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DR TERRY MULHERN



Contact Details

Organization: Biochemistry and Molecular Biology
Position: SENIOR LECTURER
Email:
Homepage: http://www.biochemistry.unimelb.edu.au/research/res_mulhern.htm
Work: 03 8344 2277
Fax: 03 9348 1421
Room: 126
Level: 01
Building: David Pennington Building
Campus: Parkville

Research Expertise and International Linkages

Research Expertise

Research Interest Key Words Country of Expertise
Small-angle x-ray scattering (SAXS) protein structure Australia
Mitochondrial protein import protein structure Australia
Nuclear magnetic resonance (NMR) spectroscopy protein structure Australia
Protein kinases signal transduction Australia

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Bachelor of Science The University of Queensland 01-Dec-1989
Doctor of Philosophy The University of Queensland 31-Dec-1995
Bachelor of Science with Honours The University of Queensland 17-Dec-1990

Memberships

Membership Type Membership Body Description Start Date End Date
Member Australian Society for Biophysics Australian Society for Biophysics 01-Nov-2002

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
AUTOCLAVES (2) 2004 NHMRC EQUIPMENT GRANT ALLOCATION Chief Investigator NHMRC Equipment Grants 01/01/2005
Regulation of activity and subcellular localisation of the tumour suppressor PTEN Chief Investigator CANCER COUNCIL VICTORIA Grants-in-Aid 01/01/2005
Evolution, structure and function of key components in a molecular machine Chief Investigator AUST RESEARCH COUNCIL Discovery Projects 01/01/2005
SMALL-ANGLE SCATTERING ANALYSIS OF INHIBITED PROTO-ONCOGENIC ENZYME COMPLEXES Chief Investigator AINSE Awards 01/01/2006
SMALL ANGLE SCATTERING ANALYSIS OF STRUCTURAL REARRANGEMENTS OF PARKINSONS DISEASE ASSOCIATED PROTEIN KINASES Principal Supervisor AINSE Postgraduate Awards 01/07/2006
NEW INHIBITORS OF HIV BASED ON CELLULAR ENZYMES Chief Investigator AUST RESEARCH COUNCIL Linkage International Awards 01/01/2007
DECIPHERING THE BIOCHEMICAL PROPERTIES OF PARKINSONS DISEASE-ASSOCIATED LEUCINE-RICH REPEAT KINASE 2 Chief Investigator BRAIN FOUNDATION Specific Research Grants 01/09/2007
Testing a new HIV/AIDS inhibitor Chief Investigator NHMRC Project Grants 01/01/2008
Investigating the subunit interactions of a molecular protein import machine Chief Investigator AUST RESEARCH COUNCIL Discovery Projects 01/01/2008
INVESTIGATING PROTEIN/PROTEIN INTERACTIONS Chief Investigator AUST RESEARCH COUNCIL Linkage Infrastructure (Equipment and Facilities) 01/01/2008
Structural investigations of the mitochondrial protein import receptor complex Chief Investigator AINSE Awards 01/01/2008

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2009

Journal Articles

  • Evidence of a reduced and modified mitochondrial protein import apparatus in microsporidian mitosomes.
    Year: 2009
    Journal: Eukaryotic Cell
    Volume: 8
    Page numbers: 19-26
    Author(s):
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  • Domain Organization of the Monomeric Form of the Tom70 Mitochondrial Import Receptor
    Year: 2009
    Journal: Journal of Molecular Biology
    Volume: 388
    Issue: 5
    Page numbers: 1043-1058
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Publications in 2008

Journal Articles

Publications in 2007

Journal Articles

  • A Novel Binding Site for the Human Insulin-like Growth Factor-II (IGF-II)/Mannose 6-Phosphate Receptor on IGF-II
    Year: 2007
    Journal: Journal of Biological Chemistry
    Volume: 282
    Issue: 26
    Page numbers: 18886-18894
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  • PTEN catalysis of phospholipid dephosphorylation reaction follows a two-step mechanism in which the conserved aspartate-92 does not function as the general acid - Mechanistic analysis of a familial Cowden disease-associated PTEN mutation.
    Year: 2007
    Journal: Cellular Signaling
    Volume: 19
    Issue: 7
    Page numbers: 1434-1445
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Publications in 2006

