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DR ROBERT DE ROSE



Contact Details

Organization: Microbiology and Immunology
Position: SENIOR RESEARCH OFFICER
Email:
Work: (03) 8344 9938
Fax: (03) 8344 3846
Room: 203
Level: 02
Building: Microbiology Building
Campus: Parkville

Research Expertise and International Linkages

Research Expertise

Research Interest Country of Expertise
Nanoparticle vaccines. We are investigating these vaccines which have the potential for controlled release of important HIV vaccine antigens Australia, Indonesia, United States of America
Combined Influenza-AIDS vaccines Australia, Indonesia, United States of America
CD4 T cell subsets: what really counts in preventing HIV disease? Australia, Indonesia, United States of America
Immune escape. We are studying how immune pressures result in immune escape variants and the impact this has on the fitness of the virus Australia, Indonesia, United States of America
Immune therapy. We have shown that reinfusing autologous cells coated with overlapping peptide (termed OPAL) can induce high levels of T cell immunity Australia, United States of America, Indonesia

International Linkages

Country Establishment Collaboration
United States National Institutes of Health Exchange, Research
United States University of Wisconsin Exchange, Research, Technical Assistance/Training
United States Johns Hopkins University Research
Indonesia Bogor Agricultural University Exchange, Research, Technical Assistance/Training

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Bachelor of Science La Trobe University 31-Dec-1988
Masters Preliminary Monash University 31-Dec-1992
Doctor of Philosophy University of Melbourne 01-Dec-2003

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
Establishment of the HIV reservoir during acute infection Chief Investigator THE AMERICAN FOUNDATION FOR AIDS RESEARCH (AMFAR) Targeted RFP: Optimizing the Treatment of HIV Infection 01/07/2007

Contracts

Title Role Funding Source Award Date
SAFETY STUDIES OF OPAL VACCINE TECHNOLOGY Chief Investigator OPAL PTY LTD 01/01/2006
EFFICACY STUDIES OF OPAL VACCINE TECHNOLOGY Chief Investigator OPAL PTY LTD 30/01/2006

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2009

Journal Articles

Publications in 2008

Journal Articles

Publications in 2007

Journal Articles

Publications in 2006

Book Chapters

  • Prime-boost strategies in DNA vaccines
    Year: 2006
    Book: Methods in Molecular Medicine, Vol. 127: DNA vaccines: methods and protocols
    Publisher: Humana Press(New Jersey)
    Authors(s):
    Editors(s):

Journal Articles

  • CD127+CCR5+CD38+++ CD4+ Th1 effector cells are an early component of the primary immune response to vaccinia virus and precede development of interleukin-2+ Memory CD4+ T cells
    Year: 2006
    Journal: Journal of Virology
    Volume: 80
    Issue: 20
    Page numbers: 10151-10161
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  • Characteristics of effective immune control of simian/human immunodeficiency virus in pigtail macaques
    Year: 2006
    Journal: AIDS Research and Human Retroviruses
    Volume: 22
    Issue: 1
    Page numbers: 27-32
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  • Comparative evaluation of simian, simian-human, and human immunodeficiency virus infections in the pigtail macaque (Macaca nemestrina) model
    Year: 2006
    Journal: AIDS Research and Human Retroviruses
    Volume: 22
    Issue: 6
    Page numbers: 580-588
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  • Dose-response relationship of DNA and recombinant fowlpox virus prime-boost HIV vaccines. Implications for future trials
    Year: 2006
    Journal: Human Vaccines
    Volume: 2
    Issue: 3
    Page numbers: 134-136
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Publications in 2005

