Has subject area
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For 2008 6 Digit Code
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Seo 2008 6 Digit Code
PROF Andrew Brooks
Positions
- Academic, Microbiology and Immunology
- Immunology (Natural killer cells, Herpes simplex virus, MHC)
Overview
Affiliation
Member of
- Australasian Society for Immunology. Member 2009 -
Publications
Selected publications
2019
Journal Articles Refereed
- Broadening our knowledge of the differences between HIV-2 and HIV-1 innate sensing: HIV-2 infected cells selectively express B7-H6 and engage NKp30 on natural killer cells. AIDS. 33. 2019
- Classical Type 1 Dendritic Cells Dominate Priming of Th1 Responses to Herpes Simplex Virus Type 1 Skin Infection. Journal of Immunology. 202. 2019
- Downregulation of MHC Class I Expression by Influenza A and B Viruses. Frontiers in Immunology. 10. 2019
- Enrichment of Cytomegalovirus-induced NKG2C(+) Natural Killer Cells in the Lung Allograft. Transplantation. 103. 2019
- IFITM3 and type I interferons are important for the control of influenza A virus replication in murine macrophages. 2019
- The complex existence of gamma delta T cells following transplantation: the good, the bad and the simply confusing. Clinical & Translational Immunology. 8. 2019
- Unique Transcriptional Architecture in Airway Epithelial Cells and Macrophages Shapes Distinct Responses following Influenza Virus Infection Ex Vivo. Journal of Virology. 93. 2019
2018
Journal Articles Refereed
- Activating killer-cell immunoglobulin-like receptor haplotype influences clinical outcome following HLA-matched sibling haematopoietic stem cell transplantation 2018
- Changes in Gut Microbiota Prior to Influenza A Virus Infection Do Not Affect Immune Responses in Pups or Juvenile Mice. Frontiers in Cellular and Infection Microbiology. 8. 2018
- Induction and Measurement of Cytotoxic T Lymphocyte Activity. 2018
- Killer cell immunoglobulin-like receptor 3DL1 variation modifies HLA-B*57 protection against HIV-1. Journal of Clinical Investigation. 128. 2018
2017
Journal Articles Refereed
- A conserved energetic footprint underpins recognition of human leukocyte antigen-E by two distinct alpha beta T cell receptors. Journal of Biological Chemistry. 292. 2017
- Host Cell Restriction Factors that Limit Influenza A Infection. Viruses. 9. 2017
- MHC-I peptides get out of the groove and enable a novel mechanism of HIV-1 escape. Nature Structural and Molecular Biology. 24. 2017
- Nasal-associated lymphoid tissues (NALTs) support the recall but not priming of influenza virus-specific cytotoxic T cells. Proceedings of the National Academy of Sciences of the United States of America. 114. 2017
- Pattern recognition receptor immunomodulation of innate immunity as a strategy to limit the impact of influenza virus. Journal of Leukocyte Biology. 101. 2017
- Resident memory CD8(+) T cells in the upper respiratory tract prevent pulmonary influenza virus infection 2017
- The molecular basis for peptide repertoire selection in the human leukocyte antigen (HLA) C*06:02 molecule. Journal of Biological Chemistry. 292. 2017
2016
Journal Articles Refereed
- DC-SIGN and L-SIGN Are Attachment Factors That Promote Infection of Target Cells by Human Metapneumovirus in the Presence or Absence of Cellular Glycosaminoglycans. Journal of Virology. 90. 2016
- Endocytic function is critical for influenza A virus infection via DC-SIGN and L-SIGN. Scientific Reports. 6. 2016
- Killer cell immunoglobulin-like receptor 3DL1 polymorphism defines distinct hierarchies of HLA class I recognition. Journal of Experimental Medicine. 213. 2016
- Neutralizing inhibitors in the airways of naive ferrets do not play a major role in modulating the virulence of H3 subtype influenza A viruses. Virology. 494. 2016
- Recognition of the Major Histocompatibility Complex (MHC) Class Ib Molecule H2-Q10 by the Natural Killer Cell Receptor Ly49C. Journal of Biological Chemistry. 291. 2016
- The C-type Lectin Langerin Functions as a Receptor for Attachment and Infectious Entry of Influenza A Virus. Journal of Virology. 90. 2016
