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PROF PETER DOHERTY



Contact Details

Organization: Microbiology and Immunology
Position: LAUREATE PROFESSOR
Email:
Homepage: http://www.microbiol.unimelb.edu.au/people/doherty/
Work: 8344 7968
Fax: 8344 7990
Room: 206
Level: 02
Building: Microbiology Building
Campus: Parkville

Biography

Professor Peter Doherty shared the Nobel Prize in Physiology or Medicine in 1996 with Swiss colleague Rolf Zinkernagel, for their discovery of how the immune system recognises virus-infected cells. He was Australian of the Year in 1997, and has since been commuting between St Jude Children’s Research Hospital in Memphis and the Department of Microbiology and Immunology at the University of Melbourne. His research is mainly in the area of defence against viruses. He regularly devotes time to delivering public lectures, writing articles for newspapers and magazines and participating in radio discussions.

Peter Doherty graduated from the University of Queensland in Veterinary Science and became a veterinary officer.  Moving to Scotland, he received his PhD from the University of Edinburgh Medical School. He is the first person with a veterinary qualification to win a Nobel Prize.

Peter is also the author of several books, including “A Light History of Hot Air” and “The Beginners Guide to Winning the Nobel Prize”.

Research Expertise and International Linkages

Research Expertise

Research Interest Country of Expertise
Viral Immunity United States of America, Australia

International Linkages

Country Establishment Collaboration
United States St Judes Children's Research Hospital Research, Technical Assistance/Training

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Bachelor of Veterinary Science The University of Queensland 31-Dec-1962
Master of Veterinary Science The University of Queensland 31-Dec-1966
Doctor of Philosophy The University of Edinburgh 31-Dec-1970

Memberships

Membership Type Membership Body Description Start Date End Date
Member American Association of Immunologists American Association of Immunologists 11-Sep-1990
Member Australian Society for Immunology Australain Society for Immunology 04-Sep-1990
Member American Association of Pathologists American Assoication of Pathologists 19-Sep-1991
Member Neuroimmunology Society Neuroimmunology Society 18-Sep-1991
Associate American Association of Veterinary Immunologists American Association of Veterinary Immunologists 17-Sep-1991
Member Scandinavian Society of Immunology Scandinavian Society of Immunology 15-Sep-1992
Member Australian Society for Medical Research Australian Society for Medical Research 12-Sep-1993
Member American College of Veterinary Pathologists American College of Veterinary Pathologists 30-Sep-1994
Member Royal College of Veterinary Surgeons Royal College of Veterinary Surgeons 28-Sep-1995

Honours

Honour Date Awarded
Companion of the Order of Australia 1997

Fellowships

Fellowship Date Awarded
Fellow of the Royal Australasian College of Physicians (FRACP) 08-Sep-1998
Fellow of the Australian Academy of Science (FAA) 01-Aug-1983
Fellow of the Royal Society (FRS) 09-Jul-1987
Fellow of the Royal College of Pathologists, Australia (FRCPA) 15-Oct-1998
Fellow of the Royal Society of Edinburgh (FRSEDIN) 07-May-2008

Other Awards

Award Type Awarding Body Comments Date Awarded
Other (Award) Member of the Institute of Medicine of the National Academy of Science, Washington DC, USA 19-Jun-2008
Other (Award) The Woodrow Wilson Award, Melbourne 26-Mar-2007
Prize Paul Ehrlich Prize, Germany 09-Sep-1983
Medal Curtin Medal 06-Dec-2003
Medal Centenary Medal 17-Dec-2003
Other (Award) Associate Member of the Academy of Medicine, Paris 04-Aug-2001
Medal Foreign Associate, National Academy of Sciences, USA 12-Mar-1998
Other (Award) Nobel Prize for Physiology or Medicine 20-Oct-1996
Other (Award) Albert Lasker Basic Medical Research Award, USA 02-Sep-1995
Other (Award) Gairdner International Award for Medical Science, Canada 17-Aug-1986

