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PROF MARK SMYTH



Contact Details

Organization: Pathology
Position: Honorary (Professorial Fellow)
Email:
Homepage: http://www.petermac.unimelb.edu.au
Work: 9656 1111
Building: No Building
Campus: Peter Maccallum Hospital

Research Expertise and International Linkages

Research Expertise

Research Interest Country of Expertise
immunology, T cells Australia

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Bachelor of Science (Hons) University of Melbourne 31-Dec-1984
PhD University of Melbourne 31-Dec-1988

Memberships

Membership Type Membership Body Description Start Date End Date
Member Australian Society for Immunology Member 22-Sep-2006
Member The Transplantation Society of Australia and New Zealand Member 22-Sep-2006
Member American Association of Immunologists Member 22-Sep-2006

Other Awards

Award Type Awarding Body Comments Date Awarded
Medal Australian Academy of Society Gottschalk Medal 01-Jan-1995
Other (Award) Australian Life Sciences Research Award 01-Jan-1993
Other (Award) NHMRC R Douglas Wright Fellowship 01-Jan-1993
Other (Award) NIH Fogarty Visiting Fellowship 01-Jan-1988

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
Natural killer cells; a novel mechanism of suppression of autoimmune demyelination and inflammation? Chief Investigator MS AUSTRALIA Project Grants 01/01/2002
Immune regulation, effector function and therapy Chief Investigator NHMRC Program Grants 01/01/2003
Renewal with promotion to SPRF Chief Investigator NHMRC Research Fellowship 01/01/2004
TRAIL mediated immunosurveillance, immunoselection, and immunotherapy of cancer Chief Investigator CANCER COUNCIL VICTORIA Grants-in-Aid 01/01/2005
Immunogene therapy of breast cancer Chief Investigator THE SUSAN G KOMEN BREAST CANCER FOUNDATION Basic, Clinical or Translational Research 01/01/2005
PHASE 1 STUDY FOR INFUSION OF AUTOLOGOUS PERIFERAL BLOOD T LYMPHOCYTES TRANDUSCED WITH AN ANTI LEWIS Y CHIMERIC RECEPTOR GENE IN PATIENTS WITH LEWIS Y POSITIVE MULTIPLE MYELOMA Chief Investigator LEUKEMIA & LYMPHOMA SOCIETY Translational Research Program 01/10/2005
Combination immunotherapy of established breast cancer. Chief Investigator THE SUSAN G KOMEN BREAST CANCER FOUNDATION Basic, Clinical or Translational Research 01/05/2006
2007 PROGRAM GRANT - (IMMUNE REGULATION, EFFECTOR FUNCTION AND HUMAN IMMUNOTHERAPY) Chief Investigator NHMRC Program Grants 01/01/2007
RESEARCH FELLOWSHIP 2007 - SMYTH Chief Investigator NHMRC Research Fellowship 01/01/2007
COMBINED CHEMO-IMMUNOTHERAPIES THAT ERADICATE ESTABLISHED TUMORS Chief Investigator CANCER COUNCIL VICTORIA Grants-in-Aid 01/01/2008
COMBINATION CHEMO-IMMUNOTHERAPY FOR ESTABLISHED BREAST CANCER Chief Investigator THE SUSAN G KOMEN BREAST CANCER FOUNDATION Investigator Initiated Research 31/03/2008
Novel mechansims of inflammation amplified by lymphocytes Chief Investigator NHMRC Project Grants 01/01/2010

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2009

Journal Articles

Publications in 2008

Journal Articles

  • Demonstration of inflammation-induced cancer and cancer immunoediting during primary tumorigenesis


    Year: 2008
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 105
    Issue: 2
    Page numbers: 652-656
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  • Absence of retroviral vector-mediated transformation of gene-modified T cells after long-term engraftment in mice
    Year: 2008
    Journal: Gene Therapy
    Volume: 15
    Page numbers: 1056-1066
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  • Adoptive transfer of Gene-modified primary NK cells can specifically inhibit tumor progression In Vivo
    Year: 2008
    Journal: Journal of Immunology
    Volume: 181
    Issue: 5
    Page numbers: 3449-3455
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  • Combination therapy of established cancer using a histone deacetylase inhibitor and a TRAIL receptor agonist
    Year: 2008
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 105
    Issue: 32
    Page numbers: 11317-11322
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Publications in 2007

