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PROF PAUL A GLEESON



Contact Details

Organization: Biochemistry and Molecular Biology
Position: PROFESSOR
Email:
Homepage: http://www.biochemistry.unimelb.edu.au/research/res_gleeson.htm
Work: 8344 2321
Fax: 9348 1421
Room: 335
Level: 03
Building: David Pennington Building
Campus: Parkville

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Doctor of Philosophy University of Melbourne 31-Dec-1980

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
Biochemical, genomic & phenomic analysis of gastric parietal cells from wildtype & mutant mice Chief Investigator AUST RESEARCH COUNCIL Discovery Projects 01/01/2003
Investigating T cell tolerance and organ-specific auotimmunity using autoantigen deficient mice Chief Investigator NHMRC Project Grants 01/01/2003
The role of a novel family of Golgi proteins in maintaining the structure and function of the trans-Golgi network Chief Investigator AUST RESEARCH COUNCIL Discovery Projects 01/01/2004
Sorting nexins and their role in endosomal trafficking Chief Investigator NHMRC Project Grants 01/01/2004
AUTOCLAVES (2) 2004 NHMRC EQUIPMENT GRANT ALLOCATION Chief Investigator NHMRC Equipment Grants 01/01/2005
Population dynamics of tissue-specific effector and regulatory CD4+ T cells Chief Investigator NHMRC Project Grants 01/01/2005
Cell biology of gastric acid secretion Chief Investigator AUST RESEARCH COUNCIL Discovery Projects 01/01/2005
Organ-specific autoimmunity: The role of the thymus and periphery in shaping the gastric-specific T cell repertoire Chief Investigator NHMRC Project Grants 01/01/2006
The functional organisation of the trans-Golgi network: From cultured cells to physiological systems Chief Investigator AUST RESEARCH COUNCIL Discovery Projects 01/01/2007
NINETEENTH INTERNATIONAL SYMPOSIUM ON GLYCOCONJUGATES (GLYCO-19) Chief Investigator DEPT OF INNOVATION INDUSTRY SCIENCE & RESEARCH,
DEPT OF EDUCATION SCIENCE & TRAINING
International Science Linkages - Competitive Grants (DEPT OF EDUCATION SCIENCE & TRAINING) 08/03/2007
Development of cellular therapies for autoimmunity Chief Investigator NHMRC Project Grants 01/01/2008
Intracellular transport pathways Chief Investigator NHMRC Project Grants 01/01/2009
Internalisation pathways into cells Chief Investigator NHMRC Project Grants 01/01/2009
Multi-photon imaging for infection, immunity, and self recognition Chief Investigator AUST RESEARCH COUNCIL Linkage Infrastructure (Equipment and Facilities) 01/01/2009

Contracts

Title Role Funding Source Award Date
BIOLOGY OF THE PROTEIN CLATHRIN HEAVY CHAIN Chief Investigator UNIVERSITY OF CALIFORNIA 21/01/2009

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2009

Journal Articles

  • Regulation of HLA class I surface expression requires CD99 and p230/golgin-245 interaction
    Year: 2009
    Journal: Blood
    Volume: 113
    Issue: 2
    Page numbers: 347-57
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Publications in 2008

Book Chapters

  • Structure and domain oganisation of the trans-Golgi network
    Year: 2008
    Book: The Golgi Apparatus
    Publisher: Springer(New York)
    Authors(s):

Journal Articles

Publications in 2007

Journal Articles

Publications in 2006

Journal Articles

Publications in 2005

Journal Articles

  • A Novel Mammalian Retromer Component, Vps26B
    Year: 2005
    Journal: Traffic
    Volume: 6
    Issue: 11
    Page numbers: 991-1001
    Publisher: Munksgaard International Publishers(Copenhagen)
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  • E-Cadherin Transport from the trans-Golgi Network in Tubulovesicular Carriers is Selectively Regulated by Golgin-97.
    Year: 2005
    Journal: Traffic
    Volume: 6
    Issue: 12
    Page numbers: 1142-1156
    Publisher: Munksgaard International Publishers(Copenhagen)
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  • Promiscuous Thymic Expression of an Autoantigen Gene Does Not Result in Negative Selection of Pathogenic T Cells
    Year: 2005
    Journal: Journal of Immunology
    Volume: 175
    Page numbers: 5759-5764
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  • Reciprocal changes in trefoil 1 and 2 expression in stomachs of mice with gastic unit hypertrophy and inflammation
    Year: 2005
    Journal: Journal of Pathology
    Volume: 207
    Issue: 1
    Page numbers: 43-52
    Publisher: John Wiley & Sons(West Sussex)
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  • Shaping the T cell repertoire to a bona fide autoantigen: lessons from autoimmune gastritis
    Year: 2005
    Journal: Current Opinion in Immunology
    Volume: 17
    Issue: 6
    Page numbers: 570-576
    Publisher: Current Biology(London)
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  • The trans-Golgi network GRIP-domain proteins form alpha-helical homodimers
    Year: 2005
    Journal: Biochemical Journal
    Volume: 388
    Issue: 3
    Page numbers: 835-841
    Publisher: Portland Press(London)
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Publications in 2004

