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PROF TREVOR LITHGOW



Contact Details

Organization: Biochemistry and Molecular Biology
Position: HONORARY PROFESSORIAL FELLOW SUPERVISOR
Email:
Homepage: http://www.biochemistry.unimelb.edu.au/research/res_lithgow.htm
Work: 8344 2312
Fax: 9348 1421
Room: 234
Level: 02
Building: David Pennington Building
Campus: Parkville

Research Expertise and International Linkages

Research Expertise

Research Interest Country of Expertise
Cell Structure and protein targeting Australia
Bioinformatics Australia

International Linkages

Country Establishment Collaboration
United States National Institutes of Health Exchange, Research, Technical Assistance/Training
Czech Republic Charles University in Prague Exchange, Research
Switzerland University of Fribourg Research
United States Yale University Exchange, Research, Technical Assistance/Training
United Kingdom University of Warwick Research, Technical Assistance/Training
Greece Institute of Molecular Biology & Biotechnology Exchange, Research
Switzerland University of Geneva Exchange, Research, Technical Assistance/Training

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Bachelor of Science La Trobe University
Doctor of Philosophy La Trobe University

Memberships

Membership Type Membership Body Description Start Date End Date
Member Australian Society for Biochemistry and Molecular Biology Regular 01-Apr-1986
Member American Society for Cell Biology Regular 01-Jan-2000

Other Awards

Award Type Awarding Body Comments Date Awarded
David Syme Research Prize University of Melbourne 01-May-2005
Medal Victor Chang Cardiac Research Institute 04-Nov-2005
Medal Australian Society for Biochemistry and Molecular Biology 01-Jul-2004
Other (Award) Human Frontiers Science Program 01-Jul-1999
Other (Award) AMRAD 01-Feb-1995
Medal La Trobe University 01-Feb-1985

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
Differences in the pathways of mitochondrial protein import in the malarialparasite Plasmodium falciparum and humans Principal Supervisor NHMRC Dora Lush Biomedical Postgraduate Scholarship 01/01/2004
Insertion and assembly of proteins and lipids into biological membranes. Chief Investigator AUST RESEARCH COUNCIL Discovery Projects 01/01/2005
Evolution, structure and function of key components in a molecular machine Chief Investigator AUST RESEARCH COUNCIL Discovery Projects 01/01/2005
Regulated targeting of cell death effectors to and from mitochondria. Chief Investigator NHMRC Project Grants 01/01/2006
High resolution cellular and molecular imaging system Chief Investigator MONASH UNIVERSITY,
DEAKIN UNIVERSITY,
AUST RESEARCH COUNCIL
Linkage Infrastructure (Equipment and Facilities) (AUST RESEARCH COUNCIL) 01/01/2006
Mitochondrial biogenesis: the evolution of molecular machines Chief Investigator AUST RESEARCH COUNCIL Discovery Projects 01/01/2007
STRUCTURE AND FUNCTION OF NOVEL TRANSPORTERS IN ALPHAPROTEOBACTERIA Chief Investigator AUST RESEARCH COUNCIL Linkage International Awards 01/01/2007
PFAM-REVERSE SEARCH OF SEQUENCE DATABASES BASED ON CUSTOM-BUILT PROTEIN FAMILIES Chief Investigator VIC PARTNERSHIP FOR ADVANCED COMPUTING LTD E-Research Program Scheme 01/03/2007
Surface details of pathogenic bacteria. Chief Investigator NHMRC Project Grants 01/01/2008
Reducible complexity in the molecular machines of humans and bacteria Chief Investigator AUST RESEARCH COUNCIL Discovery Projects 01/01/2008
MASS SPECTROMETRY FACILITY FOR THE QUANTITATION AND ANALYSIS OF POST-TRANSLATIONALLY MODIFIED PEPTIDES Chief Investigator AUST RESEARCH COUNCIL Linkage Infrastructure (Equipment and Facilities) 01/01/2008
Determining how the ability to secrete proteins assists E. coli to cause disease Chief Investigator NHMRC Project Grants 01/01/2009
LPS and capsules Chief Investigator NHMRC Project Grants 01/01/2010

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2009

Journal Articles

  • Evidence of a reduced and modified mitochondrial protein import apparatus in microsporidian mitosomes.
    Year: 2009
    Journal: Eukaryotic Cell
    Volume: 8
    Page numbers: 19-26
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  • Domain Organization of the Monomeric Form of the Tom70 Mitochondrial Import Receptor
    Year: 2009
    Journal: Journal of Molecular Biology
    Volume: 388
    Issue: 5
    Page numbers: 1043-1058
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  • The Major Surface-Associated Saccharides of Klebsiella pneumoniae Contribute to Host Cell Association
    Year: 2009
    Journal: PLoS One
    Volume: 3
    Issue: 11
    Page numbers: E3817
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  • The Protein Import Channel in the Outer Mitosomal Membrane of Giardia intestinalis
    Year: 2009
    Journal: Molecular Biology and Evolution
    Volume: 26
    Issue: 9
    Page numbers: 1941-7
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  • The Protein Import Channel in the Outer Mitosomal Membrane of Giardia intestinalis
    Year: 2009
    Journal: Molecular Biology and Evolution
    Volume: 26
    Issue: 9
    Page numbers: 1941-7
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  • The reducible complexity of a mitochondrial molecular machine
    Year: 2009
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 106
    Issue: 37
    Page numbers: 15791-5
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Publications in 2008