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
Burnet Award Chief Investigator NHMRC Burnet Award 01/01/2002
Immunological response of T-cells Chief Investigator DEPT OF INNOVATION INDUSTRY & REGIONAL DEVELOPMENT 2002 Federation Fellowships Complementary STI Grants (VIC GOVERNMENT SCIENCE, TECHNOLOGY & INNOVATION INITIATIVE) 11/02/2003
Investigation of the signal(s) involved in the selection of memory T cells from the effector CD8+ cell pool following viral infection Chief Investigator NHMRC CJ Martin Fellowships 01/01/2004
HIV Infection: Immunobiology and Vaccine design Chief Investigator NHMRC Program Grants 01/01/2004
Establishing the capacity for H5N1 challenge of ferrets within Australia & optimising pandemic vaccines in this model Chief Investigator NHMRC Potential Avian Influenza-Induced Pandemic Research Grants 01/01/2006
Determinants of virus specific CD8+ T cell hierarchies. Chief Investigator NHMRC Project Grants 01/01/2007
Multi-photon imaging for infection, immunity, and self recognition Chief Investigator AUST RESEARCH COUNCIL Linkage Infrastructure (Equipment and Facilities) 01/01/2009
UNDERSTANDING AND CONTROLLING INFLUENZA Chief Investigator NHMRC Program Grants 01/01/2010

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2009

Journal Articles

  • Combined NKT cell activation and influenza virus vaccination boosts memory CTL generation and protective immunity
    Year: 2009
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 106
    Issue: 9
    Page numbers: 3330-3335
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  • Division-linked differentiation can account for CD8(+) T-cell phenotype in vivo
    Year: 2009
    Journal: European Journal of Immunology
    Volume: 39
    Issue: 1
    Page numbers: 67-77
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  • Evaluation of Recombinant Influenza Virus-Simian Immunodeficiency Virus Vaccines in Macaques
    Year: 2009
    Journal: Journal of Virology
    Volume: 83
    Issue: 15
    Page numbers: 7619
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  • Finding multiple needles in one immune haystack
    Year: 2009
    Journal: Nature Methods
    Volume: 6
    Issue: 7
    Page numbers: 489-490
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  • Functional implications of T cell receptor diversity
    Year: 2009
    Journal: Current Opinion in Immunology
    Volume: 21
    Issue: 3
    Page numbers: 286-290
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  • Granzyme A expression reveals distinct cytolytic CTL subsets following influenza A virus infection
    Year: 2009
    Journal: European Journal of Immunology
    Volume: 39
    Issue: 5
    Page numbers: 1203-1210
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  • Immunity to avian influenza A viruses
    Year: 2009
    Journal: OIE Revue Scientifique et Technique
    Volume: 28
    Issue: 1
    Page numbers: 175-185
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  • Q&A: What have we found out about the influenza A (H1N1) 2009 pandemic virus?
    Year: 2009
    Journal: Journal of Biology
    Volume: 8
    Page numbers: 69-69.4
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  • Q&A: What have we found out about the influenza A (H1N1) 2009 pandemic virus?
    Year: 2009
    Journal: Journal of Biology
    Volume: 8
    Issue: 8
    Page numbers: 69
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  • Rules to 'prime' by
    Year: 2009
    Journal: Nature Immunology
    Volume: 10
    Issue: 1
    Page numbers: 14-16
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  • TNF/iNOS-producing dendric cells are the necessary evil of lethal influenza virus infection
    Year: 2009
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 106
    Issue: 13
    Page numbers: 5306-5311
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  • The Intracellular Sensor NLRP3 Mediates Key Innate and Healing Responses to Influenza A Virus via the Regulation of Caspase-1
    Year: 2009
    Journal: Immunity
    Volume: 30
    Issue: 4
    Page numbers: 566-75
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  • Thinking About Broadly Cross-Reactive Vaccines
    Year: 2009
    Journal: Clinical Pharmacology and Therapeutics
    Volume: 85
    Issue: 6
    Page numbers: 665-668
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  • Transience of MHC Class I-restricted antigen presentation after influenza A virus infection
    Year: 2009
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 106
    Issue: 16
    Page numbers: 6724-6729
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  • Visualizing CTL activity for different CD8+ effector T cells supports the idea that lower TCR/epitope avidity may be advantageous for target cell killing
    Year: 2009
    Journal: Cell Death & Differentiation
    Volume: 16
    Page numbers: 537-542
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Publications in 2008

