A/PROF ANTHONY PURCELL

Contact Details

Organization:	Biochemistry and Molecular Biology
Position:	PRINCIPAL RESEARCH FELLOW
Email:
Homepage:	http://www.biochemistry.unimelb.edu.au/research/res_purcell.htm
Work:	8344 2288
Fax:	93481421

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title	Institution	Date Awarded	Abbreviation
Bachelor of Science (honours)	Monash University	31-Dec-1988
Doctor of Philosophy	Monash University	31-Dec-1994

Memberships

Membership Type	Membership Body	Description	Start Date	End Date
Member	Australasian Society for Biochemistry and Molecular Biology	ordinary member	01-Jan-1990	31-Dec-2005

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Prevention - biologicals (e.g. vaccines) (HUMAN PHARMACEUTICAL PRODUCTS) (670401)
Human pharmaceutical products (PREVENTION AND TREATMENT OF POLLUTION) (671704)
Infectious diseases (CLINICAL; ORGANS, DISEASES AND ABNORMAL CONDITIONS) (730101)
Immune system and allergy (CLINICAL; ORGANS, DISEASES AND ABNORMAL CONDITIONS) (730102)
Nervous system and disorders (CLINICAL; ORGANS, DISEASES AND ABNORMAL CONDITIONS) (730104)
Endocrine organs and diseases (incl. Diabetes) (CLINICAL; ORGANS, DISEASES AND ABNORMAL CONDITIONS) (730105)
Cardiovascular system and diseases (CLINICAL; ORGANS, DISEASES AND ABNORMAL CONDITIONS) (730106)
Cancer and related disorders (CLINICAL; ORGANS, DISEASES AND ABNORMAL CONDITIONS) (730108)
Skeletal system and disorders (incl. Arthritis) (CLINICAL; ORGANS, DISEASES AND ABNORMAL CONDITIONS) (730114)
Organs, diseases & abnormal conditions not elsewhere classified (CLINICAL; ORGANS, DISEASES AND ABNORMAL CONDITIONS) (730118)
Women's health (PUBLIC HEALTH) (730201)
Preventive medicine (PUBLIC HEALTH) (730213)
Health and support services not elsewhere classified (HEALTH AND SUPPORT SERVICES) (730399)
Biological sciences (NON-ORIENTED RESEARCH) (780105)

