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DR ANTHONY WHITE



Contact Details

Organization: Medicine, Dentistry and Health Sciences, Pathology
Position: Honorary (Fellow), SENIOR RESEARCH FELLOW
Email:
Homepage: http://www.path.unimelb.edu.au/research/labs/white/
Work: 41805
Room: 243
Level: 02
Building: 101 Barry St.
Campus: Parkville

Research Expertise and International Linkages

Research Expertise

Research Interest Key Words Country of Expertise
Alzheimer's disease biometals, neurodegenerative disease Australia

International Linkages

Country Establishment Collaboration
United States Massachusetts Institute of Technology Research

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Bachelor of Science Murdoch University 31-Dec-1989
Bachelor of Science (honours) Murdoch University 31-Dec-1991
Doctor of Philosophy Murdoch University 31-Dec-1995

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
NEURODEGENERATIVE DISEASES OF THE AGING BRAIN: DIAGNOSIS & THERAPY BASED ON THE STUDY OF AGGREAGATED PROTEIN DEPOSITIONS Chief Investigator NHMRC Program Grants 01/01/2002
RD Wright Biomedical Career Development Award Chief Investigator NHMRC R Douglas Wright Awards 01/01/2004
Development of a protein-based diagnostic assay for the detection of asymptomatci Parkinson's disease Chief Investigator BRAIN FOUNDATION Parkinson's Disease Research Grant 01/01/2005
NEUROPROTECTIVE ACTIVITY OF METAL COMPLEXES THROUGH ACTIVATION OF HTE EPIDERMAL GROWTH FACTOR RECEPTOR Chief Investigator ANZ CHARITABLE TRUSTS Wicking Trust 24/09/2007
THE USE OF CU-ATSM TREATMENT TO IDENTIFY CELLULAR MECHANISMS OF MOTOR NEURON DEGENERATION IN AMYOTROPHIC LATERAL SCLEROSIS. Chief Investigator MOTOR NEURONE DISEASE INST OF AUST Grants-in-Aid 07/11/2007
Modulation of cell signalling by metal-based compounds as a therapeutic treament for Alzheimer's disease. Chief Investigator NHMRC Project Grants 01/01/2009
Improving synaptic function in Alzheimer's disease by increasing neuronal copper bioavailability Chief Investigator ANZ CHARITABLE TRUSTS Mason Foundation 26/10/2009

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2009

Journal Articles

  • Increasing Cu bioavailability inhibits Aβ oligomers and tau phosphorylation
    Year: 2009
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 106
    Issue: 2
    Page numbers: 381-386
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  • Restored degradation of the Alzheimer's amyloid-beta peptide by targeting amyloid formation
    Year: 2009
    Journal: Journal of Neurochemistry
    Volume: 108
    Page numbers: 1198-1207
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Publications in 2008

Book Chapters

  • Neurotoxicity of Prion Peptides on Cultured Cerebellar Neurons
    Year: 2008
    Book: Prion Protein Protocols
    Publisher: Humana Press
    Authors(s):

Journal Articles

  • Activation of epidermal growth factor receptor by metal-ligand complexes decreases levels of extracellular amyloid beta peptide


    Year: 2008
    Journal: International Journal of Biochemistry and Cell Biology
    Volume: 40
    Issue: 9
    Page numbers: 1901-1917
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  • Clioquinol inhibits peroxide-mediated toxicity through up-regulation of phosphoinositol-3-kinase and inhibition of p53 activity


    Year: 2008
    Journal: International Journal of Biochemistry and Cell Biology
    Volume: 40
    Issue: 5
    Page numbers: 1030-1042
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  • Neurotoxicity from glutathione depletion is mediated by Cu-dependent p53 activation


    Year: 2008
    Journal: Free Radical Biology and Medicine
    Volume: 44
    Issue: 1
    Page numbers: 44-55
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  • Platinum-based inhibitors of amyloid-β as therapeutic agents for Alzheimer’s disease


