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DR STUART RALPH



Contact Details

Organization: Biochemistry and Molecular Biology
Position: ARC FUTURE FELLOWSHIP
Email:
Homepage: http://www.biochemistry.unimelb.edu.au/research/res_ralph.html
Room: 303
Level: 03
Building: David Pennington Building
Campus: Parkville

Research Expertise and International Linkages

Research Expertise

Research Interest Key Words Country of Expertise
Malaria parasites drug targets, plasmodium Australia

International Linkages

Country Establishment Collaboration
United States University of Pennsylvania Research, Teaching, Technical Assistance/Training
United States University of Washington Research, Technical Assistance/Training
India Central Drug Research Institute Research, Technical Assistance/Training

Languages

Languages

Language Proficiency
French Speak, Read & Write

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Doctor of Philosophy University of Melbourne 31-Dec-2003
Bachelor of Science University of Melbourne 31-Dec-1997

Memberships

Membership Type Membership Body Description Start Date End Date
Member Australian Society of Parasitology Member 28-Mar-2009

Fellowships

Fellowship Date Awarded
C.J. Martin Research Fellowship (National Health & Medical Research Council, Australia) (CJMARTIN) 01-Jan-2003

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
Chromatin barriers in Plasmodium falciparum gene regulation Chief Investigator AUST RESEARCH COUNCIL Discovery Projects 01/01/2008
tRNA synthetases as drug targets in Plasmodium falciparum Chief Investigator AUST RESEARCH COUNCIL Future Fellowships 01/01/2009
CURATION OF PARASITIC HELMINTH DRUG TARGET DATA AS PART OF THE TDRTARGETS.ORG PROJECT Chief Investigator THE WELLCOME TRUST SANGER INSTITUTE Collaborative Research Project (WORLD HEALTH ORGANIZATION) 15/06/2009
Drug targets in the malaria parasite Chief Investigator NHMRC Career Development Awards 29/10/2009
Understanding protein translation in the malaria parasite Chief Investigator NHMRC Project Grants 01/01/2010
DISSECTING THE MOLECULAR BASIS OF THE MALARIA PARASITE-ERYTHROCYTE TIGHT JUNCTION COMPLEX Chief Investigator WALTER & ELIZA HALL INSTITUTE OF MEDICAL RESEARCH Project Grants (NHMRC) 01/01/2010
TARGETING PROTEIN SYNTHESIS IN THE APICOPLAST AND CYTOPLASM OF PLASMODIUM Chief Investigator NHMRC European Union Health Collaborative Research Grants 01/01/2010
Metabolomic analysis of malaria and antimalarial drugs Chief Investigator NHMRC Project Grants 01/01/2011
Unlocking malaria invasion by ultraresolution microscopy Chief Investigator AUST RESEARCH COUNCIL Discovery Projects 01/01/2012
TARGETING PROTEIN SYNTHESIS IN THE APICOPLAST & CYTOPLAMS OF PLASMODIUM (MEPHITIS) Chief Investigator IRB BARCELONA 7th Framework Programme (EUROPEAN COMMISSION)
EPIGENETIC CONTROL OF ANTIGENETIC VARIATION IN PLASMODIUM FALCIPARUM Chief Investigator MACFARLANE BURNET INSTITUTE FOR MEDICAL RESEARCH AND PUBLIC HEALTH LTD Project Grants (NHMRC)

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2011

Journal Articles

  • A Genome-wide Chromatin-associated Nuclear Peroxiredoxin from the Malaria Parasite Plasmodium falciparum