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title	Role	Funding Source	Scheme	Award Date
AUTOCLAVES (2) 2004 NHMRC EQUIPMENT GRANT ALLOCATION	Chief Investigator	NHMRC	Equipment Grants	01/01/2005
Structural basis of influenza A virus-specific CD8+ T cell Receptor Diversity	Chief Investigator	NHMRC	Project Grants	01/01/2005
Role of post-translationally modified antigen in rheumatoid arthritis	Chief Investigator	ARTHRITIS FOUNDATION OF AUST	Grant in Aid	01/01/2005
DEVELOPMENT OF A STABLE AND SPECIFIC PEPTIDE BASED VACCINE FOR CANCER THERAPY USING PEPTIDES CONTAINING BETA-AMINO ACIDS FOR IMPROVED STABILITY AND DELIVERY CHARACTERISTICS	Chief Investigator	MONASH UNIVERSITY	Linkage Projects (AUST RESEARCH COUNCIL)	01/07/2005
Antigen post-translational modification and autoimmunity	Chief Investigator	MS AUSTRALIA	Summer Vacation Scholarships	01/01/2006
ER PROTEINS EFFECT ON CLASS I MHC ASSEMBLY	Chief Investigator	UNIVERSITY OF NEBRASKA MEDICAL CENTER	Research Project Grants (NATIONAL INSTITUTE OF HEALTH)	01/05/2006
THE ROLE OF CTL ESCAPE MUTANTS IN MHV-INDUCED DEMYELINATON	Chief Investigator	UNIVERSITY OF IOWA	Research Project Grants (NATIONAL INSTITUTE OF HEALTH)	16/08/2006
THE ROLE OF ANTIGEN POST TRANSLATIONAL MODIFICATIONS IN RHEUMATIOD ARTHRITIS	Principal Supervisor	ARTHRITIS AUSTRALIA, ARTHRITIS FOUNDATION OF AUST	Scholarships (ARTHRITIS FOUNDATION OF AUST)	20/11/2007
RESEARCH FELLOWSHIP 2008 - PURCELL	Chief Investigator	NHMRC	Research Fellowship	01/01/2008
MASS SPECTROMETRY FACILITY FOR THE QUANTITATION AND ANALYSIS OF POST-TRANSLATIONALLY MODIFIED PEPTIDES	Chief Investigator	AUST RESEARCH COUNCIL	Linkage Infrastructure (Equipment and Facilities)	01/01/2008
Surface details of pathogenic bacteria.	Chief Investigator	NHMRC	Project Grants	01/01/2008
Understanding the recognition requirements for virus-specific T cells	Chief Investigator	NHMRC	Project Grants	01/01/2008
Does modification of joint proteins contribute to arthritis	Chief Investigator	NHMRC	Project Grants	01/01/2008
NEW TECHNOLOGY FOR THE DELIVERY OF PEPTIDE-BASED T-CELL VACCINES FOR TUMOUR IMMUNOTHERAPY	Chief Investigator	MONASH UNIVERSITY	Linkage Projects (AUST RESEARCH COUNCIL)	01/07/2008
Multi-photon imaging for infection, immunity, and self recognition	Chief Investigator	AUST RESEARCH COUNCIL	Linkage Infrastructure (Equipment and Facilities)	01/01/2009
CHEMICAL AIDED PHOSPOPROTEOME SEQUENCING WITH MASS SPECTROMETRY	Principal Supervisor	NHMRC	Training (Postdoctoral) Fellowships	01/01/2009
CHARACTERISATION OF VIRUS-SPECIFIC IMMUNE RECOGNITION	Principal Supervisor	NHMRC	Training (Postdoctoral) Fellowships	01/01/2009
PROTEIN EXPRESSION PROFILING OF MULTIPLE SCLEROSIS AND IT'S MURINE MODEL	Principal Supervisor	MULTIPLE SCLEROSIS RESEARCH AUSTRALIA	Postgraduate Research Scholarships	01/01/2009
A PROTEIN MOLECULAR INTERACTION AND LOCALIZATION FACILITY LE100100036	Chief Investigator	AUST RESEARCH COUNCIL	Linkage Infrastructure (Equipment and Facilities)	01/01/2010
CHANGES IN THE ANTIGENIC PEPTIDE REPERTOIRE DURING PROGRESSION TO TYPE 1 DIABETES	Chief Investigator	DIABETES AUST RESEARCH TRUST	General Grants	01/01/2011
A STRUCTURAL INVESTIGATION INTO THE ADAPTIVE IMMUNE RESPONSE TO A PERSISTENT AND UBIQUITOUS HUMAN VIRUS	Chief Investigator	MONASH UNIVERSITY	Project Grants (NHMRC)	01/01/2011
Biosynthesis, folding and modification of conotoxins	Chief Investigator	AUST RESEARCH COUNCIL	Discovery Projects	01/01/2011
Vaccination against Helicobacter pylori and gastric barrier function	Chief Investigator	NHMRC	Project Grants	01/01/2012
QUANTIFICATION OF ANTIGEN PRESENTATION TO CD8 T CELLS DURING VIRUS INFECTION	Chief Investigator	THE AUSTRALIAN NATIONAL UNIVERSITY	Project Grants (NHMRC)	01/01/2012
Role of modified antigen in rheumatoid arthritis	Chief Investigator	ANZ CHARITABLE TRUSTS	Medical Research and Technology Grants

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2011

Journal Articles

β2-Glycoprotein I and Protection from Anti-SSA/Ro60-Associated Cardiac Manifestations of Neonatal Lupus

Year:	2011
Journal:	Journal of Immunology
Volume:	187
Issue:	1
Page numbers:	520-526
Author(s):
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A novel strategy for the targeted analysis of protein and peptide metabolites

Year:	2011
Journal:	Proteomics
Volume:	11
Issue:	2
Page numbers:	183-192
Author(s):
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Defining the Substrate Specificity Determinants Recognized by the Active Site of C-Terminal Src Kinase-Homologous Kinase (CHK) and Identification of β-Synuclein as a Potential CHK Physiological Substrate

Year:	2011
Journal:	Biochemistry
Volume:	50
Issue:	31
Page numbers:	6667-6677
Author(s):
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Direct quantitation of MHC-bound peptide epitopes by selected reaction monitoring.