Journal Articles

  • Combined natural killer T-cell-based immunotherapy eradicates established tumors in mice


    Year: 2007
    Journal: Cancer Research
    Volume: 67
    Issue: 15
    Page numbers: 7495-7504
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  • Sustained antigen-specific antitumor recall response mediated by gene-modified CD4(+) T helper-1 and CD8(+) T cells


    Year: 2007
    Journal: Cancer Research
    Volume: 67
    Issue: 23
    Page numbers: 11428-11437
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  • Adaptive immunity maintains occult cancer in an equilibrium state

    Year: 2007
    Journal: Nature
    Volume: 450
    Issue: 7171
    Page numbers: 903-907
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  • Analysis of the apoptotic and therapeutic activities of histone deacetylase inhibitors by using a mouse model of B cell lymphoma

    Year: 2007
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 104
    Issue: 19
    Page numbers: 8071-8076
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  • Antitumor activity of dual-specific T cells and influenza virus
    Year: 2007
    Journal: Cancer Gene Therapy
    Volume: 14
    Page numbers: 499-508
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Publications in 2006

Journal Articles

  • Adoptive transfer of chimeric Fc(epsilon)Ri gene-modified human T cells for cells for cancer immunotherapy


    Year: 2006
    Journal: Human Gene Therapy
    Volume: 17
    Issue: 11
    Page numbers: 1134-1143
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  • NKT cells are not critical for HSV-1 disease resolution
    Year: 2006
    Journal: Immunology and Cell Biology
    Volume: 84
    Issue: 1
    Page numbers: 13-19
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Publications in 2005

