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PROF WILLIAM HEATH



Contact Details

Organization: Microbiology and Immunology
Position: FEDERATION FELLOW
Email:
Homepage: http://www.microbiol.unimelb.edu.au/research/groups/heath
Work: 83445682
Fax: 93471540
Room: 5.18
Level: 05
Building: Microbiology Building
Campus: Parkville

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Bachelor of Science University of Melbourne 31-Dec-1983
Doctor of Philosophy University of Melbourne 31-Dec-1988

Fellowships

Fellowship Date Awarded
Fellow of the Australian Academy of Science (FAA) 19-Mar-2008

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
Antigen presentation, recognition and the immune response Chief Investigator NHMRC Program Grants 01/01/2002
2007 PROGRAM GRANT - (ANTIGEN PRESENTATION, RECOGNITION AND THE IMMUNE RESPONSE) Chief Investigator NHMRC Program Grants 01/01/2007
IN VIVO IMAGING OF THE IMMUNE SYSTEM IN SELF TOLERANCE AND INFECTIOUS DISEASE Chief Investigator AUST RESEARCH COUNCIL Federation Fellowships 11/07/2007
A DENDRITIC CELL SUBSET TARGETING APPROACH FOR DEFINING IMMUNE FUNCTION AND TAILORING IMMUNOTHERAPY Chief Investigator NHMRC Project Grants 01/01/2008
NHMRC RESEARCH FELLOWSHIP 2007 - HEATH Chief Investigator NHMRC Research Fellowship 01/01/2008
DENDRITIC CELL SUBSETS AND T CELL IMMUNITY TO BLOOD STAGE MALARIA INFECTION Chief Investigator HOWARD HUGHES MEDICAL INSTITUTE International Research Scholars Program, Infectious Diseases and Parasitology 01/09/2008
Multi-photon imaging for infection, immunity, and self recognition Chief Investigator AUST RESEARCH COUNCIL Linkage Infrastructure (Equipment and Facilities) 01/01/2009

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2009

Journal Articles

  • Autoimmune Regulator Controls T Cell Help for Pathogenetic Autoanitbody Production in Collagen-Induced Arthritis
    Year: 2009
    Journal: Arthritis and Rheumatism
    Volume: 60
    Issue: 6
    Page numbers: 1683-1693
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  • Characterization of an Immediate Splenic Precursor of CD8+ Dendritic Cells Capable of Inducing Antiviral T Cell Responses
    Year: 2009
    Journal: Journal of Immunology
    Volume: 182
    Page numbers: 4200-4207
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  • Cross-presentation of viral and self antigens by skin-derived CD103+ dendritic cells
    Year: 2009
    Journal: Nature Immunology
    Volume: 10
    Issue: 5
    Page numbers: 488-495
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  • Differential Migration of Epidermal and Dermal Dendritic Cells during Skin Infection
    Year: 2009
    Journal: Journal of Immunology
    Volume: 182
    Page numbers: 3165-3172
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  • Equivalent stimulation of naive and memory CD8 T cells by DNA vaccination: a dendritic cell-dependent process
    Year: 2009
    Journal: Immunology and Cell Biology
    Volume: 87
    Page numbers: 255-259
    Author(s):
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  • IP-10-mediated T cell homing promotes cerebral inflammation over splenic immunity to malaria infection
    Year: 2009
    Journal: PLoS Pathogens
    Volume: 5
    Issue: 4
    Page numbers: 1-16
    Author(s):
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  • Memory T cells in nonlymphoid tissue that provide enhanced local immunity during infection with herpes simplex virus
    Year: 2009
    Journal: Nature Immunology
    Volume: 10
    Issue: 5
    Page numbers: 524-530
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  • Selected Toll-like Receptor Ligands and Viruses Promote Helper-Independent Cytotoxic T Cell Priming by Upregulating CD40L on Dendritic Cells
    Year: 2009
    Journal: Immunity
    Volume: 30
    Page numbers: 218-227
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  • The C-Type Lectin Clec12A Present on Mouse and Human Dendritic Cells Can Serve as a Target for Antigen Delivery and Enhancement of Antibody Responses
    Year: 2009
    Journal: Journal of Immunology
    Volume: 182
    Page numbers: 7587-7594
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  • The Molecular signature of CD8+ T cells undergoing deletional tolerance
    Year: 2009
    Journal: Blood
    Volume: 118
    Issue: 19
    Page numbers: 4575-4585
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  • Tissue destruction caused by cytotoxic T lymphocytes induces deletional tolerance
    Year: 2009
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 106
    Issue: 10
    Page numbers: 3901-3906
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Publications in 2008

