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PROF ANDREW SINCLAIR



Contact Details

Organization: Paediatrics Royal Children's Hospital
Position: SENIOR PRINCIPAL RESEARCH FELLOW NH&MRC
Email:

Biography


Professor Andrew Sinclair holds a joint appointment with the University of Melbourne, Department of Paediatrics and the Murdoch Children’s Research Institute as  Divisional Director of Early Development and Disease.   He leads an internationally recognised research group that focuses on gonad development and dysfunction.  His contributions have been fundamental to the advancement of the field, including the identification and characterisation of the testis determining gene (SRY) and other genes critical for gonad development.  Andrew has an extensive publication record, including six Nature papers, some of which have become ISI citation classics with over 1,000 citations each. He has been awarded over $10 million in competitive grant funding, including an ARC National Centre of Excellence and an NHMRC Program Grant.  He is regularly invited to present plenary lectures at national and international meetings.  Andrew was President of the Australian Society for Medical Research in 2004, and led national advocacy efforts seeking increased Federal Government funding of health and medical research. In 2005, the Federal Minister for Health appointed Andrew to the Australian Biotechnology Advisory Council which provides high-level independent advice to the Federal Ministers for Health, Education & Science, and Industry.

Research Expertise and International Linkages

Research Expertise

Research Interest Key Words Country of Expertise
Molecular Development, Genetics, Sexual Differentiation, Sex Determination Australia

International Linkages

Country Establishment Collaboration
United States University of Miami Research
Indonesia Diponegro University Exchange, Research, Technical Assistance/Training
United States Children's Hospital Boston Research
United States New York University Research
Netherlands Erasmus University Rotterdam Research

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Bachelor of Science Monash University 31-Dec-1981
Doctor of Philosophy La Trobe University 31-Dec-1988

Memberships

Membership Type Membership Body Description Start Date End Date
Member NHMRC Grant Review Panel / NHMRC Fellowship Committee Member of NHMRC Grant Review Panel - Genetics 01-Jan-2006 31-Dec-2006
Member NHMRC Grant Review Panel / NHMRC Fellowship Committee Committee (ex-officio as President of ASMR) 01-Jan-2004 31-Dec-2004
Member Research Advisory Committee for Turning Point Alcohol and Drug Centre Member 01-Jan-2005
Member Australian Society for Medical Research President-Elect 01-Jan-2003 31-Dec-2003
Member Australian Society for Medical Research National Secretary and Executive 01-Jan-2000 31-Dec-2003
Member Australian Society for Medical Research Board Director 01-Jan-1998 31-Dec-2002
Member Australian Society for Medical Research President 01-Jan-2004 31-Dec-2004
Member NHMRC Project Grant Review Panel - Genetics Chair 01-Jan-2007 31-Dec-2008
Member NHMRC Project Grant Review Panel - Genetics Panel member 01-Jan-2006 31-Dec-2006
Member PathoGenetics Editorial Board Member 01-Jan-2008
Member Sexual Development Editorial Board Member 01-Jan-2008
Council Australian Biotechnology Advisory Council Member 01-Jan-2005 31-Dec-2008
Member OzBio 2010 Program Committee Member 01-Oct-2008

Other Awards

Award Type Awarding Body Comments Date Awarded
Other (Award) Genetics Society of Australia Smith-White Award 01-Jan-1987
Other (Award) Royal Society, UK Outstanding Research Award 01-Jan-1990
Other (Award) LaTrobe University Distinguished Alumni Award for outstanding professional achievement and leadership 01-Jan-1998
Other (Award) Human Genetics Society of Australasia Sutherland Award 01-Mar-2009
Other (Award) Imperial Cancer Research Fund, UK Imperial Cancer Research Fellowship 01-Jan-1988
Other (Award) Museum of Victoria Biomedical Research exhibit (permanent) 01-Jan-1999