Year:	2011
Journal:	Proteomics
Volume:	11
Issue:	11
Page numbers:	2336-2340
Author(s):
URL - open access	http://onlinelibrary.wiley.com/doi/10.1002/pmic.201000531/abstract;jsessionid=23EAAD252C2043E9D5335136266D436B.d01t04
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Embryonic Toxin Expression in the Cone Snail Conus victoriae PRIMED TO KILL OR DIVERGENT FUNCTION?

Year:	2011
Journal:	Journal of Biological Chemistry
Volume:	286
Issue:	25
Page numbers:	22546-22557
Author(s):
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Experimental autoimmune encephalomyelitis (EAE) IN C57Bl/6 mice is not associated with astrogliosis

Year:	2011
Journal:	Journal of Neuroimmunology
Volume:	232
Issue:	1-2
Page numbers:	51-62
Author(s):
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Peptidomimetics: modifying peptides in the pursuit of better vaccines.

Year:	2011
Journal:	Expert Review of Vaccines
Volume:	10
Issue:	2
Page numbers:	211-226
Author(s):
URL - open access	http://www.expert-reviews.com/doi/abs/10.1586/erv.10.161?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed
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Specialisation of the Venom Gland Proteome in Predatory Cone Snails Reveals Functional Diversification of the Conotoxin Biosynthetic Pathway

Year:	2011
Journal:	Journal of Proteome Research
Volume:	10
Issue:	9
Page numbers:	3904-3919
Author(s):
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Stable isotope shifted matrices enable the use of low mass ion precursor scanning for targeted metabolite identification

Year:	2011
Journal:	Proteome Science
Volume:	9
Issue:	2
Author(s):
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Structural basis for enabling T-cell receptor diversity wihtin biased virus-specific CD8+ T-cell responses

Year:	2011
Journal:	Proceedings of the National Academy of Sciences of the United States of America
Volume:	108
Issue:	23
Page numbers:	9536-9541
Author(s):
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Publications in 2010

Journal Articles

A Modular BAM Complex in the Outer Membrane of the alpha-Proteobacterium Caulobacter crescentus

Year:	2010
Journal:	PLoS One
Volume:	5
Issue:	1
Author(s):
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Allelic polymorphism in the T cell receptor and its impact on immune responses

Year:	2010
Journal:	Journal of Experimental Medicine
Volume:	207
Issue:	7
Page numbers:	1555-1567
Author(s):
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Constraints within major histocompatibility complex class I restricted peptides: Presentation and consequences for T-cell recognition

Year:	2010
Journal:	Proceedings of the National Academy of Sciences of the United States of America
Volume:	107
Issue:	12
Page numbers:	5534-5539
Author(s):
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Enhancing tumor vaccines: catalyzing MHC class II peptide exchange.

Year:	2010
Journal:	Expert Review of Vaccines
Volume:	9
Issue:	2
Page numbers:	129-32
Author(s):
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Epitope discovery and their use in Peptide based vaccines

Year:	2010
Journal:	Current Pharmaceutical Design
Volume:	16
Issue:	28
Page numbers:	3149-3157
Author(s):
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Hard wiring of T cell receptor specificity for the major histocompatibility complex is underpinned by TCR adaptability

Year:	2010
Journal:	Proceedings of the National Academy of Sciences of the United States of America
Volume:	107
Issue:	23
Page numbers:	10608-10613
Author(s):
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Identification of Conus Peptidylprolyl Cis-Trans Isomerases (PPIases) and Assessment of Their Role in the Oxidative Folding of Conotoxins

Year:	2010
Journal:	Journal of Biological Chemistry
Volume:	285
Issue:	17
Page numbers:	12735-12746
Author(s):
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Protective Efficacy of Cross-Reactive CD8⁺T Cells Recognising Mutant Viral Epitopes Depends on Peptide-MHC-I Structural Interactions and T Cell Activation Threshold

Year:	2010
Journal:	PLoS Pathogens
Volume:	6
Issue:	8
Page numbers:	e1001039-e1001039
Author(s):
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Proteomic Interrogation of Venom Delivery in Marine Cone Snails: Novel Insights into the Role of the Venom Bulb

Year:	2010
Journal:	Journal of Proteome Research
Volume:	9
Issue:	11
Page numbers:	5610-5619
Author(s):
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Rapid microscale in-gel processing and digestion of proteins using surface acoustic waves

Year:	2010
Journal:	Lab On a Chip: Microfluidic and nanotechnologies for chemistry, biology, and bioengineering
Volume:	10
Issue:	12
Page numbers:	1518-1520
Author(s):
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Reactivity with dichotomous determinants of Ro 60 stratifies autoantibody responses in lupus and primary Sjögren's syndrome

