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DR ELIZABETH SCARR



Contact Details

Organization: Medicine, Dentistry and Health Sciences
Position: ROYCE ABBEY ROTARY RESEARCH FELLOW
Email:
Homepage: http://www.cns.unimelb.edu.au/research/schizophrenia/
Work: 9389 2990
Fax: 9387 5061
Room: 310
Level: 03
Building: Alan Gilbert Building
Campus: Parkville

Biography

Elizabeth graduated with a BSc. honours in Pharmacology from Sunderland University and went to the University of Saskatchewan where she studied Neuropsychopharmacology. Having been awarded a PhD she spent a year in Dunedin, New Zealand working on the rat hypoxic/ischaemic model. In 1996 she moved to Melbourne, joining the Rebecca L. Cooper Research Laboratories at the Mental Health Research Institute, where she started working with human post-mortem tissue. Dr Scarr is currently the Royce Abbey Postdoctoral Fellow, funded by the Australian Rotary Health Research Fund at the Centre for Neuroscience. She continues to work towards understanding the chemical changes associated with psychiatric disorders, in particular schizophrenia and bipolar disorder in the Rebecca L. Cooper Research Laboratories.

Research Expertise and International Linkages

Research Expertise

Research Interest Key Words Country of Expertise
Psychiatric disorders Schizophrenia, Bipolar Disorder, Neurochemistry, Post-mortem Australia

International Linkages

Country Establishment Collaboration
United States University of Michigan Research
Israel Ben-Gurion University of The Negev Research
United States The Scripps Research Institute Research
United States University of Alabama at Birmingham Research

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Bachelor of Science (Honours) Pharmacology University of Sunderland 27-Jun-1989
PhD Neuropsychopharmacology University of Saskatchewan 28-Oct-1995

Memberships

Membership Type Membership Body Description Start Date End Date
Member Australian Society for Psychiatric Research General 18-Oct-2006
Member Australian Neuroscience Society General 02-Feb-1997
Member Society for Neuroscience General 19-May-2003
Member Australian Society for Medical Research General 01-Jul-2000 01-Jul-2007
Member Collegium Interationale Neuropsychopharmacologicum General 31-Dec-2004

Other Awards

Award Type Awarding Body Comments Date Awarded
Other (Award) International Congress on Schizophrenia Research 16-Dec-1998
Other (Award) Collegium Internationale Neuro-Psychopharmacologium 14-Jul-2000
Other (Award) Finkel Foundation 11-Nov-2003

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
MUSCARINIC M1 RECEPTOR, COGNITION AND SCHIZOPHREMIA Chief Investigator NHMRC Project Grants 01/01/2005
Royce Abbey Postdoctoral Fellowship Chief Investigator AUST ROTARY HEALTH RESEARCH FUND Mental Illness Research Royce Abbey Postdoctoral Fellowship 01/01/2008
Studies on the mechanisms by which muscarinic receptors might cause schizophrenia Chief Investigator NHMRC Project Grants 01/01/2008
Defining the pathology of a sub-type of schizophrenia Chief Investigator NHMRC Project Grants 01/01/2009

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2009

Journal Articles

  • Clozapine reverses schizophrenia-related behaviors in the metabotropic glutamate receptor 5 knockout mouse: association with N-methyl-D-aspartic acid receptor upregulation
    Year: 2009
    Journal: International Journal of Neuropsychopharmacology
    Volume: 12
    Page numbers: 45-60
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  • Recent advances in post-mortem pathology and neurochemistry in schizophrenia.
    Year: 2009
    Journal: Current Opinion in Psychiatry
    Volume: 22
    Page numbers: 154-160
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  • The role of the cholinergic system in the pathology and treatment of schizophrenia.
    Year: 2009
    Journal: Expert Review of Neurotherapeutics
    Volume: 9
    Page numbers: 73-86
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Publications in 2008

Journal Articles

  • Evidence for altered post-receptor modulation of the serotonin 2a receptor in schizophrenia


    Year: 2008
    Journal: Schizophrenia Research
    Volume: 104
    Page numbers: 185-197
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  • Levels of [3H]pirenzepine binding in Brodmann's area 6 from subjects with schizophrenia is not associated with changes in the transcription factor SP1 or BACE1


    Year: 2008
    Journal: Schizophrenia Research
    Volume: 106
    Page numbers: 229-236
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  • Muscarinic receptors: Do they have a role in the pathology and treatment of schizophrenia?