2015
Journal Articles Refereed
- A bird's eye view of NK cell receptor interactions with their MHC class I ligands. Immunological Reviews. 267. 2015
- Antibodies targeting Clec9A promote strong humoral immunity without adjuvant in mice and non-human primates. European Journal of Immunology. 45. 2015
- Endogenous Murine BST-2/Tetherin Is Not a Major Restriction Factor of Influenza A Virus Infection. PLoS One. 10. 2015
- Human CD8 T lymphocytes recognize Mycobacterium tuberculosis antigens presented by HLA-E during active tuberculosis and express type 2 cytokines. European Journal of Immunology. 45. 2015
- Infection of Mouse Macrophages by Seasonal Influenza Viruses Can Be Restricted at the Level of Virus Entry and at a Late Stage in the Virus Life Cycle. Journal of Virology. 89. 2015
- Limited Internodal Migration of T Follicular Helper Cells after Peripheral Infection with Herpes Simplex Virus-1. Journal of Immunology. 195. 2015
- Peptide-Dependent Recognition of HLA-B*57:01 by KIR3DS1. Journal of Virology. 89. 2015
- Spatiotemporally Distinct Interactions with Dendritic Cell Subsets Facilitates CD4(+) and CD8(+) T Cell Activation to Localized Viral Infection. Immunity. 43. 2015
- The Interaction of KIR3DL1*001 with HLA Class I Molecules Is Dependent upon Molecular Microarchitecture within the Bw4 Epitope. Journal of Immunology. 194. 2015
- The Presence of HLA-E-Restricted, CMV-Specific CD8(+) T Cells in the Blood of Lung Transplant Recipients Correlates with Chronic Allograft Rejection. PLoS One. 10. 2015
- The Structure of the Atypical Killer Cell Immunoglobulin-like Receptor, KIR2DL4. Journal of Biological Chemistry. 290. 2015
Other Refereed Contribution to Refereed Journals
2014
Journal Articles Refereed
- A Single Amino Acid Substitution in the Hemagglutinin of H3N2 Subtype Influenza A Viruses Is Associated with Resistance to the Long Pentraxin PTX3 and Enhanced Virulence in Mice. Journal of Immunology. 192. 2014
- Anti-HIV Antibody-Dependent Activation of NK Cells Impairs NKp46 Expression. Journal of Immunology. 192. 2014
- Distinct APC Subtypes Drive Spatially Segregated CD4+ and CD8+ T-Cell Effector Activity during Skin Infection with HSV-1. PLoS Pathogens. 10. 2014
- Distinct APC subtypes drive spatially segregated CD4+ and CD8+ T-cell effector activity during skin infection with HSV-1. PLoS Pathogens. 10. 2014
- Mutational and Structural Analysis of KIR3DL1 Reveals a Lineage-Defining Allotypic Dimorphism That Impacts Both HLA and Peptide Sensitivity. Journal of Immunology. 192. 2014
- The Ly49 natural killer cell receptors: a versatile tool for viral self-discrimination. Immunology and Cell Biology. 92. 2014
- The Macrophage Galactose-Type Lectin Can Function as an Attachment and Entry Receptor for Influenza Virus. Journal of Virology. 88. 2014
- The Structure of the Cytomegalovirus-Encoded m04 Glycoprotein, a Prototypical Member of the m02 Family of Immunoevasins. Journal of Biological Chemistry. 289. 2014
2013
Journal Articles Refereed
- Addition of Glycosylation to Influenza A Virus Hemagglutinin Modulates Antibody-Mediated Recognition of H1N1 2009 Pandemic Viruses. Journal of Immunology. 190. 2013
- Age-Associated Cross-reactive Antibody-Dependent Cellular Cytotoxicity Toward 2009 Pandemic Influenza A Virus Subtype H1N1. Journal of Infectious Diseases. 208. 2013
- Contribution of Thy1(+) NK cells to protective IFN-gamma production during Salmonella Typhimurium infections. Proceedings of the National Academy of Sciences of the United States of America. 110. 2013
- Cross-Reactive Influenza-Specific Antibody-Dependent Cellular Cytotoxicity Antibodies in the Absence of Neutralizing Antibodies. Journal of Immunology. 190. 2013
- HLA Peptide Length Preferences Control CD8(+) T Cell Responses. Journal of Immunology. 191. 2013
- Polymorphism in Human Cytomegalovirus UL40 Impacts on Recognition of Human Leukocyte Antigen-E (HLA-E) by Natural Killer Cells. Journal of Biological Chemistry. 288. 2013
