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Find an ExpertProfiling the University of Melbourne's Researchers

DR HONGJIAN ZHU



Contact Details

Organization: Surgery - Royal Melbourne and Western Hospital
Position: SENIOR RESEARCH FELLOW
Email:
Homepage: www.surgeryrmh.unimelb.edu.au
Work: 84335492
Building: Med Research Building
Campus: Royal Melbourne Hospital

Research Expertise and International Linkages

Research Expertise

Research Interest Country of Expertise
Cancer Research Australia

International Linkages

Country Establishment Collaboration
United States Baylor College of Medicine Exchange, Research, Technical Assistance/Training
Netherlands Leiden University Exchange, Research, Technical Assistance/Training
Sweden Ludwig Institute for Cancer Research Exchange, Research, Technical Assistance/Training

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
PhD Deakin University 31-Dec-1994
Msc Chemistry Nanjing University 31-Dec-1986
BSc Dept of Chemistry Nanjing University 31-Dec-1983

Memberships

Membership Type Membership Body Description Start Date End Date
Member Australian International Development Assistance Bureau 01-Jan-1988
Member ASMR 01-Jan-2000
Member ASBMB 01-Jan-2002
Associate AACR 01-Jan-2000

Other Awards

Award Type Awarding Body Comments Date Awarded
Prize 1st Electronic Lorne Cancer Conference 01-Jan-1998
Prize Deakin University 01-Jan-2000
Scholarship Commonwealth Government of Australia 01-Jan-1990
Scholarship Deakin University 01-Jan-1990

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
Regulation of activity and subcellular localisation of the tumour suppressor PTEN Chief Investigator CANCER COUNCIL VICTORIA Grant in Aid 01/01/2005
DIFFERENTIAL COOPERATION OF MAPK WITH TGF-BETA SIGNALING IN EPITHELIAL-MESENCHYMAL TRANSITION Chief Investigator NHMRC Project Grants 01/01/2006
THE ROLE OF TGF-BETA SIGNALING IN SUPPRESSION OF STAT3-MEDIATED TUMORIGENESIS Chief Investigator LUDWIG INST CANCER RESEARCH Project Grants (NHMRC) 01/01/2006
LOSS OF CYTOSTATIC REGULATION BY TGF-BETA DURING EGFR-DRIVEN TUMOR DEVELOPMENT Chief Investigator NHMRC Project Grants 01/01/2007
EXPANSION OF TGF-BETA-SMAD SIGNALING NETWORK AND INTRINSIC EPITHELIAL-MESENCHYMAL TRANSITION Chief Investigator NHMRC Project Grants 01/01/2007

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2007

Journal Articles

  • Expression, generation, and purification of unphosphorylated and phospho-Ser-380/Thr-382/Thr-383 form of recombinant PTEN phosphatase.


    Year: 2007
    Journal: Protein Expression and Purification
    Volume: 55
    Issue: 2
    Page numbers: 334-342
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  • Analysis of Ras-induced oncogenic transformation of NIH-3T3 cells using differential-display 2-DE proteomics.
    Year: 2007
    Journal: Electrophoresis
    Volume: 28
    Issue: 12
    Page numbers: 1997-2008
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  • PTEN catalysis of phospholipid dephosphorylation reaction follows a two-step mechanism in which the conserved aspartate-92 does not function as the general acid - Mechanistic analysis of a familial Cowden disease-associated PTEN mutation.
    Year: 2007
    Journal: Cellular Signaling
    Volume: 19
    Issue: 7
    Page numbers: 1434-1445
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Publications in 2006

Journal Articles

  • Signal therapy of human pancreatic cancer and NF1-deficient breast cancer xenograft in mice by a combination of PP1 and GL-2003, anti-PAK1 drugs (Tyr-kinase inhibitors).
    Year: 2006
    Journal: Cancer Letters
    Volume: 245
    Issue: 1-2
    Page numbers: 242-251
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Publications in 2005

