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A/PROF KEVIN BARNHAM



Contact Details

Organization: Pathology
Position: PRINCIPAL RESEARCH FELLOW
Email:
Homepage: http://www.path.unimelb.edu.au/research/labs/barnham/
Work: 8344 1805
Building: Medical Centre
Campus: Parkville

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Bachelor of Science The University of Queensland
Doctor of Philosophy The University of Queensland

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
NEURODEGENERATIVE DISEASES OF THE AGING BRAIN: DIAGNOSIS & THERAPY BASED ON THE STUDY OF AGGREAGATED PROTEIN DEPOSITIONS Chief Investigator NHMRC Program Grants 01/01/2002
Biophysical approaches to understanding the role of metal ions and membranes in protein folding and their role in neurodegenerative diseases Chief Investigator NHMRC Clinical Career Development Award 01/01/2003
Research Fellowship Chief Investigator NHMRC Research Fellowship 01/01/2006
BIOPHYSICAL PROPERTIES OF PEPTIDES REPRESENTING ENDOGENOUS PROCESSING OF HUMAN PRION PROTEIN Chief Investigator BETHLEHEM GRIFFITHS RESEARCH FOUNDATION Medical Research Grants 01/01/2007
STUDIES OF PROTEINS ASSOCIATED WITH NEURODEGENERATION Chief Investigator A E ROWDEN WHITE FOUNDATION Research Grant 01/01/2007
APPLICATION OF COPPER-64 TO STUDIES ON ALZHEIMER'S DISEASE AND CHARACTERISATION OF NOVEL GENES AND PROTEINS INVOLVED IN COPPER HOMEOSTASIS Chief Investigator AINSE Awards 01/01/2007
A NATIONAL BIOMEDICAL ELECTRON PARAMAGNETIC RESONANCE AND MOLECULAR IMAGING CENTRE Chief Investigator MONASH UNIVERSITY Linkage Infrastructure (Equipment and Facilities) (AUST RESEARCH COUNCIL) 01/01/2007
THE USE OF CU-ATSM TREATMENT TO IDENTIFY CELLULAR MECHANISMS OF MOTOR NEURON DEGENERATION IN AMYOTROPHIC LATERAL SCLEROSIS. Chief Investigator MOTOR NEURONE DISEASE INST OF AUST Grants-in-Aid 07/11/2007
INVESTIGATING PROTEIN/PROTEIN INTERACTIONS Chief Investigator AUST RESEARCH COUNCIL Linkage Infrastructure (Equipment and Facilities) 01/01/2008
METAL COMPLEXES FOR MODULATING METAL-BIOAVAILABILITY IN ALZHEIMER'S DISEASE Principal Supervisor ALZHEIMER'S AUST RESEARCH LTD George Hicks P/grad Scholarship for Dementia Prevention and Risk Reduction 01/01/2008
Developing a new diagnostic method for Alzheimer's disease Chief Investigator NHMRC Project Grants 01/01/2009
APPLICATION OF COPPER-64 IN STUDIES OF THE ROLE OF COPPER IN ALZHEIMER'S DISEASE Chief Investigator AINSE Awards 01/01/2009
Studies on the structure and dynamics of misfolding proteins in neurodegenerative diseases Chief Investigator AINSE Awards 01/01/2009

Contracts

Title Role Funding Source Award Date
COLLABORATION AGREEMENT Chief Investigator THE MENTAL HEALTH RESEARCH INST,
WALTER & ELIZA HALL INST		 10/02/2009

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2009

Journal Articles

  • Dopamine and the Dopamine Oxidation Product5,6-Dihydroxylindole Promote Distinct On-Pathway and Off-Pathway Aggregation of α-Synuclein in a pH-Dependent Manner.


     


    Year: 2009
    Journal: Journal of Molecular Biology
    Volume: 387
    Page numbers: 771-785
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  • Formation of depamine-mediated α-synuclein-soluble oligomers requires methionine oxidation.