    Year: 2008
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 105
    Issue: 19
    Page numbers: 6813-6818
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  • Clioquinol Promotes Cancer Cell Toxicity through Tumor Necrosis Factor alpha release from Macrophages
    Year: 2008
    Journal: Journal of Pharmacology and Experimental Therapeutics
    Volume: 324
    Issue: 1
    Page numbers: 360-367
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  • Mechanisms of Abeta mediated neurodegeneration in Alzheimer's disease
    Year: 2008
    Journal: International Journal of Biochemistry and Cell Biology
    Volume: 40
    Page numbers: 181-198
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  • Mechanisms of aβ mediated neurodegeneration in Alzheimer's disease
    Year: 2008
    Journal: International Journal of Biochemistry and Cell Biology
    Volume: 40
    Issue: 2
    Page numbers: 181-198
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  • Selective intracellular release of copper and zinc ions from bis(thiosemicarbazonato) complexes reduces levels of Alzheimer disease amyloid-beta peptide
    Year: 2008
    Journal: Journal of Biological Chemistry
    Volume: 283
    Issue: 8
    Page numbers: 4568-4577
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  • The role of metals in modulating metalloprotease activity in the AD brain
    Year: 2008
    Journal: European Biophysics Journal with Biophysics Letters
    Volume: 37
    Issue: 3
    Page numbers: 315-321
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Publications in 2007

Journal Articles

  • Therapeutic treatment of alzheimer's disease using metal complexing agents.


     


    Year: 2007
    Journal: Recent Patents CNS Drug Discovery
    Volume: 2
    Issue: 3
    Page numbers: 180-187
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  • Copper and zinc bis(thiosemicarbazonato) complexes for the treatment of Alzheimer's disease
    Year: 2007
    Journal: Journal of Biological Inorganic Chemistry
    Volume: 12
    Page numbers: S17
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  • Differential modulation of Alzheimer's disease amyloid beta peptide accumulation by diverse classes of metal ligands.
    Year: 2007
    Journal: Biochemical Journal
    Volume: 407
    Issue: 3
    Page numbers: 435-450
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  • The modulation of metal bio-availability as a therapeutic strategy for the treatment of Alzheimer's disease.
    Year: 2007
    Journal: FEBS Journal
    Volume: 274
    Page numbers: 3775-3783
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Publications in 2006

Journal Articles

  • Correlative studies support lipid peroxidation is linked to PrPres propogation as an early primary pathogenic event in prion disease
    Year: 2006
    Journal: Brain Research Bulletin
    Volume: 68
    Page numbers: 346-354
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  • Degradation of the Alzheimer's disease amyloid beta peptide by metal-dependent up-regulation of metalloprotease activity.
    Year: 2006
    Journal: Journal of Biological Chemistry
    Volume: 281
    Page numbers: 17670-17680
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  • Metal homeostasis in Alzheimer's disease
    Year: 2006
    Journal: Expert Review of Neurotherapeutics
    Volume: 6
    Issue: 5
    Page numbers: 711-722
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  • Overexpression of Abeta is associated with acceleration of onset of motor impairment and superoxide dismutase 1 aggregation in amyotrophic lateral sclerosis mouse models
    Year: 2006
    Journal: Aging Cell
    Volume: 5
    Page numbers: 153-165
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  • Therapeutic treatments for Alzheimer's disease based on metal bioavailability
    Year: 2006
    Volume: 19
    Page numbers: 469-474
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Publications in 2005

Journal Articles

  • In vitro gamma-secretase cleavage of the Alzheimer's amyloid precursor protein correlates to a subset of presenilin complexes and is inhibited by zinc
    Year: 2005
    Journal: The FEBS Journal
    Volume: 272
    Issue: 21
    Page numbers: 5544-5557
    Publisher: Blackwell Publishers
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  • Peptide-oligonucleotide hybrids in antisense therapy
    Year: 2005
    Journal: Mini-Reviews in Medicinal Chemistry
    Volume: 5
    Issue: 1
    Page numbers: 41-55
    Publisher: Bentham Science Publishers(Hilversum)
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Publications in 2004

