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DR ALEXANDER DOBROVIC



Contact Details

Organization: Pathology
Position: Honorary (Principal Fellow)
Homepage: http://www.petermac.unimelb.edu.au
Work: 9656 1111
Building: No Building
Campus: Peter Maccallum Hospital

Research Expertise and International Linkages

Research Expertise

Research Interest Key Words Country of Expertise
cancer gene mapping Australia

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Bachelor of Science (Honors) Adelaide University 31-Dec-1976
Doctor of Philosophy La Trobe University 31-Jan-1984

Memberships

Membership Type Membership Body Description Start Date End Date
Unspecified Heamatology Society of Australia Member 23-Aug-2006
Unspecified American Association for Cancer Research member 23-Aug-2006

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
Biomolecular fingerprints as early diagnostic indicators of ovarian cancer Chief Investigator CANCER COUNCIL VICTORIA Grants-in-Aid 01/01/2004
MOLECULAR PROFILING OF SARCOMAS TO ENABLE CLINICAL PREDICTION AND ELUCIDATE MOLECULAR PATHOGENESIS Chief Investigator NHMRC Project Grants 01/01/2005
DETECTION OF OCCULT DISSEMINATING TUMOUR CELLS AND TUMOUR DNA IN EARLY STAGE OPERABLE BREAST CANCER PATIENTS Chief Investigator NHMRC Project Grants 01/01/2005
PREDICTING BREAST CANCER RISK BY ASSAYING PERIPHERAL BLOOD METHYLATION Chief Investigator US DEPT OF DEFENSE Breast Cancer Research Program - Concept Award (UNITED STATES DEPT OF DEFENSE) 15/09/2005
Identifying therapeutic targets by expression profiling of DNA repair in breast cancer. Chief Investigator THE SUSAN G KOMEN BREAST CANCER FOUNDATION Basic, Clinical or Translational Research 01/05/2006
DOES BRCA1 GERMLINE METHYLATION UNDERLIE SOME EARLY ONSET BREAST CANCER? Chief Investigator US DEPT OF DEFENSE Concept Award (CDMRP) 20/07/2006
IDENTIFYING THERAPEUTIC TARGETS BY PROFILING DNA REPAIR IN CLL Chief Investigator CLL GLOBAL RESEARCH FOUNDATION CLL Global Research Foundation 06/09/2006
SOMATIC AND GERMLINE BRCA1 METHYLATION AND BREAST CANCER PREDISPOSITION. Chief Investigator CANCER COUNCIL VICTORIA Grants-in-Aid 01/01/2007
EPITHELIAL - MESENCHYMAL INTERCONVERSIONS IN THE BREAST CANCER METASTATIC CASCADE Chief Investigator CANCER COUNCIL VICTORIA Grants-in-Aid 27/11/2007
RAPID DETECTION OF CARRIERS WITH BRCA1/2 MUTATION DETECTION IN BREAST, OVARIAN AND PROSTATE CANCER USING HIGH RESOLUTION MELTING Chief Investigator CANCER AUSTRALIA,
NATIONAL BREAST CANCER FOUNDATION
Priority-Driven Collaborative Cancer Research Scheme (CANCER AUSTRALIA) 05/02/2008
SOMATIC DNA METHYLATION AND CANCER PREDISPOSITION Chief Investigator CANCER COUNCIL VICTORIA Grants-in-Aid 01/01/2009

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2008

Journal Articles

  • In vitro sensitivity testing of minimally passaged and uncultured gliomas with TRAIL and/or chemotherapy drugs.
    Year: 2008
    Journal: British Journal of Cancer
    Volume: 99
    Issue: 2
    Page numbers: 294-304
    Author(s):
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  • Complete molecular response of e6a2 BCR-ABL-positive acute myeloid leukemia to imatinib then dasatinib


    Year: 2008
    Journal: Blood
    Volume: 111
    Issue: 5
    Page numbers: 2896-2898
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  • Sensitive melting analysis after real time-methylation specific PCR (SMART-MSP): high-throughput and probe-free quantitative DNA methylation detection


