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DR Bill Kalionis

Positions

Honorary, Obstetrics and Gynaecology Royal Women's Hospital/Mercy

Publications

Selected publications

2018
- Journal Articles
  - Expression of Homeobox Gene HLX and its Downstream Target Genes are Altered in Placentae From Discordant Twin Pregnancies. Twin Research and Human Genetics. 21. 2018
- Journal Articles Unrefereed
  - Isolation and Characterization of Mesenchymal Stem/Stromal Cells Derived from Human Third Trimester Placental Chorionic Villi and Decidua Basalis. Methods in Molecular Biology. 1710. 2018
2017
- Journal Articles
  - The effect of endothelial cell activation and hypoxia on placental chorionic mesenchymal stem/stromal cell migration. Placenta. 59. 2017
- Journal Articles Refereed
  - Decellularized extracellular matrices produced from immortal cell lines derived from different parts of the placenta support primary mesenchymal stem cell expansion. PLoS One. 12. 2017
  - Human chorionic villous mesenchymal stem/stromal cells modify the effects of oxidative stress on endothelial cell functions. Placenta. 59. 2017
  - Immunomodulatory properties of human placental mesenchymal stem/stromal cells. Placenta. 59. 2017
  - Increased methylation and decreased expression of homeobox genes TLX1, HOXA10 and DLX5 in human placenta are associated with trophoblast differentiation. Scientific Reports. 7. 2017
  - Mesenchymal Stem/Multipotent Stromal Cells from Human Decidua Basalis Reduce Endothelial Cell Activation. Stem Cells and Development. 26. 2017
  - Native and solubilized decellularized extracellular matrix: A critical assessment of their potential for improving the expansion of mesenchymal stem cells. Acta Biomaterialia. 55. 2017
  - Placental Vitamin D-Binding Protein Expression in Human Idiopathic Fetal Growth Restriction. Journal of Pregnancy. 2017. 2017
  - Reduced aldehyde dehydrogenase expression in preeclamptic decidual mesenchymal stem/stromal cells is restored by aldehyde dehydrogenase agonists. Scientific Reports. 7. 2017
  - The application of decellularized human term fetal membranes in tissue engineering and regenerative medicine (TERM). Placenta. 59. 2017
- Journal Articles Unrefereed Letters or Notes
  - Extracellular vesicles, exosomes and shedding vesicles in regenerative medicine - a new paradigm for tissue repair. Biomaterials Science. 6. 2017
- Other Refereed Contribution to Refereed Journals
  - Circular RNAs: Isolation, characterization and their potential role in diseases 2017
2016
- Journal Articles Refereed
  - An Update on Inflamm-Aging: Mechanisms, Prevention, and Treatment. Journal of Immunology Research. 2016
  - Decorin expression is decreased in first trimester placental tissue from pregnancies with small for gestation age infants at birth. Placenta. 45. 2016
  - EGb761 protects against A beta(1-42) oligomer-induced cell damage via endoplasmic reticulum stress activation andHsp70 protein expression increase in SH-SY5Y cells. Experimental Gerontology. 75. 2016
  - Epithelial-mesenchymal transition during extravillous trophoblast differentiation. Cell Adhesion & Migration. 10. 2016
  - Establishment and characterization of fetal and maternal mesenchymal stem/stromal cell lines from the human term placenta. Placenta. 39. 2016
  - Low-Dose Acetylsalicylic Acid Treatment Modulates the Production of Cytokines and Improves Trophoblast Function in an in Vitro Model of Early-Onset Preeclampsia. American Journal of Pathology. 186. 2016
  - Mesenchymal Stem/Stromal Cells Derived From a Reproductive Tissue Niche Under Oxidative Stress Have High Aldehyde Dehydrogenase Activity. Stem Cell Reviews and Reports. 12. 2016
  - Phenotypic and Functional Characterization of Mesenchymal Stem/Multipotent Stromal Cells From Decidua Parietalis of Human Term Placenta. Reproductive Sciences. 23. 2016
