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PROF IAN EVERALL



Contact Details

Organization: Psychiatry
Position: CATO CHAIR OF PSYCHIATRY-ROYAL MELBOURNE HOSPITAL
Email:
Work: +61 3 8344 5509
Fax: +61 3 90358842
Room: N10018
Level: 01
Building: Main Block
Campus: Royal Melbourne Hospital

Biography

Professor Ian Everall obtained his MBChB at Leicester University School of Medicine. He trained in psychiatry at the Bethlem royal and Maudsley Hospitals, London. In 1989 he obtained Membership of the Royal College of Psychiatrists and a MRC Clinical Research Training Fellowship, followed in 1992 by an advanced MRC Clinician Scientist Fellowship in the Department of Neuropathology, Institute of Psychiatry. He obtained his PhD in 1992. In 1993 he was appointed Senior Lecturer at the Institute of Psychiatry and Honorary Consultant Psychiatrist at The Maudsley Hospital. In 1999 he was appointed Professor of Psychiatry at the University of California, San Diego. At the end of 2009 Professor Everall took up the role of Cato Chair and Head of Department of Psychiatry, University of Melbourne.

Professor  Everall has been at the forefront of research into cellular, molecular and genetic changes in the brain in major psychiatric disorders for over twenty years. His area of interest includes psychosis, major depression, bipolar disorder and cognitive impairment, especially when associated with HIV infection and methamphetamine use which is becoming a growing social and psychiatric concern globally. Professor Everall is currently working on research into blood based biomarkers to aid in the diagnosis of psychosis, the discovery of the role of a group of proteins, called immunophilins, in major depressive disorder, and further refining the molecular neuropathology of schizophrenia

Research Expertise and International Linkages

Research Expertise

Research Interest Key Words Country of Expertise
HIV major psychiatric disorders Australia, United Kingdom, United States of America

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Bachelor Degree Class I in Medical Sciences University of Leicester 01-Dec-1982
PhD University of London 01-Dec-1993
Bachelor of Medicine and Bachelor of Surgery with the award of Honours University of Leicester 02-Dec-1985

Fellowships

Fellowship Date Awarded
Fellow of the Royal College of Psychiatrists (FRCPSYCH) 01-Jan-2004
Member of the Royal College of Psychiatrists (MRCPSYC) 02-Jan-1989
Fellow of the Royal Australian and New Zealand College of Psychiatrists (FRANZCP) 01-Jun-2010
Fellow of the Royal College of Pathologists, Australia (FRCPA) 01-Jan-2004

Government Research Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
SOMATOSTAIN & STRESS-RELATED GENES IN HIV & COMORBID MAJOR DEPRESSIVE DISORDER Chief Investigator NATIONAL INSTITUTE OF HEALTH Research Project Grants 01/05/2010
COMT GENOTYPE AND EXECUTIVE FUNCTION IN HIV INFECTION AND METHAMPHETAMINE USE Chief Investigator NATIONAL INSTITUTE OF HEALTH Exploratory/Developmental Research Grant Program (Parent R21) 03/07/2010
Development of a prediction tool for persistent depression using genetic analysis Chief Investigator L.E.W. CARTY CHARITABLE FUND Research Grants 01/07/2011
Investigation of the expression and function of selenium binding protein-1 (SELENBP1) in schizophrenia Chief Investigator REBECCA L COOPER MEDICAL RESEARCH FOUNDATION LTD Research Grants 01/01/2012
IDENTIFYING NEUROIMAGING BIOMARKERS OF PSYCHOSIS ONSET Chief Investigator NARSAD Distinguished Investigator Award

Contracts

Title Role Funding Source Award Date
CRC FOR MENTAL HEALTH (ROUND 13 SELECTION) Chief Investigator CRC FOR MENTAL HEALTH LTD 01/07/2011
GOVERNANCE OF CLINICAL TRIAL UNIT (NATIONAL PSYCHIATRIC RESEARCH CENTRE NPRC) Chief Investigator MELBOURNE HEALTH 14/03/2012