Journal Articles

  • A network of PDZ-containing proteins regulate T cell polarity and morphology during motility and immunological synapse formation
    Year: 2005
    Journal: Immunity
    Volume: 22
    Page numbers: 737-748
    Publisher: Cell Press(Massachusetts)
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  • A nonclassical non-Vα14α18 CD1d-restricted (type II) NKT cell is sufficient for down-regulation of tumor immunosurveillance
    Year: 2005
    Journal: Journal of Experimental Medicine
    Volume: 202
    Issue: 12
    Page numbers: 1627-1633
    Publisher: Rockefeller University Press(New York)
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  • Activation of NK cell cytotoxicity
    Year: 2005
    Journal: Molecular Immunology
    Volume: 42
    Page numbers: 501-510
    Publisher: Pergamon-Elsevier Science(Oxford)
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  • Are we on the right TRAIL?
    Year: 2005
    Journal: Immunologic Research
    Volume: 31
    Page numbers: 161-164
    Publisher: Humana Press
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  • Calcium-dependent plasma membrane binding and cell lysis by perforin are mediated through its C2 domain: A critical role for aspartate residues 429, 435, 483, and 485 but not 491
    Year: 2005
    Journal: Journal of Biological Chemistry
    Volume: 280
    Issue: 9
    Page numbers: 8426-8434
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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  • Close encounters of different kinds: dendtriric cells and NK cells take centre stage
    Year: 2005
    Journal: Nature Reviews Immunology
    Volume: 5
    Page numbers: 112-124
    Publisher: Nature Publishing Group(London)
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  • Cross-talk between dendritic cells and natural killer cells in viral infection
    Year: 2005
    Journal: Molecular Immunology
    Volume: 42
    Page numbers: 547-555
    Publisher: Pergamon-Elsevier Science(Oxford)
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  • Cutting Edge: TRAIL deficiency accelerates hematological malignancies
    Year: 2005
    Journal: Journal of Immunology
    Volume: 175
    Page numbers: 5586-5590
    Publisher: American Association of Immunologists(Maryland)
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  • DX5/CD49b-Positive T Cells Are Not Synonymous with CD1d-Dependent NKT Cells1
    Year: 2005
    Journal: Journal of Immunology
    Volume: 175
    Page numbers: 4416-4425
    Publisher: American Association of Immunologists(Maryland)
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  • Differential antitumor immunity mediated by NKT cell subsets in vivo
    Year: 2005
    Journal: Journal of Experimental Medicine
    Volume: 202
    Issue: 9
    Page numbers: 1279-1288
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  • Differential lymphotoxin-beta and interferon gamma signaling during mouse liver regeneration induced by chronic and acute injury
    Year: 2005
    Journal: Hepatology
    Volume: 41
    Issue: 2
    Page numbers: 327-335
    Publisher: WB Saunders Co(Pennsylvania)
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  • Frizzled-7 receptor ectodomain expression in a colon cancer cell line induces morphological change and attenuates tumor growth
    Year: 2005
    Journal: Differentiation
    Volume: 73
    Page numbers: 142-153
    Publisher: Blackwell Publishers
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  • Functional Analysis of Granzyme M and Its Role in Immunity to Infection1
    Year: 2005
    Journal: Journal of Immunology
    Volume: 175
    Issue: 5
    Page numbers: 3235-3243
    Publisher: American Association of Immunologists(Maryland)
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  • IFN-Γ-mediated negative feedback regulation of NKT cell function by CD94/NKG2
    Year: 2005
    Journal: Blood
    Volume: 106
    Issue: 1
    Page numbers: 184-292
    Publisher: American Society of Hematology(Washington DC)
