University home page

Find an ExpertProfiling the University of Melbourne's Researchers

PROF MALCOLM MCCONVILLE



Contact Details

Organization: Biochemistry and Molecular Biology
Position: NH&MRC PRINCIPAL RESEARCH
Email:
Homepage: http://www.biochemistry.unimelb.edu.au/research/res_mcconville.htm
Work: 83442342
Fax: 93481421
Room: 332
Level: 03
Building: Biochemistry And Molecular Biology
Campus: Parkville

Research Expertise and International Linkages

Research Expertise

Research Interest Key Words Country of Expertise
Molecular parasitology and microbiology analytical biochemistry Australia

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Bachelor of Science University of Melbourne 31-Dec-1980
Doctor of Philosophy University of Melbourne 31-Dec-1986

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
Biosynthesis of glycolipids in pathogenic protozoa and mycobacteria Chief Investigator HOWARD HUGHES MEDICAL INSTITUTE International Research Scholars Program, Infectious Diseases and Parasitology 01/09/2000
Renewal of PRF Chief Investigator NHMRC Research Fellowship 01/01/2004
Chemical tools for the study of mycobacterial glycolipid biosynthesis Chief Investigator AUST RESEARCH COUNCIL Discovery Projects 01/01/2004
AUTOCLAVES (2) 2004 NHMRC EQUIPMENT GRANT ALLOCATION Chief Investigator NHMRC Equipment Grants 01/01/2005
Metabolomic analysis of pathogenic microorganisms Principal Supervisor NHMRC Dora Lush Biomedical Postgraduate Scholarship 01/01/2005
HOST PARASITE INTERACTIONS Chief Investigator WALTER & ELIZA HALL INST Project Grants (NHMRC) 01/01/2006
Polysaccharide biosynthesis as a new drug target in Leishmania parasites Chief Investigator NHMRC Project Grants 01/01/2006
Mannose metabolism in pathogenic microorganisms Chief Investigator AUST RESEARCH COUNCIL Discovery Projects 01/01/2007
Characterization of metabolic networks in a microbial pathogen Chief Investigator AUST RESEARCH COUNCIL Discovery Projects 01/01/2008
Novel metabolic enzyme in Leishmania parasites Chief Investigator NHMRC Project Grants 01/01/2009
NHMRC Research Fellowship 2009 - MCCONVILLE Chief Investigator NHMRC Research Fellowship 01/01/2009

Contracts

Title Role Funding Source Award Date
METABOLOMIC ANALYSIS OF PRIMARY SKIN FIBROBLASTS AND KERATINOCYTES Chief Investigator DEFENCE SCIENCE & TECHNOLOGY ORGANISATION 15/06/2009

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2009

Journal Articles

  • LeishCyc: a biochemical pathways database for Leishmania major.
    Year: 2009
    Journal: BMC Systems Biology
    Volume: 3
    Page numbers: 57
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Oocyst wall formation and composition in coccidian parasites
    Year: 2009
    Journal: Memorias do Instituto Oswaldo Cruz
    Volume: 104
    Issue: 2
    Page numbers: 281-289
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.

