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A/PROF HELMUT BUTZKUEVEN



Contact Details

Organization: Medicine, Dentistry and Health Sciences
Position: Honorary (Principal Fellow)
Email:
Level: 01
Building: Howard Florey
Campus: Parkville

Research Expertise and International Linkages

Research Expertise

Research Interest Country of Expertise
Glial Biology Australia
Genetics Australia
Multiple Sclerosis Australia
Multipel Sclerosis Registries Australia

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Bachelor of Medicine and Surgery University of Melbourne 01-Jan-1992
Doctorate of Philosophy Walter and Eliza Hall Institute of Medical Research 01-Oct-2003

Memberships

Membership Type Membership Body Description Start Date End Date
Member Society for Neuroscience Member 01-Nov-2005
Member Australian Neuroscience Society Member 20-Jan-2004
Member Australian Association of Neurologists Member 01-Jan-2000
Member American Association of Neurologists Member 01-Jan-1999

Fellowships

Fellowship Date Awarded
Fellow of the Royal Australasian College of Physicians (FRACP) 01-Dec-1999

Other Awards

Award Type Awarding Body Comments Date Awarded
Other (Award) Eureka Prize for Medical Research (for the MS Group) 20-Aug-2008
Other (Award) Bethlehem Griffith Research Foundation Award for Medical Research 03-Jun-2004
Prize Royal Melbourne Hospital Cleveland Prize for Medical Research 01-Jul-2002
Medal Novartis Medal for Medical Research, St Vincent's Hospital, Melbourne 01-Jun-1998
Other (Award) RACP GSK Fellowship in Neurology 01-Jan-2006
Other (Award) Betty Cuthbert Fellowship NHMRC/MSRA 30-Nov-2005

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
Investigating glial responses promoting remyelination and repair after demyelinating insults Chief Investigator NHMRC Peter Doherty Fellowships 01/01/2006
GLAXOSMITHKLINE AUSTRALIA FELLOWSHIP IN NEUROLOGY Chief Investigator ROYAL AUST COLLEGE OF PHYSICIANS RACP Fellowship 10/02/2006
Neuroprotection in Multiple Sclerosis Chief Investigator NHMRC Project Grants 01/01/2007
Protecting the nervous system from inflammation Chief Investigator NHMRC Project Grants 01/01/2008

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2009

Journal Articles

  • Optic nerve diffusion changes and atrophy jointly predict visual dysfunction after optic neuritis
    Year: 2009
    Journal: Neuroimage
    Volume: 45
    Page numbers: 679-686
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Publications in 2008

Journal Articles

  • Replication of KIAA0350, IL2RA, RPL5 and CD58 as multiple sclerosis susceptibility genes in Australians


    Year: 2008
    Journal: Genes and Immunity
    Volume: 9
    Page numbers: 624-360
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  • SNP mapping and candidate gene sequencing in the class I region of the HLA complex: searching for multiple sclerosis susceptibility genes in Tasmanians


    Year: 2008
    Journal: Tissue Antigens
    Volume: 71
    Page numbers: 42-50
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  • Validation of a Novel Biomarker for Acute Axonal Injury in Experimental Autoimmune Encephalomyelitis


    Year: 2008
    Journal: Journal of Neuroscience Research
    Volume: 86
    Page numbers: 3548-3555
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  • Validation of linear cerebral atrophy markers in multiple sclerosis


    Year: 2008
    Journal: Journal of Clinical Neuroscience
    Volume: 15
    Page numbers: 130-137
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  • Efficacy and tolerability of intramuscular interferon beta-1a compared with subcutaneous interferon beta-1a in relapsing MS: results from PROOF
    Year: 2008
    Journal: Current Medical Research and Opinion
    Volume: 24
    Issue: 4
    Page numbers: 1049-1055
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  • Gas6 deficiency increases oligodendrocyte loss and microglial activation in response to cuprizone-induced demyelination
    Year: 2008
    Journal: Journal of Neuroscience
    Volume: 28
    Issue: 20
    Page numbers: 5195-5206
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  • Leukemia inhibitory factor signaling modulates both central nervous system demyelination and myelin repair
    Year: 2008
    Journal: Glia
    Volume: 56
    Page numbers: 686-698
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Publications in 2007