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2012

Books

  • The Neurology of AIDS
    Year: 2012
    Publisher: Oxford University Press(New York)
    Authors(s):

Book Chapters

  • Neuronal Injury, White Matter Disease, and Neurothrophic Factors


    Year: 2012
    Book: The Neurology of AIDS
    Publisher: Oxford University Press(New York)
    Authors(s):
  • HIV and Psychiatric Comorbidities
    Year: 2012
    Book: The Neurology of AIDS
    Publisher: Oxford University Press
    Authors(s):
  • HIV-1 gp120
    Year: 2012
    Book: The Neurology of AIDS
    Publisher: Oxford University Press(New York)
    Authors(s):

Journal Articles

  • Chronic Illness Histories of Adults Entering Treatment for Co-occurring Substance Abuse and Other Mental Health Disorders
    Year: 2012
    Journal: American Journal on Addictions
    Volume: 21
    Issue: 1
    Page numbers: 1-4
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Publications in 2011

Book Chapters

  • Methamphetamine-Associated Psychosis: a Model for Biomarker Discovery in Schizophrenia
    Year: 2011
    Book: Handbook of Schizophrenia Spectrum Disorders, Volume I
    Publisher: Springer(New York)
    Authors(s):

Journal Articles

  • Dopamine receptor D3 genetic polymorphism (rs6280TC) is associated with rates of cognitive impairment in methamphetamine-dependent men with HIV: preliminary findings.
    Year: 2011
    Journal: Journal of NeuroVirology
    Volume: 17
    Issue: 3
    Page numbers: 239-247
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  • Formidable Challenges in the Search for Biomarkers of Psychiatric Disorders
    Year: 2011
    Journal: Metabolomics
    Volume: 1
    Issue: 2
    Article number: 105e
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  • Increased CDK5 expression in HIV encephalitis contributes to neurodegeneration via tau phosphorylation and is reversed with Roscovitine
    Year: 2011
    Journal: American Journal of Pathology
    Volume: 178
    Issue: 4
    Page numbers: 1646-1661
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  • Neurotoxic effects of the HCV core protein are mediated by sustained activation of ERK via TLR2 signaling
    Year: 2011
    Journal: Journal of NeuroVirology
    Volume: 17
    Issue: 4
    Page numbers: 327-340
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  • Tyrosine kinase B protein expression is reduced in the cerebellum of patients with bipolar disorder
    Year: 2011
    Journal: Journal of Affective Disorders
    Volume: 133
    Issue: 3
    Page numbers: 646-654
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Publications in 2010

Book Chapters

  • HIV, Methamphetamine, and the Brain in the Era of Antiretroviral Treatment.
    Year: 2010
    Book: Physical and Mental Illness: The Interface
    Publisher: Australian Postgraduate Medicine(Melbourne)
    Authors(s):

