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DR MARTHA LAPPAS



Contact Details

Organization: Obstetrics and Gynaecology Royal Women's Hospital/Mercy
Position: R D WRIGHT FELLOW
Email:
Homepage: www.obsgyn.unimelb.edu.au
Work: 8458 4381
Fax: 8458 4380
Level: 04
Building: No Building
Campus: Mercy Hospital

Research Expertise and International Linkages

Research Expertise

Research Interest Key Words Country of Expertise
Pregnancy complications diabetes, preterm labour Australia

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Bachelor of Science (honours) Monash University 31-Dec-1995
Doctor of Philosophy University of Melbourne 31-Dec-2002

Memberships

Membership Type Membership Body Description Start Date End Date
Member Australasian Diabetes in Pregnancy Society Regular Member 10-Jan-2003
Member Australian Diabetes Society Regular Member 01-Jan-2005
Member Australian & New Zealand Placental Research Association Regular Member 23-Aug-2004
Member Endocrine Society of Australia Regular Member 01-Dec-2002
Member European Association for the Study of Diabetes Regular Member 01-Jun-2007
Member Perinatal Society of Australia and New Zealand Regular Member 02-Sep-2002
Member American Diabetes Association Member 01-Oct-2008

Other Awards

Award Type Awarding Body Comments Date Awarded
Scholarship Puzey Postdoctoral Research Fellowship (University of Melbourne) 01-Jan-2003
Scholarship NHMRC RD Wright Fellow 01-Jan-2007

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
Assessing key regulators of apoptosis in human term fetal membranes at the putative supra-cervical site Chief Investigator MEDICAL RESEARCH FOUNDATION FOR WOMAN & BABIES Research Grants 01/01/2005
THE EFFECT OF GESTATIONAL DIABETES MELLITUS (GDM) ON THE PROTEIN PROFILE OF HUMAN PLACENTA, ADIPOSE TISSUE AND SKELETAL MUSCLE Chief Investigator DIABETES AUST RESEARCH TRUST Research Grants 01/01/2006
The effect of gestational diabetes mellitus on proteins expressed in human placenta, adipose tissue and skeletal muscle Chief Investigator ANZ CHARITABLE TRUSTS Medical Research and Technology Grants 01/01/2006
Understanding the pathophysiology of Gestational Diabetes Mellitus Chief Investigator NHMRC Project Grants 01/01/2007
R. DOUGLAS WRIGHT BIOMEDICAL CAREER DEVELOPMENT AWARD - (UNDERSTANDING THE MECHANISMS THAT REGULATE THE ONSET OF HUMAN LABOUR AND DELIVERY) Chief Investigator NHMRC Career Development Awards 01/01/2007
Unique insights into the causes of preterm labour - understanding fetal membrane rupture Chief Investigator ANZ CHARITABLE TRUSTS Medical Research and Technology Grants 15/10/2007
1st trimester ghrelin and its relationship to low birthweight Chief Investigator MEDICAL RESEARCH FOUNDATION FOR WOMAN & BABIES Research Grants 12/11/2007
Is the antioxidant status altered in placenta, adipose tissues and skeletal muscle Chief Investigator MEDICAL RESEARCH FOUNDATION FOR WOMAN & BABIES Research Grants 12/11/2007
Molecular Mechanisms that Regulate the Onset of Gestational Diabetes Mellitus Chief Investigator MEDICAL RESEARCH FOUNDATION FOR WOMAN & BABIES Research Grants 12/11/2007
THE ROLE OF FATTY ACIDS IN THE PATHOPHYSIOLOGY OF DIABETES IN PREGNANCY Chief Investigator DIABETES AUST RESEARCH TRUST Research Grants 01/01/2009
INFLAMMATORY GENE EXPRESSION IN GESTATIONAL TISSUES FROM TERM AND PRETERM PREGNANCIES Principal Supervisor MEDICAL RESEARCH FOUNDATION FOR WOMAN & BABIES Research Grants

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2009

Journal Articles

  • Defective insulin signalling in placenta from pregnancies complicated by gestatinal diabetes mellitus.