     


    Year: 2009
    Journal: Free Radical Biology and Medicine
    Volume: 46
    Page numbers: 1328-1337
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  • Alanine-2 Carbonyl is an Oxygen Ligand in Cu2+ Coordination of Alzheimer’s
    Disease Amyloid-β Peptide - Relevance to N-Terminally Truncated Forms
    Year: 2009
    Journal: Journal of the American Chemical Society
    Volume: 131
    Page numbers: 8760-8761
    Author(s):
    URL - restricted access http://pubs.acs.org/articlesonrequest/AOR-qQNcZvsq3Gkv6JnFnqy6
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  • Dominant roles of the polybasic proline motif and copper in the PrP23-89-mediated stress protection response
    Year: 2009
    Journal: Journal of Cell Science
    Volume: 122
    Issue: 10
    Page numbers: 1518-1528
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  • Increasing Cu bioavailability inhibits Aβ oligomers and tau phosphorylation
    Year: 2009
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 106
    Issue: 2
    Page numbers: 381-386
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  • Pleomorphic Copper Coordination by Alzheimer’s Disease Amyloid-β Peptide
    Year: 2009
    Journal: Journal of the American Chemical Society
    Volume: 131
    Issue: 3
    Page numbers: 1195-1207
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  • Restored degradation of the Alzheimer's amyloid-beta peptide by targeting amyloid formation
    Year: 2009
    Journal: Journal of Neurochemistry
    Volume: 108
    Page numbers: 1198-1207
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Publications in 2008

Book Chapters

Journal Articles

  • Activation of epidermal growth factor receptor by metal-ligand complexes decreases levels of extracellular amyloid beta peptide


    Year: 2008
    Journal: International Journal of Biochemistry and Cell Biology
    Volume: 40
    Issue: 9
    Page numbers: 1901-1917
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  • Amyloid-β Peptide (Aβ) Neurotoxicity Is Modulated by the Rate of Peptide Aggregation: Aβ Dimers and Trimers Correlate with Neurotoxicity


    Year: 2008
    Journal: Journal of Neuroscience
    Volume: 28
    Issue: 46
    Page numbers: 11950-11958
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  • Amyloid-β-Anti-Amyloid-β Complex Structure Reveals an Extended confirmation in the Immunodominant B-Cell Epitope


    Year: 2008
    Journal: Journal of Molecular Biology
    Volume: 377
    Issue: 1
    Page numbers: 181-192
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  • Copper binding to the Alzheimer's disease amyloid precursor protein


    Year: 2008
    Journal: European Biophysics Journal with Biophysics Letters
    Volume: 37
    Issue: 3
    Page numbers: 269-279
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  • Crystallization and preliminary X-ray diffraction analysis of the Fab fragment of WO2, an antibody specific for the Aβ peptides associated with Alzheimer’s disease


    Year: 2008
    Journal: Acta Crystallographica Section F - Structural Biology and Crystallization Communications
    Volume: n/a
    Issue: F64
    Page numbers: 438-441
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  • Delineating the Mechanism of Alzheimer’s Disease Aβ Peptide Neurotoxicity


    Year: 2008
    Journal: Neurochemical Research
    Volume: 33
    Issue: 3
    Page numbers: 526-532
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  • Dimeric structures of α-synuclein bind preferentially to lipid membranes


    Year: 2008
    Journal: Biochimica et Biophysica Acta-Biomembranes
    Volume: 1778
    Issue: 4
    Page numbers: 1112-1119
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  • Inhibition of γ-secretase causes increased secretion of amyloid precursor C-terminal fragments in association with exosomes


    Year: 2008
    Journal: FASEB Journal
    Volume: 22
    Issue: 5
    Page numbers: 1469-1478
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  • Inhibition of gamma-secretase causes increased secretion of amyloid precursor protein C-terminal fragments in association with exosomes
    Year: 2008
    Journal: FASEB Journal
    Volume: 22
    Issue: 5
    Page numbers: 1469-1478
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    URL - restricted access http://www.fasebj.org/cgi/content/abstract/22/5/1469
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  • Is Covalently Crosslinked Aβ Responsible for Synaptotoxicity in Alzheimer’s Disease?