    Year: 2008
    Journal: Journal of Neurochemistry
    Volume: 107
    Page numbers: 1188-1195
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  • Phospholipase C-b1 knockout mice exhibit endophenotypes modeling schizophrenia which are rescued by environmental enrichment and clozapine administration


    Year: 2008
    Volume: 13
    Page numbers: 661-672
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  • Possible involvement of post-dopamine D2 receptor signalling components in the pathophysiology of schizophrenia


    Year: 2008
    Journal: International Journal of Neuropsychopharmacology
    Volume: 11
    Page numbers: 197-205
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  • Role of muscarinic receptors in the activity of N-desmethylclozapine: reversal of hyperactivity in the phospholipase C knockout mouse


    Year: 2008
    Volume: 19
    Page numbers: 543-547
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  • Decreased cortical muscarinic receptors define a subgroup of subjects with schizophrenia
    Year: 2008
    Journal: Molecular Psychiatry
    Volume: 2008
    Page numbers: 1-7
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  • Increased levels of serotonin2A receptors and serotonin transporter in the CNS of neuregulin 1 hypomorphic/mutant mice
    Year: 2008
    Journal: Schizophrenia Research
    Volume: 99
    Page numbers: 341-349
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  • Plasma apolipoprotein E is decreased in schizophrenia spectrum and bipolar disorder
    Year: 2008
    Journal: Psychiatry Research
    Volume: 158
    Page numbers: 75-78
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  • Regulator of G-protein signalling 4 expression is not altered in the prefrontal cortex in schizophrenia
    Year: 2008
    Journal: Australian and New Zealand Journal of Psychiatry
    Volume: 42
    Page numbers: 740-745
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Publications in 2007

Journal Articles

  • Decreased NR1, NR2A, and SAP102 transcript expression in the hippocampus in bipolar disorder


    Year: 2007
    Journal: Brain Research
    Volume: 1127
    Issue: 1
    Page numbers: 108-118
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  • Altered hippocampal muscarinic M4, but not M1, receptor expression from subjects with schizophrenia.
    Year: 2007
    Journal: Biological Psychiatry
    Volume: 61
    Page numbers: 1161-1170
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  • Gene expression profiling in Brodmann’s area 46 from subjects with schizophrenia
    Year: 2007
    Journal: Australian and New Zealand Journal of Psychiatry
    Volume: 41
    Issue: 4
    Page numbers: 308-320
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Publications in 2006

Journal Articles

  • Cortical serotonin7, 1D and 1F receptors: Effects of schizophrenia, suicide and antipsychotic drug treatment


     


    Year: 2006
    Journal: Schizophrenia Research
    Volume: 88
    Page numbers: 265-274
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  • Serotonin 1a receptor and associated G-protein activation in schizophrenia and bipolar disorder


    Year: 2006
    Journal: Psychiatry Research
    Volume: 143
    Issue: 2006
    Page numbers: 111-120
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  • Increased levels of SNAP-25 and synaptophysin in the dorsolateral prefontal cortex in bipolar I disorder
    Year: 2006
    Journal: Bipolar Disorders
    Volume: 8
    Page numbers: 133-143
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  • N-Ethylmaleimide sensitive factor in the cortex of subjects with schizophrenia and bipolar 1 disorder.
    Year: 2006
    Journal: Neuroscience Letters
    Volume: 391
    Issue: 2006
    Page numbers: 112-115
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  • No change in cortical muscarinic M2, M3 receptors or [35S]GTPϒS binding in schizophrenia.
    Year: 2006
    Journal: Life Sciences
    Volume: 78
    Issue: 2006
    Page numbers: 1231-1237
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  • Postmortem brain calcineurin protein levels in schizophrenia patients are not different from controls
    Year: 2006
    Journal: Schizophrenia Research
    Volume: 83
    Page numbers: 173-177
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  • Regionally specific changes in levels of cortical S100β in bipolar 1 disorder but not schizophrenia
    Year: 2006
    Journal: Australian and New Zealand Journal of Psychiatry
    Volume: 40
    Page numbers: 217-224
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  • Reply: Autoradiography of [3H]aspartate and Glutamate Transport in Schizophrenia.
    Year: 2006
    Journal: Neuropsychopharmacology
    Volume: 31
    Issue: 2006
    Page numbers: 687-688
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Publications in 2005

Journal Articles

  • Changes in hippocampal GABAΑ receptor subunit composition in bipolar 1 disorder
    Year: 2005
    Journal: Molecular Brain Research
    Volume: 138
    Issue: 2005
    Page numbers: 145-155
    Publisher: Elsevier Science(Amsterdam)
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  • Cortical glutamatergic markers in schizophrenia
    Year: 2005
    Journal: Neuropsychopharmacology
    Volume: 30
    Issue: 2005
    Page numbers: 1521-1531
    Publisher: Nature Publishing Group
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  • Differential changes in apolipoprotein E in schizophrenia and bipolar 1 disorder.
    Year: 2005
    Journal: Biological Psychiatry
    Volume: 57
    Issue: 2005
    Page numbers: 711-715
    Publisher: Elsevier Science(New York)
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  • Understanding the pathology of schizophrenia: The impact of high-throughput screening of the genome and proteome in postmortem CNS
    Year: 2005
    Journal: Current Psychiatry Reviews
    Volume: 1
    Issue: 2005
    Page numbers: 1-9
    Publisher: Bentham Science Publishers(Hilversum)
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Publications in 2004