    Year: 2009
    Journal: European Journal of Endocrinology
    Volume: 160
    Issue: 4
    Page numbers: 567-578
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  • Localisation and expression of FoxO1 proteins in human gestational tissues.
    Year: 2009
    Journal: Placenta
    Volume: 30
    Issue: 3
    Page numbers: 256-262
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  • Peroxisome proliferator-activated receptors and retinoid X receptor-alpha in term human gestational tissues: tissue specific and labour-associated changes.
    Year: 2009
    Journal: Placenta
    Volume: 30
    Issue: 2
    Page numbers: 176-186
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  • Transcriptional regulation of the processes of human labour and delivery.
    Year: 2009
    Journal: Placenta
    Volume: 30
    Issue: Suppl A
    Page numbers: S90-S95
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Publications in 2008

Journal Articles

  • Pre-labour fetal membranes overlying the cervix display alterations in inflammation and NF-kB signalling pathways.
    Year: 2008
    Journal: Placenta
    Volume: 29
    Page numbers: 995-1002
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  • Screening for biomarkers predictive of gestational diabetes mellitus
    Year: 2008
    Journal: Acta Diabetologica
    Volume: 45
    Page numbers: 157-165
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Publications in 2007

Journal Articles

  • Mitogen-activated protein kinase proteins regulate LPS-stimulated release of pro-inflammatory cytokines and prostaglandins from human gestational tissues.


    Year: 2007
    Journal: Placenta
    Volume: 28
    Issue: 8-9
    Page numbers: 936-945
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  • Advanced glycation endproducts mediate pro-inflammatory actions in human gestational tissues via nuclear factor-kB and extracellular signal-regulated kinase 1/2.
    Year: 2007
    Journal: Journal of Endocrinology
    Volume: 193
    Issue: 2
    Page numbers: 269-277
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  • Anti-inflammatory effects of the cyclopentenone isoprostane 15-A2-IsoP in human gestational tissues.
    Year: 2007
    Journal: Free Radical Biology and Medicine
    Volume: 42
    Issue: 12
    Page numbers: 1791-1796
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  • Effect of high oxygen on placental function in short-term explant cultures.
    Year: 2007
    Journal: Cell and Tissue Research
    Volume: 328
    Issue: 3
    Page numbers: 607-616
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  • The role and regulation of the nuclear factor kappa B signalling pathway in human labour.
    Year: 2007
    Journal: Placenta
    Volume: 28
    Issue: 5-6
    Page numbers: 543-556
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  • Why do membranes rupture at term? Evidence of increased cellular apoptosis in the supra-cervical fetal membranes.
    Year: 2007
    Journal: American Journal of Obstetrics and Gynecology
    Volume: 196
    Page numbers: 484.e1 - 484.e10
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Publications in 2006

Journal Articles

  • 15-Deoxy-Δ12,14-Prostaglandin, J2 and Troglitazone Regulation of the Release of Phosolipid Metabolites, Inflammatory Cytokines and Proteases from Human Gestational Tissues
    Year: 2006
    Journal: Placenta
    Volume: 27
    Page numbers: 1060-1072
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  • Lipopolysaccharide and TNF-α Activate the Nuclear Factor Kappa B Pathway in the Human Placental JEG-3 Cells
    Year: 2006
    Journal: Placenta
    Volume: 27
    Page numbers: 568-575
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Publications in 2005