    Year: 2008
    Journal: Current Alzheimer Research
    Volume: 5
    Issue: 6
    Page numbers: 533-539
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  • Metals in Alzheimer's and Parkinson's Diseases


    Year: 2008
    Journal: Current Opinion in Chemical Biology
    Volume: 12
    Issue: 2
    Page numbers: 222-228
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  • Platinum-based inhibitors of amyloid-β as therapeutic agents for Alzheimer’s disease


    Year: 2008
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 105
    Issue: 19
    Page numbers: 6813-6818
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  • Cu2+ Binding Modes of Recombinant α-Synuclein – Insights from EPR Spectroscopy
    Year: 2008
    Journal: Journal of the American Chemical Society
    Volume: 130
    Issue: 24
    Page numbers: 7766-7773
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  • Electron paramagnetic resonance characterization of the copper-resistance protein PcoC from Escherichia coli
    Year: 2008
    Journal: Journal of Biological Inorganic Chemistry
    Volume: 13
    Issue: 6
    Page numbers: 899-907
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  • Formation of a High Affinity Lipid-Binding Intermediate during the Early Aggregation Phase of α-Synuclein
    Year: 2008
    Journal: Biochemistry
    Volume: 47
    Issue: 5
    Page numbers: 1425-1434
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  • Is covalently crosslinked Abeta responsible for synaptotoxicity in Alzheimer's disease
    Year: 2008
    Journal: Current Alzheimer Research
    Volume: 5
    Issue: 6
    Page numbers: 533-539
    Author(s):
    URL - restricted access http://www.benthamdirect.org/pages/content.php?CAR/2008/00000005/00000006/005AT.SGM
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  • Neurotoxicity in Alzheimer's disease: is covalently crosslinked A beta responsible
    Year: 2008
    Journal: European Biophysics Journal with Biophysics Letters
    Volume: 37
    Issue: 3
    Page numbers: 265-268
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    URL - restricted access http://www.springerlink.com/content/3w664m6qum269667/
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  • Rapid Restoration of Cognition in Alzheimer’s Transgenic Mice with 8-Hydroxy Quinoline Analogs Is Associated with Decreased Interstitial Aβ
    Year: 2008
    Journal: Neuron
    Volume: 59
    Issue: 1
    Page numbers: 43-55
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  • Selective intracellular release of copper and zinc ions from bis(thiosemicarbazonato) complexes reduces levels of Alzheimer disease amyloid-beta peptide
    Year: 2008
    Journal: Journal of Biological Chemistry
    Volume: 283
    Issue: 8
    Page numbers: 4568-4577
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  • Stabilization of Neurotoxic Soluble β-Sheet-Rich Conformations of the Alzheimer’s Disease Amyloid-β Peptide
    Year: 2008
    Journal: Biophysical Journal
    Volume: 94
    Page numbers: 2752-2766
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  • The Structure of the Amyloid-β Peptide High-Affinity Copper II Binding Site in Alzheimer Disease
    Year: 2008
    Journal: Biophysical Journal
    Volume: 95
    Issue: 7
    Page numbers: 3447-3456
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Publications in 2007

Journal Articles

  •  Concentration dependent Cu2+ induced aggregation and dityrosine formation of the Alzheimer's disease Amyloid-β peptide.
    Year: 2007
    Journal: Biochemistry
    Volume: 46
    Issue: 10
    Page numbers: 2881-91
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  • Molecular determinants of Alzheimer's diesase AB peptide neurotoxicity


    Year: 2007
    Journal: Future Neurology
    Volume: 2
    Issue: 4
    Page numbers: 397-409
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  • Cholesterol and Clioquinol modulation of Ab(1-42) interaction with phospholipid bilayers and metals
    Year: 2007
    Journal: Biochimica et Biophysica Acta-Biomembranes
    Volume: 1768
    Page numbers: 3135-3144
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  • Concentration dependent Cu2+ induced aggregation and dityrosine