  - Phenotypic and Functional Characterization of Mesenchymal Stem/Multipotent Stromal Cells from Decidua Basalis of Human Term Placenta. Stem Cells International. 36. 2016
  - Pyrroloquinoline quinone enhances the resistance to oxidative stress and extends lifespan upon DAF-16 and SKN-1 activities in C-elegans. Experimental Gerontology. 80. 2016
  - The Emerging Role of HMGB1 in Neuropathic Pain: A Potential Therapeutic Target for Neuroinflammation. Journal of Immunology Research. 2016
2015
- Journal Articles Refereed
  - A(1-42) oligomer-induced leakage in an invitro blood-brain barrier model is associated with up-regulation of RAGE and metalloproteinases, and down-regulation of tight junction scaffold proteins. Journal of Neurochemistry. 134. 2015
  - An EG-VEGF-Dependent Decrease in Homeobox Gene NKX3.1 Contributes to Cytotrophoblast Dysfunction: A Possible Mechanism in Human Fetal Growth Restriction. Molecular Medicine. 21. 2015
  - Anti-angiogenic collagen fragment arresten is increased from 16 weeks' gestation in pre-eclamptic plasma. Placenta. 36. 2015
  - Applications of Induced Pluripotent Stem Cells in Studying the Neurodegenerative Diseases. Stem Cells International. 2015
  - Decreased STAT3 in human idiopathic fetal growth restriction contributes to trophoblast dysfunction. Reproduction. 149. 2015
  - Ectopic Bone Formation by Mesenchymal Stem Cells Derived from Human Term Placenta and the Decidua. PLoS One. 10. 2015
  - Effects of normal and high circulating concentrations of activin A on vascular endothelial cell functions and vasoactive factor production. Pregnancy Hypertension: an international journal of women's cardiovascular health. 5. 2015
  - Genome-Wide Transcriptome Directed Pathway Analysis of Maternal Pre-Eclampsia Susceptibility Genes. PLoS One. 10. 2015
  - Human Chorionic Villous Mesenchymal Stem Cells Modify the Functions of Human Dendritic Cells, and Induce an Anti-Inflammatory Phenotype in CD1+Dendritic Cells. Stem Cell Reviews and Reports. 11. 2015
  - Icariin Intervenes in Cardiac Inflammaging through Upregulation of SIRT6 Enzyme Activity and Inhibition of the NF-Kappa B Pathway. BioMed Research International. 2015
  - Mesenchymal stem cells reside in a vascular niche in the decidua basalis and are absent in remodelled spiral arterioles. Placenta. 36. 2015
  - Oleanolic Acid Induces Differentiation of Neural Stem Cells to Neurons: An Involvement of Transcription Factor Nkx-2.5. Stem Cells International. 2015
  - Placenta-derived angiogenic proteins and their contribution to the pathogenesis of preeclampsia. Angiogenesis. 18. 2015
  - Role of Exosomal Noncoding RNAs in Lung Carcinogenesis. BioMed Research International. 2015
2014
- Journal Articles Refereed
  - A novel combination of homeobox genes is expressed in mesenchymal chorionic stem/stromal cells in first trimester and term pregnancies. Reproductive Sciences. 2014
  - Analysis of homeobox gene action may reveal novel angiogenic pathways in normal placental vasculature and in clinical pregnancy disorders associated with abnormal placental angiogenesis. Frontiers in Pharmacology. 5. 2014
  - Dysfunctional Wnt/beta-catenin signaling contributes to blood-brain barrier breakdown in Alzheimer's disease. Neurochemistry International. 75. 2014
  - EGb761 Provides a Protective Effect against A beta(1-42) Oligomer-Induced Cell Damage and Blood-Brain Barrier Disruption in an In Vitro bEnd.3 Endothelial Model. PLoS One. 9. 2014
  - Hepatocyte-Like Cells Derived from Human Amniotic Epithelial Cells Can Be Encapsulated Without Loss of Viability or Function In Vitro. Stem Cells and Development. 23. 2014
  - Increased decidual mRNA expression levels of candidate maternal pre-eclampsia susceptibility genes are associated with clinical severity. Placenta. 35. 2014
  - Stem Cell Research and Regenerative Medicine at King Abdullah International Medical Research Center. Stem Cells and Development. 23. 2014
  - The Role of Oxidative Stress and Inflammation in Cardiovascular Aging. BioMed Research International. 2014
