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Find an ExpertProfiling the University of Melbourne's Researchers

PROF KONG CHOO



Contact Details

Organization: Paediatrics Royal Children's Hospital
Position: Honorary (Professorial Fellow)
Email:

Biography

Prefered Name - Andy

Andy is the Theme Director of Laboratory & Community Genetics at the Murdoch Childrens Research Institute and his e-mail address is andy.choo@mcri.edu.au, he was awarded Professor, Department of Paediatrics, University of Melbourne in 2002.

Research Expertise and International Linkages

Research Expertise

Research Interest Key Words Country of Expertise
Genetic research Centromere, Artificial Chromosome Construction, Gene Therapy Australia

Qualifications, Honours, Fellowships and Other Awards

Qualifications

Title Institution Date Awarded Abbreviation
Bachelor of Science University of Melbourne 31-Dec-1976
Doctor of Philosophy University of Melbourne 31-Dec-1979

Government Research Classifications

Research Fields, Courses and Discipline Classifications

Socio-Economic Objective Classifications

Grants and Contracts

Research Grants, Contracts and Consultancies awarded to the University of Melbourne as the administering institution (since 2003) as recorded in Themis Agreements.

Grants

Title Role Funding Source Scheme Award Date
Taming the intruders: the domestication of Tigger transposable elements in mammals Chief Investigator AUST RESEARCH COUNCIL Discovery Projects 01/01/2007

Publications

Publications produced at the University of Melbourne and reported in the Annual Publications Collection and 'Research Report' since 2001. The Themis Publications module, released in November 2006, allows additional publications from previous institutions and publications from past years to be entered.

Publications in 2009

Journal Articles

  • Histone H3.3 incorporation provides a unique and functionally essential telomeric chromatin in embryonic stem cells
    Year: 2009
    Journal: Genome Research
    Volume: 19
    Page numbers: 404-414
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  • LINE retrotransposon RNA is an essential structural and functional epigenetic component of a core neocentromeric chromatin
    Year: 2009
    Journal: PLoS Genetics
    Volume: 5
    Issue: 1
    Page numbers: 354-363
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Publications in 2008

Journal Articles

Publications in 2007

Journal Articles

  • Centromere RNA is a key component for the assembly of nucleoproteins at the nucleous and centromere
    Year: 2007
    Journal: Genome Research
    Volume: 17
    Page numbers: 1146-60
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Publications in 2006

Journal Articles

  • High-Throughput Analysis of Chromosome Abnormality in Spontaneous Miscarriage Using an MLPA Subtelomere Assay With an Ancillary FISH Test for Polyploidy
    Year: 2006
    Journal: American Journal of Medical Genetics
    Volume: 140A
    Page numbers: 2786-2793
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  • Mouse telocentric sequences reveal a high rate of homogenization and possible role in Robertsonian translocation
    Year: 2006
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 103
    Issue: 23
    Page numbers: 8786-8791
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Publications in 2005