    Year: 2008
    Journal: Nucleic Acids Research
    Volume: 36
    Issue: 7
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  • BRCA1 promoter methylation in peripheral blood DNA of mutation negative familial breast cancer patients with BRCA1 tumour phenotype
    Year: 2008
    Journal: Breast Cancer Research
    Volume: 10
    Issue: 1
    Page numbers: 1-8
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  • Complete molecular resonose of e6a2 BRC-ALB-positive acute myeloid leukemia to imatinib then dasatinib
    Year: 2008
    Journal: Blood
    Volume: 111
    Issue: 5
    Page numbers: 2896-8
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  • Detection of NPM1 exon 12 mutations and FLT3 – internal tandem
    duplications by high resolution melting analysis in normal karyotype
    acute myeloid leukemia
    Year: 2008
    Journal: Journal of Hematology & Oncology
    Volume: 1
    Issue: 10
    Page numbers: 1-5
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  • Detection of NPM1 exon 12 mutations and FLT3 - internal tandem duplications by high resolution melting analysis in normal karyotype acute myeloid leukemia
    Year: 2008
    Journal: Journal of Hematology & Oncology
    Volume: 1
    Issue: 10
    Page numbers: 1-5
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  • Direct genotyping of single nucleotide polymorphisms in methyl metabolism genes using probe-free high-resolution melting analysis
    Year: 2008
    Journal: Cancer Epidemiology, Biomarkers & Prevention
    Volume: 17
    Issue: 5
    Page numbers: 1240-1247
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  • High resolution melting analysis for rapid and sensitive EGFR and KRAS mutation detection in formalin fixed paraffin embedded biopsies
    Year: 2008
    Journal: BMC Cancer
    Volume: 8
    Page numbers: 142
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  • Negative selection of chronic lymphocytic leukaemia cells using a
    bifunctional rosette-based antibody cocktail
    Year: 2008
    Journal: BMC Biotechnology
    Volume: 8
    Issue: 6
    Page numbers: 1-5
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  • Negative selection of chronic lymphocytic leukaemia cells using a bifunctional rosette-based antibody cocktail
    Year: 2008
    Journal: BMC Biotechnology
    Volume: 8
    Issue: 6
    Page numbers: 1-5
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  • Rapid detection of carriers with BRCA1 and BRCA2 mutations using high resolution melting analysis
    Year: 2008
    Journal: BMC Cancer
    Volume: 8
    Page numbers: 1-7
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Publications in 2007

Journal Articles

  • Incorporation of somatic BRAF mutation testing into an algorithm for the investigation of hereditary non-polyposis colorectal cancer


    Year: 2007
    Journal: Familial Cancer
    Volume: 6
    Page numbers: 301-310
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  • Methylation-sensitive high resolution melting (MS-HRM): a new approach for sensitive and high-throughput assessment of methylation


    Year: 2007
    Journal: Nucleic Acids Research
    Volume: 35
    Issue: 6
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  • A simple, rapid, and sensitive method for the detection of the JAK2 V617F mutation.
    Year: 2007
    Journal: American Journal of Clinical Pathology
    Volume: 127
    Issue: 6
    Page numbers: 977-81
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  • High resolution melting for mutation scanning of TP53 exons 5-8
    Year: 2007
    Journal: BMC Cancer
    Volume: 7
    Page numbers: 168
    Author(s):
    URL - open access http://www.ncbi.nlm.nih.gov/pubmed/17764544?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
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Publications in 2006

Journal Articles

  • High resolution melting analysis for the rapid and sensitive detection of mutations in clinical samples: KRAS codon 12 and 13 mutations in non-small cell lung cancer.
    Year: 2006
    Journal: BMC Cancer
    Volume: 21
    Issue: 6
    Page numbers: 295
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  • Mutations in the MYB Intron I Regulatory Sequence Increase Transcription in Colon Cancers
    Year: 2006
    Journal: Genes, Chromosomes & Cancer
    Volume: 45
    Page numbers: 1143-1154
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  • Sensitive detection of KIT D816V in patients with Mastocytosis
    Year: 2006
    Journal: Clinical Chemistry
    Volume: 52
    Issue: 12
    Page numbers: 2250-7
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