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
Establishment of ARC Centre of Excellence in Biotechnology & Development Chief Investigator UNIVERSITY OF NEWCASTLE Centres of Excellence (AUST RESEARCH COUNCIL) 01/01/2003
Establishment of ARC Centre of Excellence in Biotechnology & Development Chief Investigator UNIVERSITY OF NEWCASTLE Centres of Excellence (AUST RESEARCH COUNCIL) 01/01/2003
Renewal of PRF Chief Investigator NHMRC Research Fellowship 01/01/2004
A bird's eye view of sex: the chicken embryo as a model for gonadal development Chief Investigator AUST RESEARCH COUNCIL Discovery Projects 01/01/2006
NHMRC Research Fellowship 2009 - SINCLAIR Chief Investigator NHMRC Research Fellowship 01/01/2009

Contracts

Title Role Funding Source Award Date
ASSOCIATES AGREEMENT - DR.DUANGPORN JAMSAI, UNIVERSITY OF NEWCASTLE, UQ, MONASH - COLLABORATION WITH INDIVIDUAL RESEARCHERS FOR ARC CENTRE OF EXCELLENCE IN BIOTECHNOLOGY AND DEVELOPMENT Chief Investigator MONASH UNIVERSITY,
UNIVERSITY OF NEWCASTLE,
UNIVERSITY OF QUEENSLAND
20/08/2007
ASSOCIATES AGREEMENT - DR.BRETT NIXON, UNIVERSITY OF NEWCASTLE, UQ, MONASH - COLLABORATION WITH INDIVIDUAL RESEARCHERS FOR ARC CENTRE OF EXCELLENCE IN BIOTECHNOLOGY AND DEVELOPMENT Chief Investigator MONASH UNIVERSITY,
UNIVERSITY OF NEWCASTLE,
UNIVERSITY OF QUEENSLAND
ASSOCIATES AGREEMENT - DR.JOSEPHINE BOWLES, UNIVERSITY OF NEWCASTLE, UQ, MONASH - COLLABORATION WITH INDIVIDUAL RESEARCHERS FOR ARC CENTRE OF EXCELLENCE IN BIOTECHNOLOGY AND DEVELOPMENT Chief Investigator MONASH UNIVERSITY,
UNIVERSITY OF NEWCASTLE,
UNIVERSITY OF QUEENSLAND
ASSOCIATES AGREEMENT - DR.MARK BAKER, UNIVERSITY OF NEWCASTLE, UQ, MONASH - COLLABORATION WITH INDIVIDUAL RESEARCHERS FOR ARC CENTRE OF EXCELLENCE IN BIOTECHNOLOGY AND DEVELOPMENT Chief Investigator MONASH UNIVERSITY,
UNIVERSITY OF NEWCASTLE,
UNIVERSITY OF QUEENSLAND

Additional Grant and Contract Information

"Molecular genetics of sex determination and gonad development"
A.H. Sinclair, P.A. Koopman, V.R. Harley
2005-2009 and 2010-2014
National Health and Medical Research Council Program Grant of $9.3 million total

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2009

Journal Articles

Publications in 2008

Journal Articles

  • Cloning and expression of R-spondin1 in different vertebrates suggests a conserved role in ovarian development
    Year: 2008
    Journal: BMC Developmental Biology
    Volume: 8
    Page numbers: 72
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  • Dynamic regulation of mitotic arrest in fetal male germ cells
    Year: 2008
    Journal: Stem Cells
    Volume: 26
    Page numbers: 339-347
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  • Endothelial cell igration directs testis cord formation
    Year: 2008
    Journal: Developmental Biology
    Volume: 326
    Issue: 1
    Page numbers: 112-120
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  • Onset of meiosis in the chicken embryo; evidence of a role for retinoic acid
    Year: 2008
    Journal: BMC Developmental Biology
    Volume: 8
    Page numbers: 85
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  • Sox9-dependent expression of Gstm6 in Sertoli cells during testis development in mice
    Year: 2008
    Journal: Reproduction
    Volume: 1
    Issue: 1
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  • Testis development, fertility, and survival in Ethanolamine kinase 2-deficient mice
    Year: 2008
    Journal: Endocrinology
    Volume: 149
    Issue: 12
    Page numbers: 6176-6186
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  • The Rhox homeobox gene family shows sexually dimorphic and dynamic expression during mouse embryonic gonad development
    Year: 2008
    Journal: Biology of Reproduction
    Volume: 79
    Page numbers: 468-474
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Publications in 2007

