical Member of the m02 Family of Immunoevasins. Journal of Biological Chemistry. 289. 2014 2013 Journal Articles Refereed Addition of Glycosylation to Influenza A Virus Hemagglutinin Modulates Antibody-Mediated Recognition of H1N1 2009 Pandemic Viruses. Journal of Immunology. 190. 2013 Age-Associated Cross-reactive Antibody-Dependent Cellular Cytotoxicity Toward 2009 Pandemic Influenza A Virus Subtype H1N1. Journal of Infectious Diseases. 208. 2013 Contribution of Thy1(+) NK cells to protective IFN-gamma production during Salmonella Typhimurium infections. Proceedings of the National Academy of Sciences of the United States of America. 110. 2013 Cross-Reactive Influenza-Specific Antibody-Dependent Cellular Cytotoxicity Antibodies in the Absence of Neutralizing Antibodies. Journal of Immunology. 190. 2013 HLA Peptide Length Preferences Control CD8(+) T Cell Responses. Journal of Immunology. 191. 2013 Polymorphism in Human Cytomegalovirus UL40 Impacts on Recognition of Human Leukocyte Antigen-E (HLA-E) by Natural Killer Cells. Journal of Biological Chemistry. 288. 2013 Recognition of vitamin B metabolites by mucosal-associated invariant T cells. Nature Communications. 4. 2013 Serum Amyloid P Is a Sialylated Glycoprotein Inhibitor of Influenza A Viruses. PLoS One. 8. 2013 Targeting of a natural killer cell receptor family by a viral immunoevasin. Nature Immunology. 14. 2013 Journal Articles Unrefereed Letters or Notes Non-classical MHC Class I molecules regulating natural killer cell function. OncoImmunology. 2. 2013 2012 Journal Articles Refereed A Structural Basis for Antigen Presentation by the MHC Class Ib Molecule, Qa-1(b). Journal of Immunology. 188. 2012 Cell-surface receptors on macrophages and dendritic cells for attachment and entry of influenza virus. Journal of Leukocyte Biology. 92. 2012 Comparison of Influenza and SIV Specific CD8 T Cell Responses in Macaques. PLoS One. 7. 2012 DEC-205 is a cell surface receptor for CpG oligonucleotides. Proceedings of the National Academy of Sciences of the United States of America. 109. 2012 Degenerate Recognition of MHC Class I Molecules with Bw4 and Bw6 Motifs by a Killer Cell Ig-like Receptor 3DL Expressed by Macaque NK Cells. Journal of Immunology. 189. 2012 MHC Class Ib-Restricted CD8 T Cells Differ in Dependence on CD4 T Cell Help and CD28 Costimulation over the Course of Mouse Polyomavirus Infection. Journal of Immunology. 188. 2012 Neutrophils sustain effective CD8(+) T-cell responses in the respiratory tract following influenza infection. Immunology and Cell Biology. 90. 2012 Recognition of the nonclassical MHC class I molecule H2-M3 by the receptor Ly49A regulates the licensing and activation of NK cells. Nature Immunology. 13. 2012 Soluble Host Defense Lectins in Innate Immunity to Influenza Virus. Journal of Biomedicine and Biotechnology. 2012. 2012 The fate of influenza A virus after infection of human macrophages and dendritic cells. Journal of General Virology. 93. 2012 2011 Journal Articles Diverse roles of non-diverse molecules: MHC class Ib molecules in host defense and control of autoimmunity. Current Opinion in Immunology. 23. 2011 Immunoreceptor intramembrane assembly How opposites attract. Immunology and Cell Biology. 89. 2011 Journal Articles Refereed A Molecular Basis for the Exquisite CD1d-Restricted Antigen Specificity and Functional Responses of Natural Killer T Cells. Immunity. 34. 2011 A semi-invariant V(alpha)10(+) T cell antigen receptor defines a population of natural killer T cells with distinct glycolipid antigen-recognition properties. Nature Immunology. 12. 2011 Blood-Stage Plasmodium berghei Infection Generates a Potent, Specific CD8(+) T-Cell Response Despite Residence Largely in Cells Lacking MHC I Processing Machinery. Journal of Infectious Diseases. 204. 2011 Correlation between sialic acid expression and infection of murine macrophages by different strains of influenza virus. Microbes and Infection. 13. 2011 Different patterns of peripheral migration by memory CD4(+) and CD8(+) T cells. Nature. 477. 2011 Glycosylation of the hemagglutinin modulates the sensitivity of H3N2 influenza viruses to innate proteins in airway secretions and virulence in mice. Virology. 