University home page

Find an ExpertProfiling the University of Melbourne's Researchers

A/PROF ANDREW HILL



Contact Details

Organization: Biochemistry and Molecular Biology
Position: PRINCIPAL RESEARCH FELLOW
Email:
Homepage: http://www.biochemistry.unimelb.edu.au/research/res_hill.html
Work: 83442308
Fax: 93481421
Room: 231
Level: 02
Building: David Pennington Building
Campus: Parkville

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Bachelor of Science - Honours Victoria University of Wellington 31-Dec-1992
Doctor of Philosophy Imperial College of Science Technology and Medicine 31-Dec-1998
Diploma of Imperial College Imperial College of Science Technology and Medicine
Bachelor of Science Victoria University of Wellington 31-Dec-1991

Memberships

Membership Type Membership Body Description Start Date End Date
Member ASBMB Ordinary Member 01-Jan-2003
Member International Society for Neurochemistry Ordinary Member 01-Jan-2005
Member Society for Neuroscience Ordinary Member 01-Jan-2006

Other Awards

Award Type Awarding Body Comments Date Awarded
Prize Young Tall Poppy Award 06-Dec-2006
Prize ASBMB / Applied Biosystems Edman Award 28-Sep-2005

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
NEURODEGENERATIVE DISEASES OF THE AGING BRAIN: DIAGNOSIS & THERAPY BASED ON THE STUDY OF AGGREAGATED PROTEIN DEPOSITIONS Chief Investigator NHMRC Program Grants 01/01/2002
Investigation into the pathogenesis of prion diseases Chief Investigator NHMRC Clinical Career Development Award 01/01/2003
AUTOCLAVES (2) 2004 NHMRC EQUIPMENT GRANT ALLOCATION Chief Investigator NHMRC Equipment Grants 01/01/2005
How do glycosaminoglycans promote the propagation of prions? Chief Investigator NHMRC Project Grants 01/01/2006
BIOPHYSICAL PROPERTIES OF PEPTIDES REPRESENTING ENDOGENOUS PROCESSING OF HUMAN PRION PROTEIN Chief Investigator BETHLEHEM GRIFFITHS RESEARCH FOUNDATION Medical Research Grants 01/01/2007
The Role of Exosomes in Genetic Signalling Mechanisms and the Implications in Alzheimer's Disease Pathogenesis Chief Investigator ALZHEIMER'S AUST RESEARCH LTD Dementia Research Grants 14/09/2007
Identifying key steps in the processing of proteins involved in Alzheimer's and Prion diseases Chief Investigator NHMRC Career Development Awards 01/01/2008
The molecular evolution of cephalopod venoms. Chief Investigator HERMON SLADE FOUNDATION Grants 15/05/2008
Investigating exosomes as novel secretory carriers of APP and Abeta Chief Investigator ALZHEIMER'S ASSOC USA New Investigator Research Grants 01/08/2008
REAL-TIME CELLULAR IMAGING OF KEY EVENTS IN THE TRAFFICKING AND PROCESSING OF THE ALZHEIMER'S DISEASE AMYLOID PRECURSOR PROTEIN Chief Investigator ANZ CHARITABLE TRUSTS Judith Jane Mason & Harold Stannett Williams Memorial Foundation 29/09/2008
Role of the GxxxG domain in the function of mammalian prion proteins Chief Investigator AUST RESEARCH COUNCIL Discovery Projects 01/01/2009

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2009

Journal Articles

Publications in 2008

Books

  • Prion Protein Protocols
    Year: 2008
    Publisher: Humana Press(New Jersey)
    Authors(s):

Book Chapters

  • Generation of Cell Lines Propagating Infectious Prions and the Isolation and Characterization of Cell-derived Exosomes


    Year: 2008
    Book: Prion Protein Protocol
    Publisher: Humana Press
    Authors(s):
  • Analysis of PrP Conformation Using Circular Dichroism
    Year: 2008
    Book: Prion Protein Protocols
    Publisher: Humana Press(New Jersey)
    Authors(s):
  • Molecular typing of PrPres in human sporadic CJD brain tissue
    Year: 2008
    Book: Prion Protein Protocols
    Publisher: Humana Press(New Jersey)
    Authors(s):