Journal Articles

  • Human embryonic stem cell research: an Australian perspective


    Year: 2007
    Journal: Cell
    Volume: 128
    Issue: 2
    Page numbers: 221-223
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  • Sex-specific expression of a novel gene Tmem184a during mouse testis differentiation


    Year: 2007
    Journal: Reproduction
    Volume: 133
    Issue: 5
    Page numbers: 983-989
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  • Avian sex determination: what, when and where?

    Year: 2007
    Journal: Cytogenetic and Genome Research
    Volume: 117
    Page numbers: 165-173
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  • Dppa2 and Dppa4 are closely linked SAP motif genes restricted to pluripotent cells and the germ line
    Year: 2007
    Journal: Stem Cells
    Volume: 25
    Page numbers: 19-28
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  • Expression of Wsb2 in the developing and adult mouse testis
    Year: 2007
    Journal: Reproduction
    Volume: 133
    Page numbers: 753-761
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Publications in 2005

Journal Articles

  • A long-term outcome study of intersex conditions.
    Year: 2005
    Journal: Journal of Pediatric Endocrinology and Metabolism
    Volume: 18
    Issue: 6
    Page numbers: 555-567
    Publisher: Freund Publishing House
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  • Annexin XI co-localises with calcyclin in proliferating cells of the embryonic mouse testis
    Year: 2005
    Journal: Developmental Dynamics
    Volume: 234
    Issue: 2
    Page numbers: 432-437
    Publisher: Wiley-Liss(New York)
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  • Aromatase inhibition reduces expression of FOXL2 in the embryonic chicken ovary.
    Year: 2005
    Journal: Developmental Dynamics
    Volume: 233
    Issue: 3
    Page numbers: 1052-1055
    Publisher: Wiley-Liss(New York)
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  • Conserved expression of a novel gene during gonadal development.
    Year: 2005
    Journal: Developmental Dynamics
    Volume: 233
    Issue: 3
    Page numbers: 1083-1090
    Publisher: Wiley-Liss(New York)
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  • Evaluation of candidate markers for the peritubular myoid cell lineage in the developing murine testes
    Year: 2005
    Journal: Reproduction
    Volume: 130
    Page numbers: 509-516
    Publisher: Society of Reproduction and Fertility(Cambridge)
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  • Expression profile of the RNA-binding protein gene hermes during chicken embryonic development.
    Year: 2005
    Journal: Developmental Dynamics
    Volume: 233
    Issue: 3
    Page numbers: 1045-1051
    Publisher: Wiley-Liss(New York)
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  • Identification and study of genes important for fetal germ biology in mice
    Year: 2005
    Journal: Reproduction, Fertility and Development
    Volume: 16S
    Page numbers: 21
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  • Male-specific cell migration into the developing gonad is a conserved process involving PDGF signalling.
    Year: 2005
    Journal: Developmental Biology
    Volume: 284
    Issue: 2
    Page numbers: 337-350
    Publisher: Academic Press(California)
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  • Novel scavenger receptor gene is differentially expresssed in the embryonic and adult mouse testis.
    Year: 2005
    Journal: Developmental Dynamics
    Volume: 234
    Issue: 4
    Page numbers: 1026-1033
    Publisher: Wiley-Liss(New York)
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  • Second report on chicken genes and chromosomes 2005
    Year: 2005
    Journal: Cytogenetic and Genome Research
    Volume: 109
    Issue: 4
    Page numbers: 415-479
    Publisher: S Karger AG
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  • Temporal and spatial expression profile of the novel armadillo-related gene,Alex2, during testicluar differentation in the mouse embryo.
    Year: 2005
    Journal: Developmental Dynamics
    Volume: 233
    Issue: 1
    Page numbers: 188-193
    Publisher: Wiley-Liss(New York)
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Publications in 2004