    formation of the Alzheimer's disease Amyloid- peptide
    Year: 2007
    Journal: Biochemistry
    Volume: 46
    Issue: 10
    Page numbers: 2881-91
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  • Copper and zinc bis(thiosemicarbazonato) complexes for the treatment of Alzheimer's disease
    Year: 2007
    Journal: Journal of Biological Inorganic Chemistry
    Volume: 12
    Page numbers: S17
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  • Differential modulation of Alzheimer's disease amyloid beta peptide accumulation by diverse classes of metal ligands.
    Year: 2007
    Journal: Biochemical Journal
    Volume: 407
    Issue: 3
    Page numbers: 435-450
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  • In vitro characterisation of Pittsburgh compound-B (PIB) binding to Lewy bodies
    Year: 2007
    Journal: Journal of Neuroscience
    Volume: 27
    Issue: 39
    Page numbers: 10365-10371
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  • Membrane interactions and the effect of metal ions on the amyloidogenic fragment Ab(25-35) in comparison to Ab(1-42).
    Year: 2007
    Journal: Biochimica et Biophysica Acta-Biomembranes
    Volume: 1768
    Page numbers: 2400-2408
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  • Neurotoxic species in prion disease: a role for PrP isoforms
    Year: 2007
    Journal: Journal of Neurochemistry
    Volume: 103
    Issue: 5
    Page numbers: 1709-1720
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  • Structural studies of the Alzheimer's amyloid precursor protein copper-binding domain reveal how it binds copper ions.
    Year: 2007
    Journal: Journal of Molecular Biology
    Volume: 367
    Issue: 1
    Page numbers: 148-161
    Author(s):
    URL - open access http://www.ncbi.nlm.nih.gov/pubmed/17239395?ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
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  • The redox chemistry of the Alzheimer's disease Amyloid-β peptide.
    Year: 2007
    Journal: Biochimica et Biophysica Acta-Biomembranes
    Volume: 1768
    Page numbers: 1976-1990
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Major Reference Works

  • Handbook of Metalloproteins:Amyloid precursor protein
    Year: 2007
    Reference Work Title: Handbook of Metalloproteins
    Publisher: John Wiley & Sons
    Author(s):

Publications in 2006

Journal Articles

  • Amyloid-beta peptide disruption of lipid membranes and the effect of metal ions.
    Year: 2006
    Journal: Journal of Molecular Biology
    Volume: 356
    Page numbers: 759-770
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  • Copper and Zinc Mediated Oligomerisation of Abeta peptides
    Year: 2006
    Journal: International Journal of Peptide Research and Therapeutics
    Volume: 12
    Issue: 2
    Page numbers: 153-164
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  • Copper-dependent inhibition of cytochrome c oxidase by Aβ1-42 requires reduced methionine at residue 35 of the Aβ peptide
    Year: 2006
    Journal: Journal of Neurochemistry
    Volume: 99
    Page numbers: 226-236
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  • Copper-mediated Amyloid-beta toxicity Is Associated with an Intermolecular Histidine Bridge
    Year: 2006
    Journal: Journal of Biological Chemistry
    Volume: 281
    Issue: 22
    Page numbers: 15145-15154
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  • Degradation of the Alzheimer's disease amyloid beta peptide by metal-dependent up-regulation of metalloprotease activity.
    Year: 2006
    Journal: Journal of Biological Chemistry
    Volume: 281
    Page numbers: 17670-17680
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  • Delineating common molecular mechanisms in Alzheimer's and prion diseases
    Year: 2006
    Journal: Trends in Biochemical Sciences
    Volume: 31
    Issue: 8
    Page numbers: 465-472
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  • Dimerisation of N-acetyl-L-tyrosine ethyl ester and Abeta peptides via formation of dityrosine
    Year: 2006
    Journal: Free Radical Research
    Volume: 40(1)
    Page numbers: 1-9
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  • Metal homeostasis in Alzheimer's disease
    Year: 2006
    Journal: Expert Review of Neurotherapeutics
    Volume: 6
    Issue: 5
    Page numbers: 711-722
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  • Molecular mechanisms for Alzheimer ’s disease: implications for neuroimaging and therapeutics
    Year: 2006
    Journal: Journal of Neurochemistry
    Volume: 97
    Page numbers: 1700-1725
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  • RADIOIODINATED CLIOQUINOL AS A BIOMARKER FOR β-AMYLOID: Zn2+ complexes in Alzheimer's disease
    Year: 2006
    Journal: Aging Cell
    Volume: 5
    Page numbers: 69-79
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  • Therapeutic treatments for Alzheimer's disease based on metal bioavailability
    Year: 2006
    Volume: 19
    Page numbers: 469-474
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Publications in 2005

