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PROF FRANCIS CARBONE



Contact Details

Organization: Microbiology and Immunology
Position: PROFESSOR
Email:
Homepage: http://www.microbiol.unimelb.edu.au/people/carbone/
Work: 8344-9923
Fax: 9347-1540
Room: 520
Level: 05
Building: Microbiology Building
Campus: Parkville

Research Expertise and International Linkages

Research Expertise

Research Interest Key Words Country of Expertise
Research into infection and immunity focusing on antigen presentation and cellular immunity to HSV Antigen presentation, herpesviruses, HSV, cross presentation, CTL, MHC Australia

International Linkages

Country Establishment Collaboration
United States The Scripps Research Institute Research
United States University of Washington Research
United Kingdom Medical Research Council Research

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Bachelor of Science University of Melbourne 02-Aug-1980
Doctor of Philosophy University of Melbourne 06-Mar-1985

Memberships

Membership Type Membership Body Description Start Date End Date
Member Australasian Society for Immunology Member 01-Jan-1990
Member American Association of Immunologist Member 01-Jan-1995

Other Awards

Award Type Awarding Body Comments Date Awarded
Other (Award) Australian-American Fulbright Commission Australian-American Fulbright Senior Scholar Award 12-Mar-2007

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
Antigen presentation, recognition and the immune response Chief Investigator NHMRC Program Grants 01/01/2002
2007 PROGRAM GRANT - (ANTIGEN PRESENTATION, RECOGNITION AND THE IMMUNE RESPONSE) Chief Investigator NHMRC Program Grants 01/01/2007
The role of dendritic cells in the induction of T cell tolerance to tumors Principal Supervisor CANCER COUNCIL VICTORIA Postdoctoral Research Fellowships 01/01/2007
Why eczema increases the severity of virus infections Chief Investigator NHMRC Project Grants 01/01/2008
Multi-photon imaging for infection, immunity, and self recognition Chief Investigator AUST RESEARCH COUNCIL Linkage Infrastructure (Equipment and Facilities) 01/01/2009

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2009

Journal Articles

  • Cross-presentation of viral and self antigens by skin-derived CD103+ dendritic cells
    Year: 2009
    Journal: Nature Immunology
    Volume: 10
    Issue: 5
    Page numbers: 488-495
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  • Differential Migration of Epidermal and Dermal Dendritic Cells during Skin Infection
    Year: 2009
    Journal: Journal of Immunology
    Volume: 182
    Page numbers: 3165-3172
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  • Memory T cells in nonlymphoid tissue that provide enhanced local immunity during infection with herpes simplex virus
    Year: 2009
    Journal: Nature Immunology
    Volume: 10
    Issue: 5
    Page numbers: 524-530
    Author(s):
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  • Tissue destruction caused by cytotoxic T lymphocytes induces deletional tolerance
    Year: 2009
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 106
    Issue: 10
    Page numbers: 3901-3906
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Publications in 2008

Journal Articles

Publications in 2007

Journal Articles

Publications in 2006

Journal Articles

  • Bone marrow-derived cells expand memory CD8+ T cells in response to viral infections of the lung and skin
    Year: 2006
    Journal: European Journal of Immunology
    Volume: 36
    Issue: 2
    Page numbers: 327-335
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  • CD4+ T cells can protect APC from CTL-mediated elimination
    Year: 2006
    Journal: Journal of Immunology
    Volume: 176
    Page numbers: 7379-7384
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  • CTL response compensation for the loss of an immunodominant class 1-restricted HSV-1 determinant
    Year: 2006
    Journal: Immunology and Cell Biology
    Volume: 84
    Page numbers: 543-550
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  • Central memory T cells do not show accelerated proliferation or tissue infiltration in response to localised herpes simples virus-1 infection
    Year: 2006
    Journal: Journal of Immunology
    Volume: 177
    Issue: 3
    Page numbers: 1411-1415
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  • Migratory dendritic cells transfer antigen to a lymph node-resident dendritic cell population for efficient CTL priming
    Year: 2006
    Journal: Immunity
    Volume: 25
    Issue: 1
    Page numbers: 153-162
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  • NKT cells are not critical for HSV-1 disease resolution
    Year: 2006
    Journal: Immunology and Cell Biology
    Volume: 84
    Issue: 1
    Page numbers: 13-19
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  • Systemic activation of dendritic cells by Toll-like receptor ligands or malaria infection inpairs cross-presentation and antiviral immunity
    Year: 2006
    Journal: Nature Immunology
    Volume: 7
    Issue: 2
    Page numbers: 165-172
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  • The dominant role of CD8+ dendritic cells in cross-presentation is not dictated by antigen capture
    Year: 2006
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 103
    Issue: 28
    Page numbers: 10729-10734
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Publications in 2005