    Year: 2011
    Journal: Journal of Biological Chemistry
    Volume: 286
    Issue: 13
    Page numbers: 11746-11755
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  • An EGF-like Protein Forms a Complex with PfRh5 and Is Required for Invasion of Human Erythrocytes by Plasmodium falciparum
    Year: 2011
    Journal: PLoS Pathogens
    Volume: 7
    Issue: 9
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  • An EGF-like protein forms a complex with PfRh5 and is required for invasion of human erythrocytes by Plasmodium falciparum.
    Year: 2011
    Journal: PLoS Pathogens
    Volume: 7
    Issue: 9
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  • Expression of P. falciparum var Genes Involves Exchange of the Histone Variant H2A.Z at the Promoter
    Year: 2011
    Journal: PLoS Pathogens
    Volume: 7
    Issue: 2
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  • Interaction of apicoplast-encoded elongation factor (EF) EF-Tu with nuclear-encoded EF-Ts mediates translation in the Plasmodium falciparum plastid
    Year: 2011
    Journal: International Journal for Parasitology
    Volume: 41
    Issue: 3-4
    Page numbers: 417-427
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  • Plasmodium falciparum Merozoite Invasion Is Inhibited by Antibodies that Target the PfRh2a and b Binding Domains
    Year: 2011
    Journal: PLoS Pathogens
    Volume: 7
    Issue: 6
    Article number: e1002075
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  • Protein translation in Plasmodium parasites.
    Year: 2011
    Journal: Trends in Parasitology
    Volume: 467-476
    Page numbers: 467-476
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  • Super-Resolution Dissection of Coordinated Events during Malaria Parasite Invasion of the Human Erythrocyte
    Year: 2011
    Journal: Cell Host & Microbe
    Volume: 9
    Issue: 1
    Page numbers: 9-20
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Conference Publications/Papers

  • An integrative bioinformatic predictor of protein sub-cellular localisation in malaria
    Year: 2011
    Event name: Seventh International Society for Computational Biology Student Council Symposium 2011
    Conference Publication: BMC Bioinformatics
    Volume: 12
    Issue: Suppl 11
    Publisher: Biomed Central(London)
    Author(s):

Publications in 2010

Journal Articles


  • Potential epigenetic regulatory proteins localise to distinct nuclear sub-compartments in Plasmodium falciparum
    Year: 2010
    Journal: International Journal for Parasitology
    Volume: 40
    Issue: 1
    Page numbers: 109-121
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  • Identification of Attractive Drug Targets in Neglected-Disease Pathogens Using an In Silico Approach


    Year: 2010
    Journal: PLoS Neglected Tropical Diseases
    Volume: 4
    Issue: 8
    Page numbers: e804-e804
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  • AMPK beta subunits display isoform specific affinities for carbohydrates
    Year: 2010
    Journal: FEBS Letters
    Volume: 584
    Issue: 15
    Page numbers: 3499-3503
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  • Drug target prediction and prioritization: using orthology to predict essentiality in parasite genomes
    Year: 2010
    Journal: BMC Genomics
    Volume: 11
    Article number: 222
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  • Interaction between Plasmodium falciparum Apical Membrane Antigen 1 and the Rhoptry Neck Protein Complex Defines a Key Step in the Erythrocyte Invasion Process of Malaria Parasites
    Year: 2010
    Journal: Journal of Biological Chemistry
    Volume: 285
    Issue: 19
    Page numbers: 14815-14822
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  • Isolation of viable Plasmodium falciparum merozoites to define erythrocyte invasion events and advance vaccine and drug development
    Year: 2010
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 107
    Issue: 32
    Page numbers: 14378-14383
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  • Massively parallel sequencing and analysis of the Necator americanus transcriptome
    Year: 2010
    Journal: PLoS Neglected Tropical Diseases
    Volume: 4
    Issue: 5
    Article number: e684
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  • Novel vacuoles in Toxoplasma
    Year: 2010
    Journal: Molecular Microbiology
    Volume: 76
    Issue: 6
    Page numbers: 1335-1339
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Publications in 2009

Book Chapters

  • Glycosylated compounds of parasitic protozoa
    Year: 2009
    Book: Microbial Glycobiology
    Publisher: Academic Press
    Authors(s):

