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A/PROF THIS ERNST



Contact Details

Organization: Surgery - Royal Melbourne and Western Hospital
Position: Honorary (Principal Fellow)
Email:
Homepage: www.ludwig.edu.au
Work: 9341 3155
Building: Med Research Building
Campus: Royal Melbourne Hospital

Research Expertise and International Linkages

Research Expertise

Research Interest Country of Expertise
Colon Molecular and Cellualr Biology Australia

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Bachelor of Science Swiss Federal Institute of Technology - Zurich 31-Dec-1977
Doctor of Philosophy Swiss Federal Institute of Technology - Zurich 31-Dec-1987

Other Awards

Award Type Awarding Body Comments Date Awarded
Other (Award) George Hodgson Medal 31-Jan-2007
Other (Award) Schweizerische Stiftung fur Medizinisch-Biologische Stipendien Postdoctoral Fellowship 01-Jan-1990
Other (Award) Roche Research Foundation Postdoctoral Fellowship 01-Jan-1992

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
Factors regulating initiation, progression and submucosal invasion in gastric cancer Chief Investigator NHMRC Project Grants 01/01/2004
THE ROLE OF TGF-BETA SIGNALING IN SUPPRESSION OF STAT3-MEDIATED TUMORIGENESIS Chief Investigator LUDWIG INST CANCER RESEARCH Project Grants (NHMRC) 01/01/2006

Additional Grant and Contract Information

2005
Awarded NHMRC Senior Research Fellowship

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2008

Journal Articles

  • IL-6 Regulates Neutrophil Trafficking during Acute Inflammation via STAT3.


     


    Year: 2008
    Journal: Journal of Immunology
    Volume: 181
    Page numbers: 2189-2195
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  • IL6/sIL6R complex contributes to emergency granulopoietic responses in G-CSF- and GM-CSF-deficient mice.
    Year: 2008
    Journal: Blood
    Volume: 111
    Issue: 8
    Page numbers: 3978-3985
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  • STAT3 and STAT1 mediate IL-11-dependent and inflammation-associated gastric tumorigenesis in gp130 receptor mutant mice.
    Year: 2008
    Journal: Journal of Clinical Investigation
    Volume: 118
    Issue: 5
    Page numbers: 1727-1738
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Publications in 2007

Journal Articles

  • DNA-methylation-dependent alterations of claudin-4 expression in human bladder carcinoma.

     


    Year: 2007
    Journal: Carcinogenesis
    Volume: 28
    Issue: 2
    Page numbers: 246-258
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  • TGF-ßRII rescues development of small intestinal epithelial cells in Elf3-deficient mice.


    Year: 2007
    Journal: Gastroenterology
    Volume: 132
    Issue: 2007
    Page numbers: 1410-1419
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  • c-Myb is required for progenitor cell homeostasis in colonic crypts.


    Year: 2007
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 104
    Issue: 10
    Page numbers: 3829-3834
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  • Interleukins 27 and 6 induce STAT-3-mediated T cell production of interleukin 10.
    Year: 2007
    Journal: Nature Immunology
    Volume: 8
    Issue: 12
    Page numbers: 1363-1371
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  • Pathologic consequences of STAT3 hyperactivation by IL-6 and IL-11 during hematopoeisis and lymphopoiesis.
    Year: 2007
    Journal: Blood
    Volume: 109
    Issue: 6
    Page numbers: 2380-2388
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Publications in 2006

Journal Articles

  • STAT3 activation regulates growth, inflammation, and vascularization in a mouse model of gastric tumorigenesis.


    Year: 2006
    Journal: Gastroenterology
    Volume: 131
    Issue: 4
    Page numbers: 1073-1085
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  • CNTF reverses obesity-induced insulin resistance by activating skeletal muscle AMPK.
    Year: 2006
    Journal: Nature Medicine
    Volume: 12
    Issue: 5
    Page numbers: 541-548
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  • Forced Dimerization of gp130 Leads to Constitutive STAT3 Activation, Cytokine-independent growth, and Blockade of differentiation of Embryonic Stem Cells.
    Year: 2006
    Journal: Molecular Biology of the Cell
    Volume: 17
    Page numbers: 2986-2995
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  • Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system.
    Year: 2006
    Journal: Nature Immunology
    Volume: 7
    Issue: 9
    Page numbers: 937-945
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  • SOCS3 negatively regulates LIF signaling in neural precursor cells.
    Year: 2006
    Journal: Molecular and Cellular Neurosciences
    Volume: 31
    Issue: 4
    Page numbers: 739-747
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Publications in 2005