Journal Articles

Publications in 2006

Journal Articles

  • Endogenous Leukemia Inhibitory Factor Production Limits Autoimmune Demyelination and Oligodendrocyte Loss


    Year: 2006
    Journal: Glia
    Volume: 53
    Issue: 2006
    Page numbers: 696-703
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  • Gait and balance impairment in early multiple sclerosis
    in the absence of clinical disability


    Year: 2006
    Journal: Multiple Sclerosis
    Volume: 12
    Issue: 5
    Page numbers: 620-628
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  • MSBase: an international, online registry and platform for collaborative outcomes research in multiple sclerosis
    Year: 2006
    Journal: Multiple Sclerosis
    Volume: 12
    Issue: 6
    Page numbers: 769-774
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  • Oligodendrocytes exhibit selective expression of suppressor of cytokine signaling genes and signal transducer and activator of transcription 1 independent inhibition of interferon-gamma-induced toxicity in response to leukemia inhibitory factor.
    Year: 2006
    Journal: Neuroscience
    Volume: 137
    Issue: 2006
    Page numbers: 463-472
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  • On the utility of data from the International HapMap Project for Australian association studies
    Year: 2006
    Journal: Human Genetics
    Volume: 119
    Issue: 1
    Page numbers: 220-222
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  • Short-term effects of methylprednisolone on cerebral volume in multiple sclerosis relapses.
    Year: 2006
    Journal: Journal of Clinical Neuroscience
    Volume: 13
    Page numbers: 636-638
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  • Suppressor of cytokine signaling 3 limits protection of leukemia inhibitory factor receptor signaling against central demyelination.
    Year: 2006
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 103
    Issue: 20
    Page numbers: 7859-7864
    Author(s):
    URL - restricted access www.pnas.org/cgi/doi/10.1073/pnas.0602574103
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Publications in 2005

Book Chapters

  • Multiple sclerosis: a hapoltype association study
    Year: 2005
    Book: The genetics of autoimmunity
    Publisher: Wiley-VCH(Weinheim)
    Authors(s):

Journal Articles

  • Multiple sclerosis severity score: using disability and disease duration to rate disease severity
    Year: 2005
    Journal: Neurology
    Volume: 64(7)
    Page numbers: 1144-1151
    Publisher: Lippincott Williams & Wilkins(Pennsylvania)
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Publications in 2004

Journal Articles

  • Cladribine followed by autologous stem-cell transplantation in progressive multiple sclerosis
    Year: 2004
    Journal: Internal Medicine Journal
    Volume: 34
    Page numbers: 66-69
    Publisher: Blackwell Science Asia(Carlton)
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  • Extended haplotype analysis in the HLA complex reveals an increased frequency of the HFE-C282Y mutation in individuals with multiple sclerosis
    Year: 2004
    Journal: Human Genetics
    Volume: 114
    Page numbers: 573-580
    Publisher: Springer Verlag(New York)
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  • LIF receptor signaling modulates neural stem cell renewal
    Year: 2004
    Journal: Molecular and Cellular Neurosciences
    Volume: 27
    Page numbers: 255-266
    Publisher: Academic Press
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  • Neuroglial responses to CNS injury: prospects for novel therapeutics
    Year: 2004
    Journal: Expert Review of Neurotherapeutics
    Volume: 4(5)
    Issue: 2004
    Page numbers: 869-878
    Publisher: Future Drugs(London)
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  • Serial MRI in multiple sclerosis: a prospective pilot study of lesion load, whole brain volume and thalamic atrophy
    Year: 2004
    Journal: Journal of Clinical Neuroscience
    Volume: 11
    Issue: 2
    Page numbers: 153-158
    Publisher: Churchill Livingstone(Leith Walkedinburgh)
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Publications in 2002

Journal Articles

  • Genetic dissection of the HLA Region Using Haplotypes of Tasmanians with multiple sclerosis
    Year: 2002
    Journal: American Journal of Human Genetics
    Volume: 70
    Page numbers: 1125-1137
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  • Prospects for stem cell transplantation in multiple sclerosis
    Year: 2002
    Journal: Journal of Clinical Neuroscience
    Volume: 9
    Issue: 4
    Page numbers: 361-367
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