University home page

Find an ExpertProfiling the University of Melbourne's Researchers

DR ARTHUR CHRISTOPOULOS



Contact Details

Organization: Pharmacology
Position: Honorary (Senior Fellow)
Email:

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Bachelor of Pharmacy Monash University 31-Dec-1990
Doctor of Philosophy Monash University 31-Dec-1997

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
Research Fellowship Chief Investigator NHMRC Research Fellowship 01/01/2003
Allosteric Modulation of G Protein-Coupled Receptors Chief Investigator NHMRC Project Grants 01/01/2003
Molecular pharmacology of receptor activity modifying protein (RAMP) action Chief Investigator NHMRC Project Grants 01/01/2004
Molecular mechanisms underlying G protein coupled receptor signalling Chief Investigator NHMRC Project Grants 01/01/2004
Novel modes of regulating serotonin 5HT2c receptors. Chief Investigator NHMRC Project Grants
Allosteric regulation of G protein-coupled receptors Chief Investigator NHMRC Project Grants

Contracts

Title Role Funding Source Award Date
MUSCARINIC M1 RECEPTOR STUDY Chief Investigator GLAXOSMITHKLINE AUSTRALIA 06/03/2005
NOVATION AGREEMENT - OPTIMISED SCREENING FOR ALLOSTERIC MODULATORS OF G PROTEIN-COUPLED RECEPTORS Chief Investigator MONASH UNIVERSITY,
PFIZER AUST PTY LTD

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2006

Journal Articles

  • A critical role for the short intracellular C terminus in receptor activity-modifying protein function
    Year: 2006
    Journal: Molecular Pharmacology
    Volume: 70
    Issue: 5
    Page numbers: 1750-1760
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Distinct receptor activity-modifying protein domains differentially modulate interaction with calcitonin receptors
    Year: 2006
    Journal: Molecular Pharmacology
    Volume: 69
    Issue: 6
    Page numbers: 1984-1989
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Interaction studies of multiple binding sites on M-4 muscarinic actylcholine receptors
    Year: 2006
    Journal: Molecular Pharmacology
    Volume: 70
    Issue: 2
    Page numbers: 736-746
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Probing the molecular mechanism of interaction between 4-n-butyl-1-[-4-(2-methylphenyl)-4-oxo-1-butyl]-piperidine (AC-42) and the muscarinic M-1 receptor: Direct pharmacological evidence that AC-42 is an allosteric agonist
    Year: 2006
    Journal: Molecular Pharmacology
    Volume: 69
    Issue: 1
    Page numbers: 236-246
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.

Publications in 2005

Journal Articles

  • 'Ins and outs' of seven trans-membrane receptor signalling to ERK
    Year: 2005
    Journal: Trends in Endocrinology and Metabolism
    Volume: 16
    Page numbers: 26-33
    Publisher: Elsevier Science London(London)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Allosteric modulation of the cannabinoid CB1 receptor
    Year: 2005
    Journal: Molecular Pharmacology
    Volume: 68
    Page numbers: 1484-1495
    Publisher: American Society for Pharmacology and Experimental Therapeutics(Maryland)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Characterization of serotonin 5-HT2C receptor signaling to extracellular signal-regulated kinases 1 and 2
    Year: 2005
    Journal: Journal of Neurochemistry
    Volume: 93
    Page numbers: 1603-1615
    Publisher: Blackwell Science(Oxford)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Effects of urea pretreatment on the binding properties of adenosine A1 receptors
    Year: 2005
    Journal: British Journal of Pharmacology
    Volume: 146
    Page numbers: 1119-1129
    Publisher: Nature Publishing Group(Basingstroke)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Evidence for pleiotropic signalling at the mouse β-adrenoceptor revealed by SR59230A [3-[2-ethylphenoxy)-1-[(1,S)-1,2,3,4-tetrahydronapth-1-ylamino]-2S-2-propanol oxalate]
    Year: 2005
    Journal: Journal of Pharmacology and Experimental Therapeutics
    Volume: 312
    Page numbers: 1064-1074
    Publisher: The American Society for Pharmacology and Experimental Therapeutics(Maryland)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • G-protein-coupled receptor Mas is a physiological antagonist of the angiotensin II type 1 receptor
    Year: 2005
    Journal: Circulation
    Volume: 111
    Page numbers: 1806-1813
    Publisher: Lippincott Williams & Wilkins(Pennsylvania)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Pharmacological discrimination of calcitonin receptor: receptor activity-modifying protein complexes
    Year: 2005
    Journal: Molecular Pharmacology
    Volume: 67
    Page numbers: 1655-1665
    Publisher: American Society for Pharmacology and Experimental Therapeutics(Maryland)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Regulation of M2 muscarinic acetylcholine receptor expression and signalling by prolonged exposure to allosteric modulators
    Year: 2005
    Journal: Journal of Pharmacology and Experimental Therapeutics
    Volume: 312
    Page numbers: 382-390
    Publisher: The American Society for Pharmacology and Experimental Therapeutics(Maryland)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.

