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A/PROF KEVIN JEFFREY BARNHAM



Contact Details

Organization: Pathology
Position: PRINCIPAL RESEARCH FELLOW
Email:
Homepage: http://www.path.unimelb.edu.au/research/labs/barnham/
Work: 8344 1805
Building: Medical Centre
Campus: Parkville

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Bachelor of Science The University of Queensland
Doctor of Philosophy The University of Queensland

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
NEURODEGENERATIVE DISEASES OF THE AGING BRAIN: DIAGNOSIS & THERAPY BASED ON THE STUDY OF AGGREAGATED PROTEIN DEPOSITIONS Chief Investigator NHMRC Program Grants 01/01/2002
Biophysical approaches to understanding the role of metal ions and membranes in protein folding and their role in neurodegenerative diseases Chief Investigator NHMRC Clinical Career Development Award 01/01/2003
Research Fellowship Chief Investigator NHMRC Research Fellowship 01/01/2006
BIOPHYSICAL PROPERTIES OF PEPTIDES REPRESENTING ENDOGENOUS PROCESSING OF HUMAN PRION PROTEIN Chief Investigator BETHLEHEM GRIFFITHS RESEARCH FOUNDATION Medical Research Grants 01/01/2007
STUDIES OF PROTEINS ASSOCIATED WITH NEURODEGENERATION Chief Investigator A E ROWDEN WHITE FOUNDATION Research Grant 01/01/2007
APPLICATION OF COPPER-64 TO STUDIES ON ALZHEIMER'S DISEASE AND CHARACTERISATION OF NOVEL GENES AND PROTEINS INVOLVED IN COPPER HOMEOSTASIS Chief Investigator AINSE Awards 01/01/2007
A NATIONAL BIOMEDICAL ELECTRON PARAMAGNETIC RESONANCE AND MOLECULAR IMAGING CENTRE Chief Investigator MONASH UNIVERSITY Linkage Infrastructure (Equipment and Facilities) (AUST RESEARCH COUNCIL) 01/01/2007
THE USE OF CU-ATSM TREATMENT TO IDENTIFY CELLULAR MECHANISMS OF MOTOR NEURON DEGENERATION IN AMYOTROPHIC LATERAL SCLEROSIS. Chief Investigator MOTOR NEURONE DISEASE INST OF AUST Grants-in-Aid 07/11/2007
INVESTIGATING PROTEIN/PROTEIN INTERACTIONS Chief Investigator AUST RESEARCH COUNCIL Linkage Infrastructure (Equipment and Facilities) 01/01/2008
METAL COMPLEXES FOR MODULATING METAL-BIOAVAILABILITY IN ALZHEIMER'S DISEASE Principal Supervisor ALZHEIMER'S AUST RESEARCH LTD George Hicks P/grad Scholarship for Dementia Prevention and Risk Reduction 01/01/2008

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2008

Journal Articles

  • Selective intracellular release of copper and zinc ions from bis(thiosemicarbazonato) complexes reduces levels of Alzheimer?s disease amyloid-beta peptide
    Year: 2008
    Journal: Journal of Biological Chemistry
    Volume: 283
    Issue: 8
    Page numbers: 4568-4577
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Publications in 2007

Journal Articles

  •  Concentration dependent Cu2+ induced aggregation and dityrosine formation of the Alzheimer's disease Amyloid-β peptide.
    Year: 2007
    Journal: Biochemistry
    Volume: 46
    Issue: 10
    Page numbers: 2881-91
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  • Molecular determinants of Alzheimer's diesase AB peptide neurotoxicity


    Year: 2007
    Journal: Future Neurology
    Volume: 2
    Issue: 4
    Page numbers: 397-409
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  • Cholesterol and Clioquinol modulation of Ab(1-42) interaction with phospholipid bilayers and metals
    Year: 2007
    Journal: Biochimica et Biophysica Acta-Biomembranes
    Volume: 1768
    Page numbers: 3135-3144
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  • Concentration dependent Cu2+ induced aggregation and dityrosine