Journal Articles

Publications in 2007

Journal Articles

  • Conserved Motifs Reveal Details Of  Ancestry and Structure in the Small TIM Chaperones of the Mitochondrial Intermemberane Space
    Year: 2007
    Journal: Molecular Biology and Evolution
    Volume: 24
    Issue: 5
    Page numbers: 1149-1160
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  • Domain Stealing by Receptors in a Protein Transport Complex
    Year: 2007
    Journal: Molecular Biology and Evolution
    Volume: 24
    Issue: 9
    Page numbers: 1909-1911
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  • Re-assessing the locations of components of the classical vesicle-mediated trafficking machinery in transfected Plasmodium falciparum
    Year: 2007
    Journal: International Journal for Parasitology
    Volume: 37
    Issue: 10
    Page numbers: 1127-1141
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Publications in 2006

Journal Articles

Publications in 2005

Journal Articles

  • 1H, 13C and 15N Resonance Assignments of the Cytosolic Domain of Tom20 from Arabidopsis thaliana
    Year: 2005
    Journal: Journal of Biomolecular NMR
    Volume: 33
    Page numbers: 198-198
    Publisher: Kluwer Academic Publishers(Dordrecht)
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  • Giardia mitosomes and trichomonad hydrogenosomes share a common mode of protein targeting
    Year: 2005
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 102
    Issue: 31
    Page numbers: 10924-10929
    Publisher: National Academy of Sciences(Washington DC)
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  • Mature DIABLO/Smac Is Produced by the IMP Protease Complex on the Mitochondrial Inner Membrane
    Year: 2005
    Journal: Molecular Biology of the Cell
    Volume: 16
    Issue: 6
    Page numbers: 2926-2933
    Publisher: American Society for Cell Biology(Maryland)
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  • Mitochondrial Release of Pro-apoptotic Proteins
    Year: 2005
    Journal: Journal of Biological Chemistry
    Volume: 280
    Issue: 3
    Page numbers: 2266-2274
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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  • Molecular architecture and function of the Omp85 familyof proteins
    Year: 2005
    Journal: Molecular Microbiology
    Volume: 58
    Issue: 5
    Page numbers: 1216-1225
    Publisher: Blackwell Science(Oxford)
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  • Patterns that define the four domains conserved in known and novel isoforms of the protein import receptor Tom20
    Year: 2005
    Journal: Journal of Molecular Biology
    Volume: 347
    Page numbers: 81-93
    Publisher: Academic Press(London)
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  • Protein import into mitochondria: origins and functions today
    Year: 2005
    Journal: Molecular Membrane Biology
    Volume: 22
    Issue: 1-2
    Page numbers: 87-100
    Publisher: Taylor & Francis Ltd(London)
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  • Protein targeting: entropy, energetics and modular machines.
    Year: 2005
    Journal: Current Biology
    Volume: 15
    Issue: 11
    Page numbers: 423-425
    Publisher: Cell Press(Massachusetts)
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Publications in 2004

Journal Articles

  • A Complete Set of SNAREs in Yeast
    Year: 2004
    Journal: Traffic
    Volume: 5
    Issue: 1
    Page numbers: 45
    Publisher: Munksgaard International Publishers(Copenhagen)
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  • A biophysical analysis of the TPR-rich mitochondrial import receptor, Tom70, reveals an elongated monomer that is inherently flexible, unstable and unfolds via a multi-state pathway
    Year: 2004
    Journal: Journal of Biological Chemistry
    Volume: 279
    Issue: 45
    Page numbers: 46448-46454
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  • Assembling the mitochondrial outer membrane
    Year: 2004
    Journal: Nature
    Volume: 11
    Page numbers: 1044-1048
    Publisher: Macmillan Publishers(London)
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  • Bacterial proteins predisposed for targeting to mitochondria
    Year: 2004
    Journal: Molecular Biology and Evolution
    Volume: 21
    Issue: 4
    Page numbers: 652-658
    Publisher: Society for Molecular Biology and Evolution(Kansas)
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  • Distinct roles for the Hsp40 and Hsp90 molecular chaperones during cystic fibrosis transmembrane conductance regulator degradation in yeast
    Year: 2004
    Journal: Molecular Biology of the Cell
    Volume: 15
    Issue: 11
    Page numbers: 4787-4797
    Publisher: American Society for Cell Biology(Maryland)
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  • Protein hijacking: Key proteins held captive against their will
    Year: 2004
    Journal: Cancer Cell
    Volume: 5
    Issue: 2
    Page numbers: 107-108
    Publisher: Cell Press(Philadelphia)
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  • The J-protein family: modulating protein assembly, disassembly and translocation
    Year: 2004
    Journal: EMBO Journal
    Volume: 5
    Issue: 6
    Page numbers: 567-571
    Publisher: Oxford University Press(Oxford)
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  • The Omp85 family of proteins is essential for outer membrane biogenesis in mitochondria and bacteria
    Year: 2004
    Journal: Journal of Cell Biology
    Volume: 164
    Issue: 1
    Page numbers: 19-24
    Publisher: Rockefeller University Press(New York)
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  • Tom22', an 8-kDa trans-site receptor in plants and protozoans, is a conserved feature of the TOM complex that appeared early in the evolution of eukaryotes
    Year: 2004
    Journal: Molecular Biology and Evolution
    Volume: 21
    Issue: 8
    Page numbers: 1557-1564
    Publisher: Society for Molecular Biology and Evolution(Kansas)
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  • Zim17, a Novel Zinc Finger Protein Essential for Protein import into Mitochondria
    Year: 2004
    Journal: Journal of Biological Chemistry
    Volume: 279
    Issue: 48
    Page numbers: 50243-50249
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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Publications in 2003