Journal Articles

  • Analysis of mitotic and expression properties of human neocentromere-based transchromosomes in mice
    Year: 2005
    Journal: Journal of Biological Chemistry
    Volume: 280
    Issue: 5
    Page numbers: 3954-3962
    Publisher: American Society for Biochemistry and Molecular Biology(Maryland)
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  • BAC-based PCR fragment microarray: High resolution detection of chromosomal deletion and duplication breakpoints
    Year: 2005
    Journal: Human Mutation
    Volume: 25
    Issue: 5
    Page numbers: 476-482
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  • Detection of cryptic subtelomeric chromosome abnormalities and identification of anonymous chromatin using a quantitative multiplex ligation-dependent probe amplification (MLPA)
    Year: 2005
    Journal: Human Mutation
    Volume: 26
    Issue: 5
    Page numbers: 477-486
    Publisher: Wiley-Liss(New York)
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  • Engineering chromosomes for delivery of therapeutic genes.
    Year: 2005
    Journal: Trends in Biotechnology
    Volume: 23
    Issue: 12
    Page numbers: 575-583
    Publisher: Elsevier Science London(London)
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  • High-resolution identification of chromosomal abnormalities using oligonucleotide arrays containing 166,204 SNPs
    Year: 2005
    Journal: American Journal of Human Genetics
    Volume: 77
    Issue: 5
    Page numbers: 709-726
    Publisher: University of Chicago Press(Illinois)
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  • Increased chromosome instability but not cancer predisposition in haploinsufficient Bub3 mice.
    Year: 2005
    Journal: Genes, Chromosomes & Cancer
    Volume: 44
    Issue: 1
    Page numbers: 29-36
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  • Kiss and break up - a safe passage to anaphase in mitosis and meiosis
    Year: 2005
    Journal: Chromosoma
    Volume: 114
    Issue: 4
    Page numbers: 252-262
    Publisher: Springer Verlag(New York)
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  • Molecular distinction between true centric fission and pericentric duplication-fisson
    Year: 2005
    Journal: Human Genetics
    Volume: 116
    Issue: 4
    Page numbers: 300-316
    Publisher: Springer Verlag(New York)
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  • Mosaic monosomy for 13q31.1-13q32.3 with neocentromere stabilisation of the deleted region maps brachyphalangy, growth hormone deficiency and a neocentromere site to 13q31.1-13q32.3
    Year: 2005
    Journal: American Journal of Medical Genetics
    Volume: 133A
    Issue: 2
    Page numbers: 151-157
    Publisher: Wiley-Liss(New York)
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  • Spef1, a conserved novel testis protein found in mouse sperm flagella
    Year: 2005
    Journal: Gene
    Volume: 353
    Issue: 2
    Page numbers: 189-199
    Publisher: Elsevier Science(Amsterdam)
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  • Unstable robertsonian translocations der(13q;15q): Heritable chromosome fission without phenotypic effect in two kindreds
    Year: 2005
    Journal: American Journal of Medical Genetics
    Volume: 136
    Page numbers: 25-30
    Author(s):
    URL - restricted access http://www3.interscience.wiley.com/journal/110493218/abstract?CRETRY=1&SRETRY=0
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  • Variable and hierarchicalsiz distribution of L1-retroelement-enriched CENP-A clusters within a functional human nencentromere.
    Year: 2005
    Journal: Human Molecular Genetics
    Volume: 14
    Issue: 1
    Page numbers: 85-93
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  • Variable and hierarchicalsiz distribution of L1-retroelement-enriched CENP-A clusters within a functional human nencentromere.
    Year: 2005
    Journal: Human Molecular Genetics
    Volume: 14
    Issue: 1
    Page numbers: 85-93
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Publications in 2004

Journal Articles

  • Centromere protein b-null mice display decreasing reproductive performance through successive generations of breeding due to diminishing endometrial glands.
    Year: 2004
    Journal: Reproduction
    Volume: 127
    Issue: 3
    Page numbers: 367-377
    Publisher: Society of Reproduction and Fertility(Cambridge)
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  • Building the centromere: from foundation proteins to 3D organization.
    Year: 2004
    Journal: Trends in Cell Biology
    Volume: 14
    Issue: 7
    Page numbers: 359-368
    Publisher: Elsevier Science London(London)
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  • Centric fission - simple and complex mechanisms.
    Year: 2004
    Journal: Chromosome Research
    Volume: 12
    Issue: 6
    Page numbers: 627-640
    Publisher: Kluwer Academic Publishers(Dordrecht)
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  • Chromosome size and origin as determinants of the level of CENP-A incorporation into human centromeres
    Year: 2004
    Journal: Chromosome Research
    Volume: 12
    Page numbers: 805-815
    Publisher: Kluwer Academic Publishers(Dordrecht)
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  • Effects of scaffold/matrix alteration on centromeric function and gene expression.
    Year: 2004
    Journal: Journal of Biochemistry
    Volume: 279
    Issue: 36
    Page numbers: 37631-37639
    Publisher: Japanese Biochemical Society(Tokyo)
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  • Evolutionary dynamics of transposable elements at the centromere
    Year: 2004
    Journal: Trends in Genetics
    Volume: 20
    Page numbers: 611-616
    Publisher: Elsevier Science London(London)
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  • Human centromere repositioning "in progress"
    Year: 2004
    Journal: Proceedings of the National Academy of Sciences of the United States of America
    Volume: 101
    Issue: 17
    Page numbers: 6542-6547
    Publisher: National Academy of Sciences(Washington DC)
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  • Improved testing for CMT1A and HNPP using multiplex ligation-dependent probe amplification (MLPA) with rapid DNA preparations: comparison with the interphase FISH method.
    Year: 2004
    Journal: Human Mutation
    Volume: 24
    Issue: 2
    Page numbers: 164-171
    Publisher: Wiley-Liss(New York)
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  • Mosaic monosomy of a neocentric ring chromosome maps brachyphalangy and growth hormone deficiency to 13q31.1-13q32.3
    Year: 2004
    Journal: American Journal of Medical Genetics
    Volume: 133A
    Page numbers: 151-157
    Publisher: Wiley-Liss(New York)
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Publications in 2003

