Nutritional and environmental factors that affect early embryo development (diet, metabolism, sex ratio, uterine environment, ovary, oocyte, blastocyst, ART, SCNT, cloning)
I completed my Doctorate at The University of Nottingham, UK, investigating the role of progesterone in early embryo development and how nutrition can affect the dialogue between the early embryo and maternal uterine environment. Following this in 2002, I was awarded a Life Sciences Postdoctoral Fellowship to work at the University of Missouri, Dept. of Animal Sciences with Professor Mike Roberts investigating how glucose and a high-fat diet can skew sex ratio in mammals; both in vitro
and in vivo
, as well as elucidating embryonic signals responsible for the maternal recognition of pregnancy.
In 2004, I moved to New Zealand and as the inaugural Maurice Paykel Fellow began working at the Liggins Institute University of Auckland, in the area of developmental programming. Over seven years, as a member of the Placental and Endocrinology Groups, I continued to investigate how dietary intake (under and over nutrition) impacted embryonic and foetal development in trans-generational sheep and rat research models. In addition, I embarked upon research with Fertility Associates Ltd., the largest Human Fertility Company in New Zealand, to improve the efficiency of IVF technologies in humans, as well as to investigate whether the phenotype of IVF children differed from the phenotype of children that were naturally conceived. Alongside this from 2006, I held a joint appointment at AgResearch Ltd. as a senior scientist researching how reproductive technologies, specifically IVF and somatic cell nuclear transfer (cloning), influence offspring phenotype. During this period I also focused on enhancing fertility of the dairy cow by understanding the long-term consequences of uterine infection on the follicular environment and uterine stem cell turnover during involution.
In late 2011, I moved to the Department of Zoology (now School of BioSciences), University of Melbourne to begin my appointment as the Merck Serono Lecturer of Reproducti
RESEARCH FUNDING (Last 5 years only): Project grants/Fellowships
2015 National Health and Medical Research Council (NH&MRC) Development grant ‘Development of novel microfluidic device to treat male infertility’ AU$492,574 for three years MP Green (CIA), B Wright (CIB), T Peura (CIC), S Lanyon (CID).
2014 Hermon Slade Foundation. ‘The dark side of light: species and community level impact of artificial night lighting”, AU$76,000 for three years. TM Jones (CI), MP Green (CI)
2014 Merck Serono Lectureship, Merck Serono Australia, AU$195,000 for three years. MP Green (CI)
2012 Early Career Grant, University of Melbourne ‘Effects of endocrine disruptors on embryo developmental competence and metabolism’, AU$40,000 for one year. MP Green (CI)
2012 Research Collaboration Grant, University of Melbourne ‘Sorting of sperm by microfluidics: improved reproductive outcomes’, AU$19,992 for one year. MP Green (CI)
2012 Nuture Foundation, New Zealand ‘The use of next generation sequencing technology to study the effect of ovarian ageing and stimulation regimens on the mitochondrial genome’, AU$8,312 for one year. L Cree (CI), MP Green (AI), A Shelling (AI)
2012 Fertility Society of Australia (FSA) ‘The use of next generation sequencing technology to study the effect of ovarian ageing and stimulation regimens on the mitochondrial genome’, AU$18,000 for one year. MP Green (CI), L Cree (AI), A Shelling (AI)
2011 UniServices Ltd, University of Auckland ‘Microfluidic sperm sorting for assisted reproductive technologies’, NZD $216,319 for one year
MP Green (co-PI) and BE Wright (co-PI)
2011 Pearce Trust, The Liggins Institute “Strategies for improving reproductive technologies", NZD $99,353 for two years
MP Green (PI)