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  • IL-21 enhances tumor rejection through a NKG2D-dependent mechanism
    Year: 2005
    Journal: Journal of Immunology
    Volume: 175
    Issue: 4
    Page numbers: 2167-2173
    Publisher: American Association of Immunologists(Maryland)
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  • Immune surveillance of lymphoma in humans?
    Year: 2005
    Journal: Blood
    Volume: 105
    Page numbers: 4159-4160
    Publisher: American Society of Hematology(Washington DC)
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  • KHYG-1, a model for the study of enhanced natural killer cytotoxicity
    Year: 2005
    Journal: Experimental Hematology
    Volume: 33
    Page numbers: 1160-1171
    Publisher: Elsevier Science(New York)
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  • Limited correlation between human thymus and blood NKT cell content revealed by an ontogeny study of paired tissue samples
    Year: 2005
    Journal: European Journal of Immunology
    Volume: 35
    Issue: 5
    Page numbers: 1399-1407
    Publisher: Wiley-VCH(Berlin)
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  • NKG2D protects the host from tumor initiation
    Year: 2005
    Journal: Journal of Experimental Medicine
    Volume: 202
    Page numbers: 583-588
    Publisher: Rockefeller University Press(New York)
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  • NKT Cell Stimulation with Glycolipid Antigen In Vivo: Costimulation-Dependent Expansion, Bim-Dependent Contraction, and Hyporesponsiveness to Further Antigenic Challenge1
    Year: 2005
    Journal: Journal of Immunology
    Volume: 175
    Issue: 5
    Page numbers: 3092-3101
    Publisher: American Association of Immunologists(Maryland)
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  • NKT cell–dependent leukemia eradication following stem cell mobilization with potent G-CSF analogs
    Year: 2005
    Journal: Journal of Clinical Investigation
    Volume: 115
    Issue: 11
    Page numbers: 3093-3103
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  • Sequential activation of NKT cells and NK cells provides effective innate immunotherapy of cancer
    Year: 2005
    Journal: Journal of Experimental Medicine
    Volume: 201
    Issue: 12
    Page numbers: 1973-1985
    Publisher: Rockefeller University Press(New York)
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  • Supernatural T cells: genetic modification of T cells for cancer therapy
    Year: 2005
    Journal: Nature Reviews Immunology
    Volume: 5
    Issue: 12
    Page numbers: 928-940
    Publisher: Nature Publishing Group(London)
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  • TNF-related apoptosis-inducing ligand (TRAIL)/Apo2L suppresses experimental autoimmune encephalomyelitis in mice
    Year: 2005
    Journal: Immunology and Cell Biology
    Volume: 83
    Issue: 5
    Page numbers: 511-519
    Publisher: Blackwell Science Asia(Carlton)
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  • TRAIL identifies immature natural killer cells in newborn mice and adult mouse liver
    Year: 2005
    Journal: Blood
    Volume: 105
    Issue: 5
    Page numbers: 2082-2089
    Publisher: American Society of Hematology(Washington DC)
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  • The Influence of CD1d in Postselection NKT Cell Maturation and Homeostasis1
    Year: 2005
    Journal: Journal of Immunology
    Volume: 175
    Issue: 8
    Page numbers: 3762-3768
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  • Type 1 interferon and cancer immunoediting
    Year: 2005
    Journal: Nature Immunology
    Volume: 6
    Issue: 7
    Page numbers: 646-648
    Publisher: Nature America(New York)
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  • Working with NKT cells-pitfalls and practicalities
    Year: 2005
    Journal: Current Opinion in Immunology
    Volume: 17
    Issue: 4
    Page numbers: 448-454
    Publisher: Current Biology(London)
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Publications in 2004