- Recognition of vitamin B metabolites by mucosal-associated invariant T cells. Nature Communications. 4. 2013
- Serum Amyloid P Is a Sialylated Glycoprotein Inhibitor of Influenza A Viruses. PLoS One. 8. 2013
- Targeting of a natural killer cell receptor family by a viral immunoevasin. Nature Immunology. 14. 2013
Journal Articles Unrefereed Letters or Notes
- Non-classical MHC Class I molecules regulating natural killer cell function. OncoImmunology. 2. 2013
2012
Journal Articles Refereed
- A Structural Basis for Antigen Presentation by the MHC Class Ib Molecule, Qa-1(b). Journal of Immunology. 188. 2012
- Cell-surface receptors on macrophages and dendritic cells for attachment and entry of influenza virus. Journal of Leukocyte Biology. 92. 2012
- Comparison of Influenza and SIV Specific CD8 T Cell Responses in Macaques. PLoS One. 7. 2012
- DEC-205 is a cell surface receptor for CpG oligonucleotides. Proceedings of the National Academy of Sciences of the United States of America. 109. 2012
- Degenerate Recognition of MHC Class I Molecules with Bw4 and Bw6 Motifs by a Killer Cell Ig-like Receptor 3DL Expressed by Macaque NK Cells. Journal of Immunology. 189. 2012
- MHC Class Ib-Restricted CD8 T Cells Differ in Dependence on CD4 T Cell Help and CD28 Costimulation over the Course of Mouse Polyomavirus Infection. Journal of Immunology. 188. 2012
- Neutrophils sustain effective CD8(+) T-cell responses in the respiratory tract following influenza infection. Immunology and Cell Biology. 90. 2012
- Recognition of the nonclassical MHC class I molecule H2-M3 by the receptor Ly49A regulates the licensing and activation of NK cells. Nature Immunology. 13. 2012
- Soluble Host Defense Lectins in Innate Immunity to Influenza Virus. Journal of Biomedicine and Biotechnology. 2012. 2012
- The fate of influenza A virus after infection of human macrophages and dendritic cells. Journal of General Virology. 93. 2012
2011
Journal Articles
- Diverse roles of non-diverse molecules: MHC class Ib molecules in host defense and control of autoimmunity. Current Opinion in Immunology. 23. 2011
- Immunoreceptor intramembrane assembly How opposites attract. Immunology and Cell Biology. 89. 2011
Journal Articles Refereed
- A Molecular Basis for the Exquisite CD1d-Restricted Antigen Specificity and Functional Responses of Natural Killer T Cells. Immunity. 34. 2011
- A semi-invariant V(alpha)10(+) T cell antigen receptor defines a population of natural killer T cells with distinct glycolipid antigen-recognition properties. Nature Immunology. 12. 2011
- Blood-Stage Plasmodium berghei Infection Generates a Potent, Specific CD8(+) T-Cell Response Despite Residence Largely in Cells Lacking MHC I Processing Machinery. Journal of Infectious Diseases. 204. 2011
- Correlation between sialic acid expression and infection of murine macrophages by different strains of influenza virus. Microbes and Infection. 13. 2011
- Different patterns of peripheral migration by memory CD4(+) and CD8(+) T cells. Nature. 477. 2011
- Glycosylation of the hemagglutinin modulates the sensitivity of H3N2 influenza viruses to innate proteins in airway secretions and virulence in mice. Virology. 413. 2011
- Inhibition of lectin-mediated innate host defences in vivo modulates disease severity during influenza virus infection. Immunology and Cell Biology. 89. 2011
- Killer cell immunoglobulin-like receptor 3DL1-mediated recognition of human leukocyte antigen B. Nature. 479. 2011
- N-Linked Glycosylation Facilitates Sialic Acid-Independent Attachment and Entry of Influenza A Viruses into Cells Expressing DC-SIGN or L-SIGN. Journal of Virology. 85. 2011
- Receptor specificity of the influenza virus hemagglutinin modulates sensitivity to soluble collectins of the innate immune system and virulence in mice. Virology. 413. 2011
- Responses of Mouse Airway Epithelial Cells and Alveolar Macrophages to Virulent and Avirulent Strains of Influenza A Virus. Viral Immunology. 24. 2011
- Specific Sites of N-Linked Glycosylation on the Hemagglutinin of H1N1 Subtype Influenza A Virus Determine Sensitivity to Inhibitors of the Innate Immune System and Virulence in Mice. Journal of Immunology. 187. 2011