Journal Articles

  • A rapid method of genomic array analysis of scaffold/matrix attachment regions (S/MARs) identifies a 2.5-Mb region of enhanced scaffold/matrix attachment at a human neocentromere.
    Year: 2003
    Journal: Genome Research
    Volume: 13
    Issue: 7
    Page numbers: 1737-1743
    Publisher: Cold Spring Harbour Laboratory Press
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  • Analysis of mammalian proteins involved in chromatin modification reveals new metaphase centromeric proteins and distinct chromosomal distribution patterns.
    Year: 2003
    Journal: Human Molecular Genetics
    Volume: 12
    Issue: 23
    Page numbers: 3109-3121
    Publisher: Oxford University Press(Oxford)
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  • Centromeric chromatin pliability and memory at a human neocentromere.
    Year: 2003
    Journal: EMBO Journal
    Volume: 22
    Issue: 10
    Page numbers: 2495-2504
    Publisher: Oxford University Press(Oxford)
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  • David M. Danks, MD, AO (June 4, 1931-July 8, 2003): Founder, Murdoch Childrens Research Institute - Obituary.
    Year: 2003
    Journal: American Journal of Human Genetics
    Volume: 73
    Issue: 5
    Page numbers: 981-985
    Publisher: University of Chicago Press(Illinois)
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  • Partially functional Cenpa-GFP fusion protein causes increased chromosome missegregation and apoptosis during mouse embryogenesis.
    Year: 2003
    Journal: Chromosome Research
    Volume: 11
    Issue: 4
    Page numbers: 345-357
    Publisher: Kluwer Academic Publishers(Dordrecht)
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  • Rapid, high throughput prenatal detection of aneuploidy using a novel quantitative method (MPLA).
    Year: 2003
    Journal: Journal of Medical Genetics
    Volume: 40
    Issue: 12
    Page numbers: 907-912
    Publisher: BMJ Publishing Group(London)
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  • Transcription within a functional human centromere.
    Year: 2003
    Journal: Molecular Cell
    Volume: 12
    Issue: 2
    Page numbers: 509-516
    Publisher: Cell Press(Philadelphia)
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Publications in 2002

Journal Articles

  • Centromere proteins cenpa, cenpb, and bub3 interact with PARP-1 protein and are poly(ADP-ribosyl)ated.
    Year: 2002
    Journal: Journal of Biological Chemistry
    Volume: 277
    Issue: 30
    Page numbers: 26921-26926
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  • Construction of neocentromere-based human minichromosomes for gene delivery and centromere studies
    Year: 2002
    Journal: Gene Therapy
    Volume: 9
    Issue: 11
    Page numbers: 724-726
    Author(s):
    URL - open access http://www.nature.com/gt/journal/v9/n11/full/3301756a.html
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  • Neocentromere: role in human disease, evolution, and centromere study
    Year: 2002
    Journal: American Journal of Human Biology
    Volume: 71
    Page numbers: 695-714
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  • Poly (ADP ribose) polmerase-2 localizes to mammalian active centromeres and interacts with PARP-1, Cenpa, Cenpb, and Bub3, but not Cenpc.
    Year: 2002
    Journal: Human Molecular Genetics
    Volume: 11
    Issue: 19
    Page numbers: 2319 - 2329
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  • Strategies for engineering human chromosomes with therapeutic potential
    Year: 2002
    Journal: Journal of Gene Medicine
    Volume: 4
    Issue: 1
    Page numbers: 5-13
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