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PROF DALE GODFREY



Contact Details

Organization: Microbiology and Immunology
Position: PROFESSOR
Email:
Homepage: http://www.microbiol.unimelb.edu.au/people/godfrey/
Work: 0383446831
Fax: 0393471540
Room: 3.06
Level: 03
Building: Microbiology Building
Campus: Parkville

Research Expertise and International Linkages

Research Expertise

Research Interest Country of Expertise
NKT cells Australia

International Linkages

Country Establishment Collaboration
United States La Jolla Institute for Allergy & Immunology Exchange, Research

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Doctor of Philosophy Monash University 31-Dec-1990

Memberships

Membership Type Membership Body Description Start Date End Date
Member Australasian Society for Immunology (ASI) I have been a member of ASI for most years since 1997. 06-Jan-1997 31-Dec-2009
Member National Association of Research Fellows (NARF) Normal member - not sure of start date so have given an estimate 01-Apr-2005 31-Dec-2009
Member American Association for the Advancement of Science (AAAS) Normal member - not sure of start date so have given an estimate 01-Apr-2005 19-Sep-2008
Member American Association of Immunologists (AAI) Normal member - not sure of start date so have given an estimate 01-Apr-2005 31-Dec-2007

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
Research Fellowship SRF Level B Chief Investigator NHMRC Research Fellowship 01/01/2003
The incluence of glucocorticoid hormones in T cell development and function Chief Investigator NHMRC Project Grants 01/01/2003
Immune regulation, effector function and therapy Chief Investigator NHMRC Program Grants 01/01/2003
The role of NKT cells in teh regulation of tumour immunity Chief Investigator NHMRC Peter Doherty Fellowships 01/01/2004
Factors involved in the development and homeostasis of CD4 memory T cells Chief Investigator NHMRC CJ Martin Fellowships 01/01/2004
Development of NKT cells in the human and mouse thymus Principal Supervisor NHMRC Dora Lush Biomedical Postgraduate Scholarship 01/01/2005
Assessment of alpha-galactosylceramide as a novel adjuvant for pandemic influenza A virus vaccines Chief Investigator NHMRC Potential Avian Influenza-Induced Pandemic Research Grants 01/01/2006
2007 PROGRAM GRANT - (IMMUNE REGULATION, EFFECTOR FUNCTION AND HUMAN IMMUNOTHERAPY) Chief Investigator NHMRC Program Grants 01/01/2007
RESEARCH FELLOWSHIP 2007 - GODFREY Chief Investigator NHMRC Research Fellowship 01/01/2007
CJ MARTIN OVERSEAS BIOMEDICAL FELLOWSHIP - GENETIC REGULATION OF THYMUS DEVELOPMENT AND FUNCTION Principal Supervisor NHMRC Training (Postdoctoral) Fellowships 01/01/2008
NKT cell receptors Chief Investigator NHMRC Project Grants 01/01/2009
Multi-photon imaging for infection, immunity, and self recognition Chief Investigator AUST RESEARCH COUNCIL Linkage Infrastructure (Equipment and Facilities) 01/01/2009
DEVELOPMENT OF IL-17 PRODUCING CD43HI NKT CELLS #2 Principal Supervisor THE CASS FOUNDATION LTD Science & Medicine Grants 01/01/2009

Contracts

Title Role Funding Source Award Date
FUNCTIONAL AND PHENOTYPICAL ANALYSIS OF NKT CELLS IN BLOOD SAMPLES FROM TRIAL NN028_1614 Chief Investigator NOVO NORDISK PHARMACEUTICALS 22/06/2006
MECHANISM OF ACTION OF OGLUFANIDE DISODIUM IN VIVO Chief Investigator IMPLICIT BIOSCIENCE 05/12/2007

