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A/PROF ANDREW BROOKS



Contact Details

Organization: Microbiology and Immunology
Position: ASSOCIATE PROFESSOR
Email:
Homepage: http://www.microbiol.unimelb.edu.au/people/brooks/
Work: 61 3 8344 9925
Fax: 61 3 9347 1540
Room: 522
Level: 05
Building: Microbiology Building
Campus: Parkville

Research Expertise and International Linkages

Research Expertise

Research Interest Key Words Country of Expertise
Immunology Natural killer cells, Herpes simplex virus, MHC Australia

International Linkages

Country Establishment Collaboration
Italy University of Genoa Research
United States Emory University Research

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Bachelor of Science Monash University
Graduate Diploma in Education Victorian College of the Arts
Doctor of Philosophy Flinders University of South Australia

Memberships

Membership Type Membership Body Description Start Date End Date
Member Australasian Society for Immunology Member 21-Apr-2009

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
Antigen presentation, recognition and the immune response Chief Investigator NHMRC Program Grants 01/01/2002
The structural basis for recognition of HLA-E by both innate and adaptive immune systems. Chief Investigator NHMRC Project Grants 01/01/2006
2007 PROGRAM GRANT - (ANTIGEN PRESENTATION, RECOGNITION AND THE IMMUNE RESPONSE) Chief Investigator NHMRC Program Grants 01/01/2007
THE EARLY RECRUITMENT AND ACTIVATION OF LYMPHOCYTES FOLLOWING LOCALISED VIRAL INFECTION Principal Supervisor NHMRC Dora Lush Biomedical Postgraduate Scholarship 01/01/2007
Immune recognition of HLA-E Chief Investigator NHMRC Project Grants 01/01/2008
Multi-photon imaging for infection, immunity, and self recognition Chief Investigator AUST RESEARCH COUNCIL Linkage Infrastructure (Equipment and Facilities) 01/01/2009

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2009

Journal Articles

  • Cross-presentation of viral and self antigens by skin-derived CD103+ dendritic cells
    Year: 2009
    Journal: Nature Immunology
    Volume: 10
    Issue: 5
    Page numbers: 488-495
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  • Differential Recognition of CD1d-α-Galactosyl Ceramide by the Vβ8.2 Vβ7 Semi-invariant NKT T Cell Receptors
    Year: 2009
    Journal: Immunity
    Volume: 31
    Issue: 1
    Page numbers: 47-59
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  • The shaping of T cell receptor recognition by self-tolerance
    Year: 2009
    Journal: Immunity
    Volume: 30
    Issue: 2
    Page numbers: 193-203
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Publications in 2008

Journal Articles

Conference Publications/Papers

  • Inhibition of Influenza Viruses By Proteins of the Innate Immune System
    Year: 2008
    Event name: Options for the Control of Influenza VI
    Conference Publication: Options for the Control of Influenza VI
    Page numbers: 489-491
    Publisher: International Medical Press(London)
    Author(s):

Publications in 2007

Journal Articles

Publications in 2006

Book Chapters

  • Assays for T cell function.  Induction and Measurement of Cytotoxic T Lymphocyte Activity


    Year: 2006
    Book: Current Protocols in Immunology
    Publisher: John Wiley & Sons(New York)
    Authors(s):
    Editors(s):

Journal Articles

  • Responses against islet antigens in NOD mice prevented by tolerance to proinsulin but not IGRP


    Year: 2006
    Journal: Journal of Clinical Investigation
    Volume: 116
    Issue: 12
    Page numbers: 3258-3264
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  • The human cytomegalorvirus glycoprotein UL16 traffics through the plasma membrane and the nuclear envelope


    Year: 2006
    Journal: Cellular Microbiology
    Volume: 8
    Issue: 4
    Page numbers: 581-590
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  • CMV-specific CD8+ T-cell dynamics in the blood and the lung allograft reflect viral reactivation following lung transplantation
    Year: 2006
    Journal: American Journal of Transplantation
    Volume: 6
    Issue: 3
    Page numbers: 577-584
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  • MHC class I allele frequencies in pigtail macaques of diverse origin
    Year: 2006
    Journal: Immunogenetics
    Volume: 58
    Issue: 12
    Page numbers: 995-1001
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  • NK cells contribute to the early clearance of HSV-1 from the lung but cannot control replication in the central nervous system following intranasal infection
    Year: 2006
    Journal: European Journal of Immunology
    Volume: 36
    Issue: 4
    Page numbers: 897-905
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  • NK cells promote peritoneal xenograft rejection through an IFN-γ-dependent mechanism
    Year: 2006
    Journal: Xenotransplantation
    Volume: 13
    Issue: 6
    Page numbers: 536-546
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  • Structural basis for a major histocompatability complex class 1b-restricted T cell response
    Year: 2006
    Journal: Nature Immunology
    Volume: 7
    Issue: 3
    Page numbers: 256-264
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Publications in 2005