Book Chapters

  • The immune response to influenza A viruses
    Year: 2008
    Book: Influenza Vaccines for the Future
    Publisher: Birkhauser(Basel)
    Authors(s):

Journal Articles

Conference Publications/Papers

  • How the structure of viral peptide-MHC complexes influences cytotoxic T cell immunity to viral infections
    Year: 2008
    Event name: Immunobiology of Influenza Virus Infections: Approaches for an Emerging Zoonotic Disease
    Conference Publication: Immunology of Influenza Infection: Approaches for an emerging zoonotic disease 2008
    Page numbers: 33-45
    Publisher: Research Signpost(Trivandrum)
    Author(s):

Publications in 2007

Journal Articles

Publications in 2006

Journal Articles

  • A correlation between function and selected measures of T cell avidity in influenza virus-specific CD8+ T cell responses
    Year: 2006
    Journal: European Journal of Immunology
    Volume: 36
    Issue: 11
    Page numbers: 2951-2959
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  • A virus-specific CD8+ T cell immunodominance hierarchy determined by antigen dose and precursor frequencies
    Year: 2006
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 103
    Issue: 4
    Page numbers: 994-999
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  • Addition of a Prominant Epitope Affects Influenza A Virus-Specific CD8 + T Cell Immunodominance Hierarchies When Antigen Is Limiting1
    Year: 2006
    Journal: Journal of Immunology
    Volume: 177
    Page numbers: 2917-2925
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  • An unexpected antibody response to an engineered influenza virus modifies CD8+T cell responses
    Year: 2006
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 103
    Issue: 8
    Page numbers: 2764-2769
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  • Cell-mediated protection in influenza infection
    Year: 2006
    Journal: Emerging Infectious Diseases
    Volume: 12
    Issue: 1
    Page numbers: 48-54
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  • Early establishment of diverse T cell receptor profiles for influenza-specific CD8+CD62Lhi memory cells
    Year: 2006
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 103
    Issue: 24
    Page numbers: 9184-9189
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  • Establishment and recall of CD8+ T-cell memory in a model of localized transient infection
    Year: 2006
    Journal: Immunological Reviews
    Volume: 211
    Issue: 1
    Page numbers: 133-145
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  • Immunoproteasome Subunit Deficiencies Impact Differentially on Two Immunodominant Influenza Virus-Specific CD8+ T Cell Respones1
    Year: 2006
    Journal: Immunology
    Volume: 177
    Issue: 2006
    Page numbers: 7680-7688
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  • Influenza and the Challenge for Immunology
    Year: 2006
    Journal: Nature Immunology
    Volume: 7
    Issue: 5
    Page numbers: 449-455
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  • Preparing for an Influenza Pandemic
    Year: 2006
    Journal: Medical Journal of Australia
    Volume: 10
    Issue: 10
    Page numbers: S31
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  • Quantification of repertoire diversity of influenza-specific epitopes with predominant public or private TCR usage
    Year: 2006
    Journal: Journal of Immunology
    Volume: 177
    Issue: 10
    Page numbers: 6705-6712
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  • Sharing of T cell receptors in antigen-specific responses is driven by convergent recombination
    Year: 2006
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 103
    Page numbers: 18691-18696
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  • Structural determinants of T-cell receptor bias in immunity
    Year: 2006
    Journal: Nature Reviews Immunology
    Volume: 6
    Page numbers: 883-894
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Publications in 2005