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2009

Journal Articles

  • Combined NKT cell activation and influenza virus vaccination boosts memory CTL generation and protective immunity
    Year: 2009
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 106
    Issue: 9
    Page numbers: 3330-3335
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  • Developing NKT cells need their calcium
    Year: 2009
    Journal: Nature Immunology
    Volume: 10
    Issue: 3
    Page numbers: 231-233
    Author(s):
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  • Differential Recognition of CD1d-α-Galactosyl Ceramide by the Vβ8.2 Vβ7 Semi-invariant NKT T Cell Receptors
    Year: 2009
    Journal: Immunity
    Volume: 31
    Issue: 1
    Page numbers: 47-59
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  • Immune characteriztion of an individual with an exceptionally high natural killer T cell frequency and her immediate family.
    Year: 2009
    Journal: Clinical and Experimental Immunology
    Volume: 834
    Page numbers: 1617-1624
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  • Induction of natural killer T cell-dependent alloreactivity by administration of granulocyte colony-stimulating factor after bone marrow transplantation
    Year: 2009
    Journal: Nature Medicine
    Volume: 15
    Issue: 4
    Page numbers: 436-441
    Author(s):
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  • Perforin-mediated suppression of B-cell lymphoma
    Year: 2009
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 106
    Issue: 8
    Page numbers: 2723-2728
    Author(s):
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  • Peripheral NKT cells in simian immunodeficiency virus-infected macaques.
    Year: 2009
    Journal: Journal of Virology
    Volume: 83
    Issue: 4
    Page numbers: 1617-24
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  • T Cell Receptor CDR2β and CDR3β Loops Collaborate Functionally to Shape the iNKT Cell Repertoire
    Year: 2009
    Journal: Immunity
    Volume: 31
    Issue: 1
    Page numbers: 60-71
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  • Type I natural killer T cells suppress tumors caused by p53 loss in mice
    Year: 2009
    Journal: Blood
    Volume: 113
    Issue: 25
    Page numbers: 6382-6385
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Publications in 2008

Journal Articles

Publications in 2007

Journal Articles

Publications in 2006

Journal Articles

  • Antigen Challenge Inhibits Thymic Emigration1


    Year: 2006
    Journal: Journal of Immunology
    Volume: 176
    Page numbers: 4553-4561
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  • CD4+ CD25+ T Regulatory Cells Suppress NK Cell-Mediated Immunotherapy of Cancer1


    Year: 2006
    Journal: Journal of Immunology
    Volume: 176
    Page numbers: 1582-1587
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  • A structural basis for selection and cross-species reactivity of the semi-invariant NKT cell receptor in CD1d/glycolipid recognition
    Year: 2006
    Journal: Journal of Experimental Medicine
    Volume: 203
    Issue: 3
    Page numbers: 661-673
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  • Chewing the fat on natural killer T cell development
    Year: 2006
    Journal: Journal of Experimental Medicine
    Volume: 203
    Issue: 10
    Page numbers: 2229-2232
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  • Long-Term Retention of Mature NK1.1+ NKT Cells in the Thymus1
    Year: 2006
    Journal: Journal of Immunology
    Volume: 176
    Page numbers: 4059-4065
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  • NKT cells are not critical for HSV-1 disease resolution
    Year: 2006
    Journal: Immunology and Cell Biology
    Volume: 84
    Issue: 1
    Page numbers: 13-19
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  • NKT cells join the war on Lyme disease
    Year: 2006
    Journal: Nature Immunology
    Volume: 7
    Issue: 9
    Page numbers: 904-906
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Publications in 2005

Journal Articles

  • A nonclassical non-Vα14α18 CD1d-restricted (type II) NKT cell is sufficient for down-regulation of tumor immunosurveillance
    Year: 2005
    Journal: Journal of Experimental Medicine
    Volume: 202
    Issue: 12
    Page numbers: 1627-1633
    Publisher: Rockefeller University Press(New York)
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  • Are we on the right TRAIL?
    Year: 2005
    Journal: Immunologic Research
    Volume: 31
    Page numbers: 161-164
    Publisher: Humana Press
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  • CD1d antigen presentation: treats for NKT cells
    Year: 2005
    Journal: Nature Immunology
    Volume: 6
    Issue: 8
    Page numbers: 754-756
    Publisher: Nature America(New York)
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  • DX5/CD49b-Positive T Cells Are Not Synonymous with CD1d-Dependent NKT Cells1
    Year: 2005
    Journal: Journal of Immunology
    Volume: 175
    Page numbers: 4416-4425
    Publisher: American Association of Immunologists(Maryland)
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  • Differential antitumor immunity mediated by NKT cell subsets in vivo
    Year: 2005
    Journal: Journal of Experimental Medicine
    Volume: 202
    Issue: 9
    Page numbers: 1279-1288
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  • Functional Analysis of Granzyme M and Its Role in Immunity to Infection1
    Year: 2005
    Journal: Journal of Immunology
    Volume: 175
    Issue: 5
    Page numbers: 3235-3243
    Publisher: American Association of Immunologists(Maryland)
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  • Intrathymic Glucocorticoid Production and Thymocyte Survival: Another Piece in the Puzzle
    Year: 2005
    Journal: Endocrinology
    Volume: 146
    Issue: 6
    Page numbers: 2499-2500
    Publisher: Endocrine Society(Maryland)
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  • Limited correlation between human thymus and blood NKT cell content revealed by an ontogeny study of paired tissue samples
    Year: 2005
    Journal: European Journal of Immunology
    Volume: 35
    Issue: 5
    Page numbers: 1399-1407
    Publisher: Wiley-VCH(Berlin)
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  • Localization of Idd11 Is Not Associated With Thymus and NKT Cell Abnormalities in NOD Mice
    Year: 2005
    Journal: Diabetes
    Volume: 54
    Page numbers: 3453-3457
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  • NKT Cell Stimulation with Glycolipid Antigen In Vivo: Costimulation-Dependent Expansion, Bim-Dependent Contraction, and Hyporesponsiveness to Further Antigenic Challenge1
    Year: 2005
    Journal: Journal of Immunology
    Volume: 175
    Issue: 5
    Page numbers: 3092-3101
    Publisher: American Association of Immunologists(Maryland)
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  • NKT cell–dependent leukemia eradication following stem cell mobilization with potent G-CSF analogs
    Year: 2005
    Journal: Journal of Clinical Investigation
    Volume: 115
    Issue: 11
    Page numbers: 3093-3103
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  • Sequential activation of NKT cells and NK cells provides effective innate immunotherapy of cancer
    Year: 2005
    Journal: Journal of Experimental Medicine
    Volume: 201
    Issue: 12
    Page numbers: 1973-1985
    Publisher: Rockefeller University Press(New York)
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  • The Influence of CD1d in Postselection NKT Cell Maturation and Homeostasis1
    Year: 2005
    Journal: Journal of Immunology
    Volume: 175
    Issue: 8
    Page numbers: 3762-3768
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  • Working with NKT cells-pitfalls and practicalities
    Year: 2005
    Journal: Current Opinion in Immunology
    Volume: 17
    Issue: 4
    Page numbers: 448-454
    Publisher: Current Biology(London)
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Publications in 2004

