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PROF BRIAN DEAN



Contact Details

Organization: Pathology, Psychiatry
Position: Honorary (Principal Fellow), Honorary (Professorial Fellow)
Email:
Homepage: http://www.mhri.edu.au/cooper_lab.htm
Work: 9389 2940
Fax: 9387 5061

Biography

Associate Professor Brian Dean was awarded the degree of Doctor of Philosophy by the University of Melbourne in 1992. In 2006, Dean was appointed as a NH&MRC Senior Research Fellowship (level B) and is currently Head of the Rebecca L. Cooper Research Laboratories at the Mental Health Research Institute of Victoria. Dean holds honorary appointments of Principal Research Fellow in the Departments of Pathology and Psychiatry at the University of Melbourne and Senior Lecturer in the Department of Psychological Medicine at Monash University. Dean’s research mission is to understand the neurobiology of schizophrenia and bipolar disorder. Dean has been an author on 130 peer reviewed journal articles, 10 book chapters and 190 conference abstracts. Dean research has been cited on close to 1500 occasions and he has authorships on 5 papers that been cited on 50 or more occasion and 15 papers cited on 25 or more occasions. Dean regularly publishes in Journals with an impact factor of greater than 6.0 that include journals ranked in the top 4 of the 94 Psychiatric Journals currently published. Dean’s involvement with the broader Australian and international research community includes his role as the Victorian Coordinator of the National Brain Bank Repository and his membership on the Committee of the Australian Society of Psychiatric Research with special responsibility for biological psychiatry. Dean is also a Councilor of the Collegium Internationale Neuro-Psychopharmacologium and is a member of the Finance and Australasian Organising Committee of that organisation. Dean collaborates with other academics in Victoria, other Australian States and has extensive collaborations with both academic and commercial partners in the USA, UK, Germany, Japan and New Zealand. Dean is listed as an Inventor on four Patents, two lodged in Australia and two in the USA. Dean’s contribution to the biological sciences has been recognised by his election as a Fellow of the Institute of Biology, the Collegium Internationale Neuro-Psychopharmacologium and the International Society of Affective Disorders and as a Member of the Fukishima Academy of Science. Dean was presented with the Lily Oration Award by the Australian Society of Psychiatric Research in 2006, which recognises a member of the Society who is prominent or rising to prominence in the Australian and New Zealand psychiatric research community. Dean was a member of a NHMRC Grant Review Panel in 2006.
Dean has assisted with the organisation of various scientific meetings, the most significant of which was as a member of the International Scientific Organising Committee for the 2004 CINP meeting in Paris. Dean has also been a member of the Organising Committees for the CINP Regional Scientific Meeting (Brisbane) 2005 and the Discovery Science and Biotechnology Meetings (Melbourne) 2005 and 2006. In 1999 Dean was the first non-Japanese scientist to present a Plenary Lecture to the Japanese Brain Research Meeting and has been an invited speaker at 58 local and international scientific meetings and has made over 50 Free Communications.

Research Expertise and International Linkages

Research Expertise

Research Interest Country of Expertise
Muscarinic Receptors Australia
Bipolar Disorders Australia
mental health Australia
Apolipoproteins Australia

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Master of Science University of Melbourne 05-Mar-1986
Doctor of Philosophy University of Melbourne 24-Oct-1992

Memberships

Membership Type Membership Body Description Start Date End Date
Unspecified Australian Society of Clinical and Experimental Pharmacologists & Toxicologists Member 23-Aug-2006
Unspecified Australian Neuroscience Society Member 23-Aug-2006
Unspecified Society for Neuroscience Foreign Member 23-Aug-2006
Member American Chemical Society Member 23-Aug-2006

Fellowships

Fellowship Date Awarded
Fellow of the Institute of Biology (FIBIOL) 25-Mar-1998

Other Awards

Award Type Awarding Body Comments Date Awarded
Prize Australian Society of Psychiatric Research Lilly Oration 14-Dec-2006

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
MUSCARINIC M1 RECEPTOR, COGNITION AND SCHIZOPHREMIA Chief Investigator NHMRC Project Grants 01/01/2005
Research Fellowship Chief Investigator NHMRC Research Fellowship 01/01/2006
Studies on the mechanisms by which muscarinic receptors might cause schizophrenia Chief Investigator NHMRC Project Grants 01/01/2008
Muscarinic Receptors in Mood Disorders Chief Investigator NHMRC Project Grants 01/01/2010

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2009

Journal Articles

  • Levels of neuregulin 1 and 3 proteins in Brodmann's area 46 from subjects with schizophrenia and bipolar disorder
    Year: 2009
    Journal: Neuroscience Letters
    Volume: 466
    Page numbers: 27-29
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Publications in 2008

Journal Articles

  • Muscarinic receptors: Do they have a role in the pathology and treatment of schizophrenia?