Book Chapters

  • Post mortem brain studies: Understanding the pathology of mood disorders.
    Year: 2004
    Book: Mood Disorders: Recognition and treatment.
    Publisher: University of New South Wales Press(Sydney)
    Authors(s):

Journal Articles

  • Antipsychotic drugs: evolving mechanisms of action with improved therapeutic benefits.
    Year: 2004
    Journal: CNS & Neurological Disorders
    Volume: 3
    Issue: 3
    Page numbers: 217-225
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  • GSK-3 parameters in postmortem frontal cortex and hippocampus of schizophrenic patients.
    Year: 2004
    Journal: Schizophrenia Research
    Volume: 71
    Issue: 2-3
    Page numbers: 377-382
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  • Hippocampal 5-hydroxytryptamine receptors: Abnormalities in postmortem brain from schizophrenic subjects.
    Year: 2004
    Journal: Schizophrenia Research
    Volume: 71
    Issue: 2-3
    Page numbers: 383-392
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  • Measurement of Dopamine D2-like Receptors in Postmortem Caudate-Putamen and Pituitary: Differential Regional Changes in Schizophrenia
    Year: 2004
    Journal: Life Sciences
    Volume: 74
    Issue: 25
    Page numbers: 3115-3131
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Publications in 2003

Journal Articles

  • Decreased hippocampal NMDA, but not kainate or AMPA receptors in bipolar disorder
    Year: 2003
    Journal: Bipolar Disorders
    Volume: 5
    Page numbers: 257-264
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  • Differences in neuroanatomical sites of apoD elevation discriminate between schizophrenia and bipolar disorder
    Year: 2003
    Journal: Molecular Psychiatry
    Volume: 8
    Page numbers: 167-175
    Publisher: Macmillan Publishers(Basingstroke)
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  • Increased levels of apolipoprotein E in the frontal cortex of subjects with schizophrenia
    Year: 2003
    Journal: Biological Psychiatry
    Volume: 24
    Page numbers: 616-622
    Publisher: Elsevier Science(New York)
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  • Muscarinic receptors in schizophrenia
    Year: 2003
    Journal: Current Molecular Medicine
    Volume: 3
    Issue: 5
    Page numbers: 419-426
    Publisher: Bentham Science Publishers(Hilversum)
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  • Studies on serotonergic markers in the human hippocampus: changes in subjects with bipolar disorder
    Year: 2003
    Journal: Journal of Affective Disorders
    Volume: 75
    Issue: 1
    Page numbers: 65-69
    Publisher: Elsevier Science
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Publications in 2002

Journal Articles

  • Decreased density of [3H]TCP binding following antipsychotic drug withdrawal in rats.
    Year: 2002
    Journal: Life Sciences
    Volume: 70
    Issue: 22
    Page numbers: 2699-2705
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  • Decreased muscarinic1 receptors in the dorsolateral prefrontal cortex of subjects with schizophrenia
    Year: 2002
    Journal: Molecular Psychiatry
    Volume: 7
    Page numbers: 1083-1091
    Publisher: Macmillan Publishers(Basingstroke)
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  • Decreased phorbol ester binding in the parahippocampal gyrus from subjects with schizophrenia is not associated with changes in protein kinase C
    Year: 2002
    Journal: Molecular Psychiatry
    Volume: 7
    Page numbers: 683-688
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Publications in 2001

Book Chapters

  • Neurochemical Abnormalities in the Hippocampal Formation with Schizophrenia
    Year: 2001
    Book: Pharmacology and Therapeutics in the New Millennium.
    Publisher: Narosa Publishing House(New Delhi)
    Authors(s):

Journal Articles

  • A proposed pathological model in the hippocampus of subjects with schizophrenia
    Year: 2001
    Journal: Clinical and Experimental Pharmacology and Physiology
    Volume: 28
    Page numbers: 70-73
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  • Extended treatment with typical and atypical antipsychotic drugs: Differential effects on the densities of dopamine D2-like and GABAA receptors in rat striatum.
    Year: 2001
    Journal: Life Sciences
    Volume: 69
    Page numbers: 1257-1268
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  • Studies on [3H]CP-55940 binding in the human central nervous system: regional specific changes in density of cannabinoid-1 receptors associated with schizophrenia and cannabis use
    Year: 2001
    Journal: Neuroscience
    Volume: 103
    Issue: 1
    Page numbers: 9-15
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