  - The Role of Wnt Signaling in the Development of Alzheimer's Disease: A Potential Therapeutic Target?. BioMed Research International. 2014. 2014
- Conference Proceedings
  - IFPA Meeting 2013 Workshop Report I: Diabetes in pregnancy, maternal dyslipidemia in pregnancy, oxygen in placental development, stem cells and pregnancy pathology. Placenta. 2014
2013
- Journal Articles Refereed
  - Downstream targets of the homeobox gene DLX3 are differentially expressed in the placentae of pregnancies affected by human idiopathic fetal growth restriction. Molecular and Cellular Endocrinology. 377. 2013
  - Epimedium Flavonoids Counteract the Side Effects of Glucocorticoids on Hypothalamic-Pituitary-Adrenal Axis. Evidence-based Complementary and Alternative Medicine. 1. 2013
  - Homeobox gene transforming growth factor β-induced factor-1 (TGIF-1) is a regulator of villous trophoblast differentiation and its expression is increased in human idiopathic fetal growth restriction. Molecular Human Reproduction. 19. 2013
  - Homeobox genes and down-stream transcription factor PPARγ in normal and pathological human placental development. Placenta. 34. 2013
  - Human Placental Mesenchymal Stem Cells (pMSCs) Play a Role as Immune Suppressive Cells by Shifting Macrophage Differentiation from Inflammatory M1 to Anti-inflammatory M2 Macrophages. Stem Cell Reviews and Reports. 9. 2013
  - Phenotypic and Functional Characterization of Mesenchymal Stem Cells from Chorionic Villi of Human Term Placenta. Stem Cell Reviews and Reports. 9. 2013
2012
- Journal Articles Refereed
  - Calreticulin has opposing effects on the migration of human trophoblast and myometrial endothelial cells. Placenta. 33. 2012
  - Decidua parietalis-derived mesenchymal stromal cells reside in a vascular niche within the choriodecidua. Reproductive Sciences. 19. 2012
  - Homeobox gene Distal-Less 3 is a regulator of villous cytotrophoblast differentiation and its expression is increased in human idiopathic foetal growth restriction. Journal of Molecular Medicine. 90. 2012
  - Immunosuppressive Properties of Mesenchymal Stem Cells. Stem Cell Reviews and Reports. 8. 2012
  - The role of homeobox genes in the development of placental insufficiency. Fetal Diagnosis and Therapy. 32. 2012
- Journal Articles Unrefereed Letters or Notes
  - Letter to the Editor Re: Regulation of epithelial-mesenchymal transition by homeobox gene DLX4 in JEG-3 trophoblast cells: a role in preeclampsia. Reproductive Sciences. 19. 2012
- Other Refereed Contribution to Refereed Journals
  - IFPA Meeting 2011 workshop report III: Placental immunology; epigenetic and microRNA-dependent gene regulation; comparative placentation; trophoblast differentiation; stem cells. Placenta. 26. 2012
2011
- Journal Articles Refereed
  - Homeobox gene Distal-less 3 (DLX3) is a regulator of villous cytotrophoblast differentiation. Placenta. 2011
  - Involvement of Gax Gene in Hypoxia-Induced Pulmonary Hypertension, Proliferation, and Apoptosis of Arterial Smooth Muscle Cells. American Journal of Respiratory Cell and Molecular Biology. 44. 2011
  - The Role of Placental Homeobox Genes in Human Fetal Growth Restriction. Journal of Pregnancy. 2011. 2011
2010
- Journal Articles Refereed
  - Downstream Targets of Homeobox Gene HLX Show Altered Expression in Human Idiopathic Fetal Growth Restriction. American Journal of Pathology. 176. 2010
  - Homeobox gene HLX is a regulator of HGF/c-met mediated migration of human trophoblast-derived cell lines. Biology of Reproduction. 83. 2010
  - Homeobox gene distal-less 3 is expressed in proliferating and differentiating cells of the human placenta. Placenta. 31. 2010
  - IFPA Meeting 2009 Workshops Report. Placenta. 24. 2010
  - Mesenchymal stem cells in human placental chorionic villi reside in a vascular Niche. Placenta. 31. 2010
2009
- Journal Articles Refereed