Journal Articles

  • α-Galactosylceramide: Potential Immunomodulatory Acitvity and Future Application
    Year: 2004
    Journal: Current Medicinal Chemistry
    Volume: 11
    Issue: 2
    Page numbers: 241-252
    Publisher: Bentham Science Publishers(Hilversum)
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  • Antigen-induced tolerance by intrathymic modulation of self-recognizing inhibitory receptors
    Year: 2004
    Journal: Nature Immunology
    Volume: 5
    Page numbers: 590 - 596
    Publisher: Nature America(New York)
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  • Discordant regulation of granzyme H and granzyme B expression in human lymphocytes
    Year: 2004
    Journal: Journal of Biological Chemistry
    Volume: 279
    Page numbers: 26581-26587
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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  • Expression of the Glucocorticoid Receptor from the 1A Promoter correlates with T Lymphocyte Sensitivity to Glucocrticoid-Induced Cell Death
    Year: 2004
    Journal: Journal of Immunology
    Volume: 173
    Page numbers: 3816-3824
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  • Going both ways: immune regulation via CD1d-dependent NKT cells
    Year: 2004
    Journal: Journal of Clinical Investigation
    Volume: 114
    Issue: 10
    Page numbers: 1379-1388
    Publisher: American Society of Clinical Investigation Inc(Michigan)
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  • Innate immune surveillance of spontaneous B cell lymphomas by natural killer cells and γδ T cells
    Year: 2004
    Journal: Journal of Experimental Medicine
    Volume: 199
    Page numbers: 879-884
    Publisher: Rockefeller University Press(New York)
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  • NKT cells: what's in a name?
    Year: 2004
    Journal: Nature Reviews Immunology
    Volume: 4
    Page numbers: 231-237
    Publisher: Nature Publishing Group(London)
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  • Negative selection of semimature CD4+8-HSA+ thymocytes requires the BH3-only protein Bim but is independent of death receptor signaling
    Year: 2004
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 101
    Issue: 18
    Page numbers: 7052-7057
    Publisher: National Academy of Sciences(Washington DC)
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  • Parallels and distinctions between T and NKT cell development in the thymus
    Year: 2004
    Journal: Immunology and Cell Biology
    Volume: 82
    Page numbers: 269-275
    Publisher: Blackwell Science Asia(Carlton)
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  • Regulation of antitumour immunity by CD1d-restricted NKT cells
    Year: 2004
    Journal: Immunology and Cell Biology
    Volume: 82
    Page numbers: 323-331
    Publisher: Blackwell Science Asia(Carlton)
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  • Systemic NKT cell deficiency in NOD mice is not detected in peripheral blood: implications for human studies
    Year: 2004
    Journal: Immunology and Cell Biology
    Volume: 82
    Issue: 3
    Page numbers: 247-252
    Publisher: Blackwell Science Asia(Carlton)
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  • TCR-mediated activation promotes GITR upregulation in T cells and resistance to glucocorticoid-induced death
    Year: 2004
    Journal: International Immunology
    Volume: 16
    Issue: 9
    Page numbers: 1315-1321
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  • The Elusive NKT Cell Antigen- Is the Search Over?
    Year: 2004
    Journal: Science
    Volume: 306
    Page numbers: 1687-1689
    Publisher: American Society for the Advancement of Science(Washington DC)
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Publications in 2003