- The Role of Neutrophils during Mild and Severe Influenza Virus Infections of Mice. PLoS One. 6. 2011
- V beta 2 natural killer T cell antigen receptor-mediated recognition of CD1d-glycolipid antigen. Proceedings of the National Academy of Sciences of the United States of America. 108. 2011
Conference Proceedings
- Live Attenuated Influenza-SIV Vaccines: Efficacy Against Mucosal Challenge in Macaques. AIDS Research and Human Retroviruses. 2011
2010
Journal Articles Refereed
- Allelic polymorphism in the T cell receptor and its impact on immune responses. Journal of Experimental Medicine. 207. 2010
- Critical Role of Airway Macrophages in Modulating Disease Severity during Influenza Virus Infection of Mice. Journal of Virology. 84. 2010
- Depletion of Gr-1(+), but not Ly6G(+), immune cells exacerbates virus replication and disease in an intranasal model of herpes simplex virus type 1 infection. Journal of General Virology. 91. 2010
- Gr-1(+) cells, but not neutrophils, limit virus replication and lesion development following flank infection of mice with herpes simplex virus type-1. Virology. 407. 2010
- Hard wiring of T cell receptor specificity for the major histocompatibility complex is underpinned by TCR adaptability. Proceedings of the National Academy of Sciences of the United States of America. 107. 2010
- Influenza viruses differ in ability to infect macrophages and to induce a local inflammatory response following intraperitoneal injection of mice. Immunology and Cell Biology. 88. 2010
- Natural Killer Cell Activation in the Lung Allograft Early Posttransplantation. Transplantation. 89. 2010
- Pandemic H1N1 Influenza A Viruses Are Resistant to the Antiviral Activities of Innate Immune Proteins of the Collectin and Pentraxin Superfamilies. Journal of Immunology. 185. 2010
- The Structure and Stability of the Monomorphic HLA-G Are Influenced by the Nature of the Bound Peptide. Journal of Molecular Biology. 397. 2010
2009
Journal Articles Refereed
- A Protective Vaccine Delivery System for In Vivo T Cell Stimulation Using Nanoengineered Polymer Hydrogel Capsules. ACS Nano. 3. 2009
- Cross-presentation of viral and self antigens by skin-derived CD103(+) dendritic cells. Nature Immunology. 10. 2009
- Differential Recognition of CD1d-alpha-Galactosyl Ceramide by the V beta 8.2 and V beta 7 Semi-invariant NKT T Cell Receptors. Immunity. 31. 2009
- Killer Ig-Like Receptor Ligand Mismatch Directs NK Cell Expansion In Vitro. Journal of Immunology. 183. 2009
- Loss of a single N-linked glycan from the hemagglutinin of influenza virus is associated with resistance to collectins and increased virulence in mice. Respiratory Research. 10. 2009
- Neutrophils Ameliorate Lung Injury and the Development of Severe Disease during Influenza Infection. Journal of Immunology. 183. 2009
- T Cell Allorecognition via Molecular Mimicry. Immunity. 31. 2009
- The Shaping of T Cell Receptor Recognition by Self-Tolerance. Immunity. 30. 2009
Conference Proceedings
- RECOGNITION OF HLA-E BY NATURAL KILLER CELLS IS IMPACTED BY VARIATION IN CYTOMEGALOVIRUS UL40 SEQUENCES IN HAEMOPOIETIC STEM CELL TRANSPLANTATION. Human Immunology. 2009
- THE EFFECT OF KIR HAPLOTYPE ON CLINICAL OUTCOME FOLLOWING HLA-MATCHED SIBLING HAEMOPOIETIC STEM CELL TRANSPLANTATION. Human Immunology. 2009
2008
Journal Articles Refereed
- Antiviral activity of the long chain pentraxin PTX3 against influenza viruses. Journal of Immunology. 180. 2008
- Application of CD27 as a marker for distinguishing human NK cell subsets. International Immunology. 20. 2008
- CD94-NKG2A recognition of human leukocyte antigen (HLA)-E bound to an HLA class I leader sequence. Journal of Experimental Medicine. 205. 2008
- Porcine cells express more than one functional ligand for the human lymphocyte activating receptor NKG2D. Xenotransplantation. 15. 2008
- Protection afforded by live attenuated SIV is associated with rapid killing kinetics of CTLs. Journal of Medical Primatology. 37. 2008