Journal Articles

  • CD8+ T-cells: are they sufficient to prevent, contain or eradicate HIV-1 infection?
    Year: 2005
    Journal: Current Drug Targets
    Volume: 5
    Issue: 2
    Page numbers: 113-119
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  • Consequences of Immunodominant Epitope Deletion for Minor Influenza Virus-Specific CD8+-T-Cell Responses
    Year: 2005
    Journal: Journal of Virology
    Volume: 79
    Issue: 7
    Page numbers: 4329-4339
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  • Contribution of T cell receptor affinity to overall avidity for virus-specific CD8+ T cell responses
    Year: 2005
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 102
    Issue: 32
    Page numbers: 11432-11437
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  • Effector CD8+ T cells recovered from an influenza pneumonia differentiate to a state of focused gene expression
    Year: 2005
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 102
    Issue: 17
    Page numbers: 6074-6079
    Publisher: National Academy of Sciences(Washington DC)
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  • HIV vaccine rationale, design and testing.
    Year: 2005
    Journal: Current HIV Research
    Volume: 3
    Page numbers: 107-112
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  • Lack of prominent peptide-major histocompatibility complex features limits repertoire diversity in virus-specific CD8+ T cell populations
    Year: 2005
    Journal: Nature Immunology
    Volume: 6
    Issue: 4
    Page numbers: 382-389
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  • Long lived multi-isotype anti-HIV antibody responses following a prime-double boost immunization strategy
    Year: 2005
    Journal: Vaccine
    Volume: 23
    Issue: 19
    Page numbers: 2452-2462
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  • Pathogenesis of Hong Kong H5N1 influenza virus NS gene reassortants in mice: the role of bytokines and B- and T-cell responses
    Year: 2005
    Journal: Journal of General Virology
    Volume: 86
    Page numbers: 1121-1130
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  • T Cell Epitope "Hotspots" on the HIV Type 1 gp120 Envelope Protein Overlap with Tryptic Fragments Displayed by Mass Spectrometry
    Year: 2005
    Journal: AIDS Research and Human Retroviruses
    Volume: 21
    Issue: 2
    Page numbers: 165-170
    Publisher: Mary Ann Leibert Publishers(New Rochelle, NY)
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  • The virus-immunity ecosystem
    Year: 2005
    Journal: Archives of Virology
    Volume: 19
    Page numbers: 17-32
    Publisher: Springer-Verlag Wein(Vienna)
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  • WASP- mice exhibit defective immune responses to influenza A virus, Streptococcus pneumoniae, and Mycobacterium bovis BCG
    Year: 2005
    Journal: Experimental Hematology
    Volume: 33
    Issue: 4
    Page numbers: 443-451
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Publications in 2004

