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DR LARS KJER-NIELSEN



Contact Details

Organization: Microbiology and Immunology
Position: RESEARCH OFFICER (NH&MRC)
Email:
Homepage: www.microbiol.unimelb.edu.au/research/groups/mccluskey
Work: 83449914
Fax: 93471540
Room: 09
Level: 05
Building: Microbiology Building
Campus: Parkville

Research Expertise and International Linkages

Research Expertise

Research Interest Key Words Country of Expertise
Structural Immunology MHC; T cell receptors Australia

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Bachelor of Veterinary Science University of Melbourne 14-Dec-1984
Doctor of Philosophy Monash University 30-Apr-1990

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
NKT cell receptors Chief Investigator NHMRC Project Grants 01/01/2009

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2009

Journal Articles

  • Antigen Ligation Triggers a Conformational Change within the Constant Domain of the αβ T Cell Receptor


    Year: 2009
    Journal: Immunity
    Volume: 30
    Issue: 6
    Page numbers: 777-88
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  • Differential Recognition of CD1d-α-Galactosyl Ceramide by the Vβ8.2 Vβ7 Semi-invariant NKT T Cell Receptors
    Year: 2009
    Journal: Immunity
    Volume: 31
    Issue: 1
    Page numbers: 47-59
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  • T Cell Receptor CDR2β and CDR3β Loops Collaborate Functionally to Shape the iNKT Cell Repertoire
    Year: 2009
    Journal: Immunity
    Volume: 31
    Issue: 1
    Page numbers: 60-71
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  • The shaping of T cell receptor recognition by self-tolerance
    Year: 2009
    Journal: Immunity
    Volume: 30
    Issue: 2
    Page numbers: 193-203
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Publications in 2008

Journal Articles

Publications in 2007

Journal Articles

Publications in 2006

Journal Articles

  • Alloreactivity between Disparate Cognate and Allogeneic pMHC-I Complexes Is the Result of Highly Focused, Peptide-dependent Structural Mimicry


    Year: 2006
    Journal: Journal of Biological Chemistry
    Volume: 45
    Page numbers: 34324-34332
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  • A structural basis for selection and cross-species reactivity of the semi-invariant NKT cell receptor in CD1d/glycolipid recognition
    Year: 2006
    Journal: Journal of Experimental Medicine
    Volume: 203
    Issue: 3
    Page numbers: 661-673
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  • Disparate thermodynamics governing T cell receptor–MHC-I interactions implicate extrinsic factors in guiding MHC restriction
    Year: 2006
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 103
    Issue: 17
    Page numbers: 6641-6646
    Author(s):
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  • Structural basis for a major histocompatability complex class 1b-restricted T cell response
    Year: 2006
    Journal: Nature Immunology
    Volume: 7
    Issue: 3
    Page numbers: 256-264
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  • TCRα Genes Direct MHC Restriction in the Potent Human T Cell Response to a Class I-bound Viral Epitope
    Year: 2006
    Journal: Journal of Immunology
    Volume: 177
    Page numbers: 6804-6814
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  • The production, purification and crystallization of a soluble form of the nonclassical MHC HLA-G: the essential role of cobalt.
    Year: 2006
    Journal: Acta Crystallographica Section F - Structural Biology and Crystallization Communications
    Volume: 62
    Issue: 1
    Page numbers: 70-73
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Publications in 2005

Journal Articles

  • Antagonism of Antiviral and Allogeneic Activity of a Human Public CTL Clonotype by a Single Altered Peptide Ligand: Implications for Allograft Rejection1
    Year: 2005
    Journal: Journal of Immunology
    Volume: 174
    Issue: 9
    Page numbers: 5593-5601
    Publisher: American Association of Immunologists(Maryland)
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  • CTL Recognition of a Bulged Viral Peptide Involves Biased TCR Selection1
    Year: 2005
    Journal: Journal of Immunology
    Volume: 175
    Issue: 6
    Page numbers: 3826-3834
    Publisher: American Association of Immunologists(Maryland)
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  • High Resolution Structures of Highly Bulged Viral Epitopes Bound to Major Histocompatibility Complex Class I. Implications for T-cell Receptor Engagement and T-cell Immunodominance
    Year: 2005
    Journal: Journal of Biological Chemistry
    Volume: 280
    Issue: 25
    Page numbers: 23900-23909
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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  • Structural studies on the alphabeta T-cell receptor
    Year: 2005
    Journal: IUBMB Life
    Volume: 57
    Issue: 8
    Page numbers: 575-582
    Publisher: Taylor & Francis Ltd(Pennsylvania)
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  • T cell receptor recognition of a 'super-bulged' major histocompatibility complex class I-bound peptide
    Year: 2005
    Journal: Nature Immunology
    Volume: 6
    Issue: 11
    Page numbers: 1114-1122
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  • The CDR3 regions of an immunodominant T cell receptor dictate the 'energetic landscape' of peptide-MHC recognition
    Year: 2005
    Journal: Nature Immunology
    Volume: 6
    Issue: 2
    Page numbers: 171-180
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  • The immunogenicity of a viral cytotoxic T cell epitope is controlled by its MHC-bound conformation
    Year: 2005
    Journal: Journal of Experimental Medicine
    Volume: 202
    Issue: 9
    Page numbers: 1249-1260
    Publisher: Rockefeller University Press(New York)
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Conference Publications/Papers

