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DR PAUL DONNELLY



Contact Details

Organization: Chemistry
Position: LECTURER IN CHEMISTRY
Email:
Homepage: http://www.chemistry.unimelb.edu.au/people/donnelly.php
Work: 83442399
Room: 506
Level: 05
Building: Bio21 Incubator Building
Campus: Parkville

Research Expertise and International Linkages

Research Expertise

Research Interest Key Words Country of Expertise
Inorganic Chemistry and Metals in Medicine coordination chemistry, transition metal chemistry, radiopharmaceuticals, macrocycles, bioinorganic chemistry, inorganic synthesis Australia

International Linkages

Country Establishment Collaboration
United Kingdom University of Oxford Exchange, Research

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Bachelor of Science (honours) The University of Western Australia 31-Dec-1996
Doctor of Philosophy The University of Western Australia 31-Dec-2001

Memberships

Membership Type Membership Body Description Start Date End Date
Member Society of Biological Inorganic Chemistry Member 01-Jun-2007
Member American Chemical Society Member 01-Jan-2008
Member Royal Australian Chemical Institute MRACI CChem 01-Jan-2001

Other Awards

Award Type Awarding Body Comments Date Awarded
Other (Award) University of Melbourne Selby Research Award 18-Jun-2007
Other (Award) Royal Australian Chemical Institute Alan Sargeson Lectureship 15-Dec-2008
Other (Award) University of Melbourne Patent Support Grant 01-Jan-2005
Prize University of Melbourne Kaye Merlin Brutton Prize 18-Mar-2005
Other (Award) University of Oxford Annual Merit Award 01-Jan-2004
Other (Award) University of Oxford Annual Merit Award 01-Jan-2003
Other (Award) Somerville College, University of Oxford Fulford Junior Research Fellowship 01-Jan-2004
Other (Award) Australian Research Council Australian Postdoctoral Research Fellowship 01-Jan-2004

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
New copper and rhenium radiopharmaceuticals Chief Investigator AUST RESEARCH COUNCIL Discovery Projects 01/01/2004
Copper Radiopharmaceuticals for Molecular Imaging of Alzheimer's Disease Chief Investigator AUST RESEARCH COUNCIL Discovery Projects 01/01/2007
X-ray Molecular Structure Elucidation Facility (MSEF) Chief Investigator AUST RESEARCH COUNCIL Linkage Infrastructure (Equipment and Facilities) 01/01/2007
APPLICATION OF COPPER-64 TO STUDIES ON ALZHEIMER'S DISEASE AND CHARACTERISATION OF NOVEL GENES AND PROTEINS INVOLVED IN COPPER HOMEOSTASIS Chief Investigator AINSE Awards 01/01/2007
A NATIONAL BIOMEDICAL ELECTRON PARAMAGNETIC RESONANCE AND MOLECULAR IMAGING CENTRE Chief Investigator MONASH UNIVERSITY Linkage Infrastructure (Equipment and Facilities) (AUST RESEARCH COUNCIL) 01/01/2007
THE USE OF CU-ATSM TREATMENT TO IDENTIFY CELLULAR MECHANISMS OF MOTOR NEURON DEGENERATION IN AMYOTROPHIC LATERAL SCLEROSIS. Chief Investigator MOTOR NEURONE DISEASE INST OF AUST Grants-in-Aid 07/11/2007
Molecular Probes for Bio-Metals Chief Investigator AUST RESEARCH COUNCIL Discovery Projects 01/01/2008
INVESTIGATING PROTEIN/PROTEIN INTERACTIONS Chief Investigator AUST RESEARCH COUNCIL Linkage Infrastructure (Equipment and Facilities) 01/01/2008
Modulation of cell signalling by metal-based compounds as a therapeutic treament for Alzheimer's disease. Chief Investigator NHMRC Project Grants 01/01/2009
Enhanced Capacity in Ultra-Trace Level Detection and Speciation of Compounds of Environmental, Biological and Materials Science Interest Chief Investigator AUST RESEARCH COUNCIL Linkage Infrastructure (Equipment and Facilities) 01/01/2009
APPLICATION OF COPPER-64 IN STUDIES OF THE ROLE OF COPPER IN ALZHEIMER'S DISEASE Chief Investigator AINSE Awards 01/01/2009
The synthesis of new copper and rhenium chelators for application in medicine, industry and environment Chief Investigator AINSE Awards