413. 2011 Inhibition of lectin-mediated innate host defences in vivo modulates disease severity during influenza virus infection. Immunology and Cell Biology. 89. 2011 Killer cell immunoglobulin-like receptor 3DL1-mediated recognition of human leukocyte antigen B. Nature. 479. 2011 N-Linked Glycosylation Facilitates Sialic Acid-Independent Attachment and Entry of Influenza A Viruses into Cells Expressing DC-SIGN or L-SIGN. Journal of Virology. 85. 2011 Receptor specificity of the influenza virus hemagglutinin modulates sensitivity to soluble collectins of the innate immune system and virulence in mice. Virology. 413. 2011 Responses of Mouse Airway Epithelial Cells and Alveolar Macrophages to Virulent and Avirulent Strains of Influenza A Virus. Viral Immunology. 24. 2011 Specific Sites of N-Linked Glycosylation on the Hemagglutinin of H1N1 Subtype Influenza A Virus Determine Sensitivity to Inhibitors of the Innate Immune System and Virulence in Mice. Journal of Immunology. 187. 2011 The Role of Neutrophils during Mild and Severe Influenza Virus Infections of Mice. PLoS One. 6. 2011 V beta 2 natural killer T cell antigen receptor-mediated recognition of CD1d-glycolipid antigen. Proceedings of the National Academy of Sciences of the United States of America. 108. 2011 Conference Proceedings Live Attenuated Influenza-SIV Vaccines: Efficacy Against Mucosal Challenge in Macaques. AIDS Research and Human Retroviruses. 2011 2010 Journal Articles Refereed Allelic polymorphism in the T cell receptor and its impact on immune responses. Journal of Experimental Medicine. 207. 2010 Critical Role of Airway Macrophages in Modulating Disease Severity during Influenza Virus Infection of Mice. Journal of Virology. 84. 2010 Depletion of Gr-1(+), but not Ly6G(+), immune cells exacerbates virus replication and disease in an intranasal model of herpes simplex virus type 1 infection. Journal of General Virology. 91. 2010 Gr-1(+) cells, but not neutrophils, limit virus replication and lesion development following flank infection of mice with herpes simplex virus type-1. Virology. 407. 2010 Hard wiring of T cell receptor specificity for the major histocompatibility complex is underpinned by TCR adaptability. Proceedings of the National Academy of Sciences of the United States of America. 107. 2010 Influenza viruses differ in ability to infect macrophages and to induce a local inflammatory response following intraperitoneal injection of mice. Immunology and Cell Biology. 88. 2010 Natural Killer Cell Activation in the Lung Allograft Early Posttransplantation. Transplantation. 89. 2010 Pandemic H1N1 Influenza A Viruses Are Resistant to the Antiviral Activities of Innate Immune Proteins of the Collectin and Pentraxin Superfamilies. Journal of Immunology. 185. 2010 The Structure and Stability of the Monomorphic HLA-G Are Influenced by the Nature of the Bound Peptide. Journal of Molecular Biology. 397. 2010 2009 Journal Articles Refereed A Protective Vaccine Delivery System for In Vivo T Cell Stimulation Using Nanoengineered Polymer Hydrogel Capsules. ACS Nano. 3. 2009 Cross-presentation of viral and self antigens by skin-derived CD103(+) dendritic cells. Nature Immunology. 10. 2009 Differential Recognition of CD1d-alpha-Galactosyl Ceramide by the V beta 8.2 and V beta 7 Semi-invariant NKT T Cell Receptors. Immunity. 31. 2009 Killer Ig-Like Receptor Ligand Mismatch Directs NK Cell Expansion In Vitro. Journal of Immunology. 183. 2009 Loss of a single N-linked glycan from the hemagglutinin of influenza virus is associated with resistance to collectins and increased virulence in mice. Respiratory Research. 10. 2009 Neutrophils Ameliorate Lung Injury and the Development of Severe Disease during Influenza Infection. Journal of Immunology. 183. 2009 T Cell Allorecognition via Molecular Mimicry. Immunity. 31. 2009 The Shaping of T Cell Receptor Recognition by Self-Tolerance. Immunity. 30. 2009 Conference Proceedings RECOGNITION OF HLA-E BY NATURAL KILLER CELLS IS IMPACTED BY VARIATION IN CYTOMEGALOVIRUS UL40 SEQUENCES IN HAEMOPOIETIC STEM CELL TRANSPLANTATION. Human Immunology. 