Journal Articles

  • Coupling and cross-presentation
    Year: 2005
    Journal: Nature
    Volume: 434
    Issue: 3 March 2005
    Page numbers: 27-28
    Publisher: Macmillan Publishers(London)
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  • Latent Infection with Herpes Simplex Virus is Associated with Ongoing CD8+ T-Cell Stimulation by Parenchymal Cells within Sensory Ganglia
    Year: 2005
    Journal: Journal of Virology
    Volume: 79
    Issue: 23
    Page numbers: 14843-14851
    Publisher: American Society for Microbiology(Washington DC)
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  • SOCS-1 regulates IL-15-driven homeostatic proliferation of antigen-naive CD8 T cells, limiting their autoimmune potential
    Year: 2005
    Journal: Journal of Experimental Medicine
    Volume: 202
    Issue: 8
    Page numbers: 1099-1108
    Publisher: Rockefeller University Press(New York)
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Publications in 2004

Journal Articles

  • Cognate CD4+ T cell licensing of dendritic cells in CD8+ T cell immunity
    Year: 2004
    Journal: Nature Immunology
    Volume: 5
    Issue: 11
    Page numbers: 1143-1148
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  • Cross-presentation, dendritic cell subsets, and the generation of immunity to cellular antigens
    Year: 2004
    Journal: Immunological Reviews
    Volume: 199
    Page numbers: 9-26
    Publisher: Munksgaard International Publishers(Copenhagen)
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  • Cutting Edge: Conventional CD8α+ Dendritic Cells Are Generally Involved In Priming CTL Immunity to Viruses1
    Year: 2004
    Journal: Journal of Immunology
    Volume: 172
    Page numbers: 1996-2000
    Publisher: American Association of Immunologists(Maryland)
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  • Cutting Edge: Prolonged Antigen Presentation after Herpes Simplex Virus-1 Skin Infection1
    Year: 2004
    Journal: Journal of Immunology
    Volume: 173
    Issue: 4
    Page numbers: 2241-2244
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  • Distinct migrating and nonmigrating dendritic cell populations are involved in MHC class I-restricted antigen presentation after lung infection with virus
    Year: 2004
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 101
    Issue: 23
    Page numbers: 8670-8675
    Publisher: National Academy of Sciences(Washington DC)
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  • Helper Requirements for Generation of Effector CTL to Islet β Cell Antigens1
    Year: 2004
    Journal: Journal of Immunology
    Volume: 172
    Page numbers: 5420-5426
    Publisher: American Association of Immunologists(Maryland)
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  • Helper T cells, dendritic cells and CTL Immunity
    Year: 2004
    Journal: Immunology and Cell Biology
    Volume: 82
    Issue: 1
    Page numbers: 84-90
    Publisher: Blackwell Science Asia(Carlton)
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  • Herpes Simplex Virus-Specific CD8+ T Cells Can Clear Established Lytic Infections from Skin and Nerves and Can Partially Limit the Early Spread of Virus after Cutaneous Inoculation
    Year: 2004
    Journal: Journal of Immunology
    Volume: 172
    Issue: 1
    Page numbers: 392-397
    Publisher: American Association of Immunologists(Maryland)
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  • Persistent expression of CD94/NKG2 receptors by virus-specific CD8 T cells is initiated by TCR-mediated signals
    Year: 2004
    Journal: International Immunology
    Volume: 16
    Issue: 9
    Page numbers: 1333-1341
    Publisher: Oxford University Press(Oxford)
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  • The Structure of H-2Kb and Kbm8 Complexed to a Herpes Simplex Virus Determinant: Evidence for a Conformational Switch That Governs T Cell Repertoire Selection and Viral Resistance1,2
    Year: 2004
    Journal: Journal of Immunology
    Volume: 173
    Page numbers: 402-409
    Publisher: American Association of Immunologists(Maryland)
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  • Transfer of antigen between migrating and lymph node-resident DCs in peripheral T-cell tolerance and immunity
    Year: 2004
    Journal: Trends in Immunology (formerly Immunology Today)
    Volume: 25
    Issue: 12
    Page numbers: 655-658
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  • Unexpectedly, induction of cytotoxic T lymphocytes enhances the humoral response after DNA immunization
    Year: 2004
    Journal: Blood
    Volume: 103
    Issue: 8
    Page numbers: 3073-3075
    Publisher: American Society of Hematology(Washington DC)
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Publications in 2003

