Has subject area For 2008 6 Digit Code Bioinorganic Chemistry Electrochemistry Inorganic Chemistry not elsewhere classified Medicinal and Biomolecular Chemistry not elsewhere classified Transition Metal Chemistry Seo 2008 6 Digit Code Expanding Knowledge in the Biological Sciences Expanding Knowledge in the Chemical Sciences
Selected publications 2019 Journal Articles Molecular Mechanisms of Glutaredoxin Enzymes: Versatile Hubs for Thiol-Disulfide Exchange between Protein Thiols and Glutathione. Journal of Molecular Biology. 431. 2019 2018 Journal Articles Evaluation of Cu(I) binding to the E2 domain of the amyloid precursor protein - a lesson in quantification of metal binding to proteins via ligand competition. Metallomics: integrated biometal science. 10. 2018 di-Cysteine motifs in the C-terminus of plant HMA4 proteins confer nanomolar affinity for zinc and are essential for HMA4 function in vivo. 2018 Journal Articles Refereed Glutaredoxins employ parallel monothiol-dithiol mechanisms to catalyze thiol-disulfide exchanges with protein disulfides. Chemical Science. 9. 2018 The Human Amyloid Precursor Protein Binds Copper Ions Dominated by a Picomolar-Affinity Site in the Helix-Rich E2 Domain. Biochemistry. 57. 2018 2017 Journal Articles Refereed Copper ATPase CopA from Escherichia coli: Quantitative Correlation between ATPase Activity and Vectorial Copper Transport. Journal of the American Chemical Society. 139. 2017 Copper binding and redox chemistry of the A beta 16 peptide and its variants: insights into determinants of copper-dependent reactivity. Metallomics: integrated biometal science. 9. 2017 Molecular Aspects of a Robust Assay for Ferroxidase Function of Ceruloplasmin. Inorganic Chemistry. 56. 2017 Reduction potentials of protein disulfides and catalysis of glutathionylation and deglutathionylation by glutaredoxin enzymes. Biochemical Journal. 474. 2017 2016 Journal Articles Refereed Evaluation of employing poly-lysine tags versus poly-histidine tags for purification and characterization of recombinant copper-binding proteins. Journal of Inorganic Biochemistry. 162. 2016 Metal binding to the N-terminal cytoplasmic domain of the P-IB ATPase HMA4 is required for metal transport in Arabidopsis. Plant Molecular Biology. 90. 2016 2015 Journal Articles CopC Protein from Pseudomonas fluorescens SBW25 Features a Conserved Novel High-Affinity Cu(II) Binding Site. Inorganic Chemistry. 54. 2015 Journal Articles Refereed A set of robust fluorescent peptide probes for quantification of Cu(II) binding affinities in the micromolar to femtomolar range. Metallomics: integrated biometal science. 7. 2015 The functional roles of the three copper sites associated with the methionine-rich insert in the multicopper oxidase CueO from E. coli. Metallomics: integrated biometal science. 7. 2015 2014 Journal Articles Refereed An integrated study of the affinities of the A-beta16 peptide for Cu(I) and Cu(II): implications for the catalytic production of reactive oxygen species. Metallomics: integrated biometal science. 6. 2014 Glutaredoxin1 protects neuronal cells from copper-induced toxicity. Biometals. 27. 2014 Quantification of Copper Binding to Amyloid Precursor Protein Domain 2 and its Caenorhabditis elegans Ortholog. Implications for Biological Function. Metallomics: integrated biometal science. 6. 2014 Redox Sulfur Chemistry of the Copper Chaperone Atox1 is Regulated by the Enzyme Glutaredoxin 1, the Reduction Potential of the Glutathione Couple GSSG/2GSH and the Availability of Cu(I). Metallomics: integrated biometal science. 6. 2014 Conference Proceedings New Probes for Weaker Cu(I) Binding Sites Completes a Set of Four That Can Detect Affinities from Nanomolar to Attomolar. Journal of Biological Inorganic Chemistry. 2014 2013 Journal Articles Refereed Evaluation of quantitative probes for weaker Cu(I) binding sites completes a set of four capable of detecting Cu(I) affinities from nanomolar to attomolar. Metallomics: integrated biometal science. 5. 2013 Interaction of cisplatin and analogue Pt(en)Cl2 with the copper metallo-chaperone Atox1. Metallomics: integrated biometal science. 5. 2013 2012 Journal Articles Refereed Copper complexes of a novel non-innocent quadridentate ligand. Chemical Communications. 48. 2012 PcoE - A metal sponge expressed to the periplasm of copper resistance Escherichia coli. Implication of its function role in copper resistance. Journal of Inorganic Biochemistry. 