Journal Articles

  • Leptin and Adiponectin Stimulate the Release of Proinflammatory Cytokines and Prostoglandins from Human Placenta and Maternal Adipose Tissue via Nuclear Factor-kB, Peroxisomal Proliferator-Activated Receptor-gamma and Extracellularly Regulated Kinase 1/2.
    Year: 2005
    Journal: Endocrinology
    Volume: 146(8)
    Page numbers: 3334-3342
    Publisher: Endocrine Society(Maryland)
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  • Release and regulation of leptin, resistin and adiponectin from human placenta, fetal membranes, and maternal adipose tissue and skeletal muscle from normal and gestational diabetes mellitus-complicated pregnancies.
    Year: 2005
    Journal: Journal of Endocrinology
    Volume: 186
    Page numbers: 457-465
    Publisher: Society of Endocrinology(Stokebristol)
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  • Sulfalazine and BAY 11-7082 Interfere with the Nuclear Factor-kB and IkB Kinase Pathway to Regulate the Release of Proinflammatory Cytokines from Human Adipose Tissue and Skeletal Muscle in Vitro.
    Year: 2005
    Journal: Endocrinology
    Volume: 146(3)
    Page numbers: 1491-1497
    Publisher: Endocrine Society(Maryland)
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Publications in 2004

Journal Articles

  • Effect of Nuclear Factor-kappa B Inhibitors and Peroxisome Proliferator-activated Receptor-gamma Ligands on PTHrP Release from Human Fetal Membranes
    Year: 2004
    Journal: Placenta
    Volume: 25
    Issue: 8-9
    Page numbers: 699-704
    Publisher: WB Saunders Co(London)
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  • Phospholipase A2 isozymes in pregnancy and parturition.
    Year: 2004
    Journal: Prostaglandins Leukotrienes and Essential Fatty Acids
    Volume: 70
    Issue: 2
    Page numbers: 87-100
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  • Regulation of Phospholipase Isozymes by Nuclear Factor-kB in Human Gestational Tissues in Vitro
    Year: 2004
    Journal: Journal of Clinical Endocrinology & Metabolism
    Volume: 89
    Issue: 5
    Page numbers: 2365-2372
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  • Release of Proinflammatory Cytokines and 8-Isoprostane from Placenta, Adipose Tissue, and Skeletal Muscle from Normal Pregnant Women and Women with Gestational Diabetes Mellitus
    Year: 2004
    Journal: Journal of Clinical Endocrinology & Metabolism
    Volume: 89
    Issue: 11
    Page numbers: 5627-5633
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Publications in 2003

Journal Articles

  • N-Acetyl-Cysteine Inhibits Phospholipid Metabolism, Proinflammatory Cytokine Release, Protease Activity, and Nuclear Factor-kB Deoxyribonucleic Acid-Binding Activity in Human Fetal Membranes in Vitro
    Year: 2003
    Journal: Journal of Clinical Endocrinology & Metabolism
    Volume: 88
    Issue: 4
    Page numbers: 1723-1729
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Publications in 2002

Journal Articles

  • Nuclear Factor Kappa B Regulation of Proinflammatory Cytokines in Human Gestational Tissues in Vitro
    Year: 2002
    Journal: Biology of Reproduction
    Volume: 67
    Page numbers: 668-673
    Publisher: Society for the Study of Reproduction(Wisconsin)
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  • Regulation of Proinflammatory Cytokines in Human Gestational Tissues by Peroxisome Proliferator-Activated Receptor-ã: Effect of 15 Deoxy-Ä 12,14 -PGJ2 and Troglitazone
    Year: 2002
    Journal: Journal of Clinical Endocrinology & Metabolism
    Volume: 87
    Issue: 10
    Page numbers: 4667-4672
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Publications in 2001

Journal Articles

  • Antisense Oligonucleotide Inhibition Of Type II Phospholipase A2 Expression, Release And Activity in Vitro
    Year: 2001
    Journal: Placenta
    Volume: 22
    Issue: 5
    Page numbers: 418-424
    Publisher: WB Saunders Co(London)
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  • Type II Phospholipase A2 in Preterm Human Gestational Tissues
    Year: 2001
    Journal: Placenta
    Volume: 22
    Issue: 1
    Page numbers: 64-69
    Publisher: WB Saunders Co(London)
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