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PROF MALCOLM MCCONVILLE



Contact Details

Organization: Biochemistry and Molecular Biology
Position: NH&MRC PRINCIPAL RESEARCH
Email:
Homepage: http://www.biochemistry.unimelb.edu.au/research/res_mcconville.htm
Work: 83442342
Fax: 93481421
Room: 332
Level: 03
Building: Biochemistry And Molecular Biology
Campus: Parkville

Research Expertise and International Linkages

Research Expertise

Research Interest Key Words Country of Expertise
Molecular parasitology and microbiology analytical biochemistry Australia

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Bachelor of Science University of Melbourne 31-Dec-1980
Doctor of Philosophy University of Melbourne 31-Dec-1986

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
Biosynthesis of glycolipids in pathogenic protozoa and mycobacteria Chief Investigator HOWARD HUGHES MEDICAL INSTITUTE International Research Scholars Program, Infectious Diseases and Parasitology 01/09/2000
Renewal of PRF Chief Investigator NHMRC Research Fellowship 01/01/2004
Chemical tools for the study of mycobacterial glycolipid biosynthesis Chief Investigator AUST RESEARCH COUNCIL Discovery Projects 01/01/2004
AUTOCLAVES (2) 2004 NHMRC EQUIPMENT GRANT ALLOCATION Chief Investigator NHMRC Equipment Grants 01/01/2005
Metabolomic analysis of pathogenic microorganisms Principal Supervisor NHMRC Dora Lush Biomedical Postgraduate Scholarship 01/01/2005
HOST PARASITE INTERACTIONS Chief Investigator WALTER & ELIZA HALL INST Project Grants (NHMRC) 01/01/2006
Polysaccharide biosynthesis as a new drug target in Leishmania parasites Chief Investigator NHMRC Project Grants 01/01/2006
Mannose metabolism in pathogenic microorganisms Chief Investigator AUST RESEARCH COUNCIL Discovery Projects 01/01/2007
Characterization of metabolic networks in a microbial pathogen Chief Investigator AUST RESEARCH COUNCIL Discovery Projects 01/01/2008
Novel metabolic enzyme in Leishmania parasites Chief Investigator NHMRC Project Grants 01/01/2009

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2008

Journal Articles

Publications in 2007

Journal Articles

  • A high-resolution solution structure of a trypanosomatid FYVE domain


    Year: 2007
    Journal: Protein Science
    Volume: 16
    Page numbers: 2552-2559
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  • A Unique Thymic Fibroblast Population Revealed by the Monoclonal Antibody MTS-151
    Year: 2007
    Journal: Journal of Immunology
    Volume: 178
    Page numbers: 4956-4965
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  • Conserved Motifs Reveal Details Of  Ancestry and Structure in the Small TIM Chaperones of the Mitochondrial Intermemberane Space
    Year: 2007
    Journal: Molecular Biology and Evolution
    Volume: 24
    Issue: 5
    Page numbers: 1149-1160
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  • Down-Regulation of the Trypanosomatid Signal Recognition Particle Affects the Biogenesis of Polytopic Membrane Proteins but Not of Signal Peptide-ContainingProteins
    Year: 2007
    Journal: Eukaryotic Cell
    Volume: 6
    Issue: 10
    Page numbers: 1865-1875
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  • Galactose-based phosphonate analogues as potential inhibitors of phosphatidylinositol biosynthesis in mycobacteria
    Year: 2007
    Journal: Organic & Biomolecular Chemistry
    Volume: 5
    Page numbers: 952-959
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  • Living in a Phagolysosome; metabolism of Leishmania amastigotes
    Year: 2007
    Journal: Trends in Parasitology
    Volume: 23
    Issue: 8
    Page numbers: 368-375
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  • Molecular mimicry in Campylobacter jejuni: role of the lipo-oligosaccharide core oligosaccharide in inducing anti-ganglioside antibodies.
    Year: 2007
    Journal: FEMS Immunology and Medical Microbiology
    Volume: 50
    Issue: 1
    Page numbers: 27-36
    Author(s):
    URL - restricted access http://www.ncbi.nlm.nih.gov/pubmed/17374131?ordinalpos=12&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
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  • Secondary Acylation of Klebsiella pneumoniae Lipopolysaccharide Contributes to Sensitivity to Antibacterial Peptides
    Year: 2007
    Journal: Journal of Biological Chemistry
    Volume: 282
    Issue: 21
    Page numbers: 15569-15577
    Author(s):
    URL - open access http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17371870
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  • Serum amyloid P colocalizes with apolipoproteins in human atheroma: functional implications
    Year: 2007
    Journal: Journal of Lipid Research
    Volume: 48
    Page numbers: 2162-2171
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  • The Molecular Basis of Leishmania pathogenesis
    Year: 2007
    Journal: International Journal for Parasitology
    Volume: 37
    Issue: 10
    Page numbers: 1047-1051
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  • The reductase that catalyzes mycolic motif synthesis is required for efficient attachment of mycolic acids to arabinogalactan
    Year: 2007
    Journal: Journal of Biological Chemistry
    Volume: 282
    Issue: 15
    Page numbers: 11000-11008
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Publications in 2006

