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PROF Patrick Kwan




  • Professor Patrick Kwan, BMedSci (Hons), MB, BChir (Cambridge), PhD (Glasgow), FRCP (London), is Chair of Neurology at the University of Melbourne (RMH) and Head of Epilepsy at the Royal Melbourne Hospital. He is a medical specialist in neurology and an international authority in epileptology and antiepileptic drug development. His research portfolio encompasses both applied basic science and clinical aspects, focusing on the epidemiology, pharmacology, genetics and mechanisms of drug resistance of epilepsy. Prof. Kwan has published widely on the outcomes of epilepsy and pharmacology of antiepileptic drugs in leading medical journals including NEJM, the Lancet, the Lancet Neurology, and BMJ. His landmark study on the long-term outcome of newly diagnosed epilepsy, published in the New England Journal of Medicine in 2000, has become the most highly cited article in clinical epilepsy with >2500 citations so far (Google Scholar). The findings of the study have become the evidence base for clinical diagnosis of drug-resistant epilepsy and consideration of alternative therapies such as surgery, as well as the research drive to develop better treatments. In 2010, he chaired a task force of the International League Against Epilepsy (ILAE) to formulate the first global consensus definition of drug-resistant epilepsy. Recently, his research interest has turned to precision medicine as a new management paradigm to improve drug efficacy and safety. He has led the discovery of genetic markers for response to antiepileptic drugs as well as its translation into practice. His group was one of the first research teams in the world to report the strong link between HLA-B*1502 and antiepileptic drug-induced severe skin reactions. The discovery has made significant impact upon clinical practice, resulting in FDA recommendation and drug label change. He was instrumental in translating the research findings into health policy and practice change. He has obtained competitive research gr   


Selected publications


Investigator on

Additional Grant Information

  • NIH (USA), ARC (Australia), NHMRC (Australia), GRF (Hong Kong), HMRF (Hong Kong), HHSRF (Hong Kong), ITF (Hong Kong)   


Education and training

  • MB, BChir, University of Cambridge
  • BMedSci, University of Nottingham
  • PhD, The University of Glasgow

Awards and honors

  • Outstanding Achievement Epilepsy Award, Commission of Asian and Oceanian Affairs, International League Against Epilepsy, 2016
  • Fellow of the Royal Australasian College of Physicians, 2014
  • Fellow of the Royal College of Physicians of London, 2007


Available for supervision

  • Y