Journal Articles

  • α-Galactosylceramide: Potential Immunomodulatory Acitvity and Future Application
    Year: 2004
    Journal: Current Medicinal Chemistry
    Volume: 11
    Issue: 2
    Page numbers: 241-252
    Publisher: Bentham Science Publishers(Hilversum)
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  • A functional role for CD28 costimulation in tumor recognition by single-chain receptor-modified T cells
    Year: 2004
    Journal: Cancer Gene Therapy
    Volume: 11
    Page numbers: 371-379
    Publisher: Nature Publishing Group(London)
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  • Antigen-induced tolerance by intrathymic modulation of self-recognizing inhibitory receptors
    Year: 2004
    Journal: Nature Immunology
    Volume: 5
    Page numbers: 590 - 596
    Publisher: Nature America(New York)
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  • Cytokines in cancer immunity and immunotherapy
    Year: 2004
    Journal: Immunological Reviews
    Volume: 202
    Page numbers: 275-293
    Publisher: Munksgaard International Publishers(Copenhagen)
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  • Gene-engineered T cells as a superior adjuvant therapy for metastatic cancer
    Year: 2004
    Journal: Journal of Immunology
    Volume: 173
    Page numbers: 2143-2150
    Publisher: American Association of Immunologists(Maryland)
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  • Granzyme M mediates a novel form of perforin-dependent cell death
    Year: 2004
    Journal: Journal of Biological Chemistry
    Volume: 279
    Page numbers: 22236-22242
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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  • IL-21 induces the functional maturation of murine NK cells
    Year: 2004
    Journal: Journal of Immunology
    Volume: 172
    Page numbers: 2048-2058
    Publisher: American Association of Immunologists(Maryland)
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  • Immunotherapy of cancer using systemically delivered gene-modified human T lymphocytes
    Year: 2004
    Journal: Human Gene Therapy
    Volume: 15
    Page numbers: 699-708
    Publisher: Mary Ann Leibert Publishers
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  • Induction of tumor-specific T cell immunity by anti-DR5 antibody therapy
    Year: 2004
    Journal: Journal of Experimental Medicine
    Volume: 199
    Page numbers: 437-448
    Publisher: Rockefeller University Press(New York)
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  • Innate immune surveillance of spontaneous B cell lymphomas by natural killer cells and γδ T cells
    Year: 2004
    Journal: Journal of Experimental Medicine
    Volume: 199
    Page numbers: 879-884
    Publisher: Rockefeller University Press(New York)
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  • Interleukin 21: a key player in lymphocyte maturation
    Year: 2004
    Journal: Critical Reviews in Immunology
    Volume: 24
    Page numbers: 239-250
    Publisher: Begell House(New York)
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  • Mutational analysis of P-glycoprotein: suppression of caspase activation in the absence of ATP-dependent drug efflux
    Year: 2004
    Journal: Cell Death & Differentiation
    Volume: 11
    Page numbers: 1028-1037
    Publisher: Nature Publishing Group(Basingstroke)
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  • NK cell TRAIL eliminates immature dendritic cells in vivo and limits dendritic cell vaccination efficacy
    Year: 2004
    Journal: Journal of Immunology
    Volume: 172
    Page numbers: 123-129
    Publisher: American Association of Immunologists(Maryland)
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  • NKG2D recognition and perforin effector function mediate effective cytokine immunotherapy of cancer
    Year: 2004
    Journal: Journal of Experimental Medicine
    Volume: 200
    Page numbers: 1325-1335
    Publisher: Rockefeller University Press(New York)
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  • NKT cells: what's in a name?
    Year: 2004
    Journal: Nature Reviews Immunology
    Volume: 4
    Page numbers: 231-237
    Publisher: Nature Publishing Group(London)
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  • Parallels and distinctions between T and NKT cell development in the thymus
    Year: 2004
    Journal: Immunology and Cell Biology
    Volume: 82
    Page numbers: 269-275
    Publisher: Blackwell Science Asia(Carlton)
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  • Re: Immunologic research review (Zheng S-J and Chen YH. TRAIL, bim and thymic negative selection. Immunol Res 2003;28/3:295-301)
    Year: 2004
    Journal: Immunologic Research
    Volume: 30
    Page numbers: 255-256
    Publisher: Humana Press
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  • Regulation of antitumour immunity by CD1d-restricted NKT cells
    Year: 2004
    Journal: Immunology and Cell Biology
    Volume: 82
    Page numbers: 323-331
    Publisher: Blackwell Science Asia(Carlton)
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  • Response to 'A cancer immunosurveillance controversy'
    Year: 2004
    Journal: Nature Immunology
    Volume: 5
    Page numbers: 4-5
    Publisher: Nature America(New York)
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  • Subsite specificities of granzyme M: a study of inhibitors and newly synthesized thiobenzyl ester substrates
    Year: 2004
    Journal: Archives of Biochemistry and Biophysics
    Volume: 422
    Page numbers: 9-22
    Publisher: Academic Press(California)
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  • Systemic NKT cell deficiency in NOD mice is not detected in peripheral blood: implications for human studies
    Year: 2004
    Journal: Immunology and Cell Biology
    Volume: 82
    Issue: 3
    Page numbers: 247-252
    Publisher: Blackwell Science Asia(Carlton)
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  • TRAIL and its receptors as targets for cancer therapy
    Year: 2004
    Journal: Cancer Science
    Volume: 95
    Page numbers: 777-783
    Publisher: Japanese Cancer Association
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  • The Elusive NKT Cell Antigen- Is the Search Over?
    Year: 2004
    Journal: Science
    Volume: 306
    Page numbers: 1687-1689
    Publisher: American Society for the Advancement of Science(Washington DC)
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  • The functional basis for hemophagocytic lymphohistiocytosis in a patient with co-inherited Missense mutations in the perforin (PFN1) gene
    Year: 2004
    Journal: Journal of Experimental Medicine
    Volume: 200
    Page numbers: 811-816
    Publisher: Rockefeller University Press(New York)
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  • Unexpectedly, induction of cytotoxic T lymphocytes enhances the humoral response after DNA immunization
    Year: 2004
    Journal: Blood
    Volume: 103
    Issue: 8
    Page numbers: 3073-3075
    Publisher: American Society of Hematology(Washington DC)
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Publications in 2003