Publications in 2008

Journal Articles

Publications in 2007

Journal Articles

  • A high-resolution solution structure of a trypanosomatid FYVE domain


    Year: 2007
    Journal: Protein Science
    Volume: 16
    Page numbers: 2552-2559
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • A Unique Thymic Fibroblast Population Revealed by the Monoclonal Antibody MTS-151
    Year: 2007
    Journal: Journal of Immunology
    Volume: 178
    Page numbers: 4956-4965
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • A dynamic programming approach for the alignment of signal peaks in multiple gas chromatography-mass spectrometry experiments
    Year: 2007
    Journal: BMC Bioinformatics
    Volume: 8
    Issue: 419
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Conserved Motifs Reveal Details Of  Ancestry and Structure in the Small TIM Chaperones of the Mitochondrial Intermemberane Space
    Year: 2007
    Journal: Molecular Biology and Evolution
    Volume: 24
    Issue: 5
    Page numbers: 1149-1160
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Down-Regulation of the Trypanosomatid Signal Recognition Particle Affects the Biogenesis of Polytopic Membrane Proteins but Not of Signal Peptide-ContainingProteins
    Year: 2007
    Journal: Eukaryotic Cell
    Volume: 6
    Issue: 10
    Page numbers: 1865-1875
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Galactose-based phosphonate analogues as potential inhibitors of phosphatidylinositol biosynthesis in mycobacteria
    Year: 2007
    Journal: Organic & Biomolecular Chemistry
    Volume: 5
    Page numbers: 952-959
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Living in a Phagolysosome; metabolism of Leishmania amastigotes
    Year: 2007
    Journal: Trends in Parasitology
    Volume: 23
    Issue: 8
    Page numbers: 368-375
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Molecular mimicry in Campylobacter jejuni: role of the lipo-oligosaccharide core oligosaccharide in inducing anti-ganglioside antibodies.
    Year: 2007
    Journal: FEMS Immunology and Medical Microbiology
    Volume: 50
    Issue: 1
    Page numbers: 27-36
    Author(s):
    URL - restricted access http://www.ncbi.nlm.nih.gov/pubmed/17374131?ordinalpos=12&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum
    Super Search Source this item in the University's Catalouge locate this resource.
  • Secondary Acylation of Klebsiella pneumoniae Lipopolysaccharide Contributes to Sensitivity to Antibacterial Peptides
    Year: 2007
    Journal: Journal of Biological Chemistry
    Volume: 282
    Issue: 21
    Page numbers: 15569-15577
    Author(s):
    URL - open access http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17371870
    Super Search Source this item in the University's Catalouge locate this resource.
  • Serum amyloid P colocalizes with apolipoproteins in human atheroma: functional implications
    Year: 2007
    Journal: Journal of Lipid Research
    Volume: 48
    Page numbers: 2162-2171
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • The Molecular Basis of Leishmania pathogenesis
    Year: 2007
    Journal: International Journal for Parasitology
    Volume: 37
    Issue: 10
    Page numbers: 1047-1051
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • The reductase that catalyzes mycolic motif synthesis is required for efficient attachment of mycolic acids to arabinogalactan
    Year: 2007
    Journal: Journal of Biological Chemistry
    Volume: 282
    Issue: 15
    Page numbers: 11000-11008
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.