Journal Articles

  • Genetic Control of NKT Cell Numbers Maps to Major Diabetes and Lupus Loci1
    Year: 2003
    Journal: Journal of Immunology
    Volume: 171
    Page numbers: 2873-2878
    Publisher: American Association of Immunologists(Maryland)
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  • Glycolipid antigen drives rapid expansion and sustained cytokine production by NK T cells
    Year: 2003
    Journal: Journal of Immunology
    Volume: 171
    Page numbers: 4020-4027
    Publisher: American Association of Immunologists(Maryland)
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  • Intrathymic NKT cell development is blocked by the presence of α-galactosylceramide
    Year: 2003
    Journal: European Journal of Immunology
    Volume: 33
    Page numbers: 1816-1823
    Publisher: Wiley-VCH(Berlin)
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  • Normal thymocyte negative selection in TRAIL-deficient mice
    Year: 2003
    Journal: Journal of Experimental Medicine
    Volume: 198
    Issue: 3
    Page numbers: 491-496
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  • Normal thymocyte negative selection in TRAIL-deficient mice
    Year: 2003
    Journal: Journal of Experimental Medicine
    Volume: 198
    Issue: 3
    Page numbers: 491-496
    Publisher: Rockefeller University Press(New York)
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  • Suppressor of cytokine signaling-1 is a critical regulator of interleukin-7-dependent CD8+ T cell differentiation
    Year: 2003
    Journal: Immunity
    Volume: 18
    Page numbers: 475-487
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  • Supproessor of Cytokine Signaling-1 Has IFN-γ-Independent Actions in T Cell Homeostasis
    Year: 2003
    Journal: Journal of Immunology
    Volume: 170
    Page numbers: 878-886
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  • Without peripheral interference, thymic deletion is mediated in a cohort of double-positive cells without classical activation
    Year: 2003
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 100
    Issue: 3
    Page numbers: 1197-1202
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Publications in 2002

Journal Articles

  • A critical role for natural killer T cells in immunosurveillance of methylcholanthrene-induced sarcomas
    Year: 2002
    Journal: Journal of Experimental Medicine
    Volume: 196
    Page numbers: 119-127
    Publisher: Rockefeller University Press(New York)
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  • A natural killer T (NKT) cell developmental pathway involving a thymus-dependent NK1.1-CD4+ CD1d-dependent precursor stage
    Year: 2002
    Journal: Journal of Experimental Medicine
    Volume: 195
    Page numbers: 835-844
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  • BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes
    Year: 2002
    Journal: Nature
    Volume: 415
    Page numbers: 922-926
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  • Glucocorticoid receptor deficient thymic and peripheral T cells develop normally in adult mice
    Year: 2002
    Journal: European Journal of Immunology
    Volume: 32
    Page numbers: 3456-3555
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  • Induction of tumor-specific T cell memory by NK cell-mediated tumor rejection
    Year: 2002
    Journal: Nature Immunology
    Volume: 3
    Page numbers: 83-90
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  • Sequential production of interferon-γ by NK1.1+ T cells and natural killer cells is essential for the antimetastatic effect of α-galactosylceramide
    Year: 2002
    Journal: Immunobiology
    Volume: 99
    Issue: 4
    Page numbers: 1259-1266
    Publisher: Urban & Fischer Verlag(Jena)
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  • Thymic regeneration: teaching an old immune system new tricks.
    Year: 2002
    Journal: Trends in Molecular Medicine
    Volume: 8
    Issue: 10
    Page numbers: 469-476
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Publications in 2001

Journal Articles

  • A fresh look at tumor immunosurveillance and immunotherapy
    Year: 2001
    Journal: Nature Immunology
    Volume: 2
    Issue: 4
    Page numbers: 293-299
    Publisher: Nature America(New York)
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  • Cytometric and functional analyses of NK and NKT cell deficiencies in NOD mice
    Year: 2001
    Journal: International Immunology
    Volume: 13
    Issue: 7
    Page numbers: 887-896
    Publisher: Oxford University Press(Oxford)
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  • NK cells and NKT cells collaborate in host protection from methylcholanthrene-induced fibrosarcoma
    Year: 2001
    Journal: International Immunology
    Volume: 13
    Issue: 4
    Page numbers: 459-463
    Publisher: Oxford University Press(Oxford)
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