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DR SIMON LOUIS



Contact Details

Organization: Medicine - Austin Health and Northern Health
Position: RESEARCH FELLOW
Email:
Work: 9496 5495
Fax: 9459 3510
Room: 5.3
Level: 05
Building: Lance Townsend Building
Campus: Austin Hospital

Research Expertise and International Linkages

Research Expertise

Research Interest Key Words Country of Expertise
ATIP Renin angiotensin system, AT2-receptors, Growth Factors, diabetes, prostate cancer Australia, France
Clinical pharmacology and therapeutics Pharmacokinetics, pharmacodynamics Australia
Imadazoline receptors Alzheimers disease, central cardiovascular control Australia
Structure/function beta-andrenoceptors Cardiovascular desease, Beta-adrengergic receptors, Beta-adrenoceptor, site directed mutagenesis, pharmacology Australia

International Linkages

Country Establishment Collaboration
United States National Institutes of Health Research
France Institut Cochin Exchange, Research

Languages

Languages

Language Proficiency
English Speak, Read & Write

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Bachelor of Arts University of Melbourne 31-Dec-1988
Bachelor of Commerce University of Melbourne 31-Dec-1991
Doctor of Philosophy University of Melbourne 31-Dec-1997

Memberships

Membership Type Membership Body Description Start Date End Date
Member Australian Society of Medical Researchers Member 01-Jan-2003

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
The expression and functional role of the renin-angiotensin system in prostate cancer Chief Investigator NHMRC Dora Lush Biomedical Postgraduate Scholarship 01/01/2004
Ang II expression: A biomarker for premalignant change in prostate cancer - A study in veterans at Austin Health Chief Investigator SIR EDWARD DUNLOP MEDICAL RESEARCH FOUNDATION Medical Research Grants 01/01/2005
ATIP, a novel protein which inhibits cancer cell growth and its role in diagnosis and grading of prostate cancer in veterans Chief Investigator SIR EDWARD DUNLOP MEDICAL RESEARCH FOUNDATION Medical Research Grants 01/07/2007
Anti-growth factor actions of ATIP1 (AT2-receptor interacting protein) in diabetes Chief Investigator KIDNEY HEALTH AUST Seeding Grant 01/01/2008
Function of a Novel Growth Factor Inhibitor - ATIP - in Diabetes Principal Supervisor AUST KIDNEY FOUNDATION Biomedical Research Scholarships 01/01/2008
ATIP, a novel protein which inhibits cancer cell growth and its role in the diagnosis and development of prostate cancer in veterans Chief Investigator SIR EDWARD DUNLOP MEDICAL RESEARCH FOUNDATION Medical Research Grants 10/07/2009

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2009

Journal Articles

  • Role of the renin-angiotensin system in prostate cancer
    Year: 2009
    Journal: Molecular and Cellular Endocrinology
    Volume: 302
    Page numbers: 219-229
    Author(s):
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Publications in 2008

Journal Articles

  • Functional angiotensin II type 2 receptros inhibit growth factor signaling in LNCaP and PC3 prostate cancer cell lines
    Year: 2008
    Journal: The Prostate
    Volume: 68
    Page numbers: 651-660
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Publications in 2007

Journal Articles

  • Appearance of angiotensin II expression in non-basal epithelial cells is an early feature of malignant change in human prostate
    Year: 2007
    Journal: Cancer Detection and Prevention
    Volume: 31
    Issue: 5
    Page numbers: 391-395
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Publications in 2006

Journal Articles

  • Mutation analysis of the 8p22 candidate tumor suppressor gene ATIP1MTUS1 in hepatocellular carcinoma
    Year: 2006
    Journal: Molecular and Cellular Endocrinology
    Volume: 252
    Issue: 2006
    Page numbers: 207-215
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  • Role of Tyr 356(7.43) and Ser 190(4.57) in Antagonist Binding in the Rat β1-Adrenergic Receptor
    Year: 2006
    Journal: Journal of Medicinal Chemistry
    Volume: 49
    Issue: 2006
    Page numbers: 3467-3477
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  • Structural organization and expression of human MTUS1, a candidate 8p22 tumor suppressor gene encoding a family of angiotensin II AT2 receptor-interacting proteins, ATIP
    Year: 2006
    Journal: Gene
    Volume: 380
    Issue: 2
    Page numbers: 127-136
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Publications in 2004

Journal Articles

  • Agonist binding and activation of the rat β1-adrenergic receptor: role of Trp134 (3.28), Ser190 (4.57) and Tyr356 (7.43)
    Year: 2004
    Journal: Biochemical Pharmacology
    Volume: 68
    Page numbers: 675-688
    Publisher: Pergamon-Elsevier Science(Oxford)
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  • Site-directed mutagenesis of the rat β1-adrenoceptor. Involement of Tyr356 (7.43) in (+/-)cyanopindolol but not (+/-)[125Iodo]cyanopindolol binding
    Year: 2004
    Journal: European Journal of Medicinal Chemistry
    Volume: 39
    Page numbers: 625-631
    Publisher: Editions Scientifiques Medicales Elsevier(Paris)
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  • Trans-inactivation of receptor tyrosine kinases by novel angiotensin II AT2 receptor-interacting protein, ATIP
    Year: 2004
    Journal: Journal of Biological Chemistry
    Volume: 279
    Issue: 28
    Page numbers: 28989-28997
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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