Journal Articles

  • Amelioration of caspase 3,7 activity by SP01 in human primary neurons exposed to HIV
    Year: 2010
    Journal: Neurobehavioral HIV Medicine
    Volume: 2
    Page numbers: 33-37
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  • COMT Val158Met Polymorphism, Executive Dysfunction, and Sexual Risk Behavior in the Context of HIV-Infection and Methamphetamine Dependence
    Year: 2010
    Journal: Interdisciplinary Perspectives on Infectious Diseases
    Volume: January 3
    Article number: 678648
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  • Correlation of major depressive disorder symptoms with FKBP5 but not FKBP4 expression in human immunodeficiency virus-infected individuals
    Year: 2010
    Journal: Journal of NeuroVirology
    Volume: 16
    Issue: 5
    Article number: PMID: 20726698
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  • Cytochrome P450-2D6 extensive metabolizers are more vulnerable to methamphetamine-associated neurocognitive impairment: Preliminary findings
    Year: 2010
    Journal: Journal of the International Neuropsychological Society
    Volume: 16
    Issue: 5
    Page numbers: 890-901
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  • Evidence for Alteration of Gene Regulatory Networks through MicroRNAs of the HIV-Infected Brain: Novel Analysis of Retrospective Cases
    Year: 2010
    Journal: PLoS One
    Volume: 5
    Issue: 4
    Article number: e10337
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  • Exploration of a genomic expression and pathway analysis approach to neurocognitive performance: Preliminary findings
    Year: 2010
    Journal: Neurobehavioral HIV Medicine
    Volume: 2
    Page numbers: 23-32
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  • Expression of the Rap1 guanine nucleotide exchange factor, MR-GEF, is altered in individuals with bipolar disorder
    Year: 2010
    Journal: PLoS One
    Volume: 5
    Issue: 4
    Article number: e10392
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  • Homelessness and neuropsychological impairment: Preliminary case-control analysis of adults entering outpatient psychiatric treatment
    Year: 2010
    Journal: Journal of Nervous and Mental Disease
    Volume: 198
    Issue: 11
    Page numbers: 790-794
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  • Impact of COMT Val158Met on executive functioning in the context of HIV and methamphetamine
    Year: 2010
    Journal: Neurobehavioral HIV Medicine
    Volume: 2
    Page numbers: 1-11
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  • Impact of the Catechol-O-Methyltransferease Val158Met Polymorphism on Executive Functioning in the context of HIV-Infection and Methamphetamine Dependence
    Year: 2010
    Journal: Neurobehavioral HIV Medicine
    Volume: 2
    Page numbers: 1-11
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  • Microglial activation and increased microglial density observed in the dorsolateral prefrontal cortex in autism
    Year: 2010
    Journal: Biological Psychiatry
    Volume: 68
    Issue: 4
    Page numbers: 368-376
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  • Positive symptoms of psychosis correlate with expression of ubiquitin proteasome genes in peripheral blood
    Year: 2010
    Journal: American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics
    Volume: 153B
    Issue: 7
    Article number: PMID: 20552680
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  • Preliminary evidence of ethnic divergence in associations of putative genetic variants for methamphetamine dependence
    Year: 2010
    Journal: Psychiatry Research
    Volume: 178
    Issue: 2
    Article number: PMID: 20478633
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Publications in 2009

Book Chapters

  • Biomarker Discovery in Major Psychiatric Disorders: Approaches, Limitations, and Future Directions
    Year: 2009
    Book: Advances in Genetics Research. Volume 3
    Publisher: Nova Science Publishers(New York)
    Authors(s):

Journal Articles

  • Increased frequency of α-synuclein in the substantia nigra in human immunodeficiency virus infection