Journal Articles

  • Activation of epidermal growth factor receptor by metal-ligand complexes decreases levels of extracellular amyloid beta peptide


    Year: 2008
    Journal: International Journal of Biochemistry and Cell Biology
    Volume: 40
    Issue: 9
    Page numbers: 1901-1917
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Inhibition of γ-secretase causes increased secretion of amyloid precursor C-terminal fragments in association with exosomes


    Year: 2008
    Journal: FASEB Journal
    Volume: 22
    Issue: 5
    Page numbers: 1469-1478
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Inhibition of gamma-secretase causes increased secretion of amyloid precursor protein C-terminal fragments in association with exosomes


    Year: 2008
    Journal: FASEB Journal
    Volume: 22
    Issue: 5
    Page numbers: 1469-1478
    Author(s):
    URL - restricted access http://www.fasebj.org/cgi/content/abstract/22/5/1469
    Super Search Source this item in the University's Catalouge locate this resource.
  • Is Covalently Crosslinked Aβ Responsible for Synaptotoxicity in Alzheimer’s Disease?


    Year: 2008
    Journal: Current Alzheimer Research
    Volume: 5
    Issue: 6
    Page numbers: 533-539
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Kuru prions and sporadic Creutzfeldt-Jakob disease prions have equivalent transmission properties in transgenic and wild-type mice


    Year: 2008
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 105
    Issue: 10
    Page numbers: 3885-3890
    Author(s):
    URL - restricted access http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=18316717
    Super Search Source this item in the University's Catalouge locate this resource.
  • Mouse-adapted sporadic human Creutzfeldt-Jakob disease prions propagate in cell culture


    Year: 2008
    Journal: International Journal of Biochemistry and Cell Biology
    Volume: 40
    Issue: 12
    Page numbers: 2793-2801
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • A cell line infectible by prion strains from different species
    Year: 2008
    Journal: Journal of General Virology
    Volume: 89
    Issue: 1
    Page numbers: 341-347
    Author(s):
    URL - restricted access http://vir.sgmjournals.org/cgi/content/abstract/89/1/341
    Super Search Source this item in the University's Catalouge locate this resource.
  • ATP-binding cassette transporter A7 regulates processing of amyloid precursor protein in vitro
    Year: 2008
    Journal: Journal of Neurochemistry
    Volume: 106
    Issue: 2
    Page numbers: 793-804
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Enrichment of prion protein in exosomes derived from ovine cerebral spinal fluid
    Year: 2008
    Journal: Veterinary Immunology and Immunopathology
    Volume: 124
    Issue: 3-4
    Page numbers: 385-393
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Evidence for prion protein expression in enteroglial cells of the myenteric plexus of mouse intestine
    Year: 2008
    Journal: Autonomic Neuroscience - Basic & Clinical
    Volume: 140
    Page numbers: 17-23
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Formation of a High Affinity Lipid-Binding Intermediate during the Early Aggregation Phase of α-Synuclein
    Year: 2008
    Journal: Biochemistry
    Volume: 47
    Issue: 5
    Page numbers: 1425-1434
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Is covalently crosslinked Abeta responsible for synaptotoxicity in Alzheimer's disease
    Year: 2008
    Journal: Current Alzheimer Research
    Volume: 5
    Issue: 6
    Page numbers: 533-539
    Author(s):
    URL - restricted access http://www.benthamdirect.org/pages/content.php?CAR/2008/00000005/00000006/005AT.SGM
    Super Search Source this item in the University's Catalouge locate this resource.
  • Neurotoxicity in Alzheimer's disease: is covalently crosslinked A beta responsible
    Year: 2008
    Journal: European Biophysics Journal with Biophysics Letters
    Volume: 37
    Issue: 3
    Page numbers: 265-268
    Author(s):
    URL - restricted access http://www.springerlink.com/content/3w664m6qum269667/
    Super Search Source this item in the University's Catalouge locate this resource.
  • Selective intracellular release of copper and zinc ions from bis(thiosemicarbazonato) complexes reduces levels of Alzheimer disease amyloid-beta peptide
    Year: 2008
    Journal: Journal of Biological Chemistry
    Volume: 283
    Issue: 8
    Page numbers: 4568-4577
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.