Year:	2010
Journal:	Arthritis and Rheumatism
Volume:	62
Issue:	5
Page numbers:	1448-1456
Author(s):
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The structural basis for autonomous dimerization of the pre-T-cell antigen receptor

Year:	2010
Journal:	Nature
Volume:	467
Page numbers:	844-848
Author(s):
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Publications in 2009

Journal Articles

A long, naturally presented immunodominant epitope from NY-ESO-1 tumor antigen: Implications for cancer vaccine design

Year:	2009
Journal:	Cancer Research
Volume:	69
Issue:	3
Page numbers:	1046-1054
Author(s):
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Antigen Ligation Triggers a Conformational Change within the Constant Domain of the αβ T Cell Receptor

Year:	2009
Journal:	Immunity
Page numbers:	777-788
Author(s):
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Mass Spectral Identification of Vc1.1 and Differential Distribution of Conopeptides in the Venom Duct of Conus victoriae. Effect of Post-Translational Modifications and Disulfide Isomerisation on Bioactivity

Year:	2009
Journal:	International Journal of Peptide Research and Therapeutics
Volume:	15
Page numbers:	195-203
Author(s):
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Natural micropolymorphism in human leukocyte antigens provides a basis for genetic control of antigen recognition

Year:	2009
Journal:	Journal of Experimental Medicine
Volume:	206
Issue:	1
Page numbers:	209-219
Author(s):
URL - restricted access	http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=19139173
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Phosphorylated self-peptides alter human leukocyte antigen class I-restricted antigen presentation and generate tumor-specific epitopes.

Year:	2009
Journal:	Proceedings of the National Academy of Sciences of the United States of America
Volume:	106
Issue:	8
Page numbers:	2776-2781
Author(s):
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Post-translationally modified T cell epitopes: immune recognition and immunotherapy

Year:	2009
Journal:	Journal of Molecular Medicine
Volume:	87
Issue:	11
Page numbers:	1045-51
Author(s):
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T Cell Allorecognition via Molecular Mimicry

Year:	2009
Journal:	Immunity
Volume:	31
Page numbers:	897-908
Author(s):
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The A-chain of insulin is a hot-spot for CD4+ T-cell epitopes in human type 1 diabetes.

Year:	2009
Journal:	Clinical and Experimental Immunology
Volume:	156
Page numbers:	226-231
Author(s):
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The Protein Import Channel in the Outer Mitosomal Membrane of Giardia intestinalis

Year:	2009
Journal:	Molecular Biology and Evolution
Volume:	26
Issue:	9
Page numbers:	1941-1947
Author(s):
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The shaping of T cell receptor recognition by self-tolerance

Year:	2009
Journal:	Immunity
Volume:	30
Issue:	2
Page numbers:	193-203
Author(s):
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Publications in 2008

Journal Articles

Can alpha- and beta-alanine containing peptides be distinguished based on the CID spectra of their protonated ions?

Year:	2008
Journal:	Journal of the American Society for Mass Spectrometry
Volume:	19
Issue:	12
Page numbers:	1743-1754
Author(s):
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Complete modification of TCR specificity and repertoire selection does not perturb a CD8+ T cell immunodominance hierarchy

Year:	2008
Journal:	Proceedings of the National Academy of Sciences of the United States of America
Volume:	105
Issue:	49
Page numbers:	19408-19413
Author(s):
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Epitope-specific TCRß repertoire diversity imparts no functional advantage on the CD8+ T cell response to cognate viral peptides

Year:	2008
Journal:	Proceedings of the National Academy of Sciences of the United States of America
Volume:	105
Issue:	6
Page numbers:	2034-2039
Author(s):
URL - restricted access	http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=18238896
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Human Leukocyte Antigen Class I-Restricted Activation of CD8⁺ T Cells Provides the Immunogenetic Basis of a Systemic Drug Hypersensitivity

Year:	2008
Journal:	Immunity
Volume:	28
Page numbers:	822-832
Author(s):
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Immunodominance Hierarchies and Gender Bias in Direct T _CD8-Cell Alloreactivity

Year:	2008
Journal:	American Journal of Transplantation
Volume:	8
Page numbers:	121-132
Author(s):
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Impact of glycans on T-cell tolerance to glycosylated self-antigens.