    Year: 2009
    Journal: Journal of NeuroVirology
    Volume: 15
    Issue: 2
    Page numbers: 131-138
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  • Alternatively Spliced Genes as Biomarkers for Schizophrenia, Bipolar Disorder and Psychosis: A Blood-Based Spliceome-Profiling Exploratory Study
    Year: 2009
    Journal: Current Pharmacogenomics
    Volume: 7
    Issue: 3
    Page numbers: 164-188
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  • Cliniconeuropathologic correlates of human immunodeficiency virus in the era of antiretroviral therapy
    Year: 2009
    Journal: Journal of NeuroVirology
    Volume: 15
    Issue: 5-6
    Page numbers: 360-370
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  • Differential expression of immunophilins FKBP51 and FKBP52 in the frontal cortex of HIV-infected patients with major depressive disorder
    Year: 2009
    Journal: Journal of Neuroimmune Pharmacology
    Volume: 4
    Issue: 2
    Page numbers: 218-226
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  • Genetic Association Studies of Methamphetamine Use Disorders: A Systematic Review and Synthesis
    Year: 2009
    Journal: American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics
    Volume: 150B
    Issue: 8
    Article number: PMID: 19219857
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  • Glycogen synthase kinase-3beta (GSK-3beta) inhibitors AR-A014418 and B6B3O prevent human immunodeficiency virus-mediated neurotoxicity in primary human neurons
    Year: 2009
    Journal: Journal of NeuroVirology
    Volume: 15
    Issue: 5-6
    Page numbers: 434-438
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  • Increased accumulation of intraneuronal amyloid beta in HIV-infected patients
    Year: 2009
    Journal: Journal of Neuroimmune Pharmacology
    Volume: 4
    Issue: 2
    Page numbers: 190-199
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  • Increased frequency of alpha-synuclein in the substantia nigra in human immunodeficiency virus infection
    Year: 2009
    Journal: Journal of NeuroVirology
    Volume: 15
    Issue: 2
    Page numbers: 131-138
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  • Modulation of glucocorticoid receptor nuclear translocation in neurons by immunophilins FKBP51 and FKBP52: implications for major depressive disorder
    Year: 2009
    Journal: Brain Research
    Volume: 1286
    Page numbers: 1-12
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  • Molecular pathology of neuro-AIDS (CNS-HIV)
    Year: 2009
    Journal: International Journal of Molecular Sciences
    Volume: 10
    Issue: 3
    Page numbers: 1045-1063
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  • Negative mood and sexual behavior among non-monogamous men who have sex with men in the context of methamphetamine and HIV
    Year: 2009
    Journal: Journal of Affective Disorders
    Volume: 119
    Issue: 1-3
    Article number: PMID: 19419773
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  • Preliminary evidence of ubiquitin proteasome system dysregulation in schizophrenia and bipolar disorder: Convergent pathway analysis findings from two independent samples
    Year: 2009
    Journal: American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics
    Volume: 153B
    Issue: 2
    Page numbers: 494-502
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  • Two-dimensional assessment of cytoarchitecture in the superior temporal white matter in schizophrenia, major depressive disorder and bipolar disorder
    Year: 2009
    Journal: Schizophrenia Research
    Volume: 115
    Issue: 2-3
    Page numbers: 156-162
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  • Upregulation of NRG-1 and VAMP-1 in human brain aggregates exposed to clozapine
    Year: 2009
    Journal: Schizophrenia Research
    Volume: 113
    Issue: 2-3
    Page numbers: 273-276
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Publications in 2008

Journal Articles

  • The Utility of SELENBP1 Gene Expression as a Biomarker for Major Psychotic Disorders: Replication in Schizophrenia and Extension to Bipolar Disorder With Psychosis


    Year: 2008
    Journal: American Journal of Medical Genetics. Part B: Neuropsychiatric Genetics
    Volume: 147B
    Issue: 6
    Page numbers: 686-689
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  • Glial cell number and nuclear size in the mediodorsal thalamic nucleus (MDNT) in schizophrenia
    Year: 2008
    Journal: Schizophrenia Research
    Volume: 102
    Issue: 1-3
    Page numbers: 344-345
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  • Neurobiology of HIV
    Year: 2008
    Journal: International Review of Psychiatry
    Volume: 20
    Issue: 1
    Page numbers: 3-13
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Publications in 2007

Journal Articles

  • Escalating dose-multiple binge methamphetamine exposure results in degeneration of the neocortex and limbic system in the rat
    Year: 2007
    Journal: Experimental Neurology
    Volume: 207
    Issue: 1
    Page numbers: 42-51
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  • Pathogenesis of hepatitis C virus coinfection in the brains of patients infected with HIV
    Year: 2007
    Journal: Journal of Infectious Diseases
    Volume: 196
    Issue: 3
    Page numbers: 361-370
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  • Psychiatry residency training around the world
    Year: 2007
    Journal: Academic Psychiatry
    Volume: 31
    Issue: 4
    Page numbers: 309-325
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  • Toll-like receptor pathway gene expression is associated with human immunodeficiency virus-associated neurodegeneration
    Year: 2007
    Journal: Journal of NeuroVirology
    Volume: 13
    Issue: 6
    Page numbers: 496-503
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Publications in 2006