    Year: 2008
    Journal: Journal of Neurochemistry
    Volume: 107
    Page numbers: 1188-1195
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  • Possible involvement of post-dopamine D2 receptor signalling components in the pathophysiology of schizophrenia


    Year: 2008
    Journal: International Journal of Neuropsychopharmacology
    Volume: 11
    Page numbers: 197-205
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  • Decreased cortical muscarinic receptors define a subgroup of subjects with schizophrenia
    Year: 2008
    Journal: Molecular Psychiatry
    Volume: 2008
    Page numbers: 1-7
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  • Increased levels of serotonin2A receptors and serotonin transporter in the CNS of neuregulin 1 hypomorphic/mutant mice
    Year: 2008
    Journal: Schizophrenia Research
    Volume: 99
    Page numbers: 341-349
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  • Individual differences in allocation of funds in the dictator game associated with length of the arginine vasopressin 1a receptor RS3 promoter region and correlation between RS3 length and hippocampal mRNA
    Year: 2008
    Journal: Genes, Brain and Behavior
    Volume: 7
    Page numbers: 266-275
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  • Plasma apolipoprotein E is decreased in schizophrenia spectrum and bipolar disorder
    Year: 2008
    Journal: Psychiatry Research
    Volume: 158
    Page numbers: 75-78
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  • Regulator of G-protein signalling 4 expression is not altered in the prefrontal cortex in schizophrenia
    Year: 2008
    Journal: Australian and New Zealand Journal of Psychiatry
    Volume: 42
    Page numbers: 740-745
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  • SLC25A12 expression is associated with neurite outgrowth and is upregulated in the prefrontal cortex of autistic subjects
    Year: 2008
    Journal: Molecular Psychiatry
    Volume: 13
    Page numbers: 385-397
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  • Treatment with haloperidol and diazepam alters GABAA receptor density in the rat brain
    Year: 2008
    Journal: Progress in Neuro-Psychopharmacology & Biological Psychiatry
    Volume: 32
    Page numbers: 560-567
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Publications in 2007

Journal Articles

  • CNS 14-3-3zeta: Changes with sex but not psychiatric diagnoses or psychotropic drug treatment


    Year: 2007
    Journal: Schizophrenia Research
    Volume: 93
    Page numbers: 51-57
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  • Decreased NR1, NR2A, and SAP102 transcript expression in the hippocampus in bipolar disorder


    Year: 2007
    Journal: Brain Research
    Volume: 1127
    Issue: 1
    Page numbers: 108-118
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  • Altered hippocampal muscarinic M4, but not M1, receptor expression from subjects with schizophrenia.
    Year: 2007
    Journal: Biological Psychiatry
    Volume: 61
    Page numbers: 1161-1170
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  • Consistent with dopamine supersensitivity, RGS9 expression is diminished in the amphetamine-treated animal model of schizophrenia and in postmortem schizophrenia brain
    Year: 2007
    Journal: Synapse
    Volume: 61
    Page numbers: 303-309
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  • Gene expression profiling in Brodmann’s area 46 from subjects with schizophrenia
    Year: 2007
    Journal: Australian and New Zealand Journal of Psychiatry
    Volume: 41
    Issue: 4
    Page numbers: 308-320
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  • Towards a muscarinic hypothesis of schizophrenia
    Year: 2007
    Journal: Molecular Psychiatry
    Volume: 12
    Page numbers: 232-246
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Publications in 2006

Journal Articles

  • Cortical serotonin7, 1D and 1F receptors: Effects of schizophrenia, suicide and antipsychotic drug treatment


     


    Year: 2006
    Journal: Schizophrenia Research
    Volume: 88
    Page numbers: 265-274
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  • Genome-wide expression analysis detects eight genes with robust alterations specific to bipolar I disorder: relevance to neuronal network perturbation


     


    Year: 2006
    Journal: Human Molecular Genetics
    Volume: 15
    Issue: 12
    Page numbers: 1949-1962
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  • Serotonin 1a receptor and associated G-protein activation in schizophrenia and bipolar disorder