Publications in 2007

Journal Articles

  • Packaging of prions into exosomes is associated with a novel pathway of PrP processing.


    Year: 2007
    Journal: Journal of Pathology
    Volume: 211
    Issue: 5
    Page numbers: 582-590
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Differential modulation of Alzheimer's disease amyloid beta peptide accumulation by diverse classes of metal ligands.
    Year: 2007
    Journal: Biochemical Journal
    Volume: 407
    Issue: 3
    Page numbers: 435-450
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Neurotoxic species in prion disease: a role for PrP isoforms
    Year: 2007
    Journal: Journal of Neurochemistry
    Volume: 103
    Issue: 5
    Page numbers: 1709-1720
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Role of ABCG1 and ABCA1 in regulation of neuronal cholesterol efflux to apolipoprotein E discs and suppression of amyloid-beta peptide generation
    Year: 2007
    Journal: Journal of Biological Chemistry
    Volume: 282
    Issue: 5
    Page numbers: 2851-61
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.

Publications in 2006

Journal Articles

  • C-terminal truncation and Parkinson's disease-associated mutations down regulate the protein serine/threonine kinase activity of PTEN-induced kinase-1
    Year: 2006
    Journal: Human Molecular Genetics
    Volume: 15
    Issue: 21
    Page numbers: 3251-3262
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Correlative studies support lipid peroxidation is linked to PrPres propogation as an early primary pathogenic event in prion disease
    Year: 2006
    Journal: Brain Research Bulletin
    Volume: 68
    Page numbers: 346-354
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Degradation of the Alzheimer's disease amyloid beta peptide by metal-dependent up-regulation of metalloprotease activity.
    Year: 2006
    Journal: Journal of Biological Chemistry
    Volume: 281
    Page numbers: 17670-17680
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Delineating common molecular mechanisms in Alzheimer's and prion diseases
    Year: 2006
    Journal: Trends in Biochemical Sciences
    Volume: 31
    Issue: 8
    Page numbers: 465-472
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Distinct glycoform ratios of protease resistant prion protein associated with PRNP point mutations.
    Year: 2006
    Journal: Brain
    Volume: 129
    Issue: 3
    Page numbers: 676-85
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • High density lipoproteins bind Aβ and apolipoprotein C-II amyloid fibrils
    Year: 2006
    Journal: Journal of Lipid Research
    Volume: 47
    Issue: 4
    Page numbers: 755-60
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.

Publications in 2005

Book Chapters

  • Mechanisms of prion toxicity and its relation to prion infectivity
    Year: 2005
    Book: Neurodegeneration and Prion disease
    Publisher: Springer Verlag(New York)
    Authors(s):

Journal Articles

  • Australian sporadic CJD analysis supports endogenous determinants of molecular-clinical profiles
    Year: 2005
    Journal: Neurology
    Volume: 65
    Issue: 1
    Page numbers: 113-118
    Publisher: Lippincott Williams & Wilkins(Pennsylvania)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Detection of prion epitopes on PrPc and PrPsc of transmissible spongiform encephalopathies using specific monoclonal antibodies to PrP
    Year: 2005
    Journal: Immunology and Cell Biology
    Volume: 83
    Issue: 6
    Page numbers: 632-637
    Publisher: Blackwell Science Asia(Carlton)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Dopamine promotes α-synuclein aggregation into SDS-resistant soluble oligomers via a distinct folding pathway
    Year: 2005
    Journal: FASEB Journal
    Volume: 10
    Issue: 19
    Page numbers: 1377-1399
    Publisher: Federation of American Societies for Experimental Biology(Maryland)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Extended period of asymptomatic prion disease after low dose inoculation: Assessment of detection methods and implcations for infection control
    Year: 2005
    Journal: Neurobiology of Disease
    Volume: 20
    Issue: 2
    Page numbers: 336-346
    Publisher: Academic Press(California)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Impaired extracellular secretion of mutant superoxide dismutase 1 associates with neurotoxicity in familial amyotrophic lateral sclerosis
    Year: 2005
    Journal: Journal of Neuroscience
    Volume: 25
    Issue: 1
    Page numbers: 108-117
    Publisher: Society of Neuroscience(Washington DC)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Prion protein glycosylation
    Year: 2005
    Journal: Journal of Neurochemistry
    Volume: 93
    Issue: 4
    Page numbers: 793-801
    Publisher: Blackwell Science(Oxford)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.