Journal Articles

  • Theileria Apicoplast as a Target for Chemotherapy
    Year: 2009
    Journal: Antimicrobial Agents and Chemotherapy
    Volume: 53
    Issue: 3
    Page numbers: 1213-1217
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  • Plasmodium falciparum heterochromatin protein 1 marks genomic loci linked to phenotypic variation of exported virulence factors.
    Year: 2009
    Journal: PLoS Pathogens
    Volume: 5
    Issue: 9
    Article number: e1000569
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  • REX1 and Pf62: are they one and the same?
    Year: 2009
    Journal: Parasitology Research
    Volume: 104
    Issue: 5
    Page numbers: 967-8
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  • Reticulocyte-binding protein homologue 5 – An essential adhesin involved in invasion of human erythrocytes by Plasmodium falciparum
    Year: 2009
    Journal: International Journal for Parasitology
    Volume: 39
    Issue: 3
    Page numbers: 371-80
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  • Sir2 paralogues co-operate to regulate virulence genes and antigenic variation in Plasmodium falciparum
    Year: 2009
    Journal: PLoS Biology
    Volume: 7
    Issue: 4
    Article number: e84
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Publications in 2008

Journal Articles

  • Comparative genomics of the neglected human malaria parasite Plasmodium vivax
    Year: 2008
    Journal: Nature
    Volume: 455
    Issue: 9 October
    Page numbers: 757-763
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  • Evolution of malaria parasite plastid targeting sequences
    Year: 2008
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 105
    Issue: 12
    Page numbers: 4781-4785
    Author(s):
    URL - restricted access http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=18353992
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  • Genomic-scale prioritization of drug targets: the TDR Targets database
    Year: 2008
    Journal: Nature Reviews Drug Discovery
    Volume: 7
    Issue: 11
    Page numbers: 900-907
    Author(s):
    URL - restricted access http://www.nature.com/nrd/journal/v7/n11/abs/nrd2684.html
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  • Genomic-scale prioritization of drug targets: the TDR Targets database
    Year: 2008
    Journal: Nature Reviews Drug Discovery
    Volume: 7
    Issue: 11
    Page numbers: 900-907
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Publications in 2005

Journal Articles

Publications in 2003

Journal Articles

  • A Type II Pathway for Fatty Acid Biosynthesis Presents Drug Targets in Plasmodium falciparum
    Year: 2003
    Journal: Antimicrobial Agents and Chemotherapy
    Volume: 47
    Page numbers: 297-301
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  • Dissecting the apicoplast targeting in the malaria parasite Plasmodium falciparum
    Year: 2003
    Journal: Science
    Volume: 299
    Page numbers: 705-708
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  • Dynamin: the endosymbiosis ring of power?
    Year: 2003
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 100
    Issue: 7
    Page numbers: 3557-3559
    Publisher: National Academy of Sciences(Washington DC)
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  • Phenotypic variation of Plasmodium falciparum merozoite proteins directs receptor targeting for invasion of human erythrocytes
    Year: 2003
    Journal: EMBO Journal
    Volume: 22
    Issue: 5
    Page numbers: 1047-1057
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  • Properties and prediction of mitochondrial transit peptides from Plasmodium falciparum
    Year: 2003
    Journal: Molecular and Biochemical Parasitology
    Volume: 132
    Page numbers: 59-66
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Publications in 2002

Journal Articles

  • Genome sequence of the human malaria parasite Plasmodium falciparum
    Year: 2002
    Journal: Nature
    Volume: 419
    Page numbers: 498-511
    Publisher: Macmillan Publishers(London)
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  • Independent Translocation of Two Micronemal Proteins in Developing Plasmodium falciparum Merozoites
    Year: 2002
    Journal: Infection and Immunity
    Volume: 70
    Issue: 10
    Page numbers: 5751-5758
    Publisher: American Society for Microbiology(Washington DC)
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Publications in 2001

Journal Articles

  • Deciphering apicoplast targeting signals - feature extraction from nuclear-encoded precursors of Plasmondium falciparum apicoplast proteins
    Year: 2001
    Journal: Gene
    Volume: 280
    Page numbers: 19-26
    Publisher: Elsevier Science(Amsterdam)
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  • The apicoplast as an antimalarial drug target
    Year: 2001
    Journal: Drug Resistance Update
    Volume: 4
    Page numbers: 145-151
    Publisher: Churchill Livingstone(Leith Walkedinburgh)
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  • Trafficking and assembly of the cytoadherence complex in Plasmodium falciparum-infected human erythrocytes
    Year: 2001
    Journal: EMBO Journal
    Volume: 20
    Issue: 20
    Page numbers: 5636-5649
    Publisher: Oxford University Press(Oxford)
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