    Year: 2006
    Journal: Psychiatry Research
    Volume: 143
    Issue: 2006
    Page numbers: 111-120
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  • Brain distribution of selected antipsychotics in schizophrenia
    Year: 2006
    Journal: Forensic Science International
    Volume: 157
    Page numbers: 121-130
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  • Clozapine bioactivation inducse dose-dependent, drug-specific toxicity of human bone marrow stromal cells: A potential in vitro system for the study of agranulocytosis
    Year: 2006
    Journal: Biochemical Pharmacology
    Volume: 72
    Page numbers: 783-793
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  • Increased levels of SNAP-25 and synaptophysin in the dorsolateral prefontal cortex in bipolar I disorder
    Year: 2006
    Journal: Bipolar Disorders
    Volume: 8
    Page numbers: 133-143
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  • N-Ethylmaleimide sensitive factor in the cortex of subjects with schizophrenia and bipolar 1 disorder.
    Year: 2006
    Journal: Neuroscience Letters
    Volume: 391
    Issue: 2006
    Page numbers: 112-115
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  • No change in cortical muscarinic M2, M3 receptors or [35S]GTPϒS binding in schizophrenia.
    Year: 2006
    Journal: Life Sciences
    Volume: 78
    Issue: 2006
    Page numbers: 1231-1237
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  • Postmortem brain calcineurin protein levels in schizophrenia patients are not different from controls
    Year: 2006
    Journal: Schizophrenia Research
    Volume: 83
    Page numbers: 173-177
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  • Regionally specific changes in levels of cortical S100β in bipolar 1 disorder but not schizophrenia
    Year: 2006
    Journal: Australian and New Zealand Journal of Psychiatry
    Volume: 40
    Page numbers: 217-224
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  • Reply: Autoradiography of [3H]aspartate and Glutamate Transport in Schizophrenia.
    Year: 2006
    Journal: Neuropsychopharmacology
    Volume: 31
    Issue: 2006
    Page numbers: 687-688
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Publications in 2005

Journal Articles

  • 5-HT2A and muscarinic receptors in schizophrenia: a postmortem study
    Year: 2005
    Journal: Neuroscience Letters
    Volume: 379
    Issue: 3
    Page numbers: 164-168
    Publisher: Elsevier Science Ireland(Coclare)
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  • A family-based association study and gene expression analysis of netrin-G1 and -G2 genes in schizophrenia
    Year: 2005
    Journal: Biological Psychiatry
    Volume: 57
    Issue: 4
    Page numbers: 382-393
    Publisher: Elsevier Science(New York)
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  • Changes in hippocampal GABAΑ receptor subunit composition in bipolar 1 disorder
    Year: 2005
    Journal: Molecular Brain Research
    Volume: 138
    Issue: 2005
    Page numbers: 145-155
    Publisher: Elsevier Science(Amsterdam)
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  • Clozapine decreases [3H]CP 55940 binding to the cannabinoid1 receptor in the rat nucleus accumbens
    Year: 2005
    Journal: Naunyn-Schmiedebergs Archives of Pharmacology
    Volume: 371
    Issue: 5
    Page numbers: 428-433
    Publisher: Springer Verlag(New York)
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  • Cortical glutamatergic markers in schizophrenia
    Year: 2005
    Journal: Neuropsychopharmacology
    Volume: 30
    Issue: 2005
    Page numbers: 1521-1531
    Publisher: Nature Publishing Group
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  • Differential changes in apolipoprotein E in schizophrenia and bipolar 1 disorder.
    Year: 2005
    Journal: Biological Psychiatry
    Volume: 57
    Issue: 2005
    Page numbers: 711-715
    Publisher: Elsevier Science(New York)
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  • Understanding the pathology of schizophrenia: The impact of high-throughput screening of the genome and proteome in postmortem CNS
    Year: 2005
    Journal: Current Psychiatry Reviews
    Volume: 1
    Issue: 2005
    Page numbers: 1-9
    Publisher: Bentham Science Publishers(Hilversum)
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Publications in 2004

Journal Articles

  • Antipsychotic drugs: evolving mechanisms of action with improved therapeutic benefits.
    Year: 2004
    Journal: CNS & Neurological Disorders
    Volume: 3
    Issue: 3
    Page numbers: 217-225
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  • Expression of truncated presenilin 2 splice variant in Alzheimer's disease, bipolar disorder, and schizophrenia brain cortex
    Year: 2004
    Journal: Molecular Brain Research
    Volume: 127
    Issue: 1-2
    Page numbers: 128-135
    Publisher: Elsevier Science(Amsterdam)
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  • GSK-3 parameters in postmortem frontal cortex and hippocampus of schizophrenic patients.
    Year: 2004
    Journal: Schizophrenia Research
    Volume: 71
    Issue: 2-3
    Page numbers: 377-382
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  • Hippocampal 5-hydroxytryptamine receptors: Abnormalities in postmortem brain from schizophrenic subjects.
    Year: 2004
    Journal: Schizophrenia Research
    Volume: 71
    Issue: 2-3
    Page numbers: 383-392
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  • Measurement of Dopamine D2-like Receptors in Postmortem Caudate-Putamen and Pituitary: Differential Regional Changes in Schizophrenia
    Year: 2004
    Journal: Life Sciences
    Volume: 74
    Issue: 25
    Page numbers: 3115-3131
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Publications in 2003

