Human sperm function, male fertility, IVF, ICSI (sperm-oocyte interaction, sperm capacitation and the acrosome reaction, clinical tests of sperm function)
A brief CV for Dr De-Yi Liu
Dr De-Yi Liu is currently a Senior Research Fellow in the Department of Obstetrics & Gyneacology, University of Melbourne, Australia. Over the last 20 years, His main research interests are human sperm function, Assisted Reproductive techniques (ART) and male infertility. He has developed various sperm function tests, particularly sperm-zona pellucida (ZP) binding, sperm-oolemma binding, ZP-induced acrosome reaction and sperm-ZP penetration for screening sperm defects causing male infertility. The new sperm tests are able to diagnose subtle sperm defects which can not be detected by conventional semen analysis. He and his collegues first discovered a new cause of infertility, known as "disordered zona pellucida-induced acrosome reaction" which impairs sperm-ZP penetration. Men with this condition usually have normal semen analyses and normal sperm-ZP binding results and are previously classified as having unexplained infertility. This condition can only be diagnosed by sperm-oocyte interaction tests, and intra-cytoplasmic sperm injection (ICSI) is needed to achieve pregnancy. His research is now focused on the study of the mechanism of causes of defective sperm-oocyte interaction in infertile men. He has published extensively in this field with over 70 scientific papers, 5 book chapters and over 100 abstracts presented at national and international conferences. He has been frequently invited as speaker to international symposia and workshops. He was an Associate Editor for Human Reproduction (2003-2006) and a current Editorial Board Member for the Asian Journal of Andrology and the Reproduction and Contraception. He is also a regular reviewer for several reproductive medical journals.