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DR RICHARD HUGHES



Contact Details

Organization: Pharmacology
Position: SENIOR LECTURER
Email:
Homepage: www.pharmacology.unimelb.edu.au/research/drugdesign.html
Work: 48604
Fax: 40241
Room: W811
Level: 08
Building: Medical Centre
Campus: Parkville

Research Expertise and International Linkages

International Linkages

Country Establishment Collaboration
Singapore A-Star Research
Germany Universitaet Wuerzburg Research

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Master of Pharmacy Victorian College of Pharmacology 01-Oct-1988
Doctor of Philosophy University of London 01-Oct-1990

Memberships

Membership Type Membership Body Description Start Date End Date
Member Australian Peptide Society Ordinary member 01-Oct-2005

Other Awards

Award Type Awarding Body Comments Date Awarded
Other (Award) AMRAD 01-Oct-2005

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
Design of low molecular weight mimetics of vascular enothelial growth factor for therapeutic angiogenesis Principal Supervisor NATIONAL HEART FOUNDATION Vacation Scholarships 05/11/2004
Structure-function and domain minimization of insulin-like peptide 3, a novel member of the insulin superfamily Chief Investigator NHMRC Project Grants 01/01/2005
Structure-function relationship of human relaxins. Chief Investigator NHMRC Project Grants 01/01/2008
Structure-function relationship of human insulin-like peptide 3. Chief Investigator NHMRC Project Grants 01/01/2008
New treatments for cancer Chief Investigator NHMRC Project Grants 01/01/2009

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2009

Book Chapters

  • Development of lanthanide-labelled human INSL3 as an alternative probe to radioactively-labelled INSL3 for use in bioassays
    Year: 2009
    Book: Relaxin and Related Peptides: Fifth International Conference, Ann NY Acad Sci Vol 1160
    Publisher: Wiley-Blackwell Publishing
    Authors(s):
  • The chemistry and biology of insulin-like peptide 3, a novel member of the insulin superfamily.
    Year: 2009
    Book: Bioactive Peptides
    Publisher: Taylor & Francis Ltd(Abingdon)
    Authors(s):

Publications in 2008

Journal Articles

  • Design of a conformationally-defined and proteolytically stable circular mimetic of brain-derived neurotrophic factor
    Year: 2008
    Journal: Journal of Biological Chemistry
    Volume: 283
    Issue: 48
    Page numbers: 33375-33383
    Author(s):
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  • Solid-phase synthesis of europium-labeled human INSL3 as a novel probe for the study of ligand-receptor interactions
    Year: 2008
    Journal: Bioconjugate Chemistry
    Volume: 19
    Page numbers: 1456-1463
    Author(s):
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  • Understanding the cardioprotective effects of flavonols: Discovery of relaxant flavonols without antioxidant activity
    Year: 2008
    Journal: Journal of Medicinal Chemistry
    Volume: 51
    Page numbers: 1874-1884
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Publications in 2007

Journal Articles

  • 2-Methoxyestradiol - a unique blend of activities generating a new class of anti-tumor/anti-inflammatory agents
    Year: 2007
    Journal: Drug Discovery Today
    Volume: 12
    Issue: 13
    Page numbers: 577-584
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  • Carbohydrate-based VEGF inhibitors
    Year: 2007
    Journal: European Journal of Organic Chemistry
    Volume: 2007
    Issue: 36
    Page numbers: 6016-6033
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  • Design, synthesis and pharmacological evaluation of cyclic mimetics of the insulin-like peptide 3 (INSL3) B-chain
    Year: 2007
    Journal: Journal of Peptide Science
    Volume: 13
    Page numbers: 113-120
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Conference Publications/Papers

  • Molecular pathways for the lymphangiogenesis and their role in human disease.
    Year: 2007
    Event name: Novartis Foundation Symposium 281
    Conference Publication: Decoding the genomic control of immune reactions
    Volume: 281
    Issue: 2007
    Page numbers: 38-43
    Publisher: Wiley - John Wiley & Sons(Chichester)
    Author(s):