    formation of the Alzheimer's disease Amyloid- peptide
    Year: 2007
    Journal: Biochemistry
    Volume: 46
    Issue: 10
    Page numbers: 2881-91
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  • Copper and zinc bis(thiosemicarbazonato) complexes for the treatment of Alzheimer's disease
    Year: 2007
    Journal: Journal of Biological Inorganic Chemistry
    Volume: 12
    Page numbers: S17
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  • Differential modulation of Alzheimer's disease amyloid beta peptide accumulation by diverse classes of metal ligands.
    Year: 2007
    Journal: Biochemical Journal
    Volume: 407
    Issue: 3
    Page numbers: 435-450
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  • In vitro characterisation of Pittsburgh compound-B (PIB) binding to Lewy bodies
    Year: 2007
    Journal: Journal of Neuroscience
    Volume: 27
    Issue: 39
    Page numbers: 10365-10371
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  • Membrane interactions and the effect of metal ions on the amyloidogenic fragment Ab(25-35) in comparison to Ab(1-42).
    Year: 2007
    Journal: Biochimica et Biophysica Acta-Biomembranes
    Volume: 1768
    Page numbers: 2400-2408
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  • Neurotoxic species in prion disease: a role for PrP isoforms
    Year: 2007
    Journal: Journal of Neurochemistry
    Volume: 103
    Issue: 5
    Page numbers: 1709-1720
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  • Structural studies of the Alzheimer's amyloid precursor protein copper-binding domain reveal how it binds copper ions.
    Year: 2007
    Journal: Journal of Molecular Biology
    Volume: 367
    Issue: 1
    Page numbers: 148-161
    Author(s):
    URL - open access http://www.ncbi.nlm.nih.gov/pubmed/17239395?ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
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  • The redox chemistry of the Alzheimer's disease Amyloid-β peptide.
    Year: 2007
    Journal: Biochimica et Biophysica Acta-Biomembranes
    Volume: 1768
    Page numbers: 1976-1990
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Major Reference Works

  • Handbook of Metalloproteins:Amyloid precursor protein
    Year: 2007
    Reference Work Title: Handbook of Metalloproteins
    Publisher: John Wiley & Sons
    Author(s):

Publications in 2006

Journal Articles

  • Amyloid-beta peptide disruption of lipid membranes and the effect of metal ions.
    Year: 2006
    Journal: Journal of Molecular Biology
    Volume: 356
    Page numbers: 759-770
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  • Copper and Zinc Mediated Oligomerisation of Abeta peptides
    Year: 2006
    Journal: International Journal of Peptide Research and Therapeutics
    Volume: 12
    Issue: 2
    Page numbers: 153-164
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  • Copper-dependent inhibition of cytochrome c oxidase by Aβ1-42 requires reduced methionine at residue 35 of the Aβ peptide
    Year: 2006
    Journal: Journal of Neurochemistry
    Volume: 99
    Page numbers: 226-236
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  • Copper-mediated Amyloid-beta toxicity Is Associated with an Intermolecular Histidine Bridge
    Year: 2006
    Journal: Journal of Biological Chemistry
    Volume: 281
    Issue: 22
    Page numbers: 15145-15154
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  • Degradation of the Alzheimer's disease amyloid beta peptide by metal-dependent up-regulation of metalloprotease activity.
    Year: 2006
    Journal: Journal of Biological Chemistry
    Volume: 281
    Page numbers: 17670-17680
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  • Delineating common molecular mechanisms in Alzheimer's and prion diseases
    Year: 2006
    Journal: Trends in Biochemical Sciences
    Volume: 31
    Issue: 8
    Page numbers: 465-472
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  • Dimerisation of N-acetyl-L-tyrosine ethyl ester and Abeta peptides via formation of dityrosine
    Year: 2006
    Journal: Free Radical Research
    Volume: 40(1)
    Page numbers: 1-9
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  • Metal homeostasis in Alzheimer's disease
    Year: 2006
    Journal: Expert Review of Neurotherapeutics
    Volume: 6
    Issue: 5
    Page numbers: 711-722
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  • Molecular mechanisms for Alzheimer ’s disease: implications for neuroimaging and therapeutics
    Year: 2006
    Journal: Journal of Neurochemistry
    Volume: 97
    Page numbers: 1700-1725
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  • RADIOIODINATED CLIOQUINOL AS A BIOMARKER FOR β-AMYLOID: Zn2+ complexes in Alzheimer's disease
    Year: 2006
    Journal: Aging Cell
    Volume: 5
    Page numbers: 69-79
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  • Therapeutic treatments for Alzheimer's disease based on metal bioavailability
    Year: 2006
    Volume: 19
    Page numbers: 469-474
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Publications in 2005

Journal Articles

  • Alzheimer disease β-amyloid activity mimics cholesterol oxidase
    Year: 2005
    Journal: Journal of Clinical Investigation
    Volume: 115
    Page numbers: 2556-2563
    Publisher: American Society of Clinical Investigation Inc(Michigan)
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  • Copper-dependent inhibition of human cytochrome c oxidase by a dimeric conformer of amyloid-bΒ1-42
    Year: 2005