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DR PHILLIP DARCY



Contact Details

Organization: Pathology
Position: Honorary (Fellow)
Homepage: http://www.petermac.unimelb.edu.au
Work: 96561111
Building: No Building
Campus: Peter Maccallum Hospital

Research Expertise and International Linkages

Research Expertise

Research Interest Country of Expertise
Microbiology and Biochemistry Australia

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Bachelor of Science La Trobe University 31-Dec-1988
Doctor of Philosophy University of Melbourne 31-Dec-1992

Memberships

Membership Type Membership Body Description Start Date End Date
Unspecified Australian Society for Microbiology Member 01-Jan-1988
Unspecified Victorian Society of Pathology & Experimental Medicine Member 01-Jan-1988
Unspecified Australian Society for Biochemistry and Molecular Biology Member 01-Jan-1992

Other Awards

Award Type Awarding Body Comments Date Awarded
Scholarship Commonwealth Post-graduate Scholarship 31-Dec-1992
Other (Award) Poster award, Australia and New Zealand Society for Cell Biology, 8th Annual Meeting, Melbourne 31-Dec-1990
Other (Award) Travel grant from Australian Society for Microbiology to attned the 1991 meeting, Brisbane 31-Dec-1991

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
Preclinical development of gene-engineered T cells for immunotherapy of cancer Chief Investigator CANCER COUNCIL VICTORIA Grants-in-Aid 01/01/2004
RD Wright Biomedical Career Development Award Chief Investigator NHMRC R Douglas Wright Awards 01/01/2004
PHASE 1 STUDY FOR INFUSION OF AUTOLOGOUS PERIFERAL BLOOD T LYMPHOCYTES TRANDUSCED WITH AN ANTI LEWIS Y CHIMERIC RECEPTOR GENE IN PATIENTS WITH LEWIS Y POSITIVE MULTIPLE MYELOMA Chief Investigator LEUKEMIA & LYMPHOMA SOCIETY Translational Research Program 01/10/2005
IMMUNOTHERAPY OF LEWIS Y+ MALIGNANCY USING GENETICALLY ENGINEERED T CELLS Chief Investigator CANCER COUNCIL VICTORIA Grants-in-Aid 01/01/2007
COMBINING VACCINES AND ADOPTIVE T CELL TRANSFER FOR BREAST CANCER IMMUNOTHERAPY Chief Investigator THE SUSAN G KOMEN BREAST CANCER FOUNDATION Basic, Clinical or Translational Research 06/09/2007
An integrated approach for the immunotherapy of cancer Chief Investigator NHMRC Project Grants 01/01/2008
Specific targeting of the immune system against cancer Chief Investigator NHMRC Career Development Awards 01/01/2009

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2009

Journal Articles

  • The Lewis-Y carbohydrate antigen is expressed by many human tumors and can serve as a target for genetically redirected T cells despite the presence of soluble antigen in serum
    Year: 2009
    Journal: Journal of Immunotherapy
    Volume: 32
    Issue: 3
    Page numbers: 292-301
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Publications in 2008

Journal Articles

  • Absence of retroviral vector-mediated transformation of gene-modified T cells after long-term engraftment in mice
    Year: 2008
    Journal: Gene Therapy
    Volume: 15
    Page numbers: 1056-1066
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  • Adoptive transfer of Gene-modified primary NK cells can specifically inhibit tumor progression In Vivo
    Year: 2008
    Journal: Journal of Immunology
    Volume: 181
    Issue: 5
    Page numbers: 3449-3455
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Publications in 2007

Journal Articles

  • Sustained antigen-specific antitumor recall response mediated by gene-modified CD4(+) T helper-1 and CD8(+) T cells


    Year: 2007
    Journal: Cancer Research
    Volume: 67
    Issue: 23
    Page numbers: 11428-11437
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Publications in 2006

Journal Articles

  • Adoptive transfer of chimeric Fc(epsilon)Ri gene-modified human T cells for cells for cancer immunotherapy


    Year: 2006
    Journal: Human Gene Therapy
    Volume: 17
    Issue: 11
    Page numbers: 1134-1143
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Publications in 2005