Publications in 2006

Journal Articles

  • Analogs of insulin-like peptide 3 (INSL3) B-Chain are LGR8 antagonists in vitro and in vivo
    Year: 2006
    Journal: Journal of Biological Chemistry
    Volume: 281
    Issue: 19
    Page numbers: 13068-74
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  • Current strategies for modulating lymphangiogenesis signalling pathways in human disease.
    Year: 2006
    Journal: Current Medicinal Chemistry
    Volume: 13
    Issue: 7
    Page numbers: 783-792
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  • Design, synthesis and pharmacological evaluation of cyclic mimetics of the insulin-like peptide 3 (INSL3) B-chain
    Year: 2006
    Journal: Journal of Peptide Science
    Volume: 13
    Page numbers: 113-120
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  • Novel monocyclic and bicyclic loop mimetics of brain-derived neurotrophic factor
    Year: 2006
    Journal: Journal of Peptide Science
    Volume: 12
    Page numbers: 515-524
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  • Solution structure and characterization of the receptor binding surface of insulin-like peptide 3*
    Year: 2006
    Journal: Journal of Biological Chemistry
    Volume: 281
    Issue: 38
    Page numbers: 28287-28295
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Conference Publications/Papers

  • Design of Conformationally-Constrained Peptides as Mimetics of Cellular Growth Factors
    Year: 2006
    Event name: 43rd Japanese Peptide Symposium & 4th Peptide Engineering International Conference
    Conference Publication: Peptide Science 2006
    Page numbers: 217-218
    Publisher: The Japanese Peptide Society(Osaka)
    Author(s):

Publications in 2005

Journal Articles

  • Conformationality constrained single-chain peptide mimics of relaxin B-chain secondary structure
    Year: 2005
    Journal: Journal of Peptide Science
    Volume: 11
    Page numbers: 564-571
    Publisher: John Wiley & Sons(West Sussex)
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  • The next generation of phosphodiesterase inhibitors: Structural clues to ligand and substrate selectivity of phosphodiesterases
    Year: 2005
    Journal: Journal of Medicinal Chemistry
    Volume: 48
    Issue: 10
    Page numbers: 3449-3462
    Publisher: American Chemical Society
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Publications in 2004

Journal Articles

  • A novel approach to the regioselective synthesis of a disulfide-linked heterodimeric bicyclic peptide mimetic of brain-derived neurotrophic factor
    Year: 2004
    Journal: Tetrahedron Letters
    Volume: 45
    Page numbers: 6999-7001
    Publisher: Pergamon-Elsevier Science(Oxford)
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  • Molecular targeting of lymphatics for therapy
    Year: 2004
    Journal: Current Pharmaceutical Design
    Volume: 10
    Page numbers: 65-74
    Publisher: Bentham Science Publishers(Sharjah)
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Publications in 2003

Book Chapters

  • Mechanisms of neurodegenerative diseases
    Year: 2003
    Book: Molecular pathomechanisms and new trends in drug research
    Publisher: Taylor & Francis Ltd(London)
    Authors(s):

Journal Articles

  • Design of potent peptide mimetics of brain-derived neurotrophic factor
    Year: 2003
    Journal: Journal of Biological Chemistry
    Volume: 278
    Issue: 28
    Page numbers: 25738-25744
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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Publications in 2002

Journal Articles

  • 2-Methoxyestradiol and analogs as novel antiproliferative agents: analysis of three-dimensional quantitative structure-activity relationships for DNA synthesis inhibition and estrogen receptor binding
    Year: 2002
    Journal: Molecular Pharmacology
    Volume: 61
    Issue: 5
    Page numbers: 1053-1069
    Publisher: American Society for Pharmacology and Experimental Therapeutics(Maryland)
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Publications in 2001

Book Chapters

  • Oestradiol Metabolites. Effects on Airway Remodelling
    Year: 2001
    Book: New Drugs for Asthma, Allergy and COPD
    Publisher: Karger AG(Basel)
    Authors(s):
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