Journal Articles

  • Constitutive activation of gp130 leads to neuroendocrine differentiation in vitro and in vivo
    Year: 2005
    Journal: The Prostate
    Volume: 62
    Issue: 3
    Page numbers: 282-289
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  • Differential regulation of gastric tumor growth by cytokines that signal exclusively through the coreceptor gp130
    Year: 2005
    Journal: Gastroenterology
    Volume: 129
    Page numbers: 1005-1018
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  • Hyperactivation of Stat3 in gp130 mutant mice promoes gastric hyperproliferation and desensitizes TGF-B signaling
    Year: 2005
    Journal: Nature Medicine
    Volume: 11
    Page numbers: 845-852
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  • IL-6 trans-signaling via STAT3 directs T cell infiltration in acute inflammation
    Year: 2005
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 102
    Issue: 27
    Page numbers: 9589-9594
    Publisher: National Academy of Sciences(Washington DC)
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  • Interleukin-11 receptor signaling is required for normal bone remodeling
    Year: 2005
    Journal: Journal of Bone & Mineral Research
    Volume: 20
    Issue: 7
    Page numbers: 1093-1102
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  • The IL-6-gp130-STAT3 pathway in hepatocytes triggers liver protection in T cell-mediated liver injury
    Year: 2005
    Journal: Journal of Clinical Investigation
    Volume: 115
    Issue: 4
    Page numbers: 860-869
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  • The threshold of gp130-dependent STAT3 signaling is critical for normal regulation of hematopoiesis
    Year: 2005
    Journal: Blood
    Volume: 105
    Issue: 9
    Page numbers: 3512-20
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Publications in 2004

Journal Articles

  • Acquiring signalling specificity from the cytokine receptor gp130
    Year: 2004
    Journal: Trends in Genetics
    Volume: 20
    Issue: 1
    Page numbers: 23-32
    Publisher: Elsevier Science London(London)
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  • Gastric cancer development in mice lacking the SHP2 binding site on the IL-6 family co-receptor gp130
    Year: 2004
    Journal: Gastroenterology
    Volume: 126
    Issue: 1
    Page numbers: 196-207
    Publisher: WB Saunders Co(Pennsylvania)
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  • Glycoprotein 130 regulates bone turnover and bone size by distinct downstream signaling pathways
    Year: 2004
    Journal: Journal of Clinical Investigation
    Volume: 113
    Issue: 3
    Page numbers: 379-389
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  • Imbalanced gp130-dependent signaling in macrophages alters macrophage colony-stimulating factor responsiveness via regulation of c-fms expression
    Year: 2004
    Journal: Molecular and Cellular Biology
    Volume: 24
    Issue: 4
    Page numbers: 1453-1463
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  • Mammary gland remodeling depends on gp130 signaling through STAT3 and MAPK
    Year: 2004
    Journal: Journal of Biological Chemistry
    Volume: 279
    Issue: 42
    Page numbers: 44093-44100
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Publications in 2002

Journal Articles

  • Analysis of the regulation of the A33 antigen gene reveals intestine-specific mechanisms of gene expression
    Year: 2002
    Journal: Journal of Biological Chemistry
    Volume: 277
    Issue: 37
    Page numbers: 34531-34539
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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  • Constitutive activation of the Src family kinase Hck results in spontaneous pulmonary inflammation and an enhanced innate immune response
    Year: 2002
    Journal: Journal of Experimental Medicine
    Volume: 196
    Issue: 589-604
    Page numbers: 5
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  • Hematopoietic abnormalities in mice deficient in gp130-mediated STAT signaling
    Year: 2002
    Journal: Experimental Hematology
    Volume: 30
    Issue: 11
    Page numbers: 1248-1256
    Publisher: Elsevier Science(New York)
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  • LIF receptor signaling limits immune-mediated demyelination by enhancing oligodendrocyte survival
    Year: 2002
    Journal: Nature Medicine
    Volume: 8
    Issue: 6
    Page numbers: 613-619
    Publisher: Nature America(New York)
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  • Reciprocal regulation of gastronintestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice
    Year: 2002
    Journal: Nature Medicine
    Volume: 8
    Page numbers: 1089-1097
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Publications in 2001

Journal Articles

  • Defective gp130-mediated signal transducer and activator of transcription (STAT) signaling results in degernerative joint disease, gastrointestinal ulceration, and failure of uterine implantation
    Year: 2001
    Journal: Journal of Experimental Medicine
    Volume: 194
    Page numbers: 189-203
    Publisher: Rockefeller University Press(New York)
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