- Subtle changes in peptide conformation profoundly affect recognition of the non-classical MHC class I molecule HLA-E by the CD94-NKG2 natural killer cell receptors. Journal of Molecular Biology. 377. 2008
- The major histocompatibility complex class Ib molecule HLA-E at the interface between innate and adaptive immunity. Tissue Antigens. 72. 2008
- The role of neutrophils in the upper and lower respiratory tract during influenza virus infection of mice. Respiratory Research. 9. 2008
Conference Proceedings
2007
Journal Articles Refereed
- A role for plasmacytoid dendritic cells in the rapid IL-18-dependent activation of NK cells following HSV-1 infection. European Journal of Immunology. 37. 2007
- CD8(+) T-cell maturation following lung transplantation: The differential impact of CMV and acute rejection. Transplant Immunology. 18. 2007
- Glycosylation as a target for recognition of influenza viruses by the innate immune system. Advances in Experimental Medicine and Biology. 598. 2007
- IL48, but not IL-12, regulates NK cell activity following intranasal herpes simplex virus type I infection. Journal of Immunology. 179. 2007
- Killing kinetics of simian immunodeficiency virus-specific CD8(+) T cells: implications for HIV vaccine strategies. Journal of Immunology. 179. 2007
- The heterodimeric assembly of the CD94-NKG2 receptor family and implications for human leukocyte antigen-E recognition. Immunity. 27. 2007
Conference Proceedings
- Glycosylation as a target for recognition of influenza viruses by the innate immune system. Advances in Experimental Medicine and Biology. 2007
- Porcine cells express more than one functional ligand for the human NK cell activating receptor NKG2D. Xenotransplantation. 2007
2006
Research Book Chapters
- Assays for T cell function. Induction and Measurement of Cytotoxic T Lymphocyte Activity. Current Protocols in Immunology. John Wiley & Sons. 2006
Journal Articles
Journal Articles Refereed
- A structural perspective on MHC class lb molecules in adaptive immunity. Trends in Immunology (formerly Immunology Today). 27. 2006
- CMV-Specific CD8(+) T-cell dynamics in the blood and the lung allograft reflect viral reactivation following lung transplantation. American Journal of Transplantation. 6. 2006
- MHC class I allele frequencies in pigtail macaques of diverse origin. Immunogenetics. 58. 2006
- NK cells contribute to the early clearance of HSV-1 from the lung but cannot control replication in the central nervous system following intranasal infection. European Journal of Immunology. 36. 2006
- NK cells promote peritoneal xenograft rejection through an IFN-gamma-dependent mechanism. Xenotransplantation. 13. 2006
- Responses against islet antigens in NOD mice are prevented by tolerance to proinsulin but not IGRP. Journal of Clinical Investigation. 116. 2006
- Structural basis for a major histocompatibility complex class Ib-restricted T cell response. Nature Immunology. 7. 2006
- The human cytomegalovirus glycoprotein UL16 traffics through the plasma membrane and the nuclear envelope. Cellular Microbiology. 8. 2006
2005
Journal Articles Refereed
- Analysis of pigtail macaque major histocompatibility complex class I molecules presenting immunodominant simian immunodeficiency virus epitopes. Journal of Virology. 79. 2005
- Crystal structure of HLA-G: A nonclassical MHC class I molecule expressed at the fetal-maternal interface. Proceedings of the National Academy of Sciences of the United States of America. 102. 2005
- DX5/CD49b-positive T cells are not synonymous with CD1d-dependent NKT cells. Journal of Immunology. 175. 2005
- The pigtail macaque MHC class I allele Mane-A*10 presents an immundominant SIV Gag epitope: identification, tetramer development and implications of immune escape and reversion. Journal of Medical Primatology. 34. 2005
Journal Articles Unrefereed
Conference Proceedings
- Identification of CD4 T cell epitopes important for the recognition of HSV-1 in C57BI/6 mice. Tissue Antigens. 2005