Journal Articles

  • α-Galactosylceramide (KRN7000) supression of chemical- and oncogene-dependent carcinogenesis
    Year: 2003
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 100
    Issue: 16
    Page numbers: 9464-9469
    Publisher: National Academy of Sciences(Washington DC)
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  • Activation of natural killer (NK) T cells during murine cytomegalovirus infection enhances the antiviral response mediated by NK cells
    Year: 2003
    Journal: Journal of Virology
    Volume: 77
    Issue: 3
    Page numbers: 1877-1884
    Publisher: American Society for Microbiology(Washington DC)
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  • Blastocyst MHC, a putative murine homologue of HLA-G, protects TAP-deficient tumor cells from natural killer cell-mediated rejection in vivo
    Year: 2003
    Journal: Journal of Immunology
    Volume: 171
    Page numbers: 1715-1721
    Publisher: American Association of Immunologists(Maryland)
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  • Cutting edge: granzymes A and B are not essential for perforin-mediated tumor rejection
    Year: 2003
    Journal: Journal of Immunology
    Volume: 171
    Issue: 2
    Page numbers: 515-518
    Publisher: American Association of Immunologists(Maryland)
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  • Discovery of an innate cancer resistance gene?
    Year: 2003
    Journal: Molecular Interventions
    Volume: 3
    Page numbers: 186-189
    Publisher: American Society for Pharmacology and Experimental Therapeutics(Maryland)
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  • Functional interactions between dendritic cells and NK cells during viral infection
    Year: 2003
    Journal: Nature Immunology
    Volume: 4
    Issue: 2
    Page numbers: 175-181
    Publisher: Nature America(New York)
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  • Glycolipid antigen drives rapid expansion and sustained cytokine production by NK T cells
    Year: 2003
    Journal: Journal of Immunology
    Volume: 171
    Page numbers: 4020-4027
    Publisher: American Association of Immunologists(Maryland)
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  • Inhibition of early tumor growth requires J α18-positive (natural killer T) cells
    Year: 2003
    Journal: Cancer Research
    Volume: 63
    Page numbers: 3058-3060
    Publisher: American Association for Cancer Research(Alabama)
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  • Innate immunity
    Year: 2003
    Journal: Immunology and Cell Biology
    Volume: 81
    Page numbers: 332-333
    Publisher: Blackwell Science Asia(Carlton)
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  • Intrathymic NKT cell development is blocked by the presence of α-galactosylceramide
    Year: 2003
    Journal: European Journal of Immunology
    Volume: 33
    Page numbers: 1816-1823
    Publisher: Wiley-VCH(Berlin)
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  • Nature's TRAIL - on a path to cancer immunotherapy
    Year: 2003
    Journal: Immunity
    Volume: 18
    Page numbers: 1-6
    Publisher: Cell Press(Massachusetts)
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  • Nonredundant roles of antibody, cytokines, and perforin in the eradication of established Her-2/neu carcinomas
    Year: 2003
    Journal: Journal of Clinical Investigation
    Volume: 111
    Page numbers: 111-1170
    Publisher: American Society of Clinical Investigation Inc(Michigan)
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  • Normal thymocyte negative selection in TRAIL-deficient mice
    Year: 2003
    Journal: Journal of Experimental Medicine
    Volume: 198
    Issue: 3
    Page numbers: 491-496
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  • Normal thymocyte negative selection in TRAIL-deficient mice
    Year: 2003
    Journal: Journal of Experimental Medicine
    Volume: 198
    Issue: 3
    Page numbers: 491-496
    Publisher: Rockefeller University Press(New York)
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  • The serine protease granzyme M is preferentially expressed in NK-cell, γδ T-cell, and intestinal T-cell lymphomas: evidence of origin from lymphocytes involved in innate immunity
    Year: 2003
    Journal: Blood
    Volume: 101
    Page numbers: 3590-3593
    Publisher: American Society of Hematology(Washington DC)
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  • Tumor necrosis factor-related apoptosis-inducing igand-mediated apoptosis is an important endogenous mechanism for resistance to liver metastases in murine renal cancer
    Year: 2003
    Journal: Cancer Research
    Volume: 63
    Page numbers: 207-213
    Publisher: American Association for Cancer Research(Alabama)
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Publications in 2002

Book Chapters

  • P-glycoprotein as a general antiapoptotic protein
    Year: 2002
    Book: Encyclopedia of cancer: volume III
    Publisher: Academic Press(California)
    Authors(s):