Journal Articles

  • Gene knockout of amyloid precursor protein and amyloid precursor-like protein-2 increases cullular copper levels in primary mouse cortical neurons and embryonic fibroblasts
    Year: 2004
    Journal: Journal of Neurochemistry
    Volume: 91
    Page numbers: 423-428
    Publisher: Blackwell Science(Oxford)
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  • Iron inhibits neurotoxicity induced by trace copper and biological reductants
    Year: 2004
    Journal: Journal of Biological Inorganic Chemistry
    Volume: 9
    Page numbers: 269-280
    Publisher: Springer Verlag(New York)
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Publications in 2003

Journal Articles

  • Acetylcholinesterase is increased in mouse neuronal and astrocyte cultures after treatment with β-amyloid peptides
    Year: 2003
    Journal: Brain Research
    Volume: 965
    Page numbers: 283-286
    Publisher: Elsevier Science(Amsterdam)
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  • Diverse fibrillar peptides directly bind the Alzheimer's amyloid precursor protein and amyloid precursor-like protein 2 resulting in cellular accumulation
    Year: 2003
    Journal: Brain Research
    Volume: 966
    Page numbers: 231-244
    Publisher: Elsevier Science(Amsterdam)
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  • Neurotoxicity from glutathione depletion is dependent on extracellular trace copper
    Year: 2003
    Journal: Journal of Neuroscience Research
    Volume: 71
    Page numbers: 889-897
    Publisher: Wiley-Liss(New York)
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  • Structure of the Alzheimer's disease amyloid precursor protein copper binding domain
    Year: 2003
    Journal: Journal of Biological Chemistry
    Volume: 278
    Issue: 19
    Page numbers: 17401-17407
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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Publications in 2002

Journal Articles

  • Alzheimer's disease amyloid beta and prion protein amyloidogenic peptides promote macrophage survival, DNA synthesis and enhanced prliferative response to CSF-1 (M-CSF)
    Year: 2002
    Journal: Brain Research
    Volume: 940
    Page numbers: 49-54
    Publisher: Elsevier Science(Amsterdam)
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  • Contrasting, species-dependent modulation of copper-mediated neurotoxicity by the Alzheimer's disease amyloid precursor protein
    Year: 2002
    Journal: Journal of Neuroscience
    Volume: 22
    Issue: 2
    Page numbers: 365-376
    Publisher: Society of Neuroscience(Washington DC)
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  • Evidence for a copper-binding superfamily of the amyloid precursor protein
    Year: 2002
    Journal: Biochemistry
    Volume: 41
    Page numbers: 9310-9320
    Publisher: American Chemical Society(Washington DC)
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  • Metalloenzyme-like activity of Alzheimer's disease β-amyloid
    Year: 2002
    Journal: Journal of Biological Chemistry
    Volume: 277
    Page numbers: 40302-40308
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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  • Overexpression of Alzheimer's disease amyloid-β opposes the age-dependent elevations of brain copper and iron
    Year: 2002
    Journal: Journal of Biological Chemistry
    Volume: 277
    Issue: 47
    Page numbers: 44670-44676
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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Publications in 2001

Journal Articles

  • Copper and zinc binding modulates the aggregation and neurotoxic properties of the prion peptide PrP106-126
    Year: 2001
    Journal: Biochemistry
    Volume: 40
    Page numbers: 8073-8084
    Publisher: American Chemical Society(Washington DC)
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  • Homocysteine potentiates copper- and amyloid beta peptide-mediated toxicity in primary neuronal cultures: possible risk factors in the Alzheimer's-type neurodegenerative pathways
    Year: 2001
    Journal: Journal of Neurochemistry
    Volume: 76
    Page numbers: 1509-1520
    Publisher: Blackwell Science(Oxford)
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  • Involvement of the 5-lipoxygenase pathway in the neurotoxicity of the prion peptide PrP106-126
    Year: 2001
    Journal: Journal of Neuroscience Research
    Volume: 65
    Page numbers: 565-572
    Publisher: Wiley-Liss(New York)
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  • Sublethal concentrations of prion peptide PrP106-126 or the amyloid beta peptide of Alzheimer's disease activates expression of proapoptotic markers in primary cortical neurons
    Year: 2001
    Journal: Neurobiology of Disease
    Volume: 8
    Page numbers: 299-316
    Publisher: Academic Press(California)
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