Journal Articles

  • Analysis of Pigtail Macaque Major Histocompatibility Complex Class I Molecules Presenting Immunodominant Simian Immunodeficiency Virus Epitopes
    Year: 2005
    Journal: Journal of Virology
    Volume: 79
    Issue: 2
    Page numbers: 684-695
    Publisher: American Society for Microbiology(Washington DC)
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  • Crystal structure of HLA-G: A nonclassical MHC class I molecule expressed at the fetal-maternal interface
    Year: 2005
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 102
    Issue: 9
    Page numbers: 3360-3365
    Publisher: National Academy of Sciences(Washington DC)
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  • DX5/CD49b-Positive T Cells Are Not Synonymous with CD1d-Dependent NKT Cells1
    Year: 2005
    Journal: Journal of Immunology
    Volume: 175
    Page numbers: 4416-4425
    Publisher: American Association of Immunologists(Maryland)
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  • T-cell grit: large clonal expansions of virus-specific CD8+ T cells can dominate in the peripheral circulation for at least 18 years
    Year: 2005
    Journal: Blood
    Volume: 106
    Issue: 13
    Page numbers: 4412-4413
    Publisher: American Society of Hematology(Washington DC)
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  • The pigtail macaque MHC class I allele Mane-A*10 presents an immundominant SIV Gag epitope: identification, tetramer development and implications of immune escape and reversion
    Year: 2005
    Journal: Journal of Medical Primatology
    Volume: 34
    Issue: 5-6
    Page numbers: 282-293
    Publisher: Munksgaard International Publishers(Copenhagen)
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Conference Publications/Papers

  • Recognition of the Non-Classical MHC Class I Molecule, HLA-E, by the Adaptive Immune System
    Year: 2005
    Event name: 35th ASI - 14th IHIWS
    Conference Publication: Tissue Antigens
    Volume: 66
    Issue: 5
    Page numbers: 443-443
    Publisher: Blackwell Publishing
    Author(s):

Publications in 2004

Journal Articles

  • Analysis of Pigtail Macaque Major Histocompatibility Complex Class I Molecules Presenting Immunodominant Simian Immunodeficiency Virus Epitopes
    Year: 2004
    Journal: Journal of Virology
    Volume: 79
    Issue: 2
    Page numbers: 684-695
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  • Crystal structure of the human T cell receptor CD3εγ heterodimer complexed to the therapeutic mAB OKT3
    Year: 2004
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 101
    Issue: 20
    Page numbers: 7675-7680
    Publisher: National Academy of Sciences(Washington DC)
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  • Distinct migrating and nonmigrating dendritic cell populations are involved in MHC class I-restricted antigen presentation after lung infection with virus
    Year: 2004
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 101
    Issue: 23
    Page numbers: 8670-8675
    Publisher: National Academy of Sciences(Washington DC)
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  • Herpes Simplex Virus-Specific CD8+ T Cells Can Clear Established Lytic Infections from Skin and Nerves and Can Partially Limit the Early Spread of Virus after Cutaneous Inoculation
    Year: 2004
    Journal: Journal of Immunology
    Volume: 172
    Issue: 1
    Page numbers: 392-397
    Publisher: American Association of Immunologists(Maryland)
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  • Natural HLA class I polymorphism controls the pathway of antigen presentation and susceptibility to viral evasion
    Year: 2004
    Journal: Journal of Experimental Medicine
    Volume: 200
    Page numbers: 13-24
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  • Persistent expression of CD94/NKG2 receptors by virus-specific CD8 T cells is initiated by TCR-mediated signals
    Year: 2004
    Journal: International Immunology
    Volume: 16
    Issue: 9
    Page numbers: 1333-1341
    Publisher: Oxford University Press(Oxford)
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  • The production and purification of the human T-cell receptors, the CD3εγ and CD3εδ heterodimers: complex formation and crystallization with OKT3, a therapeutic monoclonal antibody
    Year: 2004
    Journal: Acta Crystallographica Section D - Biological Crystallography
    Volume: D60
    Page numbers: 1425-1428
    Publisher: Munksgaard International Publishers(Copenhagen)
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  • Truncated HLA-G isoforms are retained in the endoplasmic reticulum and insufficiently provide HLA-E ligands
    Year: 2004
    Journal: Human Immunology
    Volume: 65
    Issue: 3
    Page numbers: 200-208
    Publisher: Elsevier Science(New York)
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Publications in 2003