Journal Articles

  • Characterization of CD8+ T cell repertoire diversity and persistence in the influenza A virus model of localized, transient infection
    Year: 2004
    Journal: Science
    Volume: 16
    Issue: 3
    Page numbers: 179-184
    Publisher: American Society for the Advancement of Science(Washington DC)
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  • Conserved T cell receptor usage in primary and recall responses to an immunodominant influenza virus nucleoprotein epitope
    Year: 2004
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 101
    Issue: 14
    Page numbers: 4942-4947
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  • Differential tumor necrosis factor receptor 2-mediated editing of virus-specific CD8+ effector T cells
    Year: 2004
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 101
    Issue: 10
    Page numbers: 3545-3550
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  • Hierarchies in Cytokine Expression Profiles for Acute and Resolving Influenza Virus-Specific CD8+ T cell responses: Correlation of Cytokine Profile and TCR Avidity1
    Year: 2004
    Journal: Journal of Immunology
    Volume: 172
    Page numbers: 5553-5560
    Publisher: American Association of Immunologists(Maryland)
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  • Memories of virus-specific CD8+ T cells
    Year: 2004
    Journal: Immunology and Cell Biology
    Volume: 82
    Page numbers: 136-140
    Publisher: Blackwell Science Asia(Carlton)
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  • Overcoming diversity with a multi-envelope HIV vaccine
    Year: 2004
    Journal: Current Topics in Virology
    Volume: 4
    Page numbers: 159-168
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  • Regulation of ZAP-70 Activation and TCR Signaling by Two Related Proteins, Sts-1 and Sts-2
    Year: 2004
    Journal: Immunity
    Volume: 20
    Issue: 1
    Page numbers: 37-46
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  • Subcutaneous Administration of a Recombinant Vaccinia Virus Vaccine Expressing Multiple Envelopes of HIV-1
    Year: 2004
    Journal: European Journal of Clinical Microbiology & Infectious Diseases
    Volume: 23
    Issue: 2
    Page numbers: 106-110
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  • The Collagen Binding α1β1 Integrin VLA-1 Regulates CD8 T Cell-Mediated Immune Protection against Heterologous Influenza Infection
    Year: 2004
    Journal: Immunity
    Volume: 20
    Issue: 2
    Page numbers: 167-179
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  • The Limits of protection by "memory" T cells in Ig-/-mice persistently infected with a γ -herpesvirus
    Year: 2004
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 101
    Issue: 7
    Page numbers: 2017-2022
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Publications in 2003

Journal Articles

  • Absence of a functional defect in CD8+T cells during primary murine gammaherpesvirus-68 infection of I-Ab-/-mice
    Year: 2003
    Journal: Journal of General Virology
    Volume: 84
    Page numbers: 337-341
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  • An Early CD4+ T Cell—dependent Immunoglobulin A Response to Influenza Infection in the Absence of Key Cognate T—B Interactions
    Year: 2003
    Journal: Journal of Experimental Medicine
    Volume: 198
    Issue: 7
    Page numbers: 1011-1021
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  • Analysis of Clonotype Distribution and Persistence for an Influenza Virus-Specific CD8+ T cell Response
    Year: 2003
    Journal: Immunity
    Volume: 18
    Issue: 4
    Page numbers: 549-559
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  • Clustering of Th Cell Epitopes on Exposed Regions of HIV Envelope Despite Defects in Antibody Activity1
    Year: 2003
    Journal: Journal of Immunology
    Volume: 171
    Page numbers: 4140-4148
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  • Defects in T-cell—mediated immunity to influenza virus in murine Wiskott-Aldrich syndrome are corrected by oncoretroviral vector—mediated gene transfer into repopulating hematopoietic cells
    Year: 2003
    Journal: Blood
    Volume: 10
    Issue: 9
    Page numbers: 3108-3116
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  • Differential Antigen Presentation Regulates the Changing Patterns of CD8+ T Cell Immunodominance in Primary and Secondary Influenza Virus Infections
    Year: 2003
    Journal: Journal of Experimental Medicine
    Volume: 198
    Issue: 3
    Page numbers: 399-410
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  • Host-pathogen interactionsHost defense against microbial pathogens - the immune system's weapons of mass destruction
    Year: 2003
    Journal: Current Opinion in Immunology
    Volume: 15
    Page numbers: 393-395
    Publisher: Current Biology(London)
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  • Limited Breadth of a T-Helper Cell Response to a Human Immunodeficiency Virus Envelope Protein
    Year: 2003
    Journal: Journal of Virology
    Volume: 77
    Issue: 7
    Page numbers: 4231-4236
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  • On the nose: shared themes for the sensory and immune self
    Year: 2003
    Journal: Nature Immunology
    Volume: 4
    Issue: 11
    Page numbers: 1043-1045
    Publisher: Nature America(New York)
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  • Protection and compensation in the influenza virus-specific CD8+ T cell response
    Year: 2003
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 100
    Issue: 12
    Page numbers: 7235-7240
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  • Quantitative Analysis of Long-Term Virus-Specific CD8+-T-Cell Memory in Mice Challenged with Unrelated Pathogens
    Year: 2003
    Journal: Journal of Virology
    Volume: 77
    Issue: 7756-7763
    Page numbers: 14
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Publications in 2002