Journal Articles

Publications in 2005

Journal Articles

  • C-terminal Src kinase (CSK) and CSK-homologous kinase (CHK)--endogenous negative regulators of Src-family protein kinases.
    Year: 2005
    Journal: Growth Factors
    Volume: 23
    Issue: 3
    Page numbers: 233-244
    Publisher: Harwood Academic Publishing GMBH(Reading)
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  • Endogenous and synthetic inhibitors of the Src-family protein tyrosine kinases
    Year: 2005
    Journal: Biochimica et Biophysica Acta-Proteins and Proteomics
    Volume: 1754
    Issue: 1-2
    Page numbers: 210-20
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  • Endogenous and synthetic inhibitors of the Src-family protein tyrosine kinases.
    Year: 2005
    Journal: Biochimica et Biophysica Acta-Proteins and Proteomics
    Volume: 1754
    Issue: 1-2
    Page numbers: 210-220
    Publisher: Elsevier Science(Amsterdam)
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  • Inproved antigen binding by a CD20-specific single-chain antibody fragment with a mutation in CDRH1
    Year: 2005
    Journal: Molecular Immunology
    Volume: 43
    Issue: 6
    Page numbers: 550-558
    Publisher: Pergamon-Elsevier Science(Oxford)
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Publications in 2004

Journal Articles

  • A biophysical analysis of the TPR-rich mitochondrial import receptor, Tom70, reveals an elongated monomer that is inherently flexible, unstable and unfolds via a multi-state pathway
    Year: 2004
    Journal: Journal of Biological Chemistry
    Volume: 279
    Issue: 45
    Page numbers: 46448-46454
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  • A novel non-catalytic mechanism employed by the C-terminal Src-homologous kinase to inhibit Src-family kinase activity
    Year: 2004
    Journal: Journal of Biological Chemistry
    Volume: 279
    Page numbers: 20752-20766
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  • Tom22', an 8-kDa trans-site receptor in plants and protozoans, is a conserved feature of the TOM complex that appeared early in the evolution of eukaryotes
    Year: 2004
    Journal: Molecular Biology and Evolution
    Volume: 21
    Issue: 8
    Page numbers: 1557-1564
    Publisher: Society for Molecular Biology and Evolution(Kansas)
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Publications in 2002

Journal Articles

  • 1H, 13C and 15N chemical shift assignments of the SH2 domain of the Csk homologous kinase
    Year: 2002
    Journal: Journal of Biomolecular NMR
    Volume: 24
    Page numbers: 363-364
    Publisher: Kluwer Academic Publishers(Dordrecht)
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  • The Solution Structure and Intramolecular Associations of the Tec Kinase Src Homology 3 Domain
    Year: 2002
    Journal: Journal of Biological Chemistry
    Volume: 277
    Issue: 1
    Page numbers: 755-762
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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Publications in 2001

Journal Articles

  • ATM,a central controller of cellular responses to DNA damage
    Year: 2001
    Journal: Cell Death & Differentiation
    Volume: 2001
    Issue: 8
    Page numbers: 1052-1065
    Publisher: Nature Publishing Group(Basingstroke)
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  • Mutational Analysis of Protein Substrate Presentation in the Post-translational Attachment of Biotin to Biotin Domains
    Year: 2001
    Journal: Journal of Biological Chemistry
    Volume: 276
    Issue: 5
    Page numbers: 3037-3045
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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  • Sedimentation Analysis of Novel DNA Structures Formed by Homo-Oligonucleotides
    Year: 2001
    Journal: Biophysical Journal
    Volume: 81
    Page numbers: 371-381
    Publisher: Biophysical Society(Maryland)
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  • The C-terminal domain of biotin protein ligase from E. coli is required for catalytic activity
    Year: 2001
    Journal: Protein Science
    Volume: 10
    Page numbers: 2608-2617
    Publisher: Cold Spring Harbour Laboratory Press(New York)
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  • The Role of the Src Homology 3-Src Homology 2 Interface in the Regulation of Src Kinases
    Year: 2001
    Journal: Journal of Biological Chemistry
    Volume: 276
    Issue: 20
    Page numbers: 17199-17205
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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