  - Effects of HIV-1 infection in vitro on transendothelial migration by monocytes and monocyte-derived macrophages. Journal of Leukocyte Biology. 85. 2009
2008
- Journal Articles Refereed
  - GAPDH, 18S rRNA and YWHAZ are suitable endogenous reference genes for relative gene expression studies in placental tissues from human idiopathic fetal growth restriction. Placenta. 29. 2008
  - Homeodomain protein HLX is expressed primarily in cytotrophoblast cell types in the early pregnancy human placenta. Reproduction, Fertility and Development. 20. 2008
  - Novel homeobox genes are differentially expressed in placental microvascular endothelial cells compared with macrovascular cells. Placenta. 29. 2008
2007
- Journal Articles Refereed
  - Expression and cellular localisation of chloride intracellular channel 3 in human placenta and fetal membranes. Placenta. 28. 2007
  - Homeobox gene HLX1 is a regulator of colony stimulating factor-1 dependent trophoblast cell proliferation. Placenta. 28. 2007
  - Homeobox genes are differentially expressed in macrovascular human umbilical vein endothelial cells and microvascular placental endothelial cells. Placenta. 28. 2007
  - The ABC transporter BCRP/ABCG2 is a placental survival factor, and its expression is reduced in idiopathic human fetal growth restriction. FASEB Journal. 21. 2007
2006
- Journal Articles Refereed
  - Homeobox gene DLX4 expression is increased in idiopathic human fetal growth restriction. Molecular Human Reproduction. 12. 2006
  - Homeobox gene ESX1L expression is decreased in human pre-term idiopathic fetal growth restriction. Molecular Human Reproduction. 12. 2006
  - Homeobox gene HLX1 expression is decreased in idopathic human fetal growth restriction. American Journal of Pathology. 168. 2006
  - IGFBP1 and Folistatin-like 3 genes are significantly up-regulated in expression profiels of the IUGR placenta. Placenta. 27. 2006
  - Kupffer cell function during the erythocytic stage of malaria. Journal of Gastroenterology and Hepatology. 21. 2006
- Journal Articles Unrefereed
  - Endothelium, blood vessels and angiogenesis - A workshop report. Placenta. 27. 2006
  - Trophoblast differentiation: Progenitor cells, fusion and migration - A workshop report. Placenta. 27. 2006
2005
- Journal Articles Refereed
  - Expression of GLUT12 in the fetal membranes of the human placenta. Placenta. 26. 2005
  - Fetal growth restriction is associated with increased apoptosis in the chorionic trophoblast cells of human fetal membranes. Placenta. 26. 2005
2004
- Journal Articles Refereed
  - Growth and function of the normal human placenta. Thrombosis Research. 114. 2004
  - Plasminogen fragmentation and increased production of extracellula matrix-degrading proteinases are associated with serous epithelial ovarian cancer progression. Gynecologic Oncology. 92. 2004
2003
- Journal Articles Refereed
  - Expression and localizaton of homeodomain proteins DLX4/HB9 in normal and malignant human breast tissues. Anticancer Research. 23. 2003
  - GLUT12 expression in human placenta in first trimester and term. Placenta. 24. 2003
- Other Refereed Contribution to Refereed Journals
  - Advanced molecular techniques in pregnancy research: Proteomics and genomics - A workshop report.. Placenta. 17. 2003

Research

Investigator on

Grant
- STEM CELLS IN A HUMAN PREGNANCY DISORDER (Project Grants) awarded by NHMRC 2008 - 2010
- UNDERSTANDING THE MOLECULAR MECHANISM OF FETAL GROWTH RESTRICTION; A PREGNANCY DISORDER THAT PREVENTS A HEALTHY START TO LIFE (Minter Ellison Marian and EH Flack Trust) awarded by MINISTER ELLISON TRUSTEES

Supervision

Available for supervision

Y

Contact Details
- kalionis@unimelb.edu.au
- 8345 3748
- fax: 8345 3746
- Location
  - Level: 07 Room:, No Building, Royal Womens Hospital
Graduate Study
- - Interested in Graduate Study at Melbourne? Next steps:
    - Graduate Research Programs in Medicine Dentistry and Health Sciences
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