Journal Articles

  • A Specific Anti-Aire Antibody Reveals Aire Expression Is Restricted to Medullary Thymic Epithelial Cells and Not Expressed in Periphery
    Year: 2008
    Journal: Journal of Immunology
    Volume: 180
    Page numbers: 3824-3832
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  • Cutting Edge: Local Recall Responses by Memory T Cells Newly Recruited to Peripheral Nonlymphoid Tissues
    Year: 2008
    Journal: Journal of Immunology
    Volume: 181
    Page numbers: 5837-5841
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  • Differential MHC class II synthesis and ubiquitination confers distinct antigen-presenting properties on conventional and plasmacytoid dendritic cells
    Year: 2008
    Journal: Nature Immunology
    Volume: 9
    Issue: 11
    Page numbers: 1244-52
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  • Generic construction of single component particles that elicit humoural and cellular immune responses without the need for adjuvants
    Year: 2008
    Journal: Vaccine
    Volume: 26
    Page numbers: 6824-6831
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  • Multiple Dendritic Cell Populations Activate CD4+ T Cells after Viral Stimulation
    Year: 2008
    Journal: PLoS One
    Volume: 3
    Issue: 2
    Page numbers: e1691
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  • Normal proportion and expression of maturation markers in migratory dendritic cells in the absence of germs or Toll-like receptor signaling
    Year: 2008
    Journal: Immunology and Cell Biology
    Volume: 2008
    Page numbers: 200-205
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  • Selective suicide of cross-presenting CD8+ dendritic cells by cytochrome c injection shows functional heterogeneity within this subset
    Year: 2008
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 105
    Issue: 8
    Page numbers: 3029-3034
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  • The dendritic cell subtype-restricted C-type lectin Clec9A is a target for vaccine enhancement
    Year: 2008
    Journal: Blood
    Volume: 112
    Issue: 8
    Page numbers: 3264-73
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  • Too dangerous to ignore: self-tolerance and the control of ignorant autoreative T cells
    Year: 2008
    Journal: Immunology and Cell Biology
    Volume: 2
    Issue: 86
    Page numbers: 146-152
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Publications in 2007

Journal Articles

  • Putative IKDCs are functionally and developmentally similar to natural killer cells, but not to dendritic cells
    Year: 2007
    Journal: Journal of Experimental Medicine
    Volume: 204
    Issue: 11
    Page numbers: 2579-2590
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  • The Clonal selection theory: 50 years since the revolution
    Year: 2007
    Journal: Nature Immunology
    Volume: 8
    Page numbers: 1019-1026
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Publications in 2006

Journal Articles

  • Bone marrow-derived cells expand memory CD8+ T cells in response to viral infections of the lung and skin
    Year: 2006
    Journal: European Journal of Immunology
    Volume: 36
    Issue: 2
    Page numbers: 327-335
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Publications in 2005

Journal Articles

  • CD8α+ Dendritic Cells Selectively Present MHC Class I-Restricted Noncytolytic Viral and Intracellular Bacterial Antigens In Vivo
    Year: 2005
    Journal: Journal of Immunology
    Volume: 175
    Page numbers: 196-200
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  • Life cycle, migration and antigen presenting functions of spleen and lymph node dendritic cells: Limitations of the Langerhans cells paradigm
    Year: 2005
    Journal: Seminars in Immunology
    Volume: 17
    Page numbers: 262-272
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  • No driving without a license
    Year: 2005
    Journal: Nature Immunology
    Volume: 6
    Issue: 2
    Page numbers: 125-126
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Publications in 2003

Journal Articles

  • Induction of T-cell-mediated skin disease specific for antigen transgenically expressed in keratinocytes
    Year: 2003
    Journal: European Journal of Immunology
    Volume: 33
    Page numbers: 1879-1888
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  • Induction of Tumor Cell Apoptosis In Vivo Increases Tumor Antigen Cross-Presentation, Cross-Priming Rather than Cross-Tolerizing Host Tumor-Specific CD8 T Cells
    Year: 2003
    Journal: Journal of Immunology
    Volume: 170
    Page numbers: 4905-4913
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  • Most lymphoid organ dendritic cell types are phenotypically and functionally immature
    Year: 2003
    Journal: Blood
    Volume: 102
    Page numbers: 2187-2194
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  • Supproessor of Cytokine Signaling-1 Has IFN-γ-Independent Actions in T Cell Homeostasis
    Year: 2003
    Journal: Journal of Immunology
    Volume: 170
    Page numbers: 878-886
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Publications in 2002

Journal Articles

  • Immunology: Education and promiscuity
    Year: 2002
    Journal: Nature
    Volume: 420
    Issue: 6915
    Page numbers: 468-9
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