Journal Articles

  • A critical role for natural killer T cells in immunosurveillance of methylcholanthrene-induced sarcomas
    Year: 2002
    Journal: Journal of Experimental Medicine
    Volume: 196
    Page numbers: 119-127
    Publisher: Rockefeller University Press(New York)
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  • A natural killer T (NKT) cell developmental pathway involving a thymus-dependent NK1.1-CD4+ CD1d-dependent precursor stage
    Year: 2002
    Journal: Journal of Experimental Medicine
    Volume: 195
    Page numbers: 835-844
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  • A role for IFN-γ in primary and secondary immunity generated by NK cell-sensitive tumor-expressing CD80 in vivo
    Year: 2002
    Journal: Journal of Immunology
    Volume: 168
    Page numbers: 4472-4479
    Publisher: American Association of Immunologists(Maryland)
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  • Critical role for tumor necrosis factor-related apoptosis-inducing ligand in immune surveillance against tumor development
    Year: 2002
    Journal: Journal of Experimental Medicine
    Volume: 195
    Page numbers: 161-169
    Publisher: Rockefeller University Press(New York)
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  • Cutting edge: tumor rejection mediated by NKG2D receptor-ligand interaction is dependent upon perforin
    Year: 2002
    Journal: Journal of Immunology
    Volume: 169
    Page numbers: 5377-5381
    Publisher: American Association of Immunologists(Maryland)
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  • Functional significance of the perforin/granzyme cell death pathway
    Year: 2002
    Journal: Nature Reviews Immunology
    Volume: 2
    Page numbers: 735-747
    Publisher: Nature Publishing Group(London)
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  • IFN-γ-mediated inhibition of tumor angiogenesis by natural killer T-cell ligand, α-galactosylceramide
    Year: 2002
    Journal: Blood
    Volume: 100
    Page numbers: 1728-1733
    Publisher: American Society of Hematology(Washington DC)
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  • Increased susceptibility to tumor initiation and metastasis in TNF-related apoptosis-inducing ligand-deficient mice
    Year: 2002
    Journal: Journal of Immunology
    Volume: 168
    Page numbers: 1356-1361
    Publisher: American Association of Immunologists(Maryland)
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  • Induction of tumor-specific T cell memory by NK cell-mediated tumor rejection
    Year: 2002
    Journal: Nature Immunology
    Volume: 3
    Page numbers: 83-90
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  • Interferon-γ-dependent phagocytic cells are a critical component of innate immunity against metastatic mammary carcinoma
    Year: 2002
    Journal: Cancer Research
    Volume: 62
    Page numbers: 4406-4412
    Publisher: American Association for Cancer Research(Alabama)
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  • NKT cells - conductors of tumor immunity?
    Year: 2002
    Journal: Current Opinion in Immunology
    Volume: 14
    Page numbers: 165-171
    Publisher: Current Biology(London)
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  • New aspects of natural-killer-cell surveillance and therapy of cancer
    Year: 2002
    Journal: Nature Reviews Cancer
    Volume: 2
    Page numbers: 850-861
    Publisher: Nature Publishing Group
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  • P-glycoprotein inhibits caspase-8 activation but not formation of the death inducing signal complex (disc) following Fas ligation
    Year: 2002
    Journal: Cell Death & Differentiation
    Volume: 9
    Page numbers: 1266-1272
    Publisher: Nature Publishing Group(Basingstroke)
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  • Rejection of syngeneic colon carcinoma by CTLs expressing single-chain antibody receptors codelivering CD28 costimulation
    Year: 2002
    Journal: Journal of Immunology
    Volume: 169
    Page numbers: 5780-5786
    Publisher: American Association of Immunologists(Maryland)
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  • Sequential production of interferon-γ by NK1.1+ T cells and natural killer cells is essential for the antimetastatic effect of α-galactosylceramide
    Year: 2002
    Journal: Immunobiology
    Volume: 99
    Issue: 4
    Page numbers: 1259-1266
    Publisher: Urban & Fischer Verlag(Jena)
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  • Single-chain antigen recognition receptors that costimulate potent rejection of established experimental tumours
    Year: 2002
    Journal: Gene Therapy
    Volume: 100
    Page numbers: 3155-3163
    Publisher: Nature Publishing Group(Basingstroke)
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  • Suberoylanilide hydroxamic acid (SAHA) overcomes multidrug resistance and induces cell death in P-glycoprotein-expressing cells
    Year: 2002
    Journal: International Journal of Cancer
    Volume: 99
    Page numbers: 292-298
    Publisher: Wiley-Liss(New York)
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  • Suppression of lymphoma and epithelial malignancies effected by interferon γ
    Year: 2002
    Journal: Journal of Experimental Medicine
    Volume: 196
    Page numbers: 129-134
    Publisher: Rockefeller University Press(New York)
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  • TNF contributes to the immunopathology of perforin/Fas ligand double deficiency
    Year: 2002
    Journal: Immunology and Cell Biology
    Volume: 80
    Page numbers: 436-440
    Publisher: Blackwell Science Asia(Carlton)
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  • The role of NK cells in autoimmune disease
    Year: 2002
    Journal: Autoimmunity
    Volume: 35
    Issue: 1
    Page numbers: 1-14
    Publisher: Taylor & Francis Ltd(Philadelphia)
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  • Tumor-specific CTL kill murine renal cancer cells using both perforin and Fas ligand-mediated lysis in vitro, but cause tumor regression in vivo in the absence of perforin
    Year: 2002
    Journal: Journal of Immunology
    Volume: 168
    Page numbers: 3484-3492
    Publisher: American Association of Immunologists(Maryland)
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Publications in 2001