Book Chapters

  • Molecular genetics of gonad development
    Year: 2004
    Book: Paediatric and Adolescent Gynaecology
    Publisher: Cambridge University Press(Cambridge)
    Authors(s):

Journal Articles

  • Eki2 is up-regulated specifically in the testis during mouse sex determination
    Year: 2004
    Journal: Gene Expression Patterns
    Volume: 4
    Page numbers: 135-140
    Publisher: Elsevier Science
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  • Immune function and adjustment style: do they predict survival in breast cancer?
    Year: 2004
    Journal: Psycho-Oncology
    Volume: 13
    Page numbers: 199-210
    Publisher: John Wiley & Sons(West Sussex)
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  • Pre-sertoli specific gene expression profiling reveals differential expression of Ppt1 and Brd3 genes within the mouse genital ridge at the time of sex determination.
    Year: 2004
    Journal: Biology of Reproduction
    Volume: 71
    Issue: 3
    Page numbers: 820-827
    Publisher: Society for the Study of Reproduction(Wisconsin)
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  • Sex determination: insights from the chicken.
    Year: 2004
    Journal: Bioessays
    Volume: 26
    Issue: 2
    Page numbers: 120-132
    Publisher: Company of Biologists(Cambridge)
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Publications in 2003

Journal Articles

  • DMRT1 is upregulated in the gonads during female-to-male sex reversal in ZW chicken embryos.
    Year: 2003
    Journal: Biology of Reproduction
    Volume: 68
    Issue: 2
    Page numbers: 560-570
    Publisher: Society for the Study of Reproduction(Wisconsin)
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  • Rules for clinical diagnosis in babies with ambiguous genitalia.
    Year: 2003
    Journal: Journal of Paediatrics and Child Health
    Volume: 39
    Issue: 6
    Page numbers: 406-413
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  • Sox15 is upregulated in the embryonic mouse testis.
    Year: 2003
    Journal: Gene Expression Patterns
    Volume: 3
    Issue: 4
    Page numbers: 413-417
    Publisher: Elsevier Science
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  • Subtractive hybridisation screen identifies sexually dimorphic gene expression in the embyonic mouse gonad
    Year: 2003
    Journal: Genesis
    Volume: 37
    Issue: 2
    Page numbers: 84-90
    Publisher: Wiley-Liss(New York)
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  • Type II and type IX collagen transcript isoforms are expressed during mouse testis development.
    Year: 2003
    Journal: Biology of Reproduction
    Volume: 68
    Issue: 5
    Page numbers: 1742-1747
    Publisher: Society for the Study of Reproduction(Wisconsin)
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Publications in 2002

Journal Articles

  • FET-1: a novel W-linked, female specific gene up-regulated in the embryonic chicken ovary
    Year: 2002
    Journal: Gene Expression Patterns
    Volume: 2
    Page numbers: 83-86
    Publisher: Elsevier Science
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  • Restricted expression of DMRT3 in chicken and mouse embryos
    Year: 2002
    Journal: Gene Expression Patterns
    Volume: 2
    Page numbers: 69-72
    Publisher: Elsevier Science
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  • Vertebrate sex determination: many means to an end
    Year: 2002
    Journal: Reproduction
    Volume: 124
    Page numbers: 447-457
    Publisher: Society of Reproduction and Fertility(Cambridge)
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Publications in 2001

Journal Articles

  • Rapid DNA Extraction and PCR-Sexing of Mouse Embryos
    Year: 2001
    Journal: Molecular Reproduction and Development
    Volume: 60
    Page numbers: 225-226
    Publisher: John Wiley & Sons
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  • Sex, Genes, and Heat: Triggers of Diversity
    Year: 2001
    Journal: Journal of Experimental Zoology
    Volume: 290
    Page numbers: 624-631
    Publisher: John Wiley & Sons
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