Dr Wise graduated from Monash University (PhD) in 2002 where he studied neurophysiology of the sensorimotor system. He was a post doctoral research Fellow at the Bionic Ear Institute (2001-2003). He moved to Bristol UK where he took up post doctoral position (2003-2006) before returning to Melbourne in 2006 to continue research at the Bionics Institute.
Drug delivery: Dr Wise’s research examines strategies to deliver drugs to the inner ear in order to protect against progressive hearing loss and improve the performance of the cochlear implant by protecting auditory nerves and residual sensory cells. In particular he has been investigating the protective and regenerative effects of neurotrophins; a class of proteins that can protect cochlear cells from deafness-induced degeneration. His current research projects use a number of strategies to deliver drugs to the cochlea, along with a cochlear implant, that can be translated to the clinic.
Auditory function: Dr Wise is interested in how auditory neurons respond to electrical stimulation from a cochlear implant and the effects of neurotrophin delivery on nerve function. These experiments are an important next step before we can consider the use of neurotrophins as a therapy for human cochlear implant recipients.
Tinnitus: Dr Wise is interested in understanding the changes in the auditory brain that occur following deafness and cochlear implantation. In particular, he is interested in how cochlear implant use can silence tinnitus. By providing chronic electrical stimulation via a cochlear implant it is possible to suppress tinnitus and Dr Wise is interested in using this strategy to understand and treat tinnitus