115. 2012 The challenges of using a copper fluorescent sensor (CS1) to track intracellular distributions of copper in neuronal and glial cells. Chemical Science. 3. 2012 2011 Journal Articles Refereed Metallo-Oxidase Enzymes: Design of their Active Sites. Australian Journal of Chemistry. 64. 2011 Molecular Basis of the Cooperative Binding of Cu(I) and Cu(II) to the CopK Protein from Cupriavidus metallidurans CH34. Biochemistry. 50. 2011 Unification of the Copper(I) Binding Affinities of the Metallo-Chaperones Atx1, Atox1 and Related Proteins: Detection Probes and Affinity Standards. Journal of Biological Chemistry. 286. 2011 Water soluble bis(thiosemicarbazonato)copper(II) complexes. Australian Journal of Chemistry. 64. 2011 2010 Journal Articles Refereed A Water-Soluble Bis(thiosemicarbazone) Ligand. A Sensitive Probe and Metal Buffer for Zinc. Inorganic Chemistry. 49. 2010 Challenges of Determining Metal-Protein Affinities. Natural Product Reports . 27. 2010 Reaction Mechanisms of the Multicopper Oxidase CueO from Escherichia coli Support Its Functional Role as a Cuprous Oxidase. Journal of the American Chemical Society. 132. 2010 Solvation Effects on S K-Edge XAS Spectra of Fe-S Proteins: Normal and Inverse Effects on WT and Mutant Rubredoxin. Journal of the American Chemical Society. 132. 2010 2009 Journal Articles Refereed Interaction of Cisplatin and Analogues with a Met-Rich Protein Site. Journal of Biological Inorganic Chemistry. 14. 2009 Metal binding affinities of Arabidopsis zinc and copper transporters: selectivities match the relative, but not the absolute, affinities of their amino-terminal domains. Biochemistry. 48. 2009 Metal specificities of Arabidopsis zinc and copper transport proteins match the relative, but not the absolute, affinities of their N-terminal domains. Chemical Communications. 42. 2009 Unprecedented Binding Cooperativity between CuI and CuII in the Copper Resistance Protein CopK from Cupriavidus metallidurans CH34. Implications from Structural Studies by NMR Spectroscopy and X-ray Crystallography. Journal of the American Chemical Society. 131. 2009 2008 Journal Articles Refereed Copper resistance in E-coli: The multicopper oxidase PcoA catalyzes oxidation of copper(I) in (CuCuII)-Cu-I-PcoC. ChemBioChem. 9. 2008 Electron paramagnetic resonance characterization of the copper-resistance protein PcoC from Escherichia coli. Journal of Biological Inorganic Chemistry. 13. 2008 Protonless C-13 direct detection NMR: Characterization of the 37 kDa trimeric protein CutA1. Proteins - Structure, Function, and Bioinformatics. 70. 2008 Transfer of copper between bis(thiosemicarbazone) ligands and intracellular copper-binding proteins. Insights into mechanisms of copper uptake and hypoxia selectivity. Inorganic Chemistry. 47. 2008 2007 Journal Articles Refereed Conserved Mechanism of Copper Binding and Transfer. A Comparison of the Copper-Resistance Proteins PcoC from Escherichia coli and CopC from Pseudomonas syringae. Inorganic Chemistry. 46. 2007 Copper and Alzheimer's disease. Current Opinion in Chemical Biology. 11. 2007 2006 Journal Articles Refereed Intermolecular Transfer of Copper Ions from the CopC Protein of Pseudomonas syringae. Crystal Structures of Fully Loaded CuICuII Forms. Journal of the American Chemical Society. 128. 2006 2005 Journal Articles Refereed CopC Protein from Pseudomonas syringae: Intermolecular Transfer of Copper from Both the Copper(I) and Copper(II) Sites. Inorganic Chemistry. 44. 2005 2004 Journal Articles Refereed C-Terminal domain of the membrane copper transporter Ctr1 from Saccharomyces cerevisiae binds four Cu(I) ions as a cuprous-thiolate polynuclear cluster: sub-femtomolar Cu(I) affinity of three proteins invlolved in copper trafficking. Journal of the American Chemical Society. 124. 2004 2003 Journal Articles Refereed Application of NMRD to hydration of rubredoxin and a variant containing a (Cys-S)3FeIII(OH) site. Biophysical Journal. 84. 2003 Conference Proceedings Metal binding in CopC from P-syringae pathovar tomato. Journal of Inorganic Biochemistry. 2003 The C-terminal domain of the membrane copper pump Ctr1 in yeast binds Cu as a cuprous-thiolate polynuclear cluster. Journal of Inorganic Biochemistry. 2003 2002 Research Book Chapters Determinants of the reduction potential in Rubredoxins, the simplest iron-sulfur electron-transfer proteins. Modern coordination chemistry: The legacy of Joseph Chatt. Royal Society of Chemistry. 