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PROF MARK JOHN SMYTH



Contact Details

Organization: Pathology
Position: Honorary (Professorial Fellow)
Email:
Homepage: http://www.petermac.unimelb.edu.au
Work: 9656 1111
Building: No Building
Campus: Peter Maccallum Hospital

Research Expertise and International Linkages

Research Expertise

Research Interest Country of Expertise
immunology, T cells Australia

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Bachelor of Science (Hons) University of Melbourne 31-Dec-1984
PhD University of Melbourne 31-Dec-1988

Memberships

Membership Type Membership Body Description Start Date End Date
Member Australian Society for Immunology 22-Sep-2006
Member The Transplantation Society of Australia and New Zealand 22-Sep-2006
Member American Association of Immunologists 22-Sep-2006

Other Awards

Award Type Awarding Body Comments Date Awarded
Medal Australian Academy of Society Gottschalk Medal 01-Jan-1995
Other (Award) Australian Life Sciences Research Award 01-Jan-1993
Other (Award) NHMRC R Douglas Wright Fellowship 01-Jan-1993
Other (Award) NIH Fogarty Visiting Fellowship 01-Jan-1988

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
Natural killer cells; a novel mechanism of suppression of autoimmune demyelination and inflammation? Chief Investigator MS AUSTRALIA Project Grants 01/01/2002
Immune regulation, effector function and therapy Chief Investigator NHMRC Program Grants 01/01/2003
Renewal with promotion to SPRF Chief Investigator NHMRC Research Fellowship 01/01/2004
TRAIL mediated immunosurveillance, immunoselection, and immunotherapy of cancer Chief Investigator CANCER COUNCIL VICTORIA Grant in Aid 01/01/2005
Immunogene therapy of breast cancer Chief Investigator THE SUSAN G KOMEN BREAST CANCER FOUNDATION Basic, Clinical or Translational Research 01/01/2005
PHASE 1 STUDY FOR INFUSION OF AUTOLOGOUS PERIFERAL BLOOD T LYMPHOCYTES TRANDUSCED WITH AN ANTI LEWIS Y CHIMERIC RECEPTOR GENE IN PATIENTS WITH LEWIS Y POSITIVE MULTIPLE MYELOMA Chief Investigator LEUKEMIA & LYMPHOMA SOCIETY Translational Research Program 01/10/2005
Combination immunotherapy of established breast cancer. Chief Investigator THE SUSAN G KOMEN BREAST CANCER FOUNDATION Basic, Clinical or Translational Research 01/05/2006
2007 PROGRAM GRANT - (IMMUNE REGULATION, EFFECTOR FUNCTION AND HUMAN IMMUNOTHERAPY) Chief Investigator NHMRC Program Grants 01/01/2007
RESEARCH FELLOWSHIP 2007 - SMYTH Chief Investigator NHMRC Research Fellowship 01/01/2007
COMBINED CHEMO-IMMUNOTHERAPIES THAT ERADICATE ESTABLISHED TUMORS Chief Investigator CANCER COUNCIL VICTORIA Grant in Aid 01/01/2008
COMBINATION CHEMO-IMMUNOTHERAPY FOR ESTABLISHED BREAST CANCER Chief Investigator THE SUSAN G KOMEN BREAST CANCER FOUNDATION Investigator Initiated Research 31/03/2008

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2007

Journal Articles

  • Combined natural killer T-cell-based immunotherapy eradicates established tumors in mice


    Year: 2007
    Journal: Cancer Research
    Volume: 67
    Issue: 15
    Page numbers: 7495-7504
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  • Sustained antigen-specific antitumor recall response mediated by gene-modified CD4(+) T helper-1 and CD8(+) T cells


    Year: 2007
    Journal: Cancer Research
    Volume: 67
    Issue: 23
    Page numbers: 11428-11437
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  • Adaptive immunity maintains occult cancer in an equilibrium state

    Year: 2007
    Journal: Nature
    Volume: 450
    Issue: 7171
    Page numbers: 903
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  • Analysis of the apoptotic and therapeutic activities of histone deacetylase inhibitors by using a mouse model of B cell lymphoma

    Year: 2007
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 104
    Issue: 19
    Page numbers: 8071-8076
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  • Antitumor activity of dual-specific T cells and influenza virus
    Year: 2007
    Journal: Cancer Gene Therapy
    Volume: 14
    Page numbers: 499-508
    Author(s):
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Publications in 2006

Journal Articles

  • Adoptive transfer of chimeric Fc(epsilon)Ri gene-modified human T cells for cells for cancer immunotherapy