2009 THE EFFECT OF KIR HAPLOTYPE ON CLINICAL OUTCOME FOLLOWING HLA-MATCHED SIBLING HAEMOPOIETIC STEM CELL TRANSPLANTATION. Human Immunology. 2009 2008 Journal Articles Refereed Antiviral activity of the long chain pentraxin PTX3 against influenza viruses. Journal of Immunology. 180. 2008 Application of CD27 as a marker for distinguishing human NK cell subsets. International Immunology. 20. 2008 CD94-NKG2A recognition of human leukocyte antigen (HLA)-E bound to an HLA class I leader sequence. Journal of Experimental Medicine. 205. 2008 Porcine cells express more than one functional ligand for the human lymphocyte activating receptor NKG2D. Xenotransplantation. 15. 2008 Protection afforded by live attenuated SIV is associated with rapid killing kinetics of CTLs. Journal of Medical Primatology. 37. 2008 Subtle changes in peptide conformation profoundly affect recognition of the non-classical MHC class I molecule HLA-E by the CD94-NKG2 natural killer cell receptors. Journal of Molecular Biology. 377. 2008 The major histocompatibility complex class Ib molecule HLA-E at the interface between innate and adaptive immunity. Tissue Antigens. 72. 2008 The role of neutrophils in the upper and lower respiratory tract during influenza virus infection of mice. Respiratory Research. 9. 2008 Conference Proceedings Inhibition of Influenza Viruses By Proteins of the Innate Immune System 2008 2007 Journal Articles Refereed A role for plasmacytoid dendritic cells in the rapid IL-18-dependent activation of NK cells following HSV-1 infection. European Journal of Immunology. 37. 2007 CD8(+) T-cell maturation following lung transplantation: The differential impact of CMV and acute rejection. Transplant Immunology. 18. 2007 Glycosylation as a target for recognition of influenza viruses by the innate immune system. Advances in Experimental Medicine and Biology. 598. 2007 IL48, but not IL-12, regulates NK cell activity following intranasal herpes simplex virus type I infection. Journal of Immunology. 179. 2007 Killing kinetics of simian immunodeficiency virus-specific CD8(+) T cells: implications for HIV vaccine strategies. Journal of Immunology. 179. 2007 The heterodimeric assembly of the CD94-NKG2 receptor family and implications for human leukocyte antigen-E recognition. Immunity. 27. 2007 Conference Proceedings Glycosylation as a target for recognition of influenza viruses by the innate immune system. Advances in Experimental Medicine and Biology. 2007 Porcine cells express more than one functional ligand for the human NK cell activating receptor NKG2D. Xenotransplantation. 2007 2006 Research Book Chapters Assays for T cell function. Induction and Measurement of Cytotoxic T Lymphocyte Activity. Current Protocols in Immunology. John Wiley & Sons. 2006 Journal Articles Induction and measurement of cytotoxic T lymphocyte activity. 2006 Journal Articles Refereed A structural perspective on MHC class lb molecules in adaptive immunity. Trends in Immunology (formerly Immunology Today). 27. 2006 CMV-Specific CD8(+) T-cell dynamics in the blood and the lung allograft reflect viral reactivation following lung transplantation. American Journal of Transplantation. 6. 2006 MHC class I allele frequencies in pigtail macaques of diverse origin. Immunogenetics. 58. 2006 NK cells contribute to the early clearance of HSV-1 from the lung but cannot control replication in the central nervous system following intranasal infection. European Journal of Immunology. 36. 2006 NK cells promote peritoneal xenograft rejection through an IFN-gamma-dependent mechanism. Xenotransplantation. 13. 2006 Responses against islet antigens in NOD mice are prevented by tolerance to proinsulin but not IGRP. Journal of Clinical Investigation. 116. 2006 Structural basis for a major histocompatibility complex class Ib-restricted T cell response. Nature Immunology. 7. 2006 The human cytomegalovirus glycoprotein UL16 traffics through the plasma membrane and the nuclear envelope. Cellular Microbiology. 8. 2006 2005 Journal Articles Refereed Analysis of pigtail macaque major histocompatibility complex class I molecules presenting immunodominant simian immunodeficiency virus epitopes. Journal of Virology. 