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DR MATT PERUGINI



Contact Details

Organization: Biochemistry and Molecular Biology
Position: SENIOR LECTURER
Email:
Homepage: http://www.biochemistry.unimelb.edu.au/research/res_perugini.htm
Work: 8344 5923
Fax: 9347 7730
Room: 308
Level: 03
Building: Biochemistry And Molecular Biology
Campus: Parkville

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Bachelor of Science (honours) University of Melbourne 31-Dec-1994
Doctor of Philosophy University of Melbourne 31-Dec-2002

Memberships

Membership Type Membership Body Description Start Date End Date
Member Australian Society for Biophysics (ASB) 5 year member 01-Sep-2003 01-Sep-2008
Member Australian Society for Biochemistry and Molecular Biology (ASBMB) 1 year member 01-May-2005 01-May-2006

Other Awards

Award Type Awarding Body Comments Date Awarded
Other (Award) Australian Society for Biophysics Young Biophysicist Award (YBA) 02-Oct-2004
Other (Award) Australian Research Council (ARC) Australian Postdoctoral Fellowship (APD) 01-Jan-2005

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
AUTOCLAVES (2) 2004 NHMRC EQUIPMENT GRANT ALLOCATION Chief Investigator NHMRC Equipment Grants 01/01/2005
The ApoE interactome in human plasma Chief Investigator AUST RESEARCH COUNCIL Discovery Projects 01/01/2005
HIGH-SPEED ULTRACENTRIFUGE FACILITY WITH SENSITIVE SCANNING OPTICS FOR THE ANALYSIS OF INTERACTING BIOMOLECULES Chief Investigator AUST RESEARCH COUNCIL Linkage Infrastructure (Equipment and Facilities) 01/01/2005
Apolipoprotein-Protein Interactions in Amyloidosis and Atherosclerosis Principal Supervisor NATIONAL HEART FOUNDATION National Heart Foundation Postgraduate Biomedical Research Scholarship 20/01/2005
Dissociation of a Tetrameric Enzyme with Interface-Targeted Peptides Chief Investigator AUST RESEARCH COUNCIL Discovery Projects 01/01/2007
INHIBITORS OF MESO-DAP AND LYSINE BIOSYNTHESIS: TARGETING DHDP SYNTHASE Chief Investigator AUST RESEARCH COUNCIL Linkage International Awards 01/01/2007
THREE MODES OF INHIBITING A TETRAMERIC ANTIBIOTIC TARGET FROM BACILLIUS ANTHRACIS Chief Investigator US ARMY RESEARCH OFFICE Project Grants 15/03/2007
Molecular evolution of a model oligomeric enzyme from bacterial extremophiles Chief Investigator AUST RESEARCH COUNCIL Future Fellowships 09/09/2009

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2009

Journal Articles

  • Antigen Ligation Triggers a Conformational Change within the Constant Domain of the αβ T Cell Receptor


    Year: 2009
    Journal: Immunity
    Volume: 30
    Issue: 6
    Page numbers: 777-88
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  • Specificity versus catalytic potency: The role of threonine 44 in Escherichia coli dihydrodipicolinate synthase mediated catalysis.
    Year: 2009
    Journal: Biochimie
    Volume: 91
    Issue: 8
    Page numbers: 1036-44
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  • Specificity versus catalytic potency: The role of threonine 44 in Escherichia coli dihydrodipicolinate synthase mediated catalysis.
    Year: 2009
    Journal: Biochimie
    Volume: 91
    Issue: 8
    Page numbers: 1036-44
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Publications in 2008

Journal Articles

Publications in 2007

Journal Articles

Publications in 2006

Journal Articles

Publications in 2005

Journal Articles

  • CED-4 forms a 2:2 heterotetramieric complex with CED-9 until specifically displaced by EGL-1 or CED-13
    Year: 2005
    Journal: Cell Death & Differentiation
    Volume: 10.1038
    Page numbers: 1-9
    Publisher: Nature Publishing Group(Basingstroke)
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  • Fluorescence and analytical ultracentrifugation analyses of the interaction of the tyrosine kinase inhibitor, tyrphostin AG1478-mesylate, with albumin
    Year: 2005
    Journal: Analytical Biochemistry
    Volume: 342
    Issue: 2
    Page numbers: 292-299
    Publisher: Academic Press - Elsevier Science(San Diego)
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  • Insight into the self-association of key enzymes from pathogenic species
    Year: 2005
    Journal: European Biophysics Journal with Biophysics Letters
    Volume: 34
    Issue: 5
    Page numbers: 469-476
    Publisher: Springer Verlag(New York)
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  • The 2.1A Crystal Structure of the Far-red Fluorescent Protein HcRed: Inherent Conformational Flexibility of the Chromophore
    Year: 2005
    Journal: Journal of Molecular Biology
    Volume: 349
    Issue: 1
    Page numbers: 223-227
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  • The trans-Golgi network GRIP-domain proteins form alpha-helical homodimers
    Year: 2005
    Journal: Biochemical Journal
    Volume: 388
    Issue: 3
    Page numbers: 835-841
    Publisher: Portland Press(London)
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Publications in 2004

Journal Articles

  • A biophysical analysis of the TPR-rich mitochondrial import receptor, Tom70, reveals an elongated monomer that is inherently flexible, unstable and unfolds via a multi-state pathway
    Year: 2004
    Journal: Journal of Biological Chemistry
    Volume: 279
    Issue: 45
    Page numbers: 46448-46454
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  • Non-fibrillar components of amyloid deposits mediate the self-association and tangling of amyloid fibrils
    Year: 2004
    Journal: Journal of Biological Chemistry
    Volume: 279
    Issue: 20
    Page numbers: 21038-21045
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  • Properties of GDP-mannose Pyrophosphorylase, a Critical Enzyme and Drug Target in Leishmania mexicana
    Year: 2004
    Journal: Journal of Biological Chemistry
    Volume: 279
    Issue: 13
    Page numbers: 12462-12468
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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  • Structural features of apolipoprotein B synthetic peptides that inhibit lipoprotein(a) assembly
    Year: 2004
    Journal: Journal of Lipid Research
    Volume: 45
    Page numbers: 2227-2234
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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Publications in 2003

Journal Articles

  • A Synthetic Peptide that Inhibits Lipoprotein(a) Assembly
    Year: 2003
    Journal: Arteriosclerosis Thrombosis and Vascular Biology
    Volume: 23
    Page numbers: 502
    Publisher: Lippincott Williams & Wilkins(Pennsylvania)
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  • The crystal structure of myelin oligodendrocyte glycoprotein, a key autoantigen in multiple sclerosis
    Year: 2003
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 100
    Issue: 19
    Page numbers: 11059-11064
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Publications in 2002

Journal Articles

  • Differences in the binding capacity of human apolipoprotein E3 and E4 to size-fractional lipid emulsions
    Year: 2002
    Journal: European Journal of Biochemistry
    Volume: 369
    Page numbers: 1-11
    Publisher: Blackwell Science(Oxford)
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  • Size-Distribution Analysis of Proteins by Analytical Ultracentrifugation: Strategies and Application to Model Systems
    Year: 2002
    Journal: Biophysical Journal
    Volume: 82(2)
    Page numbers: 1096-1111
    Publisher: Biophysical Society(Maryland)
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Publications in 2001

Journal Articles

  • Copper and zinc binding modulates the aggregation and neurotoxic properties of the prion peptide PrP106-126
    Year: 2001
    Journal: Biochemistry
    Volume: 40
    Page numbers: 8073-8084
    Publisher: American Chemical Society(Washington DC)
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