Journal Articles

  • Alzheimer disease β-amyloid activity mimics cholesterol oxidase
    Year: 2005
    Journal: Journal of Clinical Investigation
    Volume: 115
    Page numbers: 2556-2563
    Publisher: American Society of Clinical Investigation Inc(Michigan)
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  • Copper-dependent inhibition of human cytochrome c oxidase by a dimeric conformer of amyloid-bΒ1-42
    Year: 2005
    Journal: Journal of Neuroscience
    Volume: 25
    Issue: 3
    Page numbers: 672-679
    Publisher: Society of Neuroscience(Washington DC)
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  • Crystallisation and preliminary crystallographic studies of the copper binding domain of the amyloid recursor protein of Alzheimer's disease
    Year: 2005
    Journal: Acta Crystallographica Section F - Structural Biology and Crystallization Communications
    Volume: F61
    Page numbers: 93-95
    Publisher: Blackwell Publishers(Oxford)
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  • Dopamine promotes α-synuclein aggregation into SDS-resistant soluble oligomers via a distinct folding pathway
    Year: 2005
    Journal: FASEB Journal
    Volume: 10
    Issue: 19
    Page numbers: 1377-1399
    Publisher: Federation of American Societies for Experimental Biology(Maryland)
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  • Methionine regulates copper/hydrogen peroxide oxidation products of Aβ
    Year: 2005
    Journal: Journal of Peptide Science
    Volume: 11
    Page numbers: 353-360
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  • Methylation of the imidazole side chains of the Alzheimer disease amyloid-beta peptide results in abolition of superoxide dismutase-like structures and inhibition of neurotoxicity
    Year: 2005
    Journal: Journal of Biological Chemistry
    Volume: 280
    Page numbers: 13355-13363
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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  • Model studies of cholesterol and ascorbate oxidation by copper complexes: Relevance to Alzheimer's disease beta-amyloid metallochemistry
    Year: 2005
    Journal: Journal of Inorganic Biochemistry
    Volume: 99
    Issue: 12
    Page numbers: 2403-2422
    Publisher: Elsevier Science(New York)
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  • Surface behavior and lipid interaction of Alzheimer β-Amyloid peptide 1-42: A membrane-disrupting peptide
    Year: 2005
    Journal: Biophysical Journal
    Volume: 88
    Page numbers: 2706-2713
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Publications in 2004

Journal Articles

  • A novel effect of bismuth ions
    Year: 2004
    Journal: Journal of Biological Chemistry
    Volume: 279
    Issue: 4
    Page numbers: 2453-2460
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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  • Biological activity and ferric ion binding of fragments of glycine-extended gastrin
    Year: 2004
    Journal: Biochemistry
    Volume: 43
    Issue: 37
    Page numbers: 11853-11861
    Publisher: American Chemical Society(Washington DC)
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  • Characterizing bathocuproine self-association and subsequent binding to Alzheimer's disease amyloid Β-peptide by NMR
    Year: 2004
    Journal: Journal of Peptide Science
    Volume: 10
    Page numbers: 210-217
    Publisher: John Wiley & Sons(West Sussex)
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  • Copper catalysed oxidation of amino acids and Alzheimer's disease
    Year: 2004
    Journal: Letters in Peptide Science
    Volume: 10
    Issue: 5
    Page numbers: 405-412
    Publisher: Kluwer Academic Publishers(Dordrecht)
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  • Enhanced toxicity and cellular binding of a modified amyloid Β peptide with a methionine to valine substitution
    Year: 2004
    Journal: Journal of Biological Chemistry
    Volume: 279
    Page numbers: 42528-42534
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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  • Interaction of the molecular chaperone ΑB-crystallin with Α-synuclein: effects on amyloid fibril formation and chaperone activity
    Year: 2004
    Journal: Journal of Molecular Biology
    Volume: 340
    Page numbers: 1167-1183
    Publisher: Academic Press(London)
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  • Iron inhibits neurotoxicity induced by trace copper and biological reductants
    Year: 2004
    Journal: Journal of Biological Inorganic Chemistry
    Volume: 9
    Page numbers: 269-280
    Publisher: Springer Verlag(New York)
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  • Metal catalyzed oxidation of tyrosine residues by different oxidation systems of copper/hydrogen peroxide
    Year: 2004
    Journal: Journal of Inorganic Biochemistry
    Volume: 98
    Issue: 1
    Page numbers: 173-184
    Publisher: Elsevier Science(New York)
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  • Metal-catalyzed oxidative damage and oligomerization of the amyloid-β peptide of Alzheimer's Disease
    Year: 2004
    Journal: Australian Journal of Chemistry
    Volume: 57
    Page numbers: 511-518
    Publisher: CSIRO Publications(Collingwood)
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  • Metal-protein attenuating compounds (MPACs) for the treatment of Alzheimer's disease
    Year: 2004
    Journal: Drug Design Reviews Online
    Volume: 1
    Page numbers: 75-82
    Publisher: Bentham Science Publishers(Hilversum)
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  • Methionine oxidation: implications for the mechanism of toxicity of the β-amyloid peptide from Alzheimer's disease
    Year: 2004
    Journal: Letters in Peptide Science
    Volume: 10
    Page numbers: 413-417
    Publisher: Kluwer Academic Publishers(Dordrecht)
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  • Neurodegenerative diseases and oxidative stress
    Year: 2004
    Journal: Nature Reviews Drug Discovery
    Volume: 3
    Page numbers: 205-214
    Publisher: Nature Publishing Group(London)
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  • Tyrosine gated electron transfer is key to the toxic mechanism of Alzheimer's disease Β-amyloid
    Year: 2004
    Journal: FASEB Journal
    Volume: 18
    Page numbers: 1427-1429
    Publisher: Federation of American Societies for Experimental Biology(Maryland)
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Publications in 2003