Journal Articles

  • Hyperactivation of Stat3 in gp130 mutant mice promoes gastric hyperproliferation and desensitizes TGF-B signaling
    Year: 2005
    Journal: Nature Medicine
    Volume: 11
    Page numbers: 845-852
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  • Role of ERK1/2 and p38 Mitogen-Activated Protein Kinases in the Regulation of Thromospondin-1 by TGF-β1 in Rat proximal tubular cells and mouse fibroblasts.
    Year: 2005
    Journal: Journal of the American Society of Nephrology
    Volume: 16
    Page numbers: 899-904
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Publications in 2004

Journal Articles

  • A novel non-catalytic mechanism employed by the C-terminal Src-homologous kinase to inhibit Src-family kinase activity
    Year: 2004
    Journal: Journal of Biological Chemistry
    Volume: 279
    Page numbers: 20752-20766
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  • Advanced glycation end products activate Smad signaling via TGF-β-dependent and -independent mechanisms: implications for diabetic renal and vascular disease.
    Year: 2004
    Journal: FASEB Journal
    Volume: 18
    Issue: 1
    Page numbers: 176-8
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  • CR1/CR2 interactions modulate the functions of the cell surface epidermal growth factor receptor
    Year: 2004
    Journal: Journal of Biological Chemistry
    Volume: 279
    Issue: 21
    Page numbers: 22387-22398
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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  • Differential regulation of VEGF by TGF-β and hypoxia in rat proximal tubular cells.
    Year: 2004
    Journal: American Journal of Physiology - Renal Physiology
    Volume: 287
    Page numbers: F658 -F664
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  • Lactacystin-induced apoptosis of cultured mouse cortical neurons is associated with accumulation of PTEN in the detergent-resistant membrane fraction
    Year: 2004
    Journal: Cellular and Molecular Life Sciences
    Volume: 61
    Page numbers: 1926-1934
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  • TGF-β induces proangiogenic and antiangiogenic factors via parallel but distinct Smad pathways.
    Year: 2004
    Journal: Kidney International
    Volume: 66
    Issue: 2004
    Page numbers: 605-613
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  • The tumor-specific de2-7 epidermal growth factor receptor (EGFR) promotes cells survival and heterodimerizes with the wild-type EGFR
    Year: 2004
    Journal: Oncogene
    Volume: 23
    Issue: 36
    Page numbers: 6095-6104
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Publications in 2003

Journal Articles

  • Inhibition of renal fibrosis by gene transfer of inducible Smad7 using ultrasound-microbubble system in Rat UUO Model


    Year: 2003
    Journal: Journal of the American Society of Nephrology
    Volume: 14
    Issue: 2003
    Page numbers: 1535-1548
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  • Role of TGF-β signaling in extracellular matrix production under high glucose conditions.


    Year: 2003
    Journal: Kidney International
    Volume: 63
    Issue: 2003
    Page numbers: 2010-2019
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  • Epidermal growth factor receptor: association of extracellular domain negatively regulates intracellular kinase activation in the absence of ligand
    Year: 2003
    Journal: Growth Factors
    Volume: 21
    Issue: 1
    Page numbers: 15-30
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  • Heart and liver defects and reduced transforming growth factor beta2 sensitivity in transforming growth factor beta type III receptor-deficient embryos
    Year: 2003
    Journal: Molecular and Cellular Biology
    Volume: 23
    Issue: 12
    Page numbers: 4371-4385
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Publications in 2002

Journal Articles

  • Crystal structure of a truncated epidermal growth factor receptor extracellular domain bound to transforming growth factor alpha
    Year: 2002
    Journal: Cell
    Volume: 110
    Issue: 6
    Page numbers: 763-773
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  • Smad7 inhibits fibrotic effect of TGF-β on renal tubular epithelial cells by blocking Smad2 activation.
    Year: 2002
    Journal: Journal of the American Society of Nephrology
    Volume: 13
    Page numbers: 1464-1472
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Publications in 2001

Journal Articles

  • Platelet-derived growth factor requires epidermal growth factor receptor to activate p21-activated kinase family kinases
    Year: 2001
    Journal: Journal of Biological Chemistry
    Volume: 276
    Page numbers: 26741-26744
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  • Regulation of Transforming Growth Factor-β Signaling.
    Year: 2001
    Journal: Molecular Cell Biology Research Communications
    Volume: 4
    Issue: 2001
    Page numbers: 321-330
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