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DR JORG HEIERHORST



Contact Details

Organization: Medicine - St Vincent's Hospital
Position: Honorary (Principal Fellow)
Email:
Homepage: www.medstv.unimelb.edu.au
Work: 03 9288 2503
Fax: 03 9416 2676
Room: 213
Level: 02
Building: SVIMR
Campus: St Vincents Hospital

Research Expertise and International Linkages

Research Expertise

Research Interest Key Words Country of Expertise
Recombination-associated DNA repair pathways Molecular Genetics Australia

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Bachelor of Medicine & Bachelor of Surgery University of Hamburg 31-Dec-1992
Doctor of Medicine University of Hamburg 31-Dec-1993

Other Awards

Award Type Awarding Body Comments Date Awarded
Other (Award) St. Vincent's Hospital ASTRA Young Investigator Award 31-Dec-1996
Other (Award) National Health and Medical Research Council R.D. Wright Career Development Award 31-Dec-1998
Other (Award) Australian Academy of Sciences International Travel Award. 31-Dec-1999
Other (Award) St. Vincent's Hospital KENDRO Prize and AMRAD Senior Investigator Award 31-Dec-2001

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2008

Journal Articles

  • DNA damage response protein ASCIZ links base excision repair
    with immunoglobulin gene conversion
    Year: 2008
    Journal: Biochemical and Biophysical Research Communications
    Volume: 371
    Page numbers: 225-229
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  • Diphosphothreonine-Specific Interaction
    between an SQ/TQ Cluster and an FHA Domain
    in the Rad53-Dun1 Kinase Cascade
    Year: 2008
    Journal: Molecular Cell
    Volume: 30
    Page numbers: 767-778
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  • Location-Specific Functions of the Two Forkhead-Associated Domains in Rad53
    Checkpoint Kinase Signaling
    Year: 2008
    Journal: Biochemistry
    Volume: 47
    Page numbers: 3912-3916
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  • Mdt1/ASCIZ A new DNA damage response protein family
    Year: 2008
    Journal: Cell Cycle
    Volume: 7
    Issue: 17
    Page numbers: 2654-2660
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Publications in 2007

Journal Articles

  • Mdt1 facilitates efficient repair of blocked DNA double-strand breaks and recombinational maintenance of telomeres
    Year: 2007
    Journal: Molecular and Cellular Biology
    Volume: 27
    Issue: 18
    Page numbers: 6532-45
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  • Rad9 BRCT domain interaction with phosphorylated H2AX regulates the G1 checkpoint in budding yeast
    Year: 2007
    Journal: EMBO Reports
    Volume: 8
    Issue: 9
    Page numbers: 851-7
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  • Telomere-related functions of yeast KU in the repair of bleomycin-induced DNA damage
    Year: 2007
    Journal: Biochemical and Biophysical Research Communications
    Volume: 357
    Issue: 3
    Page numbers: 800-803
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  • Yeast DNA damage response pathways and human disease
    Year: 2007
    Journal: Microbiology Australia
    Volume: 28
    Page numbers: 60-61
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Publications in 2006

Journal Articles

  • Cardiac S100A1 protein levels determine contractile performance and propensity toward heart failure after myocardial infarction
    Year: 2006
    Journal: Circulation
    Volume: 114
    Issue: 12
    Page numbers: 1258-68
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  • Cyclin-dependent kinase 2 functions in normal DNA repair and is a therapeutic target in BRCA1-deficient cancers
    Year: 2006
    Journal: Cancer Research
    Volume: 66
    Issue: 16
    Page numbers: 8219-26
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Publications in 2005

Journal Articles

  • ASCIZ regulates lesion-specific Rad51 focus formation and apoptosis after methylating DNA damage
    Year: 2005
    Journal: EMBO Journal
    Volume: 24
    Issue: 13
    Page numbers: 2447-2457
    Publisher: Oxford University Press(Oxford)
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  • SQ/TQ cluster domains: concentrated ATM/ATR kinase phosphorylation site regions in DNA-damage-response proteins
    Year: 2005
    Journal: Bioessays
    Volume: 27
    Page numbers: 397-407
    Publisher: Company of Biologists(Cambridge)
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Publications in 2004

Journal Articles

  • Mdt1, a novel Rad53 FHA1 domain-interacting protein, modulates DNA damage tolerance and G2/M cell cycle progression in Saccharomyces cerevisiae
    Year: 2004
    Journal: Molecular and Cellular Biology
    Volume: 24
    Issue: 7
    Page numbers: 2779-2788
    Publisher: American Society for Microbiology(Washington DC)
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  • Proteasome-dependent dispersal of PML nuclear bodies in reponse to alkylating DNA damage
    Year: 2004
    Journal: Oncogene
    Volume: 23
    Page numbers: 307-310
    Publisher: Nature Publishing Group(Basingstroke)
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  • Rad53 kinase activation-independent replication checkpoint function of the N-terminal forkhead-associated (FHA1) domain
    Year: 2004
    Journal: Journal of Biological Chemistry
    Volume: 279
    Issue: 38
    Page numbers: 39636-39644
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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Publications in 2003

Journal Articles

  • Diverse but overlapping functions of the two forkhead-associated (FHA) domains in Rad53 checkpoint kinase activation
    Year: 2003
    Journal: Journal of Biological Chemistry
    Volume: 278
    Issue: 33
    Page numbers: 30421-30424
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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  • FHA domains as phospho-threonine binding modules in cell signaling
    Year: 2003
    Journal: IUBMB Life
    Volume: 55
    Page numbers: 23-27
    Publisher: Taylor & Francis Ltd(Pennsylvania)
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  • Transgenic overexpression of the Ca2+-binding protein S100A1 in the heart leads to increased in vivo myocardial contractile performance
    Year: 2003
    Journal: Journal of Biological Chemistry
    Volume: 278
    Issue: 36
    Page numbers: 33809-33817
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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Publications in 2002

Journal Articles

  • Impaired Cardiac Contractility Response to Hemodynamic Stress in S100A1-Deficient Mice
    Year: 2002
    Journal: Molecular and Cellular Biology
    Volume: 22
    Issue: 8
    Page numbers: 2821-2829
    Publisher: American Society for Microbiology(Washington DC)
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  • Posttranscriptional regulation of the RAD5 DNA repair gene by the Dun1 kinase and the Pan2-Pan3 poly(A)-nuclease complex contributes to survival of replication blocks
    Year: 2002
    Journal: Journal of Biological Chemistry
    Volume: 277
    Issue: 25
    Page numbers: 22469-22474
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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Publications in 2001

Journal Articles

  • Crystallization and preliminary X-ray diffraction studies of FHA domains of Dun1 and Rad53 protein kinases.
    Year: 2001
    Journal: Acta Crystallographica Section D - Biological Crystallography
    Volume: 57
    Page numbers: 459-461
    Publisher: Munksgaard International Publishers(Copenhagen)
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  • Role of the N-terminal Forkhead-associated Domain in the Cell Cycle Checkpoint Function of the Rad53 Kinase
    Year: 2001
    Journal: Journal of Biological Chemistry
    Volume: 276
    Issue: 17
    Page numbers: 14019-14026
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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