- Insights into effective SIV gag-specific CD8+T cell responses and fitness costs of viral escape. Tissue Antigens. 2005
- NK cells contribute to the early clearance of HSV-1 from the lung but cannot control replication in the central nervous system following intranasal infection. Tissue Antigens. 2005
- NK cells mediate control of viral replication in the nerves following HSV-1 flank zosteriform infection. Tissue Antigens. 2005
- Neutrophil recruitment and activation following intranasal infection with different influenza viruses. Tissue Antigens. 2005
- Plasmacytoid and conventional dendritic cells mediate rapid cytokine-dependent activation of NK cells to herpes simplex virus type 1. Tissue Antigens. 2005
- Recognition of the non-classical MHC class I molecule, HLA-E, by the adaptive immune system. Tissue Antigens. 2005
- Soluble MICA and reduced expression of NKG2D in preclinical type-1 diabetics. Tissue Antigens. 2005
- The role of peptide in the recognition of HLA-E by cytomegalovirus-specific CD8+T cells. Tissue Antigens. 2005
2004
Journal Articles Refereed
- Crystal structure of the human T cell receptor CD3 epsilon gamma heterodimer complexed to the therapeutic mAb OKT3. Proceedings of the National Academy of Sciences of the United States of America. 101. 2004
- Distinct migrating and nonmigrating dendritic cell populations are involved in MHC class I-restricted antigen presentation after lung infection with virus. Proceedings of the National Academy of Sciences of the United States of America. 101. 2004
- Herpes simplex virus-specific CD8(+) T cells can clear established lytic infections from skin and nerves and can partially limit the early spread of virus after cutaneous inoculation. Journal of Immunology. 172. 2004
- Natural HLA class 1 polymorphism controls the pathway of antigen presentation and susceptibility to viral evasion. Journal of Experimental Medicine. 200. 2004
- Persistent expression of CD94/NKG2 receptors by virus-specific CD8 T cells is initiated by TCR-mediated signals. International Immunology. 16. 2004
- The production and purification of the human T-cell receptors, the CD3 epsilon gamma and CD3 epsilon delta heterodimers: complex formation and crystallization with OKT3, a therapeutic monoclonal antibody. Acta Crystallographica. Section D: Structural Biology. 60. 2004
- Truncated HLA-G isoforms are retained in the endoplasmic reticulum and insufficiently provide HLA-E ligands. Human Immunology. 65. 2004
Conference Proceedings
- Impact of natural HLA class I polymorphism and the pathway of antigen presentation. Genes and Immunity. 2004
- The 2.1 angstrom crystal structure of the human T cell receptor CD3E Gamma heterodimer complexed to the therapeutic MAB OKT3. Genes and Immunity. 2004
2003
Journal Articles Refereed
- A naturally selected dimorphism within the HLA-B44 supertype alters class I structure, peptide repertoire, and T cell recognition. Journal of Experimental Medicine. 198. 2003
- A structural basis for the selection of dominant alpha beta T cell receptors in antiviral immunity. Immunity. 18. 2003
- Genetic control of NKT cell numbers maps to major diabetes and lupus loci. Journal of Immunology. 171. 2003
- Intrathymic NKT cell development is blocked by the presence of alpha-galactosylceramide. European Journal of Immunology. 33. 2003
- Novel strategy for identification of candidate cytotoxic T-cell epitopes from human preproinsulin. Tissue Antigens. 62. 2003
- Virus infection expands a biased subset of T cells that bind tetrameric class I peptide complexes. European Journal of Immunology. 33. 2003
2002
Journal Articles
- Prime-boost immunization generates a high frequency, high-avidity CD8(+) cytotoxic T lymphocyte population. International Immunology. 14. 2002
- Role that each NKG2A immunoreceptor tyrosine-based inhibitory motif plays in mediating the human CD94/NKG2A inhibitory signal.. Journal of Immunology. 169. 2002
- The 1.5 A crystal structure of a highly selected antiviral T cell receptor provides evidence for a structural basis of immunodominance.. Structure. 10. 2002