Journal Articles

  • An emerging severe leukoencephalopathy: is it due to HIV disease or highly active antiretroviral therapy?
    Year: 2006
    Journal: International Journal of STD & AIDS
    Volume: 17
    Issue: 3
    Page numbers: 205-207
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  • Calprotectin in microglia from frontal cortex is up-regulated in schizophrenia: evidence for an inflammatory process?
    Year: 2006
    Journal: European Journal of Neuroscience
    Volume: 24
    Issue: 12
    Page numbers: 3561-3566
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  • Cognitive deficits and degeneration of interneurons in HIV+ methamphetamine users
    Year: 2006
    Journal: Neurology
    Volume: 67
    Issue: 8
    Page numbers: 1486-1489
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  • Diminished somatostatin gene expression in individuals with HIV and major depressive disorder
    Year: 2006
    Journal: Neurology
    Volume: 67
    Issue: 10
    Page numbers: 1867-1869
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  • Lithium improves HIV-associated neurocognitive impairment
    Year: 2006
    Journal: AIDS
    Volume: 20
    Issue: 14
    Page numbers: 1885-1888
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  • Microarray analysis of cultured human brain aggregates following cortisol exposure: Implications for cellular functions relevant to mood disorders
    Year: 2006
    Journal: Neurobiology of Disease
    Volume: 23
    Issue: 3
    Page numbers: 630-636
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Publications in 2005

Journal Articles

  • Comparative gene expression analysis of blood and brain provides concurrent validation of SELENBP1 up-regulation in schizophrenia
    Year: 2005
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 102
    Issue: 43
    Page numbers: 15533-15538
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  • Evidence for altered neuronal organisation within the planum temporale in major psychiatric disorders
    Year: 2005
    Journal: Schizophrenia Research
    Volume: 73
    Issue: 1
    Page numbers: 69-78
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  • Methamphetamine stimulates interferon inducible genes in HIV infected brain
    Year: 2005
    Journal: Journal of Neuroimmunology
    Volume: 170
    Issue: 1-2
    Page numbers: 158-171
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  • Methamphetamine: A molecular and pathological exacerbate of HIV neurocognitive disorder
    Year: 2005
    Journal: European Journal of Psychiatry
    Volume: 19
    Issue: 4
    Page numbers: 255-262
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  • The shifting patterns of HIV encephalitis neuropathology
    Year: 2005
    Journal: Neurotoxicity Research
    Volume: 8
    Issue: 1-2
    Page numbers: 51-61
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Publications in 2002

Journal Articles

  • Density and distribution of white matter neurons in schizophrenia, bipolar disorder and major depressive disorder: no evidence for abnormalities of neuronal migration
    Year: 2002
    Journal: Molecular Psychiatry
    Volume: 7
    Issue: 6
    Page numbers: 564-570
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  • Reduced Neuronal Size and Glial Cell Density in Area 9 of the Dorsolateral Prefrontal Cortex in Subjects with Major Depressive Disorder
    Year: 2002
    Journal: Cerebral Cortex
    Volume: 12
    Issue: 4
    Page numbers: 386-394
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  • The Density and Spatial Distribution of GABAergic Neurons, Labelled using Calcium Binding Proteins, in the Anterior Cingulate Cortex in Major Depressive Disorder, Bipolar Disorder, and Schizophrenia
    Year: 2002
    Journal: Biological Psychiatry
    Volume: 51
    Issue: 5
    Page numbers: 377-386
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Publications in 2001

Journal Articles

  • Reduced Glial Cell Density and Neuronal Size in the Anterior Cingulate Cortex in Major Depressive Disorder
    Year: 2001
    Journal: Archives of General Psychiatry
    Volume: 58
    Issue: 6
    Page numbers: 545-553
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