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2009

Journal Articles

  • Increasing Cu bioavailability inhibits Aβ oligomers and tau phosphorylation
    Year: 2009
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 106
    Issue: 2
    Page numbers: 381-386
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  • Interaction of Cisplatin and Analogues with a Met-Rich Protein Site
    Year: 2009
    Journal: Journal of Biological Inorganic Chemistry
    Volume: 14
    Issue: 2
    Page numbers: 163-165
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Publications in 2008

Journal Articles

  • 'Click' cycloaddition catalysts: Copper(I) and copper(II) tris(triazolylmethyl)amine complexes
    Year: 2008
    Journal: Chemical Communications
    Volume: -
    Page numbers: 2459-2461
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  • Activation of epidermal growth factor receptor by metal-ligand complexes decreases levels of extracellular amyloid beta peptide


    Year: 2008
    Journal: International Journal of Biochemistry and Cell Biology
    Volume: 40
    Issue: 9
    Page numbers: 1901-1917
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  • Selective intracellular release of copper and zinc ions from bis(thiosemicarbazonato) complexes reduces levels of Alzheimer disease amyloid-beta peptide
    Year: 2008
    Journal: Journal of Biological Chemistry
    Volume: 283
    Issue: 8
    Page numbers: 4568-4577
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  • Transfer of copper between bis(thiosemicarbazone) ligands and intracellular copper-binding proteins. Insights into mechanisms of copper uptake and hypoxia selectivity
    Year: 2008
    Journal: Inorganic Chemistry
    Volume: 47
    Page numbers: 4338-4347
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Publications in 2007

Journal Articles

  • Alzheimer's disease and the chemistry of copper
    Year: 2007
    Journal: Chemistry in Australia
    Volume: 74
    Issue: 7
    Page numbers: 18-20
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  • Bifunctional chelators for copper radiopharmaceuticals: The synthesis of [Cu(ATSM)-amino acid] and [Cu(ATSM)-octreotide] conjugates
    Year: 2007
    Journal: Dalton Transactions
    Issue: 2
    Page numbers: 209-217
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  • Copper and Alzheimer's disease
    Year: 2007
    Journal: Current Opinion in Chemical Biology
    Volume: 11
    Page numbers: 128-133
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  • Copper and zinc bis(thiosemicarbazonato) complexes for the treatment of Alzheimer's disease
    Year: 2007
    Journal: Journal of Biological Inorganic Chemistry
    Volume: 12
    Page numbers: S17
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  • Functionalised bis(thiosemicarbazonato) complexes of zinc and copper: Synthetic platforms towards site-specific radiopharmaceuticals
    Year: 2007
    Journal: Inorganic Chemistry
    Volume: 46
    Page numbers: 465-485
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  • New bimetallic compounds based on the bis(thiosemicarbazonato) motif
    Year: 2007
    Journal: Dalton Transactions
    Issue: 3
    Page numbers: 327-331
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  • Rhenium diazenide ternary complexes with dithiocarbamate ligands: Towards new rhenium radiopharmaceuticals
    Year: 2007
    Journal: Dalton Transactions
    Issue: 1
    Page numbers: 73-82
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Publications in 2006

Journal Articles

  • Copper Complexes of Thiosemicarbazone-Pyridylhydrazine (THYNIC) Hybrid Ligands: A New Versatile Potential Bifunctional Chelator for Copper Radiopharmaceuticals
    Year: 2006
    Journal: Inorganic Chemistry
    Volume: 45
    Page numbers: 496-498
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Publications in 2005

Book Chapters

  • Therapeutic rhenium radiopharmaceuticals
    Year: 2005
    Book: Metallotherapeutics - The Use of Metal-Based Drugs in Medicine
    Publisher: Wiley - John Wiley & Sons(Chichester)
    Authors(s):

Journal Articles

  • Fluorescence studies of the intra-cellular distrubution of zinc bis(thiosemicarbazone) complexes in human cancer cells
    Year: 2005
    Journal: Chemical Communications
    Volume: 106
    Issue: 2
    Page numbers: 845-847
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  • Investigations into some aryl substituted bis(thiosemicarbazones) and their copper complexes
    Year: 2005
    Journal: Inorganica Chimica Acta
    Volume: 358
    Page numbers: 2770-2780
    Publisher: Elsevier Science(Lausanne)
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  • Radiosynthesis of novel copper(II) bis(thiosemicarbazone) PET tracers
    Year: 2005
    Journal: Journal of Labelled Compounds & Radiopharmaceuticals
    Volume: 48
    Page numbers: S163
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Publications in 2004

