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DR GIUSEPPE CICCOTOSTO



Contact Details

Organization: Pathology
Position: SENIOR RESEARCH OFFICER -NHMRC
Email:
Homepage: http://www.path.unimelb.edu.au/research/labs/cappai/
Work: 8344 2558
Fax: 9347 6750
Room: 476
Level: 04
Building: Bio21 Incubator Building
Campus: Parkville

Research Expertise and International Linkages

Research Expertise

Research Interest Key Words Country of Expertise
Neurodegenerative diseases Alzheimers Disease, CJD, Parkinsons disease Australia, United States of America

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Doctor of Philosophy University of Melbourne 31-Dec-1996

Memberships

Membership Type Membership Body Description Start Date End Date
Member Australian Neuroscience Society 01-Jan-2004

Other Awards

Award Type Awarding Body Comments Date Awarded
Scholarship Astra/Gastroenterological Society of Australia PhD Scholarship (3 Years) 01-Jan-1992
Scholarship Human Frontiers Science Program Organization Postdoctoral Fellowship 01-Jan-1998
Scholarship Prize Gastroenterological Society of Australia Travel Award 01-Sep-1996
Scholarship Prize Australian Society for Medical Research Travel award 01-Jan-1993
Scholarship Prize Australian Physiological and Pharmacological Society Travel Award 01-Jan-1990

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
Identifying the toxic principle in Alzheimer's disease/ Purification and characterisation of toxic amyloid beta species in Alzheimer's disease Principal Supervisor AUST ROTARY HEALTH RESEARCH FUND Mental Illness Research Ian Scott Fellowship 01/01/2004
MEMBRANE INTERACTIONS AND NEUROTOXICITY OF AMYLOID ABETA PEPTIDES FROM ALZHEIMER S DISEASE. Chief Investigator AUST RESEARCH COUNCIL Discovery Projects 01/01/2006

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2007

Journal Articles

  •  Concentration dependent Cu2+ induced aggregation and dityrosine formation of the Alzheimer's disease Amyloid-β peptide.
    Year: 2007
    Journal: Biochemistry
    Volume: 46
    Issue: 10
    Page numbers: 2881-91
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  • Concentration dependent Cu2+ induced aggregation and dityrosine

    formation of the Alzheimer's disease Amyloid- peptide
    Year: 2007
    Journal: Biochemistry
    Volume: 46
    Issue: 10
    Page numbers: 2881-91
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  • Trafficking of a secretory granule membrane protein is sensitive to copper.
    Year: 2007
    Journal: Journal of Biological Chemistry
    Volume: M702891200
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Publications in 2006

Book Chapters

  • The Function of the Amyloid Precursor Protein Family
    Year: 2006
    Book: Abeta Peptide and Alzheimer's Disease
    Publisher: Springer Verlag
    Authors(s):

Journal Articles

  • Copper-mediated Amyloid-beta toxicity Is Associated with an Intermolecular Histidine Bridge
    Year: 2006
    Journal: Journal of Biological Chemistry
    Volume: 281
    Issue: 22
    Page numbers: 15145-15154
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  • Correlative studies support lipid peroxidation is linked to PrPres propogation as an early primary pathogenic event in prion disease
    Year: 2006
    Journal: Brain Research Bulletin
    Volume: 68
    Page numbers: 346-354
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Publications in 2005

Journal Articles

  • Copper-dependent inhibition of human cytochrome c oxidase by a dimeric conformer of amyloid-bΒ1-42
    Year: 2005
    Journal: Journal of Neuroscience
    Volume: 25
    Issue: 3
    Page numbers: 672-679
    Publisher: Society of Neuroscience(Washington DC)
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  • Methylation of the imidazole side chains of the Alzheimer disease amyloid-beta peptide results in abolition of superoxide dismutase-like structures and inhibition of neurotoxicity
    Year: 2005
    Journal: Journal of Biological Chemistry
    Volume: 280
    Page numbers: 13355-13363
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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  • The amyloid precursor protein (APP) of Alzheimer disease and its paralog APLP2 modulate the Cu/Zn-NO catalyzed degradation of glypican-1 heparan sulfate in vivo
    Year: 2005
    Journal: Journal of Biological Chemistry
    Volume: 280
    Issue: 14
    Page numbers: 13913-13920
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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Publications in 2004

Journal Articles

  • Enhanced toxicity and cellular binding of a modified amyloid Β peptide with a methionine to valine substitution
    Year: 2004
    Journal: Journal of Biological Chemistry
    Volume: 279
    Page numbers: 42528-42534
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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  • Gene knockout of amyloid precursor protein and amyloid precursor-like protein-2 increases cullular copper levels in primary mouse cortical neurons and embryonic fibroblasts
    Year: 2004
    Journal: Journal of Neurochemistry
    Volume: 91
    Page numbers: 423-428
    Publisher: Blackwell Science(Oxford)
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  • Methionine oxidation: implications for the mechanism of toxicity of the β-amyloid peptide from Alzheimer's disease
    Year: 2004
    Journal: Letters in Peptide Science
    Volume: 10
    Page numbers: 413-417
    Publisher: Kluwer Academic Publishers(Dordrecht)
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  • Tyrosine gated electron transfer is key to the toxic mechanism of Alzheimer's disease Β-amyloid
    Year: 2004
    Journal: FASEB Journal
    Volume: 18
    Page numbers: 1427-1429
    Publisher: Federation of American Societies for Experimental Biology(Maryland)
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Publications in 2003

Book Chapters

  • Modulation of Alzheimer's Disease Aβ pathways for rational therapeutic intervention: secretase inhibition and metalloprotein active compounds.
    Year: 2003
    Book: Alzheimer's disease and related disorders: research advances
    Authors(s):

Journal Articles

  • Menkes protein contributes to the function of peptidylglycine α-amidating monooxygenase
    Year: 2003
    Journal: Endocrinology
    Volume: 144
    Issue: 1
    Page numbers: 188-200
    Publisher: Endocrine Society(Maryland)
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  • Neurotoxic, redox-competent Alzheimer's β-amyloid is released from lipid membrane by methionine oxidation
    Year: 2003
    Journal: Journal of Biological Chemistry
    Volume: 278
    Issue: 44
    Page numbers: 42959-42965
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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