Publications in 2006

Journal Articles

  • 1H, 13C and 15N Resonance Assignments of SMP-1: a Small Myristoylated Protein from Leishmania major
    Year: 2006
    Journal: Journal of Biomolecular NMR
    Volume: 36
    Issue: 5
    Page numbers: 26-26
    Author(s):
    URL - restricted access http://www.springerlink.com/content/mw56066040463n66/
    Super Search Source this item in the University's Catalouge locate this resource.
  • Chewing the fat on natural killer T cell development
    Year: 2006
    Journal: Journal of Experimental Medicine
    Volume: 203
    Issue: 10
    Page numbers: 2229-2232
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Cyanogenic glycoside from the rare Australian endemic rainforest tree Clerodendrum grayi (Lamiaceae)
    Year: 2006
    Journal: Phytochemistry
    Volume: 67
    Issue: 1
    Page numbers: 43-51
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Cyanogenic glycosides from the rare Australian endemic rainforest tree Clerodendrum grayi (Lamiaceae)
    Year: 2006
    Journal: Phytochemistry
    Volume: 67
    Page numbers: 43-51
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Identification of a novel protein with a role in lipoarabinomannan biosynthesis in mycobacteria.
    Year: 2006
    Journal: Journal of Biological Chemistry
    Volume: 281
    Issue: 14
    Page numbers: 9011-9017
    Author(s):
    URL - restricted access http://www.jbc.org/cgi/content/full/281/14/9011
    Super Search Source this item in the University's Catalouge locate this resource.
  • Leishmania β-1,2-mannan is assembled on a mannose-cyclic phosphate primer
    Year: 2006
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 103
    Issue: 25
    Page numbers: 9458-9463
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • PimE is a polyprenol-phosphate-mannose-dependent mannosyltransferase that transfers the fifth mannose of phosphatidylinositol mannoside in mycobacteria
    Year: 2006
    Journal: Journal of Biological Chemistry
    Volume: 281
    Issue: 35
    Page numbers: 25143-25155
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Progressive peak clustering in GC-MS Metabolomic experiments applied to Leishmania parasites
    Year: 2006
    Journal: Bioinformatics
    Volume: 22
    Issue: 11
    Page numbers: 1391-6
    Author(s):
    URL - restricted access http://bioinformatics.oxfordjournals.org/cgi/content/full/22/11/1391
    Super Search Source this item in the University's Catalouge locate this resource.
  • Progressive peak clustering in GC-MS Metabolomic experiments applied to Leishmania parasites
    Year: 2006
    Journal: Bioinformatics
    Volume: 22
    Issue: 11
    Page numbers: 1391-1396
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Use of Click Chemistry to Define the Substrate Specificity of Leishmania -1,2-Mannosyltransferases
    Year: 2006
    Journal: ChemBioChem
    Volume: 7
    Issue: 9
    Page numbers: 1384 - 1391
    Author(s):
    URL - restricted access http://www3.interscience.wiley.com/cgi-bin/abstract/112702656/ABSTRACT
    Super Search Source this item in the University's Catalouge locate this resource.
  • Virulence of Leishmania major in macrophages and mice requires the gluconeogenic enzyme fructose-1,6-bisphosphatase
    Year: 2006
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 103
    Issue: 14
    Page numbers: 5502-5507
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Virulence of Leishmania major in macrophages and mice requires the gluconeogenic enzyme fructose-1,6-bisphosphatase.
    Year: 2006
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 103
    Issue: 14
    Page numbers: 5502-5507
    Author(s):
    URL - restricted access http://www.pnas.org/cgi/content/full/103/14/5502
    Super Search Source this item in the University's Catalouge locate this resource.

Publications in 2005

Journal Articles

  • Compartmentalization of Lipid Biosynthysis in Mycobacteria
    Year: 2005
    Journal: Journal of Biological Chemistry
    Volume: 280
    Issue: 22
    Page numbers: 21645-21652
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Distinct Protein Classes Including Novel Merozoite Surface Antigens in Raft-like Membranes of Plasmodium falciparum
    Year: 2005
    Journal: Journal of Biological Chemistry
    Volume: 280
    Issue: 48
    Page numbers: 40169-40176
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Function of Phosphatidylinositol in Mycobacteria
    Year: 2005
    Journal: Journal of Biological Chemistry
    Volume: 280
    Issue: 12
    Page numbers: 10981-10987
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.

Publications in 2004

Journal Articles

  • Biosynthesis of mycobacterial phosphatidylinositol mannosides
    Year: 2004
    Journal: Biochemical Journal
    Volume: 378
    Page numbers: 589-597
    Publisher: Portland Press(London)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Localization and activity of multidrug resistance protein 1 in the secretory pathway of Leishmania parasites
    Year: 2004
    Journal: Molecular Microbiology
    Volume: 51
    Issue: 1563
    Page numbers: 6
    Publisher: Blackwell Science(Oxford)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Methylation of GPLs in Mycobaterium smegmatis and Mycobacterium avium
    Year: 2004
    Journal: Journal of Bacteriology
    Volume: 186
    Issue: 20
    Page numbers: 6792-6799
    Publisher: American Society for Microbiology(Washington DC)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • More plastids in human parasites?
    Year: 2004
    Journal: Trends in Parasitology
    Volume: 20
    Issue: 2
    Page numbers: 54-57
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Purification, characterization of O-acetylated sialoglycoconjugates-specific IgM, and development of an enzyme-linked immunosorbent assay for diagnosis and follow-up of Indian visceral leishmaniasis patients
    Year: 2004
    Journal: Diagnostic Microbiology and Infectious Disease
    Volume: 50
    Issue: 1
    Page numbers: 15-24
    Publisher: Elsevier(Philadelphia)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • SMP-1, a member of a new family of small myristoylated proteins in kinetoplastid parasites, is targeted to the flagellum membrane in Leishmania
    Year: 2004
    Journal: Molecular Biology of the Cell
    Volume: 15
    Page numbers: 4775-4786
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Surface determinants of Leishmania parasites and their role in infectivity in the mammalian host.
    Year: 2004
    Journal: Current Molecular Medicine
    Volume: 4
    Issue: 6
    Page numbers: 649-665
    Publisher: Bentham Science Publishers(Hilversum)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.