Journal Articles

  • A Naturally Selected Dimorphism within the HLA-B44 Supertype Alters Class I Structure, Peptide Repertoire, and T Cell Recognition
    Year: 2003
    Journal: Journal of Experimental Medicine
    Volume: 198
    Issue: 5
    Page numbers: 679-691
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  • A Structural Basis for the Selection of Dominant αβ T Cell Receptors in Antiviral Immunity
    Year: 2003
    Journal: Immunity
    Volume: 18
    Page numbers: 1-20
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  • Genetic Control of NKT Cell Numbers Maps to Major Diabetes and Lupus Loci1
    Year: 2003
    Journal: Journal of Immunology
    Volume: 171
    Page numbers: 2873-2878
    Publisher: American Association of Immunologists(Maryland)
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  • Intrathymic NKT cell development is blocked by the presence of α-galactosylceramide
    Year: 2003
    Journal: European Journal of Immunology
    Volume: 33
    Page numbers: 1816-1823
    Publisher: Wiley-VCH(Berlin)
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  • Novel strategy for identification of candidate cytotoxic T-cell epitopes from human preproinsulin
    Year: 2003
    Journal: Tissue Antigens
    Volume: 62
    Page numbers: 408-417
    Publisher: Munksgaard International Publishers(Copenhagen)
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  • Virus infection expands a biased subset of T cells that bind tetrameric class I peptide complexes
    Year: 2003
    Journal: European Journal of Immunology
    Volume: 33
    Page numbers: 1557-1567
    Publisher: Wiley-VCH(Berlin)
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Publications in 2002

Journal Articles

  • Identification of a dominant self-ligand bound to three HLA B44 alleles and the preliminary crystallographic analysis of recombinant forms of each complex
    Year: 2002
    Journal: FEBS Letters
    Volume: 527
    Page numbers: 27-32
    Publisher: Elsevier Science(Amsterdam)
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  • Peripheral Deletion of Autoreactive CD8 T Cells by Cross Presentation of Self-Antigen Occurs by a Bcl-2-inhibitable Pathway Mediated by Bim
    Year: 2002
    Journal: Journal of Experimental Medicine
    Volume: 196
    Issue: 7
    Page numbers: 947-955
    Publisher: Rockefeller University Press(New York)
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  • Progression of Armed CTL from Draining Lymph Node to Spleen Shortly After Localized Infection with Herpes Simplex Virus 11
    Year: 2002
    Journal: Journal of Immunology
    Volume: 168
    Page numbers: 834-838
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  • The 1.5 Å Crystal Structure of a Highly Selected Antiviral T Cell Receptor Provides Evidence for a Structural Basis of Immunodominance
    Year: 2002
    Journal: Structure
    Volume: 10
    Page numbers: 1521-1532
    Publisher: Cell Press(Cambridge)
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  • The Structure of HLA-B8 Complexed to an Immunodominant Viral Determinant: Peptide-Induced Conformational Changes and a Mode of MHC Class I Dimerization1
    Year: 2002
    Journal: Journal of Immunology
    Volume: 169
    Page numbers: 5153-5160
    Publisher: American Association of Immunologists(Maryland)
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  • The production, purification and crystallization of a soluble heterodimeric form of a highly selected T-cell receptor in its unliganded and liganded state.
    Year: 2002
    Journal: Acta Crystallographica Section D - Biological Crystallography
    Volume: 58
    Page numbers: 2131-2134
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Publications in 2001

Journal Articles

  • Conformational Plasticity Revealed by the Cocrystal Structure of NKG2D and Its Class I MHC-like Ligand ULBP3
    Year: 2001
    Journal: Immunity
    Volume: 15
    Page numbers: 1039-1049
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  • Structure of killer cell immunoglobulin-like receptors and their recognition of the class I MHC molecules
    Year: 2001
    Journal: Immunological Reviews
    Volume: 181
    Page numbers: 66-78
    Publisher: Munksgaard International Publishers(Copenhagen)
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