- The 1.5 angstrom crystal structure of a highly selected antiviral T cell receptor provides evidence for a structural basis of immunodominance. Structure. 10. 2002
Journal Articles Refereed
- Identification of a dominant self-ligand bound to three HLA B44 alleles and the preliminary crystallographic analysis of recombinant forms of each complex. FEBS Letters. 527. 2002
- Peripheral deletion of autoreactive CD8 T cells by cross presentation of self-antigen occurs by a Bcl-2-inhibitable pathway mediated by bim. Journal of Experimental Medicine. 196. 2002
- Progression of armed CTL from draining lymph node to spleen shortly after localized infection with herpes simplex virus 1. Journal of Immunology. 168. 2002
- The 1.5 Å Crystal Structure of a Highly Selected Antiviral T Cell Receptor Provides Evidence for a Structural Basis of Immunodominance. Structure. 10. 2002
- The production, purification and crystallization of a soluble heterodimeric form of a highly selected T-cell receptor in its unliganded and liganded state. Acta Crystallographica Section D - Biological Crystallography. 58. 2002
- The structure of HLA-B8 complexed to an immunodominant viral determinant: Peptide-induced conformational changes and a mode of MHC class I dimerization. Journal of Immunology. 169. 2002
2001
Journal Articles
- Analysis of the role that each NKG2A ITIM motif plays in CD94/NKG2A signal initiation. FASEB Journal. 15. 2001
Journal Articles Refereed
- Conformational plasticity revealed by the cocrystal structure of NKG2D and its class I MHC-like ligand ULBP3. Immunity. 15. 2001
- Structure of killer cell immunoglobulin-like receptors and their recognition of the class I MHC molecules. Immunological Reviews. 181. 2001
2000
Journal Articles
- Aberrant development of thymocytes in mice lacking laminin-2. 2000
- Crystal structure of an NK cell immunoglobulin-like receptor in complex with its class I MHC ligand. Nature. 405. 2000
- Crystal structure of the exctracellular domain of a human Fc gamma RIII. Immunity. 13. 2000
- Differential splicing of antigen-encoding RNA reduces endogenous epitope presentation that regulates the expansion and cytotoxicity of T cells.. Journal of Immunology. 165. 2000
- Herpes simplex virus type 1-specific cytotoxic T-lymphocyte arming occurs within lymph nodes draining the site of cutaneous infection. Journal of Virology. 74. 2000
- Junctional biases in the naive TCR repertoire control the CTL response to an immunodominant determinant of HSV-1. Immunity. 12. 2000
- Natural killer cell recognition of HLA class I molecules. 2000
- Peptide-MHC class I tetrameric complexes display exquisite ligand specificity. Journal of Immunology. 165. 2000
- Reconstitution of bacterial expressed human CD94: The importance of the stem region for dimer formation. Protein Expression and Purification. 18. 2000
1999
Journal Articles
- Crystal structure of the HLA-Cw3 allotype-specific killer cell inhibitory receptor KIR2DL2. Proceedings of the National Academy of Sciences of the United States of America. 96. 1999
- Human glioma-induced immunosuppression involves soluble factor(s) that alters monocyte cytokine profile and surface markers. Journal of Immunology. 162. 1999
- Specific recognition of HLA-E, but not classical, HLA class I molecules by soluble CD94/NKG2A and NK cells. Journal of Immunology. 162. 1999
- Structure of CD94 reveals a novel C-type lectin fold: Implications for the NK cell-associated CD94/NKG2 receptors. Immunity. 10. 1999
1998
Journal Articles
- HLA-E Is the Ligand for the Natural Killer Cell CD94/NKG2 Receptors. Journal of Biomedical Science. 5. 1998
- HLA-E is the ligand for the natural killer cell CD94/NKG2 receptors. Journal of Biomedical Science. 5. 1998
- Recognition of human histocompatibility leukocyte antigen (HLA)-E complexed with HLA class I signal sequence-derived peptides by CD94/NKG2 confers protection from natural killer cell-mediated lysis. Journal of Experimental Medicine. 187. 1998
1997
Journal Articles
- NKG2A complexed with CD94 defines a novel inhibitory natural killer cell receptor. Journal of Experimental Medicine. 185. 1997