Year:	2008
Journal:	Immunology and Cell Biology
Volume:	86
Issue:	7
Page numbers:	574-9
Author(s):
URL - restricted access	http://www.ncbi.nlm.nih.gov/pubmed/18626489?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum
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Molecular machinations of the MHC-I peptide loading complex

Year:	2008
Journal:	Current Opinion in Immunology
Volume:	20
Issue:	1
Page numbers:	75-81
Author(s):
URL - restricted access	http://www.ncbi.nlm.nih.gov/pubmed/18243674?ordinalpos=17&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum
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Prevention of Cytotoxic T Cell Escape Using a Heteroclitic Subdominant Viral T Cell Determinant

Year:	2008
Journal:	PLoS Pathogens
Volume:	4
Issue:	10
Article number:	e1000186
Author(s):
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Protein secretion and outer membrane assembly in Alphaproteobacteria.

Year:	2008
Journal:	FEMS Microbiology Reviews
Volume:	32
Issue:	6
Page numbers:	995-1009
Author(s):
URL - restricted access	http://www.ncbi.nlm.nih.gov/entrez/utils/fref.fcgi?PrId=3046&itool=AbstractPlus-def&uid=18759741&db=pubmed&url=http://www3.interscience.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0168-6445&date=2008&volume=32&issue=6&spage=995
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Refinement in the production and purification of recombinant HCMV IE1-pp65 protein for the generation of epitope-specific T cell immunity.

Year:	2008
Journal:	Protein Expression and Purification
Volume:	61
Issue:	1
Page numbers:	22-30
Author(s):
URL - restricted access	http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6WPJ-4SH6BBC-2&_user=10&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=a28fafac31122db39d1d1f5dbdab4ca3
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Structural and biological basis of CTL escape in coronavirus-infected mice

Year:	2008
Journal:	Journal of Immunology
Volume:	180
Issue:	6
Page numbers:	3926-3937
Author(s):
URL - restricted access	http://www.jimmunol.org/cgi/content/abstract/180/6/3926
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T-cells behaving badly: structural insights into alloreactivity and autoimmunity

Year:	2008
Journal:	Current Opinion in Immunology
Volume:	20
Page numbers:	575-580
Author(s):
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The Enantioselective Total Synthesis and Unambiguous Proof of the Absolute Stereochemistry of Pervilleine C

Year:	2008
Journal:	Synlett
Volume:	14
Page numbers:	2209-2212
Author(s):
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Publications in 2007

Journal Articles

β-Amino acid-containing hybrid peptides-new opportunities in peptidomimetics

Year:	2007
Journal:	Organic & Biomolecular Chemistry
Volume:	5
Page numbers:	2884-2890
Author(s):
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A Structural and Immunological Basis for the Role of Human Leukocyte Antigen DQ8 in Celiac Disease

Year:	2007
Journal:	Immunity
Volume:	27
Page numbers:	23-34
Author(s):
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A T cell receptor flattens a bulged antigenic peptide presented by a major histocompatibility complex class I molecule

Year:	2007
Journal:	Nature Immunology
Volume:	8
Page numbers:	268-276
Author(s):
URL - restricted access	http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17259989
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Conserved Motifs Reveal Details Of Ancestry and Structure in the Small TIM Chaperones of the Mitochondrial Intermemberane Space

Year:	2007
Journal:	Molecular Biology and Evolution
Volume:	24
Issue:	5
Page numbers:	1149-1160
Author(s):
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Expression and purification of the minor histocompatability antigen, HA-1H generated in Escherichia coli

Year:	2007
Journal:	Protein Expression and Purification
Volume:	54
Issue:	1
Page numbers:	176-182
Author(s):
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Immune responses to abacavir in antigen-presenting cells from hypersensitive patients

Year:	2007
Journal:	AIDS
Volume:	21
Page numbers:	1233-1244
Author(s):
URL - open access	http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17545699
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More than one reason to rethink the use of peptides in vaccine design

Year:	2007
Journal:	Nature Reviews Drug Discovery
Volume:	6
Issue:	5
Page numbers:	404-14
Author(s):
URL - restricted access	http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17473845
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The Molecular Basis of Cross-Reactivity in the Australian Snake Venom Detection Kit (SVDK)

Year:	2007
Journal:	Toxicon
Volume:	50
Issue:	8
Page numbers:	1041-1052
Author(s):
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Publications in 2006