Book Chapters

  • Modulation of Alzheimer's Disease Aβ pathways for rational therapeutic intervention: secretase inhibition and metalloprotein active compounds.
    Year: 2003
    Book: Alzheimer's disease and related disorders: research advances
    Authors(s):

Journal Articles

  • Aβ metallobiology and the development of novel metal-compounds (MPACs) for Alzheimer's disease
    Year: 2003
    Journal: Current Medicinal Chemistry
    Volume: 3
    Issue: 4
    Page numbers: 309-315
    Publisher: Bentham Science Publishers(Hilversum)
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  • Copper modulation of ion channels of PrP[106-126] mutant prion peptide fragments
    Year: 2003
    Journal: Journal of Membrane Biology
    Volume: 193
    Issue: 1
    Page numbers: 35-45
    Publisher: Springer-Verlag, Journals(New York)
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  • Cu2+-induced modification of the kinetics of Aβ(1-42) channels
    Year: 2003
    Journal: American Journal of Physiology - Cell Physiology
    Volume: 285
    Page numbers: C873-C880
    Publisher: American Physiological Society(Maryland)
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  • Magnetic resonance studies of β-Amyloid peptides
    Year: 2003
    Journal: Australian Journal of Chemistry
    Volume: 56
    Page numbers: 349-356
    Publisher: CSIRO Publications(Collingwood)
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  • Metal ions, pH, and cholesterol regulate the interactions of Alzheimer's disease amyloid-β peptide with membrane lipid
    Year: 2003
    Journal: Journal of Biological Chemistry
    Volume: 278
    Issue: 5
    Page numbers: 2977-2982
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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  • Neurotoxic, redox-competent Alzheimer's β-amyloid is released from lipid membrane by methionine oxidation
    Year: 2003
    Journal: Journal of Biological Chemistry
    Volume: 278
    Issue: 44
    Page numbers: 42959-42965
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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  • Structure of the Alzheimer's disease amyloid precursor protein copper binding domain
    Year: 2003
    Journal: Journal of Biological Chemistry
    Volume: 278
    Issue: 19
    Page numbers: 17401-17407
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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Publications in 2002

Journal Articles

  • Ferric ions are essential for the biological activity of the hormone glycine-extended gastrin
    Year: 2002
    Journal: Journal of Biological Chemistry
    Volume: 277
    Page numbers: 48602-48609
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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  • Structure of a novel P-superfamily spasmodic conotoxin reveals an inhibitory cystine knot motif
    Year: 2002
    Journal: Journal of Biological Chemistry
    Volume: 277
    Page numbers: 43033-43040
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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Publications in 2001

Journal Articles

  • Copper and zinc binding modulates the aggregation and neurotoxic properties of the prion peptide PrP106-126
    Year: 2001
    Journal: Biochemistry
    Volume: 40
    Page numbers: 8073-8084
    Publisher: American Chemical Society(Washington DC)
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  • Treatment with a copper-zinc chelator markedly and rapidly inhibits [beta]-amyloid accumulation in Alzheimer's disease transgenic mice
    Year: 2001
    Journal: Neuron
    Volume: 30
    Page numbers: 665-676
    Publisher: Cell Press(Massachusetts)
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