Exploring the functional roles of leukocytes in the progression of inflammatory disease (Monocytes, Macrophages, Dendritic Cells, Cytokines, Chemokines, Transcription and Epigenetic Factors)
After completing my PhD at the University of Melbourne (2007), I did my post-doctoral training at the Institute of Molecular and Cell Biology Institute, Singapore with an Australian Endeavour Research Fellowship. I pursued a short stint at the Burnet Institute in 2009, before returning to the University of Melbourne in 2010. I led a small research team to conduct a commercial contract research towards identifying a GM-CSF gene signature under the auspices of as MorphoSys AG, conducting Phase I anti-GM-CSF clinical trial in rheumatoid arthritis. Following the successful completion of the trial, GlaxoSmithKline acquired the rights to conduct Phase IIb clinical trials. Subsequently, I was instrumental in securing a four-year commercial research contract with GlaxoSmithKline to investigate the molecular mechanisms responsible for GM-CSF-mediated inflammation in rheumatoid arthritis. A number of publications in leading journals and a significant patent emerged from this. In 2018, I was appointed as the Honours Coordinator at the Department of Medicine, Royal Melbourne Hospital overseeing the largest cohort of Honour students in the Faculty of Medicine, Dentistry and Health Sciences at the University of Melbourne.
Australasian Society for Immunology.
Member 2017 -
International Cytokine & Interferon Society.
Member 2017 -
American Society for Biochemistry and Molecular Biology.
Member 2005 -
International Society for Fibrinolysis and Proteolysis.
Member 2004 -
Australian Society for Biochemistry and Molecular Biology.
Member 2002 -
2017 Milstein Travel Award by International Cytokine and Interferon Society, Cytokines 2017 Conference in Kanazawa, Japan 2017 Travel Grant by Society for Cytokines, Inflammation and Leukocytes, 13th World congress on Inflammation, London, UK 2016 Travel Award by ELSEVIER, 100 Years of Phagocytes Conference, Sicily, Italy 2014 Travel Grant by CASS Foundation, FEBS-EMBO 2014 Conference, Paris, France 2010 ASBMB Fellowship, Experimental Biology 2010 Conference, Anaheim, CA 2009 Travel Award by American Society for Biochemistry and Molecular Biology, Annual Scientific Meeting, Anaheim, CA 2008 Endeavour Research Fellowship, Institute for Molecular and Cell Biology, Singapore
Education and training
University of Melbourne
University of Melbourne
Awards and honors
Postgraduate, Melbourne Research Scholarship,
Undergraduate, Melbourne Access Scholarship,
Available for supervision
My research team consists of highly talented research students and staff, who are motivated to understand key biological processes in inflammation and pain in several chronic inflammatory diseases to ultimately develop therapeutics. More than 10 Honours, Masters and PhD students have successfully completed their research projects under my supervision in the past five years. Bachelor of Science (Hons), Bachelor of Biomedicine (Hons), Master of Biomedical Science and PhD students are welcome to join my team. Scholarships are available for high achieving students. I currently have opening for the following projects: Honours projects (also offered as Master of Biomedical Science) 1. Molecular signalling pathways controlling gene expression during chronic disease progression 2. Elucidating molecular signalling pathways controlled by anti-inflammatory steroids 3. Investigating the effects of GM-CSF and M-CSF-derived human macrophages on phagocytosing P. falciparum-infected erythrocytes and cytokine production PhD projects (also offered as Master of Philosophy): 1. Elucidating the roles of CCL17 and CCL22 in rheumatoid arthritis 2. Evaluating the role of JMJD3 in inflammation