Publications in 2004

Journal Articles

  • Human prion protein with valine 129 prevents expression of variant CJD phenotype
    Year: 2004
    Journal: Science
    Volume: 306
    Page numbers: 1793-1796
    Publisher: American Society for the Advancement of Science(Washington DC)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Identification of a new prion strain in cattle - is there more than one form of BSE?
    Year: 2004
    Journal: Australian Veterinary Journal
    Volume: 82
    Issue: 5
    Page numbers: 288-291
    Publisher: Australian Veterinary Association(Brunswick)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Prion strains and species barriers
    Year: 2004
    Journal: Contributions to Microbiology
    Volume: 11
    Page numbers: 33-49
    Publisher: Karger(Basel)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.

Publications in 2003

Journal Articles

  • Molecular and clinical classification of human prion disease.
    Year: 2003
    Journal: British Medical Bulletin
    Volume: 66
    Page numbers: 241-54
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Molecular classification of sporadic Creutzfeldt-Jakob disease
    Year: 2003
    Journal: Brain
    Volume: 126
    Page numbers: 1333-1346
    Publisher: Oxford University Press(Oxford)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Novel prion protein insert mutation associated with prolonged neurodegenerative illness
    Year: 2003
    Journal: Neurology
    Volume: 60
    Page numbers: 1620-1624
    Publisher: Lippincott Williams & Wilkins(Pennsylvania)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Possible link between bovine spongiform encephalopathy and sporadic Creutzfeldt-Jakob disease
    Year: 2003
    Journal: Australian Veterinary Journal
    Volume: 81
    Page numbers: 275-276
    Publisher: Australian Veterinary Association(Brunswick)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Proteasome-mediated degradation of the C-terminus of the Alzheimer's disease β-amyloid protein precursor: effect of C-terminal truncation on production of β-amyloid protein
    Year: 2003
    Journal: Journal of Neuroscience Research
    Volume: 74
    Page numbers: 378-385
    Publisher: Wiley-Liss(New York)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Subclinical prion infection
    Year: 2003
    Journal: Trends in Microbiology
    Volume: 11
    Page numbers: 578-584
    Publisher: Elsevier Science London(London)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Subclinical prion infection in humans and animals
    Year: 2003
    Journal: British Medical Bulletin
    Volume: 66
    Page numbers: 161-170
    Publisher: Oxford University Press
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.

Publications in 2002

Journal Articles

  • BSE prions propagate as either variant CJD-like or sporadic CJD-like prion strains in transgenic mice expressing human prion protein
    Year: 2002
    Journal: EMBO Journal
    Volume: 21
    Page numbers: 6358-6366
    Publisher: Oxford University Press(Oxford)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Creutzfeldt-Jakob disease cluster in an Australian rural city
    Year: 2002
    Journal: Annals of Neurology
    Volume: 52
    Page numbers: 115-118
    Publisher: Wiley-Liss(New York)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Quinacrine does not prolong survival in a murine Creutzfeldt-Jakob disease model
    Year: 2002
    Journal: Annals of Neurology
    Volume: 52
    Page numbers: 503-506
    Publisher: Wiley-Liss(New York)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Species-barrier-independent prion replication in apparently resistant species
    Year: 2002
    Journal: APMIS
    Volume: 110
    Page numbers: 44-53
    Publisher: Blackwell Munksgaard
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.

Publications in 2001

Book Chapters

  • Strain variations and species barriers.
    Year: 2001
    Book: Contributions to Microbiology
    Publisher: Karger(Basel)
    Authors(s):

Journal Articles

  • Sublethal concentrations of prion peptide PrP106-126 or the amyloid beta peptide of Alzheimer's disease activates expression of proapoptotic markers in primary cortical neurons
    Year: 2001
    Journal: Neurobiology of Disease
    Volume: 8
    Page numbers: 299-316
    Publisher: Academic Press(California)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Tissue distribution of protease resistant prion protein in variant CJD using a highly sensitive immuno-blotting assay.
    Year: 2001
    Journal: The Lancet
    Volume: 358
    Page numbers: 171-180
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
top of page