2002 Journal Articles Refereed A C-Terminal Domain of the Membrane Copper Pump Ctr1 Exchanges Copper(I) with the Copper Chaperone Atx1. Chemical Communications. 2002. 2002 Removal of a cysteine ligand from rubredoxin: assembly of Fe2S2 and Fe(S-Cys)3(OH) centres. Journal of Biological Inorganic Chemistry. 7. 2002 2001 Journal Articles Redox thermodynamics of mutant forms of the rubredoxin from Clostridium pasteurianum: identification of a stable Fe-111 (S-Cys)(3)(OH) centre in the C6S mutant (vol 6, pg 638, 2001). Journal of Biological Inorganic Chemistry. 6. 2001 Rubredoxin mutant proteins with Fe-III(S-CYS)(3)(OH) centres. Journal of Inorganic Biochemistry. 86. 2001 Journal Articles Refereed Redox thermodynamics of mutant forms of the rubredoxin from Clostridium pasteurianum: identification of a stable FeIII(S-Cys)3(OH) centre in the C6S mutant. Journal of Biological Inorganic Chemistry. 6. 2001 2000 Journal Articles Mutation of the surface valine residues 8 and 44 in the rubredoxin from Clostridium pasteurianum: solvent access versus structural changes as determinants of reversible potential. Journal of Biological Inorganic Chemistry. 5. 2000 1999 Journal Articles Rubredoxin from Clostridium pasteurianum. Structures of G10A, G43A and C10VG43A mutant proteins. Mutation of conserved glycine 10 to valine causes the 9-10 peptide link to invert. Acta Crystallographica Section D - Biological Crystallography. 55. 1999 The dependence of reversible potentials on the form of modification of edge plane pyrolytic graphite electrodes in voltammetric studies on rubredoxin and ferredoxin from Clostridium pasteurianum. Electrochemistry Communications. 1. 1999 Conference Proceedings Molecular engineering at the active site of rubredoxin. Journal of Inorganic Biochemistry. 1999 1998 Journal Articles The rubredoxin from Clostridium pasteurianum: Mutation of the iron cysteinyl ligands to serine. Crystal and molecular structures of oxidized and dithionite-treated forms of the Cys42Ser mutant. Journal of the American Chemical Society. 120. 1998 1996 Journal Articles A catalytic cycle related to molybdenum enzymes containing (MoO2)-O-VI(2+) oxidized active sites. Inorganic Chemistry. 35. 1996 Complexes containing cis-(MoO2)-O-V(+) and cis-(MoO)-O-V(OH)(2+) centers. Journal of the American Chemical Society. 118. 1996 Dioxomolybdenum(VI) complexes of tripodal nitrogen-donor linands: Syntheses and spectroscopic, structural, and electrochemical studies, including the generation of EPR-active molybdenum(V) species in solution. (vol 34, pg 5954, 1995). Inorganic Chemistry. 35. 1996 Rubredoxin from Clostridium pasteurianum: Mutation of the Conserved Cysteine and Glycine Residues. ACS Symposium Series. 653. 1996 The rubredoxin from Clostridium pasteurianum: Mutation of the conserved glycine residues 10 and 43 to alanine and valine. Inorganic Chemistry. 35. 1996 Trimethylsilyloxo complexes of oxomolybdenum(V) . Journal of Biological Inorganic Chemistry. 1. 1996 Trimethylsilyloxo complexes of oxomolybdenum(V) coupled electron-electrophile transfer reactions. Journal of Biological Inorganic Chemistry. 1. 1996 Conference Proceedings Rubredoxin from Clostridium pasteurianum: Mutation of the conserved cysteine and glycine residues. ACS Symposium Series. 1996 1995 Journal Articles DIOXOMOLYBDENUM(VI) COMPLEXES OF TRIPODAL NITROGEN-DONOR LIGANDS - SYNTHESES AND SPECTROSCOPIC, STRUCTURAL, AND ELECTROCHEMICAL STUDIES, INCLUDING THE GENERATION OF EPR-ACTIVE MOLYBDENUM(V) SPECIES IN SOLUTION. Inorganic Chemistry. 34. 1995 1994 Journal Articles ISOVALENT AND MIXED-VALENT DINUCLEAR MU-OXO AND MU-OXO MU-DISULFIDO COMPLEXES OF MOLYBDENUM(V) AND MOLYBDENUM(VI). Inorganic Chemistry. 33. 1994 THE CIS-DIOXOMOLYBDENUM(V) RADICAL-ANION, (HB(ME(2)C(2)N(3))(3))MOO2(SPH)(-). Journal of the Chemical Society, Chemical Communications. 1994 1992 Journal Articles A SINGLE MODEL DISPLAYING ALL THE IMPORTANT CENTERS AND PROCESSES INVOLVED IN CATALYSIS BY MOLYBDOENZYMES CONTAINING MOVIO22+ ACTIVE-SITES. Journal of the American Chemical Society. 114. 1992
Investigator on Grant Molecular study of copper-promoted ubiquitination (Discovery Projects) awarded by AUST RESEARCH COUNCIL 2019 - 2021
Education and training MSc, Fujian Normal University PhD, La Trobe University BSc, Fujian Normal University