cell metabolism, mitochondria, receptors and membrane biology, fatty acid metabolism, inflammation, signal transduction (fetal & neonatal development, regulatory mechanisms)
heart failure, cardiomyopathy, congenital disorders, mitochondria, miRNA lipid & protein signalling, oxidative stress reg, development & aging (cardioprotective therapies, cardiopulmonary bypass support, heart transplantation, cardiac complications of genetic disorders and cancer therapy)
pharmacotherapeutics, antioxidant/REDOX agents, enzyme/gene/mIR targets & reagents, opioid peptides (agents regulating post-injury and other adaptive remodelling)
A/Prof. Pepe first trained in clinical pharmacology and biochemistry, then after a PhD in cardiac physiology he trained as a Fogarty Post-Doctoral Research Fellow, based at the Johns Hopkins Bayview Medical Center Campus of the National Institute on Aging (NIH), Baltimore, USA, in the intramural research program (Laboratory of Cardiovascular Science). Previous to working at the Murdoch Childrens Research Institute and the Department of Paediatrics University of Melbourne, he was Head of the Laboratory of Cardiothoracic Surgical Research, Dept. of Cardiothoracic Surgery, Alfred Hospital and Adjunct Senior Lecturer, Department of Surgery, Monash University. His research examined dysfunctional mitochondrial metabolism in heart disease injury, therapeutics for heart failure and cardioprotection in heart transplantation and cardiopulmonary bypass surgery. He took up the challenge of paediatric heart research when he was invited to move his laboratory to the Melbourne Children's precinct in mid 2008.
A/Prof Salvatore Pepe’s work is focused on cardiovascular complications arising from congenital disorders, premature birth and palliative cardiological and surgical interventions, particularly mitochondrial cardiomyopathies and other heart failure disorders. The emphasis of the research effort is to elucidate basic disease mechanisms, new therapeutic targets and translation to clinical therapeutics.
He is an Associate Editor of Heart Lung and Circulation (Elsevier) and Clinical and Experimental Pharmacology and Physiology (Wiley), an editorial board member of the Journal of Molecular and Cellular Cardiology (Elsevier), and Past-President of the International Society for Heart Research.