Publications in 2003

Journal Articles

  • Biosynthesis of mycobacterial phosphatidylinositol mannosides
    Year: 2003
    Journal: Biochemical Journal
    Volume: 378
    Page numbers: 1-9
    Publisher: Portland Press(London)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Evidence That Intracellular B1-2 Mannan is a Virulence Factor in Leishmania Parasites
    Year: 2003
    Journal: Journal of Biological Chemistry
    Volume: 278
    Issue: 42
    Page numbers: 40757-40763
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Mannose metabolism is required for mycobacterial growth
    Year: 2003
    Journal: Biochemical Journal
    Volume: 372
    Page numbers: 77-86
    Publisher: Portland Press(London)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • MyD88 is essential for clearance of Leishmania major: possible role for lipophosphoglycan and Toll-like receptor 2 signaling
    Year: 2003
    Journal: European Journal of Immunology
    Volume: 33
    Issue: 10
    Page numbers: 2822-2831
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • MyD88 is essential for clearance of Leishmania major: possible role for lipophosphoglycan and Toll-like receptor 2 signaling
    Year: 2003
    Journal: European Journal of Immunology
    Volume: 33
    Page numbers: 2822-2831
    Publisher: Wiley-VCH(Berlin)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.

Publications in 2002

Journal Articles

  • Leishmania major proteophosphoglycans exist as membrane-bound and soluble forms and localise to the cell membrane, the flagellar pocket and the lysosome
    Year: 2002
    Journal: International Journal for Parasitology
    Volume: 32
    Page numbers: 1701-1708
    Publisher: Pergamon-Elsevier Science(Oxford)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Characterization of a Leishmania mexicana mutant defective in synthesis of free and protein-linked GPI glycolipids
    Year: 2002
    Journal: Molecular and Biochemical Parasitology
    Volume: 125
    Issue: 1-2
    Page numbers: 147-161
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Developmental changes in lysosome morphology and function Leishmania parasites
    Year: 2002
    Journal: International Journal for Parasitology
    Volume: 32
    Page numbers: 1435-1445
    Publisher: Pergamon-Elsevier Science(Oxford)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Intracellular trafficking of glycosylphosphatidylinositol (GPI)-anchored proteins and free GPIs in Leishmania mexicana
    Year: 2002
    Journal: Biochemical Journal
    Volume: 363
    Page numbers: 365-375
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Modification of glycopeptidolipids by an O-methyltransferase of Mycobacterium smegmatis a
    Year: 2002
    Journal: Microbiology
    Volume: 148
    Page numbers: 3079-3087
    Publisher: MAIK Nauka/Interperiodica(New York)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Secretory Pathway of Trypanosomatid Parasites
    Year: 2002
    Journal: Microbiology and Molecular Biology Reviews
    Volume: 66
    Page numbers: 122-154
    Publisher: American Society for Microbiology(Washington DC)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Targeting of the GRIP domain to the trans-Golgi network is conserved from protists to animals
    Year: 2002
    Journal: European Journal of Cell Biology
    Volume: 81
    Page numbers: 485-495
    Publisher: Urban & Fischer Verlag
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.

Publications in 2001

Journal Articles

  • Function and assembly of the Leishmania surface coat
    Year: 2001
    Journal: International Journal for Parasitology
    Volume: 31
    Page numbers: 899-908
    Publisher: Pergamon-Elsevier Science(Oxford)
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
  • Regulated degradation of an endoplasmic reticulum membrane protein in a tubular lysosome in Leishmania mexicana
    Year: 2001
    Journal: Molecular Biology of the Cell
    Volume: 12
    Page numbers: 2364-2377
    Author(s):
    Super Search Source this item in the University's Catalouge locate this resource.
top of page