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DR PETER JOHN CRACK



Contact Details

Organization: Pharmacology
Position: SENIOR LECTURER - PHARMACOLOGY
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Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Doctorate of Philosophy Monash Medical Centre 06-Dec-1996
Bachelor of Science with Honours Monash Medical Centre 15-Apr-1992

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
TRAUMATIC INJURY TO BRAIN & SPINAL CORD: SECONDARY INJURY, DEVELOPMENT & EVALUATION OF NEW TREATMENTS Chief Investigator TRANSPORT ACCIDENT COMMISSION Victorian Neurotrauma Initiative 01/09/2006
THE INVOLVEMENT OF TOLL-LIKE RECEPTORS IN THE PROGRESSION OF STROKE Chief Investigator ANZ CHARITABLE TRUSTS Medical Research and Technology Grants 01/01/2007
Smoking and stroke. Chief Investigator NHMRC Project Grants 01/01/2008

Contracts

Title Role Funding Source Award Date
G2-INFLAMMATION CONSULTANCY AGREEMENT Chief Investigator G2 INFLAMMATION PTY LTD 01/03/2007
MTA - G2 INFLAMMATION PTY LIMITED MATERIAL TRANSFER AGREEMENT Chief Investigator G2 THERAPIES PTY LTD

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2007

Journal Articles

  • Toll-like receptors in the brain and their potential roles in neuropathology
    Year: 2007
    Journal: Immunology and Cell Biology
    Volume: 85
    Issue: 6
    Page numbers: 476-480
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Publications in 2006

Journal Articles

  • Glutathione peroxidase 1 and a high cellular glutathione concentration are essential for effective organic hydroperoxide detoxification in astrocytes.
    Year: 2006
    Journal: Glia
    Volume: 54
    Issue: 8
    Page numbers: 873-9
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  • Glutathione peroxidase 1 is required for rapid clearance of hydrogen peroxide by mouse astrocytes and protects them from iron-mediated peroxide toxicity
    Year: 2006
    Journal: Journal of Neuroscience Research
    Volume: 84
    Issue: 3
    Page numbers: 578-86
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  • Glutathione peroxidase-1 contributes to the protection of glutamine synthetase in astrocytes during oxidative stress
    Year: 2006
    Journal: Journal of Neural Transmission
    Volume: 113
    Issue: 9
    Page numbers: 1145-1155
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  • Lack of glutathione peroxidase-1 exacerbates Aβ-mediated neurotoxicity in cortical neurons
    Year: 2006
    Journal: Journal of Neural Transmission
    Volume: 113
    Issue: 5
    Page numbers: 645-657
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  • Potential contribution of NF-κB in neuronal cell death in the glutathione peroxidase-1 knockout mouse in response to ischemia-reperfusion injury
    Year: 2006
    Journal: Stroke
    Volume: 37
    Issue: 6
    Page numbers: 1533-8
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  • Suppressor of cytokine signaling 1 negatively regulates toll-like receptor signaling by mediating Mal degradation
    Year: 2006
    Journal: Nature Immunology
    Volume: 7
    Page numbers: 148-155
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Publications in 2005

Journal Articles

  • Diminished Akt phosphorylation in neurons lacking glutathione peroxidase-1 (Gpx1) leads to increased susceptibility to oxidative stress-induced cell death
    Year: 2005
    Journal: Journal of Neurochemistry
    Volume: 92
    Page numbers: 283-293
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  • Reactive oxygen species and the modulation of stroke
    Year: 2005
    Journal: Free Radical Biology and Medicine
    Volume: 38
    Page numbers: 1433-1444
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Publications in 2004

Journal Articles

  • Akt phosphorylation and NFκB activation are counterregulated under conditions of oxidative stress
    Year: 2004
    Journal: Experimental Cell Research
    Volume: 300
    Issue: 2
    Page numbers: 463-475
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  • Fibroblasts derived from Gpx1 knockout mice display senescent-like features and are susceptible to H2O2-mediated cell death
    Year: 2004
    Journal: Free Radical Biology and Medicine
    Volume: 36
    Issue: 1
    Page numbers: 53-64
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  • Oxidative stress and neural survival
    Year: 2004
    Journal: Clinical and Experimental Pharmacology and Physiology
    Volume: 31
    Issue: 7
    Page numbers: 397-406
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  • Targeted disruption of SP13/Serpinb6 does not result in developmental or growth defects, leukocyte dysfunction, or susceptibility to stroke
    Year: 2004
    Journal: Molecular and Cellular Biology
    Volume: 24
    Issue: 9
    Page numbers: 4075-4082
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Publications in 2003

Journal Articles

  • An imbalance in antioxidant defense affects cellular function: the pathophysiological consequences of a reduction in antioxidant defense in the glutathione peroxidase-1 (Gpx1) knockout mouse.
    Year: 2003
    Journal: Redox Report
    Volume: 8
    Issue: 2
    Page numbers: 69-79
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  • Glutathione Peroxidase-1 Contributes to the Neuroprotection Seen in the Superoxide Dismutase-1 Transgenic Mouse in Response to Ischemia/Reperfusion Injury
    Year: 2003
    Journal: Journal of Cerebral Blood Flow and Metabolism
    Volume: 23
    Issue: 1
    Page numbers: 19-22
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  • Overexpression of the chromosome 21 transcription factor Ets2 induces neuronal apoptosis
    Year: 2003
    Journal: Neurobiology of Disease
    Volume: 14
    Page numbers: 349-356
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Publications in 2002

Journal Articles

  • Ets-2 is induced by oxidative stress and sensitizes cells to H2O2-induced apoptosis: implications for Down's Syndrome


    Year: 2002
    Journal: Biochemical and Biophysical Research Communications
    Volume: 287
    Page numbers: 1003-1008
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  • A mouse model  of spinal and bulbar muscular atrophy
    Year: 2002
    Journal: Human Molecular Genetics
    Volume: 11
    Issue: 18
    Page numbers: 2103-2111
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  • Mice Lacking Glutathione Peroxidaase-1 Activity Show Increased Tunel Staining and an Accelerated Inflammatory Response in Brain Following a Cold-Induced Injury
    Year: 2002
    Journal: Experimental Neurology
    Volume: 177
    Issue: 1
    Page numbers: 9-20
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Publications in 2001

Journal Articles

  • Increased infarct size and exacerbated apoptosis in the glutathione peroxidase-1 (Gpx-1) knockout mouse brain in response to ischemia/reperfusion injury.
    Year: 2001
    Journal: Journal of Neurochemistry
    Volume: 78
    Issue: 6
    Page numbers: 1389-1399
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