Journal Articles

  • A Five-Residue HIV Envelope Helper T Cell Determinant: Does This Peptide—MHC Interaction Leave the Vinding Groove Half Empty?
    Year: 2002
    Journal: AIDS Research and Human Retroviruses
    Volume: 18
    Issue: 15
    Page numbers: 1141-1144
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  • Compromised Influenza Virus-Specific CD8+-T-Cell Memory in CD4+-T-Cell-Deficient Mice
    Year: 2002
    Journal: Journal of Virology
    Volume: 76
    Issue: 23
    Page numbers: 12388-12393
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  • Reduced Functional Capacity of CD8+ T cells Expanded by Post-Exposure Vaccination of Υ -Herpesvirus-Infected CD4-Deficient Mice1
    Year: 2002
    Journal: Journal of Immunology
    Volume: 168
    Page numbers: 3477-3483
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  • The pas de deux of viruses and CD8 T cells
    Year: 2002
    Journal: Immunological Reviews
    Volume: 185
    Page numbers: 39-49
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Publications in 2001

Journal Articles

  • Analysis of Virus-Specific CD4+ T Cells during Long-Term Gammaherpesvirus Infection
    Year: 2001
    Journal: Journal of Virology
    Volume: 75
    Issue: 16
    Page numbers: 7744-7748
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  • Concurrent Naive and Memory CD8+ Cell Responses to an Influenza A Virus1
    Year: 2001
    Journal: Journal of Immunology
    Volume: 167
    Page numbers: 2753-2758
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  • Cutting Edge: Culture with High Doses of Viral Peptide Induces Previously Unprimed CD8+ T Cells to Produce by Cytokine1
    Year: 2001
    Journal: Journal of Immunology
    Volume: 167
    Page numbers: 2437-2440
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  • Direct effects of selective type 5 phosphodiesterase inhibitors alone or with other vasodilators on the erectile response in cats
    Year: 2001
    Journal: Journal of Urology
    Volume: 165
    Issue: 3
    Page numbers: 1004-9
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  • Dissecting the host response to a gamma-herpesvirus
    Year: 2001
    Journal: Proceedings of the Royal Society of London Series B - Biological Sciences
    Volume: 356
    Page numbers: 581-593
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  • Diversity of Epitope and Cytokine Profiles for Primary and Secondary Influenza A Virus-Specific CD8+ T Cell Responses1
    Year: 2001
    Journal: Journal of Immunology
    Volume: 166
    Page numbers: 4627-4633
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  • Localization of CD4+ T cell epitope hotspots to exposed strands of HIV envelope glycoprotein suggests structural influences on antigen processing
    Year: 2001
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 98
    Issue: 8
    Page numbers: 4587-4592
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  • Measuring the diaspora for virus-specific CD8+ T cells
    Year: 2001
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 98
    Issue: 11
    Page numbers: 6313-6318
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  • Perforin and Fas in murine gammaherpesvirus-specific CD8+ T cell control and morbidity
    Year: 2001
    Journal: Journal of General Virology
    Volume: 82
    Page numbers: 1971-1981
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  • The Role of Antigen in the Localization of Naive, Acutely Activated, and Memory CD8+ T Cells to the Lung During Influenza Pneumonia1
    Year: 2001
    Journal: Journal of Immunology
    Volume: 167
    Page numbers: 6983-6990
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  • Virus-Specific and Bystander CD8+ T-Cell Proliferation in the Acute and Persistent Phases of a Gammaherpesvirus Infection
    Year: 2001
    Journal: Journal of Virology
    Volume: 75
    Issue: 9
    Page numbers: 4435-4438
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