  • A Super-Bulged Epitope and Single Amino Acid Polymorphism Identify Critical Features for T Cell Recognition
    Year: 2005
    Event name: 35th ASI - 14th IHIWS
    Conference Publication: Tissue Antigens
    Volume: 66
    Issue: 5
    Page numbers: 571-571
    Publisher: Blackwell Publishing
    Author(s):
  • Recognition of the Non-Classical MHC Class I Molecule, HLA-E, by the Adaptive Immune System
    Year: 2005
    Event name: 35th ASI - 14th IHIWS
    Conference Publication: Tissue Antigens
    Volume: 66
    Issue: 5
    Page numbers: 443-443
    Publisher: Blackwell Publishing
    Author(s):

Publications in 2004

Journal Articles

  • Crystal structure of the human T cell receptor CD3εγ heterodimer complexed to the therapeutic mAB OKT3
    Year: 2004
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 101
    Issue: 20
    Page numbers: 7675-7680
    Publisher: National Academy of Sciences(Washington DC)
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  • Functional and structural characteristics of NY-ESO-1-related HLA A2-restricted epitopes and the design of a novel immunogenic analogue
    Year: 2004
    Journal: Journal of Biological Chemistry
    Volume: 279
    Issue: 22
    Page numbers: 23438-23446
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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  • Identification of a Golgi-localised GRIP domain protein from Arabidopsis thaliana
    Year: 2004
    Journal: Planta
    Volume: 219
    Page numbers: 1050-1056
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  • Natural HLA class I polymorphism controls the pathway of antigen presentation and susceptibility to viral evasion
    Year: 2004
    Journal: Journal of Experimental Medicine
    Volume: 200
    Page numbers: 13-24
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  • The Structure of H-2Kb and Kbm8 Complexed to a Herpes Simplex Virus Determinant: Evidence for a Conformational Switch That Governs T Cell Repertoire Selection and Viral Resistance1,2
    Year: 2004
    Journal: Journal of Immunology
    Volume: 173
    Page numbers: 402-409
    Publisher: American Association of Immunologists(Maryland)
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  • The production and purification of the human T-cell receptors, the CD3εγ and CD3εδ heterodimers: complex formation and crystallization with OKT3, a therapeutic monoclonal antibody
    Year: 2004
    Journal: Acta Crystallographica Section D - Biological Crystallography
    Volume: D60
    Page numbers: 1425-1428
    Publisher: Munksgaard International Publishers(Copenhagen)
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Publications in 2003

Journal Articles

  • A Naturally Selected Dimorphism within the HLA-B44 Supertype Alters Class I Structure, Peptide Repertoire, and T Cell Recognition
    Year: 2003
    Journal: Journal of Experimental Medicine
    Volume: 198
    Issue: 5
    Page numbers: 679-691
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  • A Structural Basis for the Selection of Dominant αβ T Cell Receptors in Antiviral Immunity
    Year: 2003
    Journal: Immunity
    Volume: 18
    Page numbers: 1-20
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  • Novel strategy for identification of candidate cytotoxic T-cell epitopes from human preproinsulin
    Year: 2003
    Journal: Tissue Antigens
    Volume: 62
    Page numbers: 408-417
    Publisher: Munksgaard International Publishers(Copenhagen)
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Publications in 2002

Journal Articles

  • Identification of a dominant self-ligand bound to three HLA B44 alleles and the preliminary crystallographic analysis of recombinant forms of each complex
    Year: 2002
    Journal: FEBS Letters
    Volume: 527
    Page numbers: 27-32
    Publisher: Elsevier Science(Amsterdam)
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  • The 1.5 Å Crystal Structure of a Highly Selected Antiviral T Cell Receptor Provides Evidence for a Structural Basis of Immunodominance
    Year: 2002
    Journal: Structure
    Volume: 10
    Page numbers: 1521-1532
    Publisher: Cell Press(Cambridge)
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  • The Structure of HLA-B8 Complexed to an Immunodominant Viral Determinant: Peptide-Induced Conformational Changes and a Mode of MHC Class I Dimerization1
    Year: 2002
    Journal: Journal of Immunology
    Volume: 169
    Page numbers: 5153-5160
    Publisher: American Association of Immunologists(Maryland)
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  • The production, purification and crystallization of a soluble heterodimeric form of a highly selected T-cell receptor in its unliganded and liganded state.
    Year: 2002
    Journal: Acta Crystallographica Section D - Biological Crystallography
    Volume: 58
    Page numbers: 2131-2134
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