Journal Articles

  • A Complete Set of SNAREs in Yeast
    Year: 2003
    Journal: Traffic
    Volume: 5
    Page numbers: 45-52
    Publisher: Munksgaard International Publishers(Copenhagen)
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  • A SNARE required for retrograde transport to the endoplasmic reticulum
    Year: 2003
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 100
    Issue: 17
    Page numbers: 9873-9877
    Publisher: National Academy of Sciences(Washington DC)
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  • Bipartite Signals Mediate Subcellular Targeting of Tail-anchored Membrane Proteins in Saccharomyces cerevisiae
    Year: 2003
    Journal: Journal of Biological Chemistry
    Volume: 278
    Issue: 10
    Page numbers: 8219-8223
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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  • Environmental stresses inhibit and stimulate different protein import pathways in plant mitochondria
    Year: 2003
    Journal: FEBS Letters
    Volume: 547
    Page numbers: 125-130
    Publisher: Elsevier Science(Amsterdam)
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  • Proapoptotic BH3-only proteins trigger membrane integration of prosurvival Bcl-w and neutralize its activity
    Year: 2003
    Journal: Journal of Cell Biology
    Volume: 162
    Issue: 5
    Page numbers: 877-887
    Publisher: Rockefeller University Press(New York)
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  • The Omp85 family of proteins is essential for outer membrane biogenesis in mitochondria and bacteria
    Year: 2003
    Journal: Journal of Cell Biology
    Volume: 164
    Page numbers: 19-24
    Publisher: Rockefeller University Press(New York)
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  • Tom40, the import channel of the mitochondrial outer membrane, plays an active role in sorting imported proteins
    Year: 2003
    Journal: EMBO Journal
    Volume: 22
    Issue: 10
    Page numbers: 2380-2386
    Publisher: Oxford University Press(Oxford)
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Publications in 2002

Journal Articles

  • A conserved proline residue is present in the transmembrane-spanning domain of Tom7 and other tail-anchored protein subunits of the TOM translocase
    Year: 2002
    Journal: FEBS Letters
    Volume: 514
    Issue: 2-3
    Page numbers: 347-350
    Publisher: Elsevier Science(Amsterdam)
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  • Delivery of nascent polypeptides to the mitochondrial surface
    Year: 2002
    Journal: Biochimica et Biophysica Acta - Molecular Cell Research
    Volume: 1592
    Issue: 1
    Page numbers: 35-39
    Publisher: Elsevier Science(Amsterdam)
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  • Protein structure and function by the sea
    Year: 2002
    Journal: Genome Biology
    Volume: 3
    Page numbers: 400811-400812
    Publisher: Biomed Central
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  • The nascent polypeptide-associated complex (NAC) promotes interaction of ribosomes with the mitochondrial surface in vivo
    Year: 2002
    Journal: FEBS Letters
    Volume: 516
    Issue: 1-3
    Page numbers: 213-216
    Publisher: Elsevier Science(Amsterdam)
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Publications in 2001

Journal Articles

  • RAC, a stable ribosome-associated complex in yeast formed by the DnaK-Dnaj homologs Ssz1p and zuotin
    Year: 2001
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 98
    Issue: 7
    Page numbers: 3762-3767
    Publisher: National Academy of Sciences(Washington DC)
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  • Targeting of C-Terminal (Tail)-Anchored Proteins: Understanding how Cytoplasmic Activities are Anchored to Intracellular Membranes
    Year: 2001
    Journal: Traffic
    Volume: 2
    Issue: Interchange
    Page numbers: 66-71
    Publisher: Munksgaard International Publishers(Copenhagen)
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  • The alpha and the beta: protein translocation across mitochondrial and plastid outer membranes
    Year: 2001
    Journal: Trends in Biochemical Sciences
    Volume: 26
    Issue: 1
    Page numbers: 36-40
    Publisher: Elsevier Science London(London)
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