Journal Articles

  • A fresh look at tumor immunosurveillance and immunotherapy
    Year: 2001
    Journal: Nature Immunology
    Volume: 2
    Issue: 4
    Page numbers: 293-299
    Publisher: Nature America(New York)
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  • Cancer immunotherapy - broader considerations
    Year: 2001
    Journal: Trends in Immunology (formerly Immunology Today)
    Volume: 22
    Issue: 11
    Page numbers: 642
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  • Cytometric and functional analyses of NK and NKT cell deficiencies in NOD mice
    Year: 2001
    Journal: International Immunology
    Volume: 13
    Issue: 7
    Page numbers: 887-896
    Publisher: Oxford University Press(Oxford)
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  • Granzyme A and B-deficient killer lymphocytes are defective in eliciting DNA fragmentation but retain potent in vivo anti-tumor capacity
    Year: 2001
    Journal: European Journal of Immunology
    Volume: 31
    Page numbers: 39-47
    Publisher: Wiley-VCH(Berlin)
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  • Involvement of tumor necrosis factor-related apoptosis-inducing ligand in surveillance of tumor metastasis by liver natural killer cells
    Year: 2001
    Journal: Nature Medicine
    Volume: 7
    Issue: 1
    Page numbers: 94-100
    Publisher: Nature America(New York)
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  • Lymphocyte-mediated immunosurveillance of epithelial cancers?
    Year: 2001
    Journal: Trends in Immunology (formerly Immunology Today)
    Volume: 22
    Issue: 8
    Page numbers: 409-411
    Publisher: Elsevier Science(Oxford)
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  • NK cells and NKT cells collaborate in host protection from methylcholanthrene-induced fibrosarcoma
    Year: 2001
    Journal: International Immunology
    Volume: 13
    Issue: 4
    Page numbers: 459-463
    Publisher: Oxford University Press(Oxford)
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  • P-glycoprotein does not protect cells against cytolysis induced by pore-forming proteins
    Year: 2001
    Journal: Journal of Biological Chemistry
    Volume: 276
    Page numbers: 16667-16673
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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  • Perforin and interferon-[gamma] activities independently control tumor initiation, growth, and metastasis
    Year: 2001
    Journal: Blood
    Volume: 97
    Issue: 1
    Page numbers: 192-197
    Publisher: American Society of Hematology(Washington DC)
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  • Redirecting mouse CTL against colony carcinoma: superior signaling efficacy of single-chain variable domain chimeras containg TCR-z vs FCeRI-g
    Year: 2001
    Journal: Journal of Immunology
    Volume: 166
    Page numbers: 182-187
    Publisher: American Association of Immunologists(Maryland)
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  • The histone deacetylase inhibitor and chemotherapeutic agent suberoylanilide hydroxamic acid (SAHA) induces a cell-death pathway characterized by cleavage of Bid and production of reactive oxygen species
    Year: 2001
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 98
    Page numbers: 10833-10838
    Publisher: National Academy of Sciences(Washington DC)
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  • The restricted expression of Granzyme M in human lymphocytes
    Year: 2001
    Journal: Journal of Immunology
    Volume: 166
    Page numbers: 765-771
    Publisher: American Association of Immunologists(Maryland)
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  • Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) contributes to Interferon [gamma]-dependent Natural Killer cell protection from Tumor Metastasis
    Year: 2001
    Journal: Journal of Experimental Medicine
    Volume: 193
    Issue: 6
    Page numbers: 661-670
    Publisher: Rockefeller University Press(New York)
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  • Unlocking the secrets of cytotoxic granule proteins
    Year: 2001
    Journal: Journal of Leukocyte Biology
    Publisher: Federation of American Societies for Experimental Biology(Maryland)
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