Journal Articles

  • Clathrin Isoform CHC22, a component of neuromuscular and myotendinous junctions, binds sorting Nexin 5 and has increased expression during myogenesis and muscle regeneration
    Year: 2004
    Journal: Molecular Biology of the Cell
    Volume: 15
    Issue: 7
    Page numbers: 3181-3195
    Publisher: American Society for Cell Biology(Maryland)
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  • Domains of the TGN: coats, tethers and G proteins
    Year: 2004
    Journal: Traffic
    Volume: 5
    Issue: 5
    Page numbers: 315-326
    Publisher: Munksgaard International Publishers(Copenhagen)
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  • Endocytosis H+ / K+ ATPase from the apical plasma membrane is not required for regulation of gastric acid secretion
    Year: 2004
    Journal: Gastroenterology
    Volume: 127
    Issue: 1
    Page numbers: 145-154
    Publisher: WB Saunders Co(Pennsylvania)
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  • Growth factors associated with gastric mucosal hypertrophy in autoimmune gastritis
    Year: 2004
    Journal: American Journal of Physiology: Gastrointestinal and Liver Physiology
    Volume: 287
    Page numbers: G910-G918
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  • Identification of a Golgi-localised GRIP domain protein from Arabidopsis thaliana
    Year: 2004
    Journal: Planta
    Volume: 219
    Page numbers: 1050-1056
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  • Mammalian GRIP domain proteins differ in their membrane binding properties and are recruited to distinct domains of the TGN
    Year: 2004
    Journal: Journal of Cell Science
    Volume: 117
    Page numbers: 5865-5874
    Publisher: Company of Biologists(Cambridge)
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  • Sorting nexin 5 is localized to a subdomain of the early endosomes and is recruited to the plasma membrane following EGF stimulation
    Year: 2004
    Journal: Journal of Cell Science
    Volume: 117
    Page numbers: 6413-6424
    Publisher: Company of Biologists(Cambridge)
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  • Thymic expression of a gastritogenic epitope results in positive selection of self-reactive pathogenic T cells
    Year: 2004
    Journal: Journal of Immunology
    Volume: 172
    Issue: 10
    Page numbers: 5994-6002
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Publications in 2003

Journal Articles

  • GRIP Domain-mediated Targeting of Two New Coiled-coil Proteins, GCC88 and GCC185, to Subcompartments of the trans-Golgi Network
    Year: 2003
    Journal: Journal of Biological Chemistry
    Volume: 278
    Page numbers: 4216-4226
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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  • Intracellular sorting and transport of proteins
    Year: 2003
    Journal: Progress in Biophysics & Molecular Biology
    Volume: 83
    Page numbers: 1-45
    Publisher: Pergamon
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Publications in 2002

Journal Articles

  • Endogenour H/K ATPase β-Subunit Promotes T Cell Tolerance to the Immunodominant Gastritogenic Determinant
    Year: 2002
    Journal: Journal of Immunology
    Volume: 169
    Page numbers: 2361-2367
    Publisher: American Association of Immunologists(Maryland)
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  • Immunopathogenesis, loss of T cell tolerance and genetics of autoimmune gastritis
    Year: 2002
    Journal: Autoimmunity Reviews
    Volume: 1
    Page numbers: 290-297
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  • Perturbation of gastic mucosa in mice expressing the temperature-sensitive mutant of SV40 large T antigen. Potential for establishment of an immortalised parietal cell line.
    Year: 2002
    Journal: European Journal of Cell Biology
    Volume: 81
    Page numbers: 281-293
    Publisher: Urban & Fischer Verlag
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  • Targeting of the GRIP domain to the trans-Golgi network is conserved from protists to animals
    Year: 2002
    Journal: European Journal of Cell Biology
    Volume: 81
    Page numbers: 485-495
    Publisher: Urban & Fischer Verlag
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  • The Phox homology (PX) domain-dependent, 3-phosphoinositide-mediated association of sorting nexin-1 with an early sorting endosomal compartment is required for its ability to regulate epidermal growth factor receptor degradation
    Year: 2002
    Journal: Journal of Biological Chemistry
    Volume: 277
    Page numbers: 48730-48736
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  • The role of CD4+CD25 immunoregulatory T cells in the induction of autoimmune gastritis
    Year: 2002
    Journal: Immunology and Cell Biology
    Volume: 80
    Page numbers: 567-573
    Publisher: Blackwell Science Asia(Carlton)
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Publications in 2001

Journal Articles

  • A large family of endosome localised proteins related to sorting nexin 1.
    Year: 2001
    Journal: Biochemical Journal
    Volume: 358
    Page numbers: 7-16
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  • Defining T cell receptors which recognise the immunodominant epitope of the gastric autoantigen, the H/K ATPase beta-subunit.
    Year: 2001
    Journal: Autoimmunity
    Volume: 33
    Page numbers: 1-14
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  • Regulation of gastric epithelial cell development revealed in H(+)/K(+)-ATPase beta-subunit- and gastrin-deficient mice
    Year: 2001
    Journal: American Journal of Physiology: Gastrointestinal and Liver Physiology
    Volume: 281
    Page numbers: G1502-1511
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  • Requirements for autoimmune responses to mouse gastric autoantigens
    Year: 2001
    Journal: Immunology
    Volume: 104
    Page numbers: 392-401
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  • Steady-state localisation of a medial-Golgi glycosyltransferase involves transit through the trans-Golgi network.
    Year: 2001
    Journal: Biochemical Journal
    Volume: 358
    Page numbers: 33-40
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  • The GRIP Golgi localisation domain of p230 is specific targeting for a population of trans-Golgi network derived vesicles.
    Year: 2001
    Journal: Traffic
    Volume: 2
    Page numbers: 336-344
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  • The role of natural killer cells in the induction of autoimmune gastritis.
    Year: 2001
    Journal: Autoimmunity
    Volume: 34
    Page numbers: 147-154
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  • Trafficking and localisation of resident Golgi glycosylation enzymes.
    Year: 2001
    Journal: Biochimie
    Volume: 83
    Page numbers: 763-773
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