    Year: 2006
    Journal: Human Gene Therapy
    Volume: 17
    Issue: 11
    Page numbers: 1134-1143
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  • NKT cells are not critical for HSV-1 disease resolution
    Year: 2006
    Journal: Immunology and Cell Biology
    Volume: 84
    Issue: 1
    Page numbers: 13-19
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Publications in 2005

Journal Articles

  • A network of PDZ-containing proteins regulate T cell polarity and morphology during motility and immunological synapse formation
    Year: 2005
    Journal: Immunity
    Volume: 22
    Page numbers: 737-748
    Publisher: Cell Press(Massachusetts)
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  • A nonclassical non-Vα14α18 CD1d-restricted (type II) NKT cell is sufficient for down-regulation of tumor immunosurveillance
    Year: 2005
    Journal: Journal of Experimental Medicine
    Volume: 202
    Issue: 12
    Page numbers: 1627-1633
    Publisher: Rockefeller University Press(New York)
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  • Activation of NK cell cytotoxicity
    Year: 2005
    Journal: Molecular Immunology
    Volume: 42
    Page numbers: 501-510
    Publisher: Pergamon-Elsevier Science(Oxford)
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  • Are we on the right TRAIL?
    Year: 2005
    Journal: Immunologic Research
    Volume: 31
    Page numbers: 161-164
    Publisher: Humana Press
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  • Calcium-dependent plasma membrane binding and cell lysis by perforin are mediated through its C2 domain: A critical role for aspartate residues 429, 435, 483, and 485 but not 491
    Year: 2005
    Journal: Journal of Biological Chemistry
    Volume: 280
    Issue: 9
    Page numbers: 8426-8434
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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  • Close encounters of different kinds: dendtriric cells and NK cells take centre stage
    Year: 2005
    Journal: Nature Reviews Immunology
    Volume: 5
    Page numbers: 112-124
    Publisher: Nature Publishing Group(London)
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  • Cross-talk between dendritic cells and natural killer cells in viral infection
    Year: 2005
    Journal: Molecular Immunology
    Volume: 42
    Page numbers: 547-555
    Publisher: Pergamon-Elsevier Science(Oxford)
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  • Cutting Edge: TRAIL deficiency accelerates hematological malignancies
    Year: 2005
    Journal: Journal of Immunology
    Volume: 175
    Page numbers: 5586-5590
    Publisher: American Association of Immunologists(Maryland)
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  • DX5/CD49b-Positive T Cells Are Not Synonymous with CD1d-Dependent NKT Cells1
    Year: 2005
    Journal: Journal of Immunology
    Volume: 175
    Page numbers: 4416-4425
    Publisher: American Association of Immunologists(Maryland)
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  • Differential antitumor immunity mediated by NKT cell subsets in vivo
    Year: 2005
    Journal: Journal of Experimental Medicine
    Volume: 202
    Issue: 9
    Page numbers: 1279-1288
    Publisher: Rockefeller University Press(New York)
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  • Differential lymphotoxin-beta and interferon gamma signaling during mouse liver regeneration induced by chronic and acute injury
    Year: 2005
    Journal: Hepatology
    Volume: 41
    Issue: 2
    Page numbers: 327-335
    Publisher: WB Saunders Co(Pennsylvania)
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  • Frizzled-7 receptor ectodomain expression in a colon cancer cell line induces morphological change and attenuates tumor growth
    Year: 2005
    Journal: Differentiation
    Volume: 73
    Page numbers: 142-153
    Publisher: Blackwell Publishers
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  • Functional Analysis of Granzyme M and Its Role in Immunity to Infection1
    Year: 2005
    Journal: Journal of Immunology
    Volume: 175
    Issue: 5
    Page numbers: 3235-3243
    Publisher: American Association of Immunologists(Maryland)
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  • IFN-Γ-mediated negative feedback regulation of NKT cell function by CD94/NKG2
    Year: 2005
    Journal: Blood
    Volume: 106
    Issue: 1
    Page numbers: 184-292
    Publisher: American Society of Hematology(Washington DC)
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  • IL-21 enhances tumor rejection through a NKG2D-dependent mechanism
    Year: 2005
    Journal: Journal of Immunology
    Volume: 175
    Issue: 4
    Page numbers: 2167-2173
    Publisher: American Association of Immunologists(Maryland)
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  • Immune surveillance of lymphoma in humans?
    Year: 2005
    Journal: Blood
    Volume: 105
    Page numbers: 4159-4160
    Publisher: American Society of Hematology(Washington DC)
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