79. 2005 Crystal structure of HLA-G: A nonclassical MHC class I molecule expressed at the fetal-maternal interface. Proceedings of the National Academy of Sciences of the United States of America. 102. 2005 DX5/CD49b-positive T cells are not synonymous with CD1d-dependent NKT cells. Journal of Immunology. 175. 2005 The pigtail macaque MHC class I allele Mane-A*10 presents an immundominant SIV Gag epitope: identification, tetramer development and implications of immune escape and reversion. Journal of Medical Primatology. 34. 2005 Journal Articles Unrefereed T-cell grit: large clonal expansions of virus-specific CD8(+) T cells can dominate in the peripheral circulation for at least 18 years. Blood. 106. 2005 Conference Proceedings Identification of CD4 T cell epitopes important for the recognition of HSV-1 in C57BI/6 mice. Tissue Antigens. 2005 Insights into effective SIV gag-specific CD8+T cell responses and fitness costs of viral escape. Tissue Antigens. 2005 NK cells contribute to the early clearance of HSV-1 from the lung but cannot control replication in the central nervous system following intranasal infection. Tissue Antigens. 2005 NK cells mediate control of viral replication in the nerves following HSV-1 flank zosteriform infection. Tissue Antigens. 2005 Neutrophil recruitment and activation following intranasal infection with different influenza viruses. Tissue Antigens. 2005 Plasmacytoid and conventional dendritic cells mediate rapid cytokine-dependent activation of NK cells to herpes simplex virus type 1. Tissue Antigens. 2005 Recognition of the non-classical MHC class I molecule, HLA-E, by the adaptive immune system. Tissue Antigens. 2005 Soluble MICA and reduced expression of NKG2D in preclinical type-1 diabetics. Tissue Antigens. 2005 The role of peptide in the recognition of HLA-E by cytomegalovirus-specific CD8+T cells. Tissue Antigens. 2005 2004 Journal Articles Refereed Crystal structure of the human T cell receptor CD3 epsilon gamma heterodimer complexed to the therapeutic mAb OKT3. Proceedings of the National Academy of Sciences of the United States of America. 101. 2004 Distinct migrating and nonmigrating dendritic cell populations are involved in MHC class I-restricted antigen presentation after lung infection with virus. Proceedings of the National Academy of Sciences of the United States of America. 101. 2004 Herpes simplex virus-specific CD8(+) T cells can clear established lytic infections from skin and nerves and can partially limit the early spread of virus after cutaneous inoculation. Journal of Immunology. 172. 2004 Natural HLA class 1 polymorphism controls the pathway of antigen presentation and susceptibility to viral evasion. Journal of Experimental Medicine. 200. 2004 Persistent expression of CD94/NKG2 receptors by virus-specific CD8 T cells is initiated by TCR-mediated signals. International Immunology. 16. 2004 The production and purification of the human T-cell receptors, the CD3 epsilon gamma and CD3 epsilon delta heterodimers: complex formation and crystallization with OKT3, a therapeutic monoclonal antibody. Acta Crystallographica. Section D: Structural Biology. 60. 2004 Truncated HLA-G isoforms are retained in the endoplasmic reticulum and insufficiently provide HLA-E ligands. Human Immunology. 65. 2004 Conference Proceedings Impact of natural HLA class I polymorphism and the pathway of antigen presentation. Genes and Immunity. 2004 The 2.1 angstrom crystal structure of the human T cell receptor CD3E Gamma heterodimer complexed to the therapeutic MAB OKT3. Genes and Immunity. 2004 2003 Journal Articles Refereed A naturally selected dimorphism within the HLA-B44 supertype alters class I structure, peptide repertoire, and T cell recognition. Journal of Experimental Medicine. 198. 2003 A structural basis for the selection of dominant alpha beta T cell receptors in antiviral immunity. Immunity. 18. 2003 Genetic control of NKT cell numbers maps to major diabetes and lupus loci. Journal of Immunology. 171. 