Journal Articles

C-terminal Src Kinase-homologous Kinase (CHK), a Unique Inhibitor Inactivating Multiple Active Conformations of Src Family Tyrosine Kinases

Year:	2006
Journal:	Journal of Biological Chemistry
Volume:	281
Issue:	44
Page numbers:	32988-32999
Author(s):
URL - restricted access	http://www.jbc.org/cgi/reprint/281/44/32988
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Disparate thermodynamics governing T cell receptor–MHC-I interactions implicate extrinsic factors in guiding MHC restriction

Year:	2006
Journal:	Proceedings of the National Academy of Sciences of the United States of America
Volume:	103
Issue:	17
Page numbers:	6641-6646
Author(s):
URL - restricted access	http://www.pnas.org/cgi/content/full/103/17/6641
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Responses against islet antigens in NOD mice prevented by tolerance to proinsulin but not IGRP

Year:	2006
Journal:	Journal of Clinical Investigation
Volume:	116
Issue:	12
Page numbers:	3258-3264
Author(s):
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Tumors reveal their secrets to cytotoxic T cells

Year:	2006
Journal:	Proceedings of the National Academy of Sciences of the United States of America
Volume:	103
Issue:	40
Page numbers:	14649-14650
Author(s):
URL - restricted access	http://www.pnas.org/cgi/content/full/103/40/14649
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Publications in 2005

Journal Articles

A charged Amino Acid Residue in the Transmembrane/Cytoplasmic Region of Tapasin Influences MHC Class I Assembly and Maturation¹

Year:	2005
Journal:	Journal of Immunology
Volume:	174
Issue:	2
Page numbers:	962-969
Publisher:	American Association of Immunologists(Maryland)
Author(s):
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An emerging role for comprehensive proteome analysis in human pregnancy research

Year:	2005
Journal:	Reproduction
Volume:	129
Page numbers:	685-696
Publisher:	Society of Reproduction and Fertility(Cambridge)
Author(s):
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Antagonism of Antiviral and Allogeneic Activity of a Human Public CTL Clonotype by a Single Altered Peptide Ligand: Implications for Allograft Rejection¹

Year:	2005
Journal:	Journal of Immunology
Volume:	174
Issue:	9
Page numbers:	5593-5601
Publisher:	American Association of Immunologists(Maryland)
Author(s):
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CTL Recognition of a Bulged Viral Peptide Involves Biased TCR Selection¹

Year:	2005
Journal:	Journal of Immunology
Volume:	175
Issue:	6
Page numbers:	3826-3834
Publisher:	American Association of Immunologists(Maryland)
Author(s):
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High Resolution Structures of Highly Bulged Viral Epitopes Bound to Major Histocompatibility Complex Class I. Implications for T-cell Receptor Engagement and T-cell Immunodominance

Year:	2005
Journal:	Journal of Biological Chemistry
Volume:	280
Issue:	25
Page numbers:	23900-23909
Publisher:	American Society for Biochemistry and Molecular Biology(Maryland)
Author(s):
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Lack of prominent peptide-major histocompatibility complex features limits repertoire diversity in virus-specific CD8⁺ T cell populations

Year:	2005
Journal:	Nature Immunology
Volume:	6
Issue:	4
Page numbers:	382-389
Author(s):
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Qualitative and Quantitative Differences in Peptides Bound to HLA-B27 in the Presence of Mouse versus Human Tapasin Define a Role for Tapasin as a Size-Dependent Peptide Editor¹

Year:	2005
Journal:	Journal of Immunology
Volume:	174
Issue:	12
Page numbers:	7833-7844
Publisher:	American Association of Immunologists(Maryland)
Author(s):
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T Cell Determinants Incorporating B-Amino Acid Residues Are Protease Resistant and Remain Immunogenic In Vivo

Year:	2005
Journal:	Journal of Immunology
Volume:	175
Page numbers:	3810-3818
Publisher:	American Association of Immunologists(Maryland)
Author(s):
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T cell receptor recognition of a 'super-bulged' major histocompatibility complex class I-bound peptide

Year:	2005
Journal:	Nature Immunology
Volume:	6
Issue:	11
Page numbers:	1114-1122
Author(s):
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The CDR3 regions of an immunodominant T cell receptor dictate the 'energetic landscape' of peptide-MHC recognition