Journal Articles

  • Enhanced Cellular Immunity in Macaques following a Novel Peptide Immunotherapy
    Year: 2005
    Journal: Journal of Virology
    Volume: 79
    Issue: 6
    Page numbers: 3748-3757
    Publisher: American Society for Microbiology(Washington DC)
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  • Analysis of Pigtail Macaque Major Histocompatibility Complex Class I Molecules Presenting Immunodominant Simian Immunodeficiency Virus Epitopes
    Year: 2005
    Journal: Journal of Virology
    Volume: 79
    Issue: 2
    Page numbers: 684-695
    Publisher: American Society for Microbiology(Washington DC)
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  • Comparison of Whole Gene and Whole Virus Scrambled Antigen Approaches for DNA Prime and Fowlpox Virus Boost HIV Type 1 Vaccine Regimens in Macaques
    Year: 2005
    Journal: AIDS Research and Human Retroviruses
    Volume: 21
    Issue: 4
    Page numbers: 292-300
    Publisher: Mary Ann Leibert Publishers(New Rochelle, NY)
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  • Granulocyte contamination dramatically inhibits spot formation in AIDS virus-specific ELISpot assays: Analysis and strategies to ameliorate
    Year: 2005
    Journal: Journal of Immunological Methods
    Volume: 297
    Issue: 1-2
    Page numbers: 177-186
    Publisher: Elsevier Science(Amsterdam)
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  • Mucosally-administered human-simian immunodeficiency virus DNA and fowlpoxvirus-based recombinant vaccines reduce acute phase viral replication in macaques following vaginal challenge with CCR5-tropic SHIVSF162P3
    Year: 2005
    Journal: Vaccine
    Volume: 23
    Issue: 42
    Page numbers: 5009-5021
    Publisher: Elsevier Science(Oxford)
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  • Rapid Viral Escape at an Immunodominant Simian-Human Immunodeficiency Virus Cytotoxic T-Lymphocyte Epitope Exacts a Dramatic Fitness Cost
    Year: 2005
    Journal: Journal of Virology
    Volume: 79
    Issue: 9
    Page numbers: 5721-5731
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  • Subtype AE HIV-1 DNA and recombinant Fowlpoxvirus vaccines encoding five shared HIV-1 genes: safety and T cell immunogenicity in macaques
    Year: 2005
    Journal: Vaccine
    Volume: 23
    Issue: 16
    Page numbers: 1949-1956
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  • The pigtail macaque MHC class I allele Mane-A*10 presents an immundominant SIV Gag epitope: identification, tetramer development and implications of immune escape and reversion
    Year: 2005
    Journal: Journal of Medical Primatology
    Volume: 34
    Issue: 5-6
    Page numbers: 282-293
    Publisher: Munksgaard International Publishers(Copenhagen)
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Publications in 2004

Journal Articles

  • Analysis of Pigtail Macaque Major Histocompatibility Complex Class I Molecules Presenting Immunodominant Simian Immunodeficiency Virus Epitopes
    Year: 2004
    Journal: Journal of Virology
    Volume: 79
    Issue: 2
    Page numbers: 684-695
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  • Efficacy of DNA and Fowlpox Virus Priming/Boosting Vaccines for Simian/Human Immunodeficiency Virus
    Year: 2004
    Journal: Journal of Virology
    Volume: 78
    Issue: 24
    Page numbers: 13819-13828
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  • Evaluation in macaques of HIV-1 DNA vaccines containing primate CpG motifs and fowlpoxvirus vaccines co-expressing IFNγ or IL-12
    Year: 2004
    Journal: Vaccine
    Volume: Volume 23
    Issue: 2
    Page numbers: 188-197
    Publisher: Elsevier Science(Oxford)
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  • Vaccines and Vaccine Strategies Against HIV
    Year: 2004
    Journal: Current Drug Targets
    Volume: 5
    Issue: 1
    Page numbers: 71-88
    Publisher: Bentham Science Publishers(Hilversum)
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Publications in 2002

Journal Articles

  • Chimeric Human Papilloma Virus-Simian/Human Immunodeficiency Virus Virus-like-Particle Vaccines: Immunogenicity and Protective Efficacy in Macaques
    Year: 2002
    Journal: Virology
    Volume: 301
    Page numbers: 176-187
    Publisher: Academic Press(California)
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