Journal Articles

  • Apolipoprotein D levels are elevated in prefrontal cortex of subjects with Alzheimer's disease: no relation to apolipoprotein E expression or genotype
    Year: 2003
    Journal: Biological Psychiatry
    Volume: 54
    Page numbers: 134-141
    Publisher: Elsevier Science(New York)
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  • Cannabis-sensitive dopaminergic markers in postmortem central nervous system: changes in schizophrenia
    Year: 2003
    Journal: Biological Psychiatry
    Volume: 53
    Page numbers: 585-592
    Publisher: Elsevier Science(New York)
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  • Decreased hippocampal NMDA, but not kainate or AMPA receptors in bipolar disorder
    Year: 2003
    Journal: Bipolar Disorders
    Volume: 5
    Page numbers: 257-264
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  • Differences in neuroanatomical sites of apoD elevation discriminate between schizophrenia and bipolar disorder
    Year: 2003
    Journal: Molecular Psychiatry
    Volume: 8
    Page numbers: 167-175
    Publisher: Macmillan Publishers(Basingstroke)
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  • Increased levels of apolipoprotein E in the frontal cortex of subjects with schizophrenia
    Year: 2003
    Journal: Biological Psychiatry
    Volume: 24
    Page numbers: 616-622
    Publisher: Elsevier Science(New York)
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  • Muscarinic receptors in schizophrenia
    Year: 2003
    Journal: Current Molecular Medicine
    Volume: 3
    Issue: 5
    Page numbers: 419-426
    Publisher: Bentham Science Publishers(Hilversum)
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  • Potential clozapine target sites on peripheral hematopoietic cells and stromal cells of the bone marrow
    Year: 2003
    Journal: The Pharmacogenomics Journal
    Volume: 3
    Issue: 4
    Page numbers: 227-234
    Publisher: Nature Publishing Group
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  • Studies on serotonergic markers in the human hippocampus: changes in subjects with bipolar disorder
    Year: 2003
    Journal: Journal of Affective Disorders
    Volume: 75
    Issue: 1
    Page numbers: 65-69
    Publisher: Elsevier Science
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  • The cortical serotonin2A receptor and the pathology of schizophrenia: a likely accomplice
    Year: 2003
    Journal: Journal of Neurochemistry
    Volume: 85
    Page numbers: 1-13
    Publisher: Blackwell Science(Oxford)
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  • [3H]RX 821002 in human dorsolateral prefrontal cortex: no changes in postmortem tissue from subjects with schizophrenia
    Year: 2003
    Journal: Psychiatry Research
    Volume: 119
    Issue: 1-2
    Page numbers: 25-31
    Publisher: Elsevier Ireland
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Publications in 2002

Book Chapters

  • Studies in the human frontal cortex: evidence for changes in neurochemical markers in schizophrenia and bipolar disorder
    Year: 2002
    Book: The postmortem brain in psychiatric research
    Publisher: Kluwer Academic Publishers(Dordrecht)
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Journal Articles