Year:	2005
Journal:	Nature Immunology
Volume:	6
Issue:	2
Page numbers:	171-180
Author(s):
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The immunogenicity of a viral cytotoxic T cell epitope is controlled by its MHC-bound conformation

Year:	2005
Journal:	Journal of Experimental Medicine
Volume:	202
Issue:	9
Page numbers:	1249-1260
Publisher:	Rockefeller University Press(New York)
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The insulin A-chain epitope recognized by human T cells is posttranslationally modified

Year:	2005
Journal:	Journal of Experimental Medicine
Volume:	202
Issue:	9
Page numbers:	1191-1197
Publisher:	Rockefeller University Press(New York)
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Use of proteomics to define targets of T-cell immunity

Year:	2005
Journal:	Expert Review in Proteomics
Volume:	2
Issue:	3
Page numbers:	367-380
Publisher:	Future Drugs(London)
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Conference Publications/Papers

A Super-Bulged Epitope and Single Amino Acid Polymorphism Identify Critical Features for T Cell Recognition

Year:	2005
Event name:	35th ASI - 14th IHIWS
Conference Publication:	Tissue Antigens
Volume:	66
Issue:	5
Page numbers:	571-571
Publisher:	Blackwell Publishing
Author(s):

Publications in 2004

Book Chapters

Isolation and Characterization of Naturally Processed MHC-Bound Peptides From the Surface of Antigen-Presenting Cells

Year:	2004
Book:	HPLC of Peptides and Proteins: Methods and Protocols
Publisher:	Humana Press(New Jersey)
Authors(s):

Journal Articles

Crystal structure of the human T cell receptor CD3εγ heterodimer complexed to the therapeutic mAB OKT3

Year:	2004
Journal:	Proceedings of the National Academy of Sciences of the United States of America
Volume:	101
Issue:	20
Page numbers:	7675-7680
Publisher:	National Academy of Sciences(Washington DC)
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Functional and structural characteristics of NY-ESO-1-related HLA A2-restricted epitopes and the design of a novel immunogenic analogue

Year:	2004
Journal:	Journal of Biological Chemistry
Volume:	279
Issue:	22
Page numbers:	23438-23446
Publisher:	American Society for Biochemistry and Molecular Biology(Maryland)
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Immunoproteomics: Mass spectrometry-based methods to study the target of the immune response*

Year:	2004
Journal:	Molecular and Cellular Proteomics
Volume:	3
Page numbers:	193-208
Publisher:	American Society for Biochemistry and Molecular Biology(Maryland)
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Natural HLA class I polymorphism controls the pathway of antigen presentation and susceptibility to viral evasion

Year:	2004
Journal:	Journal of Experimental Medicine
Volume:	200
Page numbers:	13-24
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Predisposition to abacavir hypersensitivity conferred by HLA-B*5701 and a haplotypic Hsp70-Hom variant

Year:	2004
Journal:	Proceedings of the National Academy of Sciences of the United States of America
Volume:	101
Issue:	12
Page numbers:	4180-4185
Publisher:	National Academy of Sciences(Washington DC)
Author(s):
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TAP genes and immunity

Year:	2004
Journal:	Current Opinion in Immunology
Volume:	16
Issue:	5
Page numbers:	651-659
Publisher:	Current Biology(London)
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The Structure of H-2K^b and K^bm8 Complexed to a Herpes Simplex Virus Determinant: Evidence for a Conformational Switch That Governs T Cell Repertoire Selection and Viral Resistance^1,2

Year:	2004
Journal:	Journal of Immunology
Volume:	173
Page numbers:	402-409
Publisher:	American Association of Immunologists(Maryland)
Author(s):
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The production and purification of the human T-cell receptors, the CD3εγ and CD3εδ heterodimers: complex formation and crystallization with OKT3, a therapeutic monoclonal antibody

Year:	2004
Journal:	Acta Crystallographica Section D - Biological Crystallography
Volume:	D60
Page numbers:	1425-1428
Publisher:	Munksgaard International Publishers(Copenhagen)
Author(s):
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Publications in 2003

Journal Articles

A Naturally Selected Dimorphism within the HLA-B44 Supertype Alters Class I Structure, Peptide Repertoire, and T Cell Recognition

Year:	2003
Journal:	Journal of Experimental Medicine
Volume:	198
Issue:	5
Page numbers:	679-691
Author(s):
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A Structural Basis for the Selection of Dominant αβ T Cell Receptors in Antiviral Immunity

Year:	2003
Journal:	Immunity
Volume:	18
Issue:	1
Page numbers:	53-64
Author(s):
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A sensitive method for detecting proliferation of rare autoantigen-specific human T cells

Year:	2003
Journal:	Journal of Immunological Methods
Volume:	283
Page numbers:	173-183
Publisher:	Elsevier Science(Amsterdam)
Author(s):
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Association of stress proteins with autoantigens: a possible mechanism for triggering autoimmunity?

Year:	2003
Journal:	Clinical and Experimental Immunology
Volume:	132
Page numbers:	193-200
Publisher:	Blackwell Science(Oxford)
Author(s):
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Dissecting the Role of Peptides in the Immune Response: Theory, Practice and the Application to Vaccine Design

Year:	2003
Journal:	Journal of Peptide Science
Volume:	9
Page numbers:	255-281
Publisher:	John Wiley & Sons(West Sussex)
Author(s):
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Human T-cells recognise N-terminally Fmoc-modified peptide

Year:	2003
Journal:	Vaccine
Volume:	21
Page numbers:	3638-3646
Publisher:	Elsevier Science(Oxford)
Author(s):
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Novel strategy for identification of candidate cytotoxic T-cell epitopes from human preproinsulin

Year:	2003
Journal:	Tissue Antigens
Volume:	62
Page numbers:	408-417
Publisher:	Munksgaard International Publishers(Copenhagen)
Author(s):
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Publications in 2002

Journal Articles

Identification of a dominant self-ligand bound to three HLA B44 alleles and the preliminary crystallographic analysis of recombinant forms of each complex

Year:	2002
Journal:	FEBS Letters
Volume:	527
Page numbers:	27-32
Publisher:	Elsevier Science(Amsterdam)
Author(s):
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Identification of an I-A^d restricted peptide on the 65-kilodalton heat shock protein of Mycobacterium avium

Year:	2002
Journal:	Immunology and Cell Biology
Volume:	80
Page numbers:	574-583
Publisher:	Blackwell Science Asia(Carlton)
Author(s):
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Optimization of the MHC Class I Peptide Cargo Is Dependent on Tapasin

Year:	2002
Journal:	Immunity
Volume:	16
Page numbers:	509-520
Publisher:	Cell Press(Massachusetts)
Author(s):
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Restricted Specificity of Intermolecular Spreading to Endogenous La (SS-B) and 60 kDa Ro (SS-A) in Experimental Autoimmunity

Year:	2002
Journal:	Scandinavian Journal of Immunology
Volume:	56
Page numbers:	168-173
Publisher:	Blackwell Publishers(Oxford)
Author(s):
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The 1.5 Å Crystal Structure of a Highly Selected Antiviral T Cell Receptor Provides Evidence for a Structural Basis of Immunodominance

Year:	2002
Journal:	Structure
Volume:	10
Page numbers:	1521-1532
Publisher:	Cell Press(Cambridge)
Author(s):
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The Central Role Played by Peptides in the Immune Response and the Design of Peptide-Based Vaccines Against Infectious Diseases and Cancer

Year:	2002
Journal:	Current Drug Targets
Volume:	3
Page numbers:	175-196
Publisher:	Bentham Science Publishers(Hilversum)
Author(s):
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The Structure of HLA-B8 Complexed to an Immunodominant Viral Determinant: Peptide-Induced Conformational Changes and a Mode of MHC Class I Dimerization¹

Year:	2002
Journal:	Journal of Immunology
Volume:	169
Page numbers:	5153-5160
Publisher:	American Association of Immunologists(Maryland)
Author(s):
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The production, purification and crystallization of a soluble heterodimeric form of a highly selected T-cell receptor in its unliganded and liganded state.

Year:	2002
Journal:	Acta Crystallographica Section D - Biological Crystallography
Volume:	58
Page numbers:	2131-2134
Author(s):
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Publications in 2001

Journal Articles

Quantitative and Qualitative Influences of Tapasin on the Class I Peptide Repertoire

Year:	2001
Journal:	Journal of Immunology
Volume:	166
Page numbers:	1016-1027
Author(s):
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The use of post-source decay in matrix-assisted laser desorption/ionisation mass spectrometry to delineate T cell determinants

Year:	2001
Journal:	Journal of Immunological Methods
Volume:	249
Page numbers:	17-31
Publisher:	Elsevier Science(Amsterdam)
Author(s):
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A/PROF ANTHONY PURCELL

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