Publications in 2004

Books

  • Fitting models to biological data using linear and nonlinear regression
    Year: 2004
    Publisher: Oxford University Press(New York)
    Authors(s):

Journal Articles

  • Allosteric modulation of G protein-coupled receptors
    Year: 2004
    Journal: Current Pharmaceutical Design
    Volume: 10
    Page numbers: 2003-2013
    Publisher: Bentham Science Publishers(Sharjah)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Amylin receptors: molecular composition and pharmacology
    Year: 2004
    Journal: Biochemical Society Transactions
    Volume: 32
    Issue: 5
    Page numbers: 865-867
    Publisher: Portland Press(London)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Application of a kinetic model to the apparently complex behavior of negative and positive allosteric modulators of muscarinic acetylcholine receptors
    Year: 2004
    Journal: Journal of Pharmacology and Experimental Therapeutics
    Volume: 308
    Issue: 3
    Page numbers: 1062-1072
    Publisher: The American Society for Pharmacology and Experimental Therapeutics(Maryland)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Effects of anandamide on the binding and signaling properties of M1 muscarinic acetylcholine receptors
    Year: 2004
    Journal: Biochemical Pharmacology
    Volume: 68
    Page numbers: 2207-2219
    Publisher: Pergamon-Elsevier Science(Oxford)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • GPCR allosterism and accessory proteins: new insights into drug discovery
    Year: 2004
    Journal: Biochemical Society Transactions
    Volume: 32
    Issue: 5
    Page numbers: 873-877
    Publisher: Portland Press(London)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Investigation of the interaction of a putative allosteric modulator, N-(2,3-Diphenyl-1,2,4-thiadiazole-5-(2H)-ylidene) methanamine hydrobromide (SCH-202676), with M1 muscarinic acetylcholine receptors
    Year: 2004
    Journal: Journal of Pharmacology and Experimental Therapeutics
    Volume: 308
    Page numbers: 830-837
    Publisher: The American Society for Pharmacology and Experimental Therapeutics(Maryland)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Regulation of serotonin 5-HT2c receptors by chronic ligand exposure
    Year: 2004
    Journal: European Journal of Pharmacology
    Volume: 498
    Issue: 1-3
    Page numbers: 59-69
    Publisher: Elsevier Science(Amsterdam)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • The state of GPCR research in 2004
    Year: 2004
    Journal: Nature Reviews Drug Discovery
    Volume: 3
    Page numbers: 577-626
    Publisher: Nature Publishing Group(London)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.

Conference Publications/Papers

  • G-protein-coupled receptor allosterism: the promise and the problem(s)
    Year: 2004
    Event name: Focused Meeting and Satellite to BioScience 2004
    Conference Publication: Biochemical Society Transactions
    Volume: 32
    Issue: 5
    Page numbers: 873-877
    Publisher: Portland Press(London)
    Author(s):

Publications in 2003

Journal Articles

  • Allosteric modulators of G-protein-coupled receptors
    Year: 2003
    Journal: Current Opinion in Pharmacology
    Volume: 3
    Page numbers: 551-556
    Publisher: Elsevier Science(Oxford)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Cellular signaling mechanisms for muscarinic acetylcholine receptors
    Year: 2003
    Journal: Receptors and Channels
    Volume: 9
    Page numbers: 241-260
    Publisher: Taylor & Francis Ltd(Abingdon)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • International Union of Pharmacology Committee on Receptor Nomenclature and Drug classification. XXXVIII. Update on terms and symbols in quantitative pharmacology
    Year: 2003
    Journal: Pharmacological Reviews
    Volume: 55
    Issue: 4
    Page numbers: 597-606
    Publisher: American Society for Pharmacology and Experimental Therapeutics(Maryland)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Novel receptor partners and function of receptor activity-modifying proteins
    Year: 2003
    Journal: Journal of Biological Chemistry
    Volume: 278
    Issue: January 31
    Page numbers: 3293-3297
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • RAMPs: 5 years on, where to now?
    Year: 2003
    Journal: Trends Pharmacological Sciences
    Volume: 24
    Issue: 11
    Page numbers: 596-601
    Publisher: Elsevier Science London
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.

Publications in 2002

Journal Articles

  • Allosteric binding sites on cell-surface receptors: novel targets for drug discovery
    Year: 2002
    Journal: Nature Reviews Drug Discovery
    Volume: 1
    Issue: 3
    Page numbers: 198-210
    Publisher: Nature Publishing Group(London)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • G protein-coupled receptor allosterism and complexing
    Year: 2002
    Journal: Pharmacological Reviews
    Volume: 54
    Issue: 2
    Page numbers: 323-374
    Publisher: American Society for Pharmacology and Experimental Therapeutics(Maryland)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Modulation of cannabinoid agonist binding by 5-HT in the rat cerebellum
    Year: 2002