Journal Articles

  • Acetylacetonate bis(thiosemicarbazone) complexes of copper and nickel: Towards new copper radiopharmaceuticals
    Year: 2004
    Journal: Dalton Transactions
    Volume: n/a
    Page numbers: 2404-2412
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  • Diazenide and hydrazide(2-) derivatives of the [Re(CO)3]+ core
    Year: 2004
    Journal: Dalton Transactions
    Volume: n/a
    Issue: 17
    Page numbers: 2610-2611
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  • Functionalised Thiosemicarbaozne Clusters of Copper(I) and Silver(I)
    Year: 2004
    Journal: Inorganic Chemistry
    Volume: 43
    Page numbers: 4121
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  • Pyridylthiocarbazide complexes of rhenium with potential radiopharmaceutical applications
    Year: 2004
    Journal: Dalton Transactions
    Issue: 16
    Page numbers: 2402-2403
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Publications in 2003

Journal Articles

  • 'Neutralmolekulcomplexe' - Structural Characterization of Some Adducts of Urea and Thiourea with N,N'-bidentate Aromatic Bases
    Year: 2003
    Journal: Australian Journal of Chemistry
    Volume: 56
    Page numbers: 1249-1253
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  • A Mono Diazenide Complex from Perrhenate: Toward a New Core for Rhenium Radiopharmaceuticals
    Year: 2003
    Journal: Inorganic Chemistry
    Volume: 42
    Page numbers: 929-931
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  • Structural trends in copper(II) bis(thiosemicarbazone) radiopharmaceuticals
    Year: 2003
    Journal: Dalton Transactions
    Issue: 23
    Page numbers: 4416-4425
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  • Synthesis and Characterisation of New Homoleptic Rhenium Thiosemicarbazone Complexes
    Year: 2003
    Journal: Dalton Transactions
    Issue: 4
    Page numbers: 748-754
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Publications in 2002

Book Chapters

  • Towards New Copper and Rhenium Based Radiopharmaceuticals
    Year: 2002
    Book: Techentium, Rhenium and Other Metals in Chemistry and Nuclear Medicine 6
    Publisher: Servizi Grafici Editoriali(Padova)
    Authors(s):
  • Towards Rhenium Radiopharmaceuticals with Diazenide and Dithiocarbamate Ligands
    Year: 2002
    Book: Technetium, Rhenium and Other Metals in Chemistry and Nuclear Medicine
    Publisher: Servizi Grafici Editoriali(Padova)
    Authors(s):

Journal Articles

  • An Unusual Dimeric Structure of a Cu(I) bis(thiosemicarbazone) Complex: Implications for the Mechanism of Hypoxic Selectivity of Cu(II) Derivatives
    Year: 2002
    Journal: Journal of the American Chemical Society
    Volume: 124
    Page numbers: 5270-5271
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  • Synthesis with Coordinated Ligands: Biomolecule Attachment to Cage Amines
    Year: 2002
    Journal: Journal of the Chemical Society - Dalton Transactions
    Issue: 6
    Page numbers: 906-913
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Publications in 2001

Journal Articles

  • An Octapositive Cation Incorporating Multiple Redox Centres: Cage Amine Complexes of Cobalt(III) Linked by a 2,2'-bis(pyrdinium) unit
    Year: 2001
    Journal: Australian Journal of Chemistry
    Page numbers: 0003-6935
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  • Carboxymethylated Cage Amines: Coordination and Lactamization
    Year: 2001
    Journal: Inorganic Chemistry
    Volume: 40
    Page numbers: 5645
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  • Chirality in Coordination Polymers: Homo-vs. Hetero-chiral Strand Construction
    Year: 2001
    Journal: Journal of the Chemical Society - Dalton Transactions
    Page numbers: 3078
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  • Functionalization of Cage Amines with Pendant Aromatic and Heteroaromatic Substituents.
    Year: 2001
    Journal: European Journal of Inorganic Chemistry
    Volume: 2001
    Page numbers: 1869
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