2003 Intrathymic NKT cell development is blocked by the presence of alpha-galactosylceramide. European Journal of Immunology. 33. 2003 Novel strategy for identification of candidate cytotoxic T-cell epitopes from human preproinsulin. Tissue Antigens. 62. 2003 Virus infection expands a biased subset of T cells that bind tetrameric class I peptide complexes. European Journal of Immunology. 33. 2003 2002 Journal Articles Prime-boost immunization generates a high frequency, high-avidity CD8(+) cytotoxic T lymphocyte population. International Immunology. 14. 2002 Role that each NKG2A immunoreceptor tyrosine-based inhibitory motif plays in mediating the human CD94/NKG2A inhibitory signal.. Journal of Immunology. 169. 2002 The 1.5 A crystal structure of a highly selected antiviral T cell receptor provides evidence for a structural basis of immunodominance.. Structure. 10. 2002 The 1.5 angstrom crystal structure of a highly selected antiviral T cell receptor provides evidence for a structural basis of immunodominance. Structure. 10. 2002 Journal Articles Refereed Identification of a dominant self-ligand bound to three HLA B44 alleles and the preliminary crystallographic analysis of recombinant forms of each complex. FEBS Letters. 527. 2002 Peripheral deletion of autoreactive CD8 T cells by cross presentation of self-antigen occurs by a Bcl-2-inhibitable pathway mediated by bim. Journal of Experimental Medicine. 196. 2002 Progression of armed CTL from draining lymph node to spleen shortly after localized infection with herpes simplex virus 1. Journal of Immunology. 168. 2002 The 1.5 Å Crystal Structure of a Highly Selected Antiviral T Cell Receptor Provides Evidence for a Structural Basis of Immunodominance. Structure. 10. 2002 The production, purification and crystallization of a soluble heterodimeric form of a highly selected T-cell receptor in its unliganded and liganded state. Acta Crystallographica Section D - Biological Crystallography. 58. 2002 The structure of HLA-B8 complexed to an immunodominant viral determinant: Peptide-induced conformational changes and a mode of MHC class I dimerization. Journal of Immunology. 169. 2002 2001 Journal Articles Analysis of the role that each NKG2A ITIM motif plays in CD94/NKG2A signal initiation. FASEB Journal. 15. 2001 Journal Articles Refereed Conformational plasticity revealed by the cocrystal structure of NKG2D and its class I MHC-like ligand ULBP3. Immunity. 15. 2001 Structure of killer cell immunoglobulin-like receptors and their recognition of the class I MHC molecules. Immunological Reviews. 181. 2001 2000 Journal Articles Aberrant development of thymocytes in mice lacking laminin-2. 2000 Crystal structure of an NK cell immunoglobulin-like receptor in complex with its class I MHC ligand. Nature. 405. 2000 Crystal structure of the exctracellular domain of a human Fc gamma RIII. Immunity. 13. 2000 Differential splicing of antigen-encoding RNA reduces endogenous epitope presentation that regulates the expansion and cytotoxicity of T cells.. Journal of Immunology. 165. 2000 Herpes simplex virus type 1-specific cytotoxic T-lymphocyte arming occurs within lymph nodes draining the site of cutaneous infection. Journal of Virology. 74. 2000 Junctional biases in the naive TCR repertoire control the CTL response to an immunodominant determinant of HSV-1. Immunity. 12. 2000 Natural killer cell recognition of HLA class I molecules. 2000 Peptide-MHC class I tetrameric complexes display exquisite ligand specificity. Journal of Immunology. 165. 2000 Reconstitution of bacterial expressed human CD94: The importance of the stem region for dimer formation. Protein Expression and Purification. 18. 2000 1999 Journal Articles Crystal structure of the HLA-Cw3 allotype-specific killer cell inhibitory receptor KIR2DL2. Proceedings of the National Academy of Sciences of the United States of America. 96. 1999 Human glioma-induced immunosuppression involves soluble factor(s) that alters monocyte cytokine profile and surface markers. Journal of Immunology. 162. 1999 Specific recognition of HLA-E, but not classical, HLA class I molecules by soluble CD94/NKG2A and NK cells. Journal of Immunology. 162. 