Journal Articles

  • 1H, 13C and 15N Resonance Assignments of SMP-1: a Small Myristoylated Protein from Leishmania major


    Year: 2006
    Journal: Journal of Biomolecular NMR
    Volume: 36
    Issue: 5
    Page numbers: 26-26
    Author(s):
    URL - restricted access http://www.springerlink.com/content/mw56066040463n66/
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  • Chewing the fat on natural killer T cell development
    Year: 2006
    Journal: Journal of Experimental Medicine
    Volume: 203
    Issue: 10
    Page numbers: 2229-2232
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  • Cyanogenic glycoside from the rare Australian endemic rainforest tree Clerodendrum grayi (Lamiaceae)
    Year: 2006
    Journal: Phytochemistry
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  • Cyanogenic glycosides from the rare Australian endemic rainforest tree Clerodendrum grayi (Lamiaceae)
    Year: 2006
    Journal: Phytochemistry
    Volume: 67
    Page numbers: 43-51
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  • Identification of a novel protein with a role in lipoarabinomannan biosynthesis in mycobacteria.
    Year: 2006
    Journal: Journal of Biological Chemistry
    Volume: 281
    Issue: 14
    Page numbers: 9011-9017
    Author(s):
    URL - restricted access http://www.jbc.org/cgi/content/full/281/14/9011
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  • Leishmania β-1,2-mannan is assembled on a mannose-cyclic phosphate primer
    Year: 2006
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 103
    Issue: 25
    Page numbers: 9458-9463
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  • PimE is a polyprenol-phosphate-mannose-dependent mannosyltransferase that transfers the fifth mannose of phosphatidylinositol mannoside in mycobacteria
    Year: 2006
    Journal: Journal of Biological Chemistry
    Volume: 281
    Issue: 35
    Page numbers: 25143-25155
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  • Progressive peak clustering in GC-MS Metabolomic experiments applied to Leishmania parasites
    Year: 2006
    Journal: Bioinformatics
    Volume: 22
    Issue: 11
    Page numbers: 1391-6
    Author(s):
    URL - restricted access http://bioinformatics.oxfordjournals.org/cgi/content/full/22/11/1391
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  • Progressive peak clustering in GC-MS Metabolomic experiments applied to Leishmania parasites
    Year: 2006
    Journal: Bioinformatics
    Volume: 22
    Issue: 11
    Page numbers: 1391-1396
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  • Use of Click Chemistry to Define the Substrate Specificity of Leishmania -1,2-Mannosyltransferases
    Year: 2006
    Journal: ChemBioChem
    Volume: 7
    Issue: 9
    Page numbers: 1384 - 1391
    Author(s):
    URL - restricted access http://www3.interscience.wiley.com/cgi-bin/abstract/112702656/ABSTRACT
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  • Virulence of Leishmania major in macrophages and mice requires the gluconeogenic enzyme fructose-1,6-bisphosphatase
    Year: 2006
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 103
    Issue: 14
    Page numbers: 5502-5507
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  • Virulence of Leishmania major in macrophages and mice requires the gluconeogenic enzyme fructose-1,6-bisphosphatase.
    Year: 2006
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 103
    Issue: 14
    Page numbers: 5502-5507
    Author(s):
    URL - restricted access