  • Actions of antipsychotic medications: shedding light on an enigma
    Year: 2002
    Journal: Trends in Pharmacological Sciences
    Volume: 23
    Page numbers: 246-247
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  • Changes in the molecular structure of the brain in bipolar disorder: findings using human postmortem brain tissue
    Year: 2002
    Journal: The World Journal of Biological Psychiatry
    Volume: 3
    Page numbers: 125-132
    Publisher: World Federation of Societies of Biological Psychiatry
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  • Decreased density of [3H]TCP binding following antipsychotic drug withdrawal in rats.
    Year: 2002
    Journal: Life Sciences
    Volume: 70
    Issue: 22
    Page numbers: 2699-2705
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  • Decreased muscarinic1 receptors in the dorsolateral prefrontal cortex of subjects with schizophrenia
    Year: 2002
    Journal: Molecular Psychiatry
    Volume: 7
    Page numbers: 1083-1091
    Publisher: Macmillan Publishers(Basingstroke)
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  • Decreased phorbol ester binding in the parahippocampal gyrus from subjects with schizophrenia is not associated with changes in protein kinase C
    Year: 2002
    Journal: Molecular Psychiatry
    Volume: 7
    Page numbers: 683-688
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  • High-resolution phosphor imaging: validation for use with human brain tissue sections to determine the affinity and density of radioligand binding
    Year: 2002
    Journal: Journal of Neuroscience Methods
    Volume: 116
    Page numbers: 157-163
    Publisher: Elsevier Science(Amsterdam)
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  • The heterogeneity of central benzodiazepine receptor subtypes in the human hippocampal formation, frontal cortex and cerebellum using [3H]flumazenil and zolpidem
    Year: 2002
    Journal: Molecular Brain Research
    Volume: 104
    Page numbers: 203-209
    Publisher: Elsevier Science(Amsterdam)
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  • Understanding the pathology of schizophrenia: recent advances from the study of the molecular architecture of postmortem CNS tissue
    Year: 2002
    Journal: Postgraduate Medical Journal
    Volume: 78
    Page numbers: 142-148
    Publisher: BMJ Publishing Group
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  • Variation at the APOE -491 promoter locus is associated with altered brain levels of apolipoprotein E
    Year: 2002
    Journal: Molecular Psychiatry
    Volume: 7
    Page numbers: 886-890
    Publisher: Macmillan Publishers(Basingstroke)
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  • [3H]Flumazenil binding in the human hippocampal formation, frontal cortex and cerebellum detected by high-resolution phosphorimaging
    Year: 2002
    Journal: Brain Research
    Volume: 926
    Page numbers: 27-32
    Publisher: Elsevier Science(Amsterdam)
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Publications in 2001

Book Chapters

  • Neurochemical changes in postmortem brain tissue from subjects with schizophrenia: implications for the illness
    Year: 2001
    Book: Contemporary neuropsychiatry
    Publisher: Springer Verlag(Tokyo)
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Journal Articles

  • A change in the density of [3H]flumazenil, but not [3H]muscimol binding, in Brodmann's Area 9 from subjects with bipolar disorder
    Year: 2001
    Journal: Journal of Affective Disorders
    Volume: 66
    Page numbers: 147-158
    Publisher: Elsevier Science
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  • A predicted cortical serotonergic/ cholinergic/ gabaergic interface as a site of pathology in schizophrenia
    Year: 2001
    Journal: Clinical and Experimental Pharmacology and Physiology
    Volume: 28
    Page numbers: 74-78
    Publisher: Blackwell Science Asia(Carlton)
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  • A proposed pathological model in the hippocampus of subjects with schizophrenia
    Year: 2001
    Journal: Clinical and Experimental Pharmacology and Physiology
    Volume: 28
    Page numbers: 70-73
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  • Extended treatment with typical and atypical antipsychotic drugs: Differential effects on the densities of dopamine D2-like and GABAA receptors in rat striatum.
    Year: 2001
    Journal: Life Sciences
    Volume: 69
    Page numbers: 1257-1268
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  • Extended treatment with typical and atypical antipsychotic drugs: differential effects on the densities of dopamine D2-like and GABAA receptors in rat striatum
    Year: 2001
    Journal: Life Sciences
    Volume: 69
    Page numbers: 1257-1268
    Publisher: Pergamon-Elsevier Science(Oxford)
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  • Increased CNS levels of apolipoprotein D in schizophrenic and bipolar subjects: implications for the pathophysiology of psychiatric disorders
    Year: 2001
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 98
    Issue: 7
    Page numbers: 4066-4071
    Publisher: National Academy of Sciences(Washington DC)
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  • Low muscarinic receptor binding in prefrontal cortex from subjects with schizophrenia: a study of Brodmann's Areas 8, 9, 10 and 46 and the effects of neuroleptic drug treatment
    Year: 2001
    Journal: American Journal of Psychiatry
    Volume: 158
    Issue: 6
    Page numbers: 918-925
    Publisher: American Psychiatric Press(Washington DC)
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  • Signal transmission, schizophrenia, and the limits to biological psychiatry
    Year: 2001
    Journal: Australian and New Zealand Journal of Psychiatry
    Volume: 35
    Issue: 1
    Page numbers: 131-132
    Publisher: Blackwell Science Asia(Carlton)
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  • Studies on [3H]CP-55940 binding in the human central nervous system: regional specific changes in density of cannabinoid-1 receptors associated with schizophrenia and cannabis use
    Year: 2001
    Journal: Neuroscience
    Volume: 103
    Issue: 1
    Page numbers: 9-15
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  • Studies on dopaminergic and GABAergic markers in striatum reveals a decrease in the dopamine transporter in schizophrenia
    Year: 2001
    Journal: Schizophrenia Research
    Volume: 52
    Page numbers: 107-114
    Publisher: Elsevier Science(Amsterdam)
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