1999 Structure of CD94 reveals a novel C-type lectin fold: Implications for the NK cell-associated CD94/NKG2 receptors. Immunity. 10. 1999 1998 Journal Articles HLA-E Is the Ligand for the Natural Killer Cell CD94/NKG2 Receptors. Journal of Biomedical Science. 5. 1998 HLA-E is the ligand for the natural killer cell CD94/NKG2 receptors. Journal of Biomedical Science. 5. 1998 Recognition of human histocompatibility leukocyte antigen (HLA)-E complexed with HLA class I signal sequence-derived peptides by CD94/NKG2 confers protection from natural killer cell-mediated lysis. Journal of Experimental Medicine. 187. 1998 1997 Journal Articles NKG2A complexed with CD94 defines a novel inhibitory natural killer cell receptor. Journal of Experimental Medicine. 185. 1997 Peptides isolated from HLA-Cw*0304 confer different degrees of protection from natural killer cell-mediated lysis. Proceedings of the National Academy of Sciences of the United States of America. 94. 1997 1995 Journal Articles Peptide binding to MHC class I molecules: implications for antigenic peptide prediction.. Immunologic Research. 14. 1995 Journal Articles Refereed Antigen processing and presentation by a murine myoblast cell line. Clinical and Experimental Immunology. 102. 1995 1994 Journal Articles ANTIGEN PRESENTATION AND ASSEMBLY BY MOUSE I-A(K) CLASS-II MOLECULES IN HUMAN APC CONTAINING DELETED OR MUTATED HLA DM GENES. Journal of Immunology. 153. 1994 1993 Journal Articles CLASS-II-RESTRICTED PRESENTATION OF A HEN EGG LYSOZYME DETERMINANT DERIVED FROM ENDOGENOUS ANTIGEN SEQUESTERED IN THE CYTOPLASM OR ENDOPLASMIC-RETICULUM OF THE ANTIGEN PRESENTING CELLS. Journal of Immunology. 150. 1993 Effects of IL-4 depletion on the antibody response to Pseudomonas aeruginosa lipopolysaccharide in mice.. Immunobiology. 188. 1993 1991 Journal Articles CLASS-II-RESTRICTED PRESENTATION OF AN ENDOGENOUSLY DERIVED IMMUNODOMINANT T-CELL DETERMINANT OF HEN EGG LYSOZYME. Proceedings of the National Academy of Sciences of the United States of America. 88. 1991 1983 Journal Articles Activation of antigen-specific suppressor T cells by B cells from mice immunized with type III pneumococcal polysaccharide.. Journal of Experimental Medicine. 158. 1983
Investigator on Grant Investigating the evolution of innate and adaptive cellular immunity (Discovery Projects) awarded by AUST RESEARCH COUNCIL 2019 - 2022 Understanding how activating and inhibitory receptors regulate natural killer cell development and function (Melbourne Research Grants Support Scheme) awarded by UNIVERSITY OF MELBOURNE 2018 ANTIGEN PRESENTATION, RECOGNITION AND THE IMMUNE RESPONSE (Program Grants) awarded by NHMRC 2017 - 2021 AFFINITY BIOSCIENCES CONTRACT (Innovation Connections Grants) awarded by AFFINITY BIO 2017 - 2018 EXPLORING THE ROLE OF HUMAN NATURAL KILLER CELLS IN TUMOUR IMMUNITY (Grants-in-Aid) awarded by MONASH UNIVERSITY 2016 - 2018 REGULATION OF NK CELL ACTIVATION BY MHC CLASS I MOLECULES (Project Grants) awarded by NHMRC 2014 - 2016 PROGNOSTIC GENETIC MARKERS OF SEVERE DENGUE (A*Star Joint Call for Research) awarded by NHMRC 2013 - 2016 ANTIGEN PRESENTATION RECOGNITION AND THE IMMUNE SYSTEM (Program Grants) awarded by NHMRC 2012 - 2016 THE ROLE OF CD4+ T CELLS IN IMMUNITY TO HSV-1 (Project Grants) awarded by NHMRC 2011 - 2013 Multi-photon imaging for infection, immunity, and self recognition (Linkage Infrastructure (Equipment and Facilities)) awarded by AUST RESEARCH COUNCIL 2009 Immune recognition of HLA-E (Project Grants) awarded by NHMRC 2008 - 2010 2007 PROGRAM GRANT - (ANTIGEN PRESENTATION, RECOGNITION AND THE IMMUNE RESPONSE) (Program Grants) awarded by NHMRC 2007 - 2011 The structural basis for recognition of HLA-E by both innate and adaptive immune systems. (Project Grants) awarded by NHMRC 2006 - 2008 Antigen presentation, recognition and the immune response (Program Grants) awarded by NHMRC 2002 - 2006 International Research and Research Training Fund (International Research & Research Training Fund (IRRTF)) awarded by UNIVERSITY OF MELBOURNE
Education and training PhD, Flinders University of South Australia BSc, Monash University DipEd, Victorian College of the Arts