Journal Articles

  • Cutting Edge: Conventional CD8α+ Dendritic Cells Are Preferentially Involved in CTL Priming After Footpad Infection with Herpes Simplex Virus-11
    Year: 2003
    Journal: Journal of Immunology
    Volume: 170
    Page numbers: 4437-4440
    Publisher: American Association of Immunologists(Maryland)
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  • Dangerous liaisons
    Year: 2003
    Journal: Nature
    Volume: 425
    Page numbers: 460-461
    Publisher: Macmillan Publishers(London)
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  • Detection of Low-Avidity CD4+ T Cells Using Recombinant Artificial APC: Following the Antiovalbumin Immune Response1
    Year: 2003
    Journal: Journal of Immunology
    Volume: 170
    Page numbers: 123-131
    Publisher: American Association of Immunologists(Maryland)
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  • Epidermal Viral Immunity Induced by CD8α+ Dendritic Cells But Not by Langerhans Cells
    Year: 2003
    Journal: Science
    Volume: 301
    Page numbers: 1925-1928
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  • Hide and Seek: The Immunology of HSV Persistence
    Year: 2003
    Journal: Immunity
    Volume: 18
    Issue: May 2003
    Page numbers: 583-586
    Publisher: Cell Press(Massachusetts)
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  • The Early Expression of Glycoprotein B from Herpes Simplex Virus Can Be Detected by Antigen-Specific CD8+ T Cells
    Year: 2003
    Journal: Journal of Virology
    Volume: 77
    Issue: 4
    Page numbers: 2445-2451
    Publisher: American Society for Microbiology(Washington DC)
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  • The role of dendritic cell subsets in immunity to viruses
    Year: 2003
    Journal: Current Opinion in Immunology
    Volume: 15
    Page numbers: 1-5
    Publisher: Current Biology(London)
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  • Virus infection expands a biased subset of T cells that bind tetrameric class I peptide complexes
    Year: 2003
    Journal: European Journal of Immunology
    Volume: 33
    Page numbers: 1557-1567
    Publisher: Wiley-VCH(Berlin)
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Publications in 2002

Journal Articles

  • CD36 Is Differentially Expressed by CD8+ Splenic Dendritic Cells But Is Not Required for Cross-Presentation in Vivo1
    Year: 2002
    Journal: Journal of Immunology
    Volume: 168
    Page numbers: 6066-6070
    Publisher: American Association of Immunologists(Maryland)
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  • Characterization of two TCR transgenic mouse lines specific for herpes simplex virus
    Year: 2002
    Journal: Immunology and Cell Biology
    Volume: 80
    Page numbers: 156-163
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  • Constitutive, but not inflammatory, cross-presentation is disabled in the pancreas of young mice.
    Year: 2002
    Journal: European Journal of Immunology
    Volume: 32
    Page numbers: 1044-1051
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  • Cross-presentation of antigens by dendritic cells
    Year: 2002
    Journal: Critical Reviews in Immunology
    Volume: 22
    Page numbers: 439-448
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  • Cutting Edge: Precursor frequency affects the helper dependence of cytotoxic T cells.
    Year: 2002
    Journal: Journal of Immunology
    Volume: 168
    Page numbers: 977-980
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  • Peripheral Deletion of Autoreactive CD8 T Cells by Cross Presentation of Self-Antigen Occurs by a Bcl-2-inhibitable Pathway Mediated by Bim
    Year: 2002
    Journal: Journal of Experimental Medicine
    Volume: 196
    Issue: 7
    Page numbers: 947-955
    Publisher: Rockefeller University Press(New York)
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  • Progression of Armed CTL from Draining Lymph Node to Spleen Shortly After Localized Infection with Herpes Simplex Virus 11
    Year: 2002
    Journal: Journal of Immunology
    Volume: 168
    Page numbers: 834-838
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  • Rapid Cytotoxic T Lymphocyte Activation Occurs in the Draining Lymph Nodes After Cutaneous Herpes Simplex Virus Infection as a Result of Early Antigen Presentation and Not the Presence of Virus
    Year: 2002
    Journal: Journal of Experimental Medicine
    Volume: 195
    Issue: 5
    Page numbers: 651-656
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  • The CD8α+ Dendritic Cell Is Responsible for Inducing Peripheral Self-Tolerance to Tissue-associated Antigens
    Year: 2002
    Journal: Journal of Experimental Medicine
    Volume: 196
    Issue: 8
    Page numbers: 1099-1104
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  • The cross-priming APC requires a Rel-dependent signal to induce CTL
    Year: 2002
    Journal: Journal of Immunology
    Volume: 168
    Page numbers: 3283-3287
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  • The role of dendritic cell subsets in selection between tolerance and immunity
    Year: 2002
    Journal: Immunology and Cell Biology
    Volume: 80
    Page numbers: 463-468
    Publisher: Blackwell Science Asia(Carlton)
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Publications in 2001

Journal Articles

  • A key role for ICAM-1 in generating effector cells mediating inflammatory responses
    Year: 2001
    Journal: Nature Immunology
    Volume: 2
    Issue: 6
    Page numbers: 523-529
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  • Cell-Associated Ovalbumin Is Cross-Presented Much More Efficiently than Soluble Ovalbumin In Vivo1
    Year: 2001
    Journal: Journal of Immunology
    Volume: 166
    Page numbers: 6099-6103
    Publisher: American Association of Immunologists(Maryland)
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  • Cross-presentation in viral immunity and self-tolerance
    Year: 2001
    Journal: Nature Reviews Immunology
    Volume: 1
    Issue: November 2001
    Page numbers: 126-134
    Publisher: Nature Publishing Group(London)
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  • Cross-presentation, dendritic cells, tolerance and immunity
    Year: 2001
    Journal: Annual Review of Immunology
    Volume: 19
    Page numbers: 47-64
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  • MHC Class II Expression Is Regulated in Dendritic Cells Independently of Invariant Chain Degradation
    Year: 2001
    Journal: Immunity
    Volume: 14
    Page numbers: 739-749
    Publisher: Cell Press(Massachusetts)
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