- Peptides isolated from HLA-Cw*0304 confer different degrees of protection from natural killer cell-mediated lysis. Proceedings of the National Academy of Sciences of the United States of America. 94. 1997
1995
Journal Articles
- Peptide binding to MHC class I molecules: implications for antigenic peptide prediction.. Immunologic Research. 14. 1995
Journal Articles Refereed
- Antigen processing and presentation by a murine myoblast cell line. Clinical and Experimental Immunology. 102. 1995
1994
Journal Articles
- ANTIGEN PRESENTATION AND ASSEMBLY BY MOUSE I-A(K) CLASS-II MOLECULES IN HUMAN APC CONTAINING DELETED OR MUTATED HLA DM GENES. Journal of Immunology. 153. 1994
1993
Journal Articles
- CLASS-II-RESTRICTED PRESENTATION OF A HEN EGG LYSOZYME DETERMINANT DERIVED FROM ENDOGENOUS ANTIGEN SEQUESTERED IN THE CYTOPLASM OR ENDOPLASMIC-RETICULUM OF THE ANTIGEN PRESENTING CELLS. Journal of Immunology. 150. 1993
- Effects of IL-4 depletion on the antibody response to Pseudomonas aeruginosa lipopolysaccharide in mice.. Immunobiology. 188. 1993
1991
Journal Articles
- CLASS-II-RESTRICTED PRESENTATION OF AN ENDOGENOUSLY DERIVED IMMUNODOMINANT T-CELL DETERMINANT OF HEN EGG LYSOZYME. Proceedings of the National Academy of Sciences of the United States of America. 88. 1991
1983
Journal Articles
- Activation of antigen-specific suppressor T cells by B cells from mice immunized with type III pneumococcal polysaccharide.. Journal of Experimental Medicine. 158. 1983
Research
Investigator on
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Grant
- Investigating the evolution of innate and adaptive cellular immunity (Discovery Projects) awarded by AUST RESEARCH COUNCIL 2019 - 2022
- Understanding how activating and inhibitory receptors regulate natural killer cell development and function (Melbourne Research Grants Support Scheme) awarded by UNIVERSITY OF MELBOURNE 2018
- ANTIGEN PRESENTATION, RECOGNITION AND THE IMMUNE RESPONSE (Program Grants) awarded by NHMRC 2017 - 2021
- AFFINITY BIOSCIENCES CONTRACT (Innovation Connections Grants) awarded by AFFINITY BIO 2017 - 2018
- EXPLORING THE ROLE OF HUMAN NATURAL KILLER CELLS IN TUMOUR IMMUNITY (Grants-in-Aid) awarded by MONASH UNIVERSITY 2016 - 2018
- REGULATION OF NK CELL ACTIVATION BY MHC CLASS I MOLECULES (Project Grants) awarded by NHMRC 2014 - 2016
- PROGNOSTIC GENETIC MARKERS OF SEVERE DENGUE (A*Star Joint Call for Research) awarded by NHMRC 2013 - 2016
- ANTIGEN PRESENTATION RECOGNITION AND THE IMMUNE SYSTEM (Program Grants) awarded by NHMRC 2012 - 2016
- THE ROLE OF CD4+ T CELLS IN IMMUNITY TO HSV-1 (Project Grants) awarded by NHMRC 2011 - 2013
- Multi-photon imaging for infection, immunity, and self recognition (Linkage Infrastructure (Equipment and Facilities)) awarded by AUST RESEARCH COUNCIL 2009
- Immune recognition of HLA-E (Project Grants) awarded by NHMRC 2008 - 2010
- 2007 PROGRAM GRANT - (ANTIGEN PRESENTATION, RECOGNITION AND THE IMMUNE RESPONSE) (Program Grants) awarded by NHMRC 2007 - 2011
- The structural basis for recognition of HLA-E by both innate and adaptive immune systems. (Project Grants) awarded by NHMRC 2006 - 2008
- Antigen presentation, recognition and the immune response (Program Grants) awarded by NHMRC 2002 - 2006
- International Research and Research Training Fund (International Research & Research Training Fund (IRRTF)) awarded by UNIVERSITY OF MELBOURNE
Awards
Education and training
- PhD, Flinders University of South Australia
- BSc, Monash University
- DipEd, Victorian College of the Arts
Linkages
Geographic focus
Supervision
Available for supervision
- Y
- Contact Details
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agbrooks@unimelb.edu.au
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61 3 8344 9925
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fax: 61 3 9347 1540
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Location
- Level: 05 Room: 522, Microbiology Building, Parkville
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