Journal Articles

  • A network of PDZ-containing proteins regulate T cell polarity and morphology during motility and immunological synapse formation
    Year: 2005
    Journal: Immunity
    Volume: 22
    Page numbers: 737-748
    Publisher: Cell Press(Massachusetts)
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  • Frizzled-7 receptor ectodomain expression in a colon cancer cell line induces morphological change and attenuates tumor growth
    Year: 2005
    Journal: Differentiation
    Volume: 73
    Page numbers: 142-153
    Publisher: Blackwell Publishers
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  • Gene modification strategies to induce tumor immunity
    Year: 2005
    Journal: Immunity
    Volume: 22
    Page numbers: 403-414
    Publisher: Cell Press(Massachusetts)
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  • Supernatural T cells: genetic modification of T cells for cancer therapy
    Year: 2005
    Journal: Nature Reviews Immunology
    Volume: 5
    Issue: 12
    Page numbers: 928-940
    Publisher: Nature Publishing Group(London)
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Publications in 2004

Journal Articles

  • Gene-engineered T cells as a superior adjuvant therapy for metastatic cancer
    Year: 2004
    Journal: Journal of Immunology
    Volume: 173
    Page numbers: 2143-2150
    Publisher: American Association of Immunologists(Maryland)
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  • Immunotherapy of cancer using systemically delivered gene-modified human T lymphocytes
    Year: 2004
    Journal: Human Gene Therapy
    Volume: 15
    Page numbers: 699-708
    Publisher: Mary Ann Leibert Publishers
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  • Mutational analysis of P-glycoprotein: suppression of caspase activation in the absence of ATP-dependent drug efflux
    Year: 2004
    Journal: Cell Death & Differentiation
    Volume: 11
    Page numbers: 1028-1037
    Publisher: Nature Publishing Group(Basingstroke)
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  • The functional basis for hemophagocytic lymphohistiocytosis in a patient with co-inherited Missense mutations in the perforin (PFN1) gene
    Year: 2004
    Journal: Journal of Experimental Medicine
    Volume: 200
    Page numbers: 811-816
    Publisher: Rockefeller University Press(New York)
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Publications in 2003

Journal Articles

  • Blastocyst MHC, a putative murine homologue of HLA-G, protects TAP-deficient tumor cells from natural killer cell-mediated rejection in vivo
    Year: 2003
    Journal: Journal of Immunology
    Volume: 171
    Page numbers: 1715-1721
    Publisher: American Association of Immunologists(Maryland)
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Publications in 2002

Journal Articles

  • A role for IFN-γ in primary and secondary immunity generated by NK cell-sensitive tumor-expressing CD80 in vivo
    Year: 2002
    Journal: Journal of Immunology
    Volume: 168
    Page numbers: 4472-4479
    Publisher: American Association of Immunologists(Maryland)
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  • Cutting edge: tumor rejection mediated by NKG2D receptor-ligand interaction is dependent upon perforin
    Year: 2002
    Journal: Journal of Immunology
    Volume: 169
    Page numbers: 5377-5381
    Publisher: American Association of Immunologists(Maryland)
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  • Induction of tumor-specific T cell memory by NK cell-mediated tumor rejection
    Year: 2002
    Journal: Nature Immunology
    Volume: 3
    Page numbers: 83-90
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  • P-glycoprotein inhibits caspase-8 activation but not formation of the death inducing signal complex (disc) following Fas ligation
    Year: 2002
    Journal: Cell Death & Differentiation
    Volume: 9
    Page numbers: 1266-1272
    Publisher: Nature Publishing Group(Basingstroke)
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  • Rejection of syngeneic colon carcinoma by CTLs expressing single-chain antibody receptors codelivering CD28 costimulation
    Year: 2002
    Journal: Journal of Immunology
    Volume: 169
    Page numbers: 5780-5786
    Publisher: American Association of Immunologists(Maryland)
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  • Single-chain antigen recognition receptors that costimulate potent rejection of established experimental tumours
    Year: 2002
    Journal: Gene Therapy
    Volume: 